CARBAMATE HERBICIDES AND FUNGICIDES
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
Methyl sulfanilylcarbamate Methyl [(4-aminophenyl)sulfonyl]carbamate CAS 3337-71-1 (asulam) CAS 2302-17-2 (asulam sodium) S-ethyl-di-isobutylthiocarbamte CAS 2008-41-5 2-Benzimidazolecarbamic acid, methyl ester Benzimidazole-2-carbamic acid, methyl ester Carbendazole Carbendazym FB642 Methyl-2-benzimidazolecarbamate CAS 10605-21-7 CAS 63090-40-4 CAS 63278-70-6 CAS 105268-95-9 CAS 16118-49-3 Isopropyl 3-chlorocarbanilate 1-methylethyl (3-chlorophenyl)carbamate CAS 101-21-3 Heylthiocarbam S-ethyl N-cyclohexyl(N-ethyl)thiocarbamate CAS 1134-23-2 ETU Iron tris(dimethyldithiocarbamate) Ferric dimethyldithiocarbamate CAS 14484-64-1 Manganese ethylenebis (dithiocarbamate) (polymeric) complex with zinc salt CAS 8018-01-7 Manganese ethylenebis (dithiocarbamate) polymeric [1,2-ethanediylbis[carbamodithioato](2)]manganese CAS 12427-38-2 S-ethyl azepane-1-carbothioate CAS 2212-67-1 Disodium ethylenebis(dithiocarbamate) CAS 142-59-6 S-propyl butyl(ethyl)thiocarbamate CAS 1114-71-2 Methyl 3-(3-methylcarbaniloyloxy)carbanilate CAS 13684-63-4 Propyl 3-(dimethylamino)propylcarbamate Propamocarb hydrochloride CAS 2506-41-1 (propamocarb hydrochloride) Isoproyl phenylcarbamate 1-methylethyl phenylcarbamate CAS 122-42-9 Bis(dimethylcarbamoyl) disulfide Bis(dimethylthiocarbamoyl) disulfide Tetramethylthioperoxydicarbonic diamide Tetramethyl thiuram disulfide Thirame TMTD TTD TMTDS CAS 137-26-8 Zebenide Zinc, (ethylenebis(dithiocarbamato))- Zinosan Molecular Formula: C4-H6-N2-S4.Zn CAS 142-14-3 CAS 12122-67-7 CAS 14039-25-9 Bis(dimethyldithiocarbamato)zinc Carbazinc Dimethyldithiocarbamate zinc salt Methyl Ziram Zinc, bis(dimethyldithiocarbamato)- Ziradin Ziride Molecular Formula: C6-H12-N2-S4.Zn CAS 137-30-4 CAS 8059-74-3 CAS 8070-07-3 FUNGICIDES, CARBAMATE CARBAMATE HERBICIDES/ FUNGICIDES CARBAMATE FUNGICIDES AND HERBICIDES BIS(DIMETHYLTHIO CARBAMOYL)DISULPHIDE HERBICIDES, CARBAMATE
Methyl sulfanilylcarbamate Methyl [(4-aminophenyl)sulfonyl]carbamate CAS 3337-71-1 (asulam) CAS 2302-17-2 (asulam sodium)
2-Benzimidazolecarbamic acid, methyl ester Benzimidazole-2-carbamic acid, methyl ester Carbendazole Carbendazym FB642 Methyl-2-benzimidazolecarbamate CAS 10605-21-7 CAS 63090-40-4 CAS 63278-70-6 CAS 105268-95-9
Propyl 3-(dimethylamino)propylcarbamate Propamocarb hydrochloride CAS 2506-41-1 (propamocarb hydrochloride)
Bis(dimethylcarbamoyl) disulfide Bis(dimethylthiocarbamoyl) disulfide Tetramethylthioperoxydicarbonic diamide Tetramethyl thiuram disulfide Thirame TMTD TTD TMTDS CAS 137-26-8
Bis(dimethyldithiocarbamato)zinc Carbazinc Dimethyldithiocarbamate zinc salt Methyl Ziram Zinc, bis(dimethyldithiocarbamato)- Ziradin Ziride Molecular Formula: C6-H12-N2-S4.Zn CAS 137-30-4 CAS 8059-74-3 CAS 8070-07-3
FUNGICIDES, CARBAMATE CARBAMATE HERBICIDES/ FUNGICIDES CARBAMATE FUNGICIDES AND HERBICIDES BIS(DIMETHYLTHIO CARBAMOYL)DISULPHIDE HERBICIDES, CARBAMATE
IDENTIFIERS
USES/FORMS/SOURCES
These chemicals are applied as dusts, sprays of solutions, and wettable powder suspensions and emulsions, depending on the chemical and physical properties of the various agents. Formulations are widely used for pest control in home gardens and in commercial agriculture. CARBENDAZIM: Used as a systemic broad-spectrum fungicide for prevention and control of plant diseases on a variety of crops (e.g., vegetables, fruits, nuts, cereals, cotton, ornamentals, mushrooms). It is a major metabolite of benomyl. The fungicidal property is due to binding of carbendazim to tubulins, thus disrupting microtubule formation and mitosis. Carbendazim is also used as a preservative in the paint, textile, papermaking and leather industries (Selmanoglu et al, 2001). Carbendazim is also currently undergoing clinical trials in adult patients with advanced malignancies (i.e., breast cancer, melanoma, colon cancer) (Hao et al, 2002). ETU (Ethylenethiourea): Used as an accelerator in rubber vulcanization, in dyes, synthetic resins, electroplating baths, and pharmaceuticals (Kurttio & Savolainen, 1990). THIRAM: Used for foliage and seed treatment, as a disinfectant for nuts, fruits, and mushrooms, and as a rodent and large animal repellent.
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- USES: These products are used to control noxious plants and fungi in home gardens and agriculture. Common examples are thiram, carbendazim, maneb, ethylene thiourea, zineb, and ziram.
- TOXICOLOGY: Some of these agents may inhibit aldehyde dehydrogenase and cause disulfiram-like reactions. Carbamate herbicides and fungicides do not inhibit the cholinesterase enzyme; therefore exposure to these agents will NOT result in cholinergic findings.
- EPIDEMIOLOGY: Exposure to these products is very rare, and there are only a few cases of serious toxicity reported in the literature.
MILD TO MODERATE POISONING: The main effects are dermal, respiratory, and gastrointestinal irritation. Dermal exposure to some of these agents may cause a disulfiram-like reaction. SEVERE POISONING: Seizures, altered mental status, and coma have been rarely reported. Renal failure has been suggested, but the reports are of questionable quality.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
- Wash exposed skin with soap and water. Remove contaminated clothing. Irrigate exposed eyes with water. Prehospital gastrointestinal decontamination is not recommended.
-RANGE OF TOXICITY
MAXIMUM TOLERATED EXPOSURE
- Carcinogenicity Ratings for CAS137-26-8 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): A4 ; Listed as: Thiram EPA (U.S. Environmental Protection Agency, 2011): Not Assessed under the IRIS program. ; Listed as: Thiram IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 3 ; Listed as: Thiram 3 : The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Thiram MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS137-26-8 (U.S. Environmental Protection Agency, 2011):
Oral: Slope Factor: RfD: 5x10(-3) mg/kg-day
Inhalation: Drinking Water:
CARBENDAZIM LD50- (ORAL)DOG: LD50- (ORAL)GUINEA_PIG: LD50- (ORAL)MOUSE: LD50- (ORAL)RABBIT: LD50- (ORAL)RAT: LD50- (SKIN)RAT:
THIRAM LC50- (INHALATION)RAT: LD50- (ORAL)MOUSE: 1250 mg/kg (RTECS , 2002) 2050-2500 mg/kg (Dalvi, 1988)
LD50- (ORAL)RABBIT: 210 mg/kg (RTECS , 2002) 350 mg/kg (Dalvi, 1988)
LD50- (ORAL)RAT:
VONDOZEB LD50- (SKIN)RABBIT: LD50- (ORAL)RAT: LD50- (SKIN)RAT:
ZINEB LD50- (ORAL)MOUSE: LD50- (ORAL)RABBIT: LD50- (ORAL)RAT: LD50- (SKIN)RAT:
ZIRAM LC50- (INHALATION)MOUSE: LC50- (INHALATION)RAT: LD50- (ORAL)GUINEA_PIG: LD50- (ORAL)MOUSE: LD50- (ORAL)RABBIT: LD50- (SKIN)RABBIT: LD50- (ORAL)RAT: LD50- (SKIN)RAT:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS137-26-8 (American Conference of Governmental Industrial Hygienists, 2010):
Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.
- AIHA WEEL Values for CAS137-26-8 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS137-26-8 (National Institute for Occupational Safety and Health, 2007):
Listed as: Thiram REL: IDLH: IDLH: 100 mg/m3 Note(s): Not Listed
- OSHA PEL Values for CAS137-26-8 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
Listed as: Thiram Table Z-1 for Thiram: 8-hour TWA: ppm: mg/m3: 5 Ceiling Value: Skin Designation: No Notation(s): Not Listed
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS137-26-8 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS137-26-8 (U.S. Environmental Protection Agency, 2010):
Listed as: Thioperoxydicarbonic diamide [(H2N)C(S)] 2S2, tetramethyl- Final Reportable Quantity, in pounds (kilograms): Additional Information: Listed as: Thiram Final Reportable Quantity, in pounds (kilograms): Additional Information:
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS137-26-8 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS137-26-8 (U.S. Environmental Protection Agency, 2010b):
Listed as: Thioperoxydicarbonic diamide [(H2 N)C(S)]2 S2, tetramethyl- P or U series number: U244 Footnote: Listed as: Thiram P or U series number: U244 Footnote: Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.
- EPA SARA Title III, Extremely Hazardous Substance List for CAS137-26-8 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS137-26-8 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS137-26-8 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS137-26-8 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS137-26-8 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 137-26-8.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS137-26-8 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS137-26-8 (NFPA, 2002):
REACTIVITY HAZARD
- Is decomposed by acids (Dalvi, 1988).
- Is somewhat decomposed on prolonged exposure to heat or moisture (Hartley & Kidd, 1987).
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS137-26-8 (AIHA, 2006):
- DOE TEEL Values for CAS137-26-8 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Thiram (Thioperoxydicarbonic diamide [(H2N)C(S)]2S2, tetramethyl-) TEEL-0 (units = mg/m3): 0.05 TEEL-1 (units = mg/m3): 10 TEEL-2 (units = mg/m3): 75 TEEL-3 (units = mg/m3): 100 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS137-26-8 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS137-26-8 (National Institute for Occupational Safety and Health, 2007):
IDLH: 100 mg/m3 Note(s): Not Listed
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Is a white, crystalline solid.
DENSITY
- OTHER TEMPERATURE AND/OR PRESSURE
SOLUBILITY
-REFERENCES
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- 65 FR 39264: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 65 FR 77866: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
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- 69 FR 54144: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2004.
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