ZINC PHOSPHIDE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
Trizinc diphosphide ZnP Zn3P2 CAS 1314-84-7
IDENTIFIERS
SYNONYM REFERENCE
- (RTECS , 1990)AAR, 1987; EPA, 1985;(HSDB , 1990)
USES/FORMS/SOURCES
Zinc phosphide is dark gray to black in color and is available as pellets, granules, dust, and tracking powders (Gervais, et al, 2010).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- USES: Zinc phosphide (Zn3P2, ZnP) is an inorganic dark gray crystalline powder used as a rodenticide.
- TOXICOLOGY: Its toxicity is secondary to the release of phosphine gas on contact with moisture or moist air. Phosphine blocks cytochrome C oxidase. This document covers effects from ingestion of zinc phosphide. Information on the effects of inhalation of phosphine gas are covered in a separate management.
- EPIDEMIOLOGY: Human poisoning is uncommon, but occurs worldwide and can be fatal.
MILD TO MODERATE TOXICITY: Nausea, vomiting, and abdominal pain are common. Tachycardia, fatigue, headache, dizziness, anxiety, restlessness, dyspnea, tachypnea, and hypoglycemia may develop. SEVERE TOXICITY: CNS excitation or depression, hypotension, dysrhythmias, metabolic and respiratory acidosis, jaundice, elevated liver enzymes, seizures, and acute lung injury may develop. Pancreatitis is a rare complication.
- POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
Highly toxic: contact with water produces toxic gas, may be fatal if inhaled. Inhalation or contact with vapors, substance, or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
- Prehospital gastrointestinal decontamination is not recommended because of the potential for formation of phosphine gas and the potential for abrupt deterioration.
-MEDICAL TREATMENT
LIFE SUPPORT
- Support respiratory and cardiovascular function.
SUMMARY
- FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, wipe from skin immediately; flush skin or eyes with running water for at least 20 minutes. Keep victim warm and quiet. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
Ingestion of 4 to 7 grams of zinc phosphide has caused death (Orak et al, 2008; EPA, 1985). Doses as low as 40 mg/kg may cause death in humans (Dipalma, 1981). Deaths have been reported from a total dose of 4 grams of zinc phosphide (Stephenson, 1967). A prospective analysis of 20 patients with acute zinc phosphide poisoning was conducted. Clinical signs and symptoms, including vomiting, restlessness and anxiety, palpitations and sweating, dyspnea, tachypnea, metabolic acidosis, hypotension, jaundice with hepatomegaly, pulmonary edema, and shock were reported following a mean ingestion of 7.5 g (ranging from 5 to 20 g). Five of the 20 patients died due to intractable shock, unresponsive to resuscitative measures (Chugh et al, 1998).
Severe metabolic acidosis (acute distal renal tubular acidosis) developed in a 25-year-old man after ingesting approximately 7 g of zinc phosphide powder in a suicide attempt. Despite supportive care, he developed cardio-pulmonary arrest and died 5 hours after admission (Orak et al, 2008). CASE REPORT: A 22-year-old woman presented to the emergency department comatose (Glasgow Coma Scale score of 8) with tachypnea, dyspnea, cyanosis, tachycardia, and hypotension after intentionally ingesting 10% zinc phosphide powder. The estimated ingested amount was approximately 10 g . Physical examination revealed hyperventilation and rales and rhonchi in lungs bilaterally, an ECG revealed depression of ST waves, laboratory data showed elevated cardiac enzyme concentrations and a chest radiograph demonstrated increased radiodensity in the basal lobes of the lungs, indicating acute pulmonary edema and congestive heart failure. Despite aggressive supportive measures, the patient had a cardiac arrest and could not be successfully resuscitated, with death occurring approximately 4 hours post-admission. Autopsy revealed congested and edematous lungs with petechial hemorrhages on the cardiac surface (Sogut et al, 2011).
MAXIMUM TOLERATED EXPOSURE
Phosphine is a highly toxic gas. The minimal detectable (decaying fish odor) concentration is 1 to 3 ppm in air. The gas dissipates rapidly in an open air environment; it is primarily a problem in confined spaces. A prospective analysis of 20 patients with acute zinc phosphide poisoning was conducted. Clinical signs and symptoms, including vomiting, restlessness and anxiety, palpitations and sweating, dyspnea, tachypnea, metabolic acidosis, hypotension, jaundice with hepatomegaly, pulmonary edema, and shock were reported following a mean ingestion of 7.5 g (ranging from 5 to 20 g). Five of the 20 patients died due to intractable shock, unresponsive to resuscitative measures (Chugh et al, 1998).
A 36-year-old male psychiatric patient ingested 2 capfuls (approximately 20 grams) of ACME(R) MOLE and RAT KILLER (PBI/Gordon Corporation) containing 2% zinc phosphide (approximately 400 milligrams) in a suicide attempt 1 to 2 hours prior to admission (Rodenberg et al, 1989). This patient was given syrup of ipecac and activated charcoal/sorbitol, and remained asymptomatic during a 4-hour observation period (Rodenberg et al, 1989). It was estimated that this patient did not ingest more than 6 milligrams/kilogram of zinc phosphide.
Survival has been reported after a total dose of 50 grams of zinc phosphide (Stephenson, 1967). Zinc phosphide ingestions of 25 to 50 grams have been survived (EPA, 1985). In a review of 21 zinc phosphide exposures, ingestion of one gram or less was associated with a good outcome (Lohani et al, 2000).
- Carcinogenicity Ratings for CAS1314-84-7 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Assessed under the IRIS program. ; Listed as: Zinc phosphide IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS1314-84-7 (U.S. Environmental Protection Agency, 2011):
Oral: Slope Factor: RfD: 3x10(-4) mg/kg-day
Inhalation: Drinking Water:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS1314-84-7 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS1314-84-7 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS1314-84-7 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS1314-84-7 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS1314-84-7 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS1314-84-7 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS1314-84-7 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS1314-84-7 (U.S. Environmental Protection Agency, 2010b):
Listed as: Zinc phosphide Zn3 P2, when present at concentrations greater than 10% P or U series number: P122 Footnote: Listed as: Zinc phosphide Zn3 P2, when present at concentrations of 10% or less P or U series number: U249 Footnote: Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.
- EPA SARA Title III, Extremely Hazardous Substance List for CAS1314-84-7 (U.S. Environmental Protection Agency, 2010):
Listed as: Zinc Phosphide Reportable Quantity, in pounds: 100 Threshold Planning Quantity, in pounds: Note(s): a a: This material is a reactive solid. The TPQ does not default to 10,000 pounds for non-powder, non-molten, non-solution form.
- EPA SARA Title III, Community Right-to-Know for CAS1314-84-7 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS1314-84-7 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS1314-84-7 (EPA, 2005):
SHIPPING REGULATIONS
- DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 1714 (49 CFR 172.101, 2005):
- ICAO International Shipping Name for UN1714 (ICAO, 2002):
LABELS
- NFPA Hazard Ratings for CAS1314-84-7 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 1314-84-7.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS1314-84-7 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
- SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
- LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
DRY sand, dry chemical, soda ash or lime or withdraw from area and let fire burn. FOR CHLOROSILANES, DO NOT USE WATER; use AFFF alcohol-resistant medium expansion foam; DO NOT USE dry chemicals, soda ash or lime on chlorosilane fires (large or small) as they may release large quantities of hydrogen gas that may explode. Move containers from fire area if you can do it without risk.
- TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not get water inside containers. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire.
- NFPA Extinguishing Methods for CAS1314-84-7 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.
- LARGE SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
Increase, in the downwind direction, as necessary, the isolation distance of at least 50 meters (150 feet) for liquids and 25 feet (75 meters) for solids in all directions.
- FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
- PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004)
CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number: MEXICO: SETIQ: 01-800-00-214-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5559-1588; For calls originating elsewhere, call: 011-52-555-559-1588.
CENACOM: 01-800-00-413-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885; For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.
ARGENTINA: CIQUIME: 0-800-222-2933 in the Republic of Argentina; For calls originating elsewhere, call: +54-11-4613-1100.
BRAZIL: PRÓ-QUÍMICA: 0-800-118270 (Toll-free in Brazil); For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).
COLUMBIA: CISPROQUIM: 01-800-091-6012 in Colombia; For calls originating in Bogotá, Colombia, call: 288-6012; For calls originating elsewhere, call: 011-57-1-288-6012.
CANADA: UNITED STATES:
For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate the area before entry.
- AIHA ERPG Values for CAS1314-84-7 (AIHA, 2006):
- DOE TEEL Values for CAS1314-84-7 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Zinc phosphide TEEL-0 (units = ppm): 0.05 TEEL-1 (units = ppm): 0.15 TEEL-2 (units = ppm): 1 TEEL-3 (units = ppm): 1.8 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS1314-84-7 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
Listed as: Zinc phosphide Final Value: AEGL-1 10 min exposure: 30 min exposure: 1 hr exposure: 4 hr exposure: 8 hr exposure:
Definitions: AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling, are transient, and are reversible upon cessation of exposure.
Listed as: Zinc phosphide Final Value: AEGL-2 10 min exposure: 30 min exposure: 1 hr exposure: 4 hr exposure: 8 hr exposure:
Definitions: AEGL-2 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape.
Listed as: Zinc phosphide Final Value: AEGL-3 10 min exposure: 30 min exposure: 1 hr exposure: 4 hr exposure: 8 hr exposure:
Definitions: AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening health effects or death.
- NIOSH IDLH Values for CAS1314-84-7 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004) Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch or walk through spilled material. Stop leak if you can do it without risk. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. FOR CHLOROSILANES, use AFFF alcohol-resistant medium expansion foam to reduce vapors.
POWDER SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004) Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 139 (ERG, 2004) Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Cubic, dark-gray, tetragonal crystalline or powder solid with a faint phosphorus odor (Budavari, 1996).
DENSITY
- TEMPERATURE AND/OR PRESSURE NOT LISTED
-REFERENCES
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- 62 FR 58840: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 1997.
- 65 FR 14186: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 65 FR 39264: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 65 FR 77866: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.
- 66 FR 21940: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2001.
- 67 FR 7164: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2002.
- 68 FR 42710: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2003.
- 69 FR 54144: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2004.
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