Hematology - Multiple Myeloma Diagnostic Criteria

Multiple Myeloma Diagnostic Criteria

Select Criteria:

Diagnostic : 1 Major Criteria and 1 Minor Criteria

Diagnostic : 0 Major Criteria and 3 Minor Criteria
Major Diagnostic Criteria
Plasmacytoma on tissue biopsy
Bone marrow plasmacytosis of > 30%
M Protein: IgG > 3.5 g/L; IgA > 2.0 g/L
Urinary kappa or lambda chain excretion of > 1g / 24 hours in absence of amyloidosis
Minor Diagnostic Criteria
Marrow plasmacytosis of 10-30%
Lytic bone lesions
Evidence of a monoclonal protein but lessor amounts than above
Hypoglobulinemia of normal proteins: IgM < 500 mg/L, IgA < 1 g/L or IgG < 6g/L
  1. Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Cancer. 1975; 36:842-854.
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