BUTYL BENZYL PHTHALATE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
BUTYL BENZYL PHTHALATE PHTHALIC ACID, BENZYL BUTYL ESTER BBP 1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER BENZYL-BUTYLESTER KYSELINY FTALOVE (Czech) BENZYL BUTYL PHTHALATE BENZYL n-BUTYL PHTHALATE n-BUTYL BENZYL PHTHALATE BUTYL PHENYLMETHYL 1,2-BENZENEDICARBOXYLATE PALATINOL BB SANTICIZER 160 SICOL 160 UNIMOLL BB
IDENTIFIERS
USES/FORMS/SOURCES
BBP is used as a chemical intermediate, plasticizer in vinyl floors, acrylic resins, adhesives and other plastics, in automotive coatings, nail polish, and gas-permeable contact lenses (HSDB; (IARC, 1982; Lewis, 1993). Butyl benzyl phthalate is considered an estrogenic environmental chemical (Sharpe et al, 1995).
BUTYL BENZYL PHTHALATE (BBP) is a clear, oily liquid with a slight odor (HSDB; (Lewis, 1993). It is only slightly soluble in water (2.9 mg/L) (HSDB). It is available in technical grade (Lewis, 1993). BBP can be contaminated with benzyl chloride and benzal chloride, known animal carcinogens (Rittfeldt, 1983; 23).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
ACUTE CLINICAL EFFECTS
- BBP is a mucous membrane irritant and a CNS depressant (HSDB). Symptoms of CNS depression include nausea, headache, weakness, dizziness, incoordination, and loss of consciousness.
CHRONIC CLINICAL EFFECTS
- BBP has caused polyneuropathy in chronically-exposed workers (HSDB). Prolonged contact with the liquid may cause irritation of the skin and eyes (HSDB). BBP was not a sensitizer in humans and guinea pigs (Baida, 1974).
- Prolonged BBP exposure affected blood circulation and clotting ability in rats (Agarwal, 1985), and also caused changes in liver function tests (Batnova, 1982). When given orally to mice, rats, or guinea pigs, BBP caused various neurological effects (Timofievskaya, 1974). Another study found BBP to be practically nontoxic and non-cumulative in mice and rats at an unspecified dosage (Statsek, 1974).
-RANGE OF TOXICITY
MAXIMUM TOLERATED EXPOSURE
- Carcinogenicity Ratings for CAS85-68-7 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): C ; Listed as: Butyl benzyl phthalate IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 3 ; Listed as: Butyl benzyl phthalate 3 : The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS85-68-7 (U.S. Environmental Protection Agency, 2011):
Oral: Slope Factor: RfD: 2x10(-1) mg/kg-day
Inhalation: Drinking Water:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS85-68-7 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS85-68-7 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS85-68-7 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS85-68-7 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS85-68-7 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS85-68-7 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS85-68-7 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS85-68-7 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS85-68-7 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS85-68-7 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS85-68-7 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS85-68-7 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS85-68-7 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 85-68-7.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS85-68-7 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS85-68-7 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS85-68-7 (AIHA, 2006):
- DOE TEEL Values for CAS85-68-7 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Phthalic acid, benzyl butyl ester; (Benzyl butyl phthalate) TEEL-0 (units = mg/m3): 5 TEEL-1 (units = mg/m3): 100 TEEL-2 (units = mg/m3): 500 TEEL-3 (units = mg/m3): 500 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS85-68-7 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS85-68-7 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Butyl benzyl phthalate is a clear, oily liquid with a slight odor (HSDB, 2005).
VAPOR PRESSURE
- 8.6 x 10(-6) mmHg (at 20 degrees C) (HSDB, 2005)
SPECIFIC GRAVITY
- STANDARD TEMPERATURE AND PRESSURE
DENSITY
FREEZING/MELTING POINT
BOILING POINT
- 370 degrees C; 698 degrees F (HSDB, 2005)
-REFERENCES
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- 65 FR 14186: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 65 FR 39264: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 65 FR 77866: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 66 FR 21940: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2001.
- 67 FR 7164: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2002.
- 68 FR 42710: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2003.
- 69 FR 54144: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2004.
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