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Hematology - Myelodysplastic Syndrome International Prognostic Scoring System

Myelodysplastic Syndrome International Prognostic Scoring System

Select Criteria:
Percentage of Bone Marrow Blasts
< 5 percent (0 points)
5 to 10 percent (0.5 points)
11 to 20 percent (1.5 points)
21 to 30 percent (2.0 points)
Karyotype
Normal, Y-, 5q-, 20q- (0 points)
Abnormal chromosome 7 or 3 or more abnormalities (1.0 points)
All other cytogenic abnormalities (0.5 points)
Cytopenias (defined as hemoglobin < 10 g/dL, absolute neutrophil count < 1800/microL, platelet count < 100,000/microL)
No cytopenia or cytopenia of 1 cell type (0 points)
Cytopenia of 2 or 3 cell types (0.5 points)
Results: Total Criteria Point Count:
Prognostic Score Interpretation
0 Points:Low (Median Survival of 5.7 yrs)
0.5 - 1 Points:Intermediate 1 (Median Survival of 3.5 yrs.)
1.5 - 2.0 Points:Intermediate 2 (Median Survival of 1.2 yrs.)
2.5-3.5 Points:High (Median Survival of 0.4 yrs.)
  1. Greenberg P, Cox C, LeBeau MM et. al. International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes. Blood. 1997; 89;6: 2079 - 2088. Erratum in Blood 1998; 91:1100.
  2. Heaney ML, Golde, DW. Medical Progress: Myelodysplasia. NEJM. 1999; 340;21: 1649-1660.
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