ARIPIPRAZOLE

OPC-31
OPC-14597
7-(4-(4-(3,4-Dichlorophenyl)-piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one
7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
Molecular Formula: C23-H27-Cl2-N3-O2
CAS 129722-12-9

IDENTIFIERS

CAS REGISTRY NUMBER

129722-12-9(Aripiprazole)

MOLECULAR FORMULA

ARIPIPRAZOLE: C23H27Cl2N3O2
ARIPIPRAZOLE LAUROXIL: C36H51C12N3O4

ERG GUIDE NUMBER

Editor's Note: An ERG guide with information appropriate to this material does not exist.

USES/FORMS/SOURCES

USES

Aripiprazole is approved for the treatment of schizophrenia and acute manic and mixed episodes associated with bipolar disorder, the maintenance treatment of bipolar disorder, the adjunctive treatment of major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar mania (Prod Info ABILIFY(R) oral tablets, oral solution, intramuscular injection solution, 2012).

FORMS

Aripiprazole is available as 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg tablets, or 10 mg and 15 mg orally disintegrating tablets, or 1 mg/mL oral solution, or 9.75 mg/1.3 mL (7.5 mg/mL) solutions for injection, available in single-dose vials as a ready-to-use (Prod Info ABILIFY DISCMELT(R) oral disintegrating tablets , 2013; Prod Info ABILIFY(R) oral tablets, oral solution, intramuscular injection solution, 2012).
Extended-release aripiprazole is available as an injectable suspension in 300 mg or 400 mg/vials of lyophilized powder for reconstitution (Prod Info ABILIFY MAINTENA intramuscular injection extended-release suspension, 2013) and as 441 mg/1.6 mL, 662 mg/2.4 mL, and 882 mg/3.2 mL injectable suspension, available as single-use pre-filled syringes (Prod Info ARISTADA(TM) intramuscular extended-release injection, 2015).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

USES: Aripiprazole is an atypical antipsychotic agent used for the treatment of acute agitation in adults with schizophrenia or bipolar mania, for mood stabilization in patients with bipolar I disorder, as an adjunctive medication for depression, and for treatment of schizophrenia. In children, it as been used for treatment of aggression, conduct disorder, Tourette syndrome, bipolar I disorder, irritability associated with autistic disorder, and schizophrenia.

PHARMACOLOGY: Aripiprazole is a quinolinone antipsychotic that has moderate to high affinity to various dopaminergic and serotonin receptors as well as H1 and alpha-1 adrenergic receptors. It also has moderate affinity for the serotonin reuptake transporter and acts as a partial agonist at the D2 and 5-HT1a receptors and as an antagonist at the 5-HT2a receptor.

TOXICOLOGY: Aripiprazole exerts its toxicity through the above effects on the various receptors.

EPIDEMIOLOGY: Overdose is fairly common; severe toxicity is rare and fatalities have not been reported from overdose with aripiprazole alone.

WITH POISONING/EXPOSURE

MILD TO MODERATE TOXICITY: In overdose, the most prominent effect seen is CNS sedation. After a mild to moderate exposure, other symptoms reported have included tachycardia, tremors, irritability, and nausea/vomiting.
SEVERE TOXICITY: More severe effects reported from aripiprazole overdoses/exposures include hypotension, coma, and neuroleptic malignant syndrome.

WITH THERAPEUTIC USE

COMMON: The most common adverse reactions include CNS symptoms (headache, agitation, insomnia, anxiety, extrapyramidal symptoms, akathisia, sedation) and gastrointestinal symptoms (weight gain, nausea, constipation, vomiting, dyspepsia).
LESS FREQUENT: Other rarer adverse effects include other CNS symptoms (dizziness, pyrexia, restlessness, fatigue, lethargy, lightheadedness, pain, dystonia, hypersomnia, irritability, impaired coordination, suicidal ideation), cardiovascular symptoms (orthostatic hypotension, tachycardia, chest pain, hypertension, peripheral edema), dermatologic symptoms (rash, hyperhidrosis), gastrointestinal symptoms (increased salivation, decreased appetite, increased appetite, xerostomia, toothache, abdominal pain, diarrhea, weight gain), neuromuscular and skeletal symptoms (tremor, extremity pain, stiffness, myalgias, spasm, arthralgias, dyskinesia, increased creatine phosphokinase, weakness), and respiratory symptoms (nasopharyngitis, pharyngolaryngeal pain, cough, rhinorrhea).

Editor's Note: An ERG guide with information appropriate to this material does not exist.

-FIRST AID

FIRST AID AND PREHOSPITAL TREATMENT

EMESIS/NOT RECOMMENDED

Ipecac-induced emesis is not recommended due to potential for CNS depression.

ACTIVATED CHARCOAL

PREHOSPITAL ACTIVATED CHARCOAL ADMINISTRATION

Consider prehospital administration of activated charcoal as an aqueous slurry in patients with a potentially toxic ingestion who are awake and able to protect their airway. Activated charcoal is most effective when administered within one hour of ingestion. Administration in the prehospital setting has the potential to significantly decrease the time from toxin ingestion to activated charcoal administration, although it has not been shown to affect outcome (Alaspaa et al, 2005; Thakore & Murphy, 2002; Spiller & Rogers, 2002).

In patients who are at risk for the abrupt onset of seizures or mental status depression, activated charcoal should not be administered in the prehospital setting, due to the risk of aspiration in the event of spontaneous emesis.
The addition of flavoring agents (cola drinks, chocolate milk, cherry syrup) to activated charcoal improves the palatability for children and may facilitate successful administration (Guenther Skokan et al, 2001; Dagnone et al, 2002).

CHARCOAL DOSE

Use a minimum of 240 milliliters of water per 30 grams charcoal (FDA, 1985). Optimum dose not established; usual dose is 25 to 100 grams in adults and adolescents; 25 to 50 grams in children aged 1 to 12 years (or 0.5 to 1 gram/kilogram body weight) ; and 0.5 to 1 gram/kilogram in infants up to 1 year old (Chyka et al, 2005).

Routine use of a cathartic with activated charcoal is NOT recommended as there is no evidence that cathartics reduce drug absorption and cathartics are known to cause adverse effects such as nausea, vomiting, abdominal cramps, electrolyte imbalances and occasionally hypotension (None Listed, 2004).

ADVERSE EFFECTS/CONTRAINDICATIONS

Complications: emesis, aspiration (Chyka et al, 2005). Aspiration may be complicated by acute respiratory failure, ARDS, bronchiolitis obliterans or chronic lung disease (Golej et al, 2001; Graff et al, 2002; Pollack et al, 1981; Harris & Filandrinos, 1993; Elliot et al, 1989; Rau et al, 1988; Golej et al, 2001; Graff et al, 2002). Refer to the ACTIVATED CHARCOAL/TREATMENT management for further information.
Contraindications: unprotected airway (increases risk/severity of aspiration) , nonfunctioning gastrointestinal tract, uncontrolled vomiting, and ingestion of most hydrocarbons (Chyka et al, 2005).

-RANGE OF TOXICITY

MAXIMUM TOLERATED EXPOSURE

SUMMARY

GUIDELINE STUDY/PEDIATRIC:A dose of more than 15 mg aripiprazole is potentially toxic in a drug naive child less than 12 years old. A dose of more than 50 mg aripiprazole is potentially toxic in a drug naive child 12 years or older. In children chronically taking aripiprazole, an acute ingestion of more than 5 times their current single dose (not daily dose) of aripiprazole is potentially toxic. (Cobaugh et al, 2007).
RETROSPECTIVE STUDY/CASE SERIES: A retrospective review of aripiprazole only exposures was conducted via the California Poison Control System electronic database from 2002 to 2006. Of 286 cases identified for analysis, 128 patients were asymptomatic and 158 patients developed symptoms following aripiprazole overdose ingestions, including somnolence, tachycardia, nausea/vomiting, dystonia, tremors, agitation, dizziness, paresthesia, and headache. In children 6 years and younger with documented doses (n=66), the median aripiprazole dose was 15 mg and 25 mg for asymptomatic and symptomatic patients, respectively. In patients 7 to 17 years of age (n=74), the median dose was 30 mg and 60 mg for asymptomatic and symptomatic patients, respectively, and in patients 18 years or older (n=114), the median dose was 75 mg and 100 mg for asymptomatic and symptomatic patients, respectively (Young et al, 2009).

CASE REPORTS

ADULT

An acute ingestion of 1260 mg of oral aripiprazole (42 times the maximum recommended dose) was reported in a patient who completely recovered (Prod Info ABILIFY(R) oral tablets, oral solution, intramuscular injection solution, 2012).
DELAYED PRESENTATION: A 25-year-old woman presented to the emergency department approximately 30 minutes after intentionally ingesting 15 15-mg aripiprazole tablets (4.5 mg/kg). Following a complete physical and neurologic exam and a 3-hour observation period, the patient remained asymptomatic and was sent to a psychiatric holding unit for evaluation, and subsequently was transferred to the psychiatric inpatient unit for treatment of her suicidal ideation. Two hours later (approximately 9 hours post-ingestion), the patient became somnolent, hypotensive (80/40 mmHg), and bradycardic (50 beats/min). With supportive care the patient recovered without sequelae (Lo & Pizon, 2008).
A 26-year-old man presented to the emergency department approximately 6 hours after intentionally ingesting 780 mg aripiprazole and 1050 mg amitriptyline. Following the overdose ingestion, the patient experienced minor signs and symptoms, including dizziness, unstable gait, tachycardia (124 bpm), and hypertension (148/94 mmHg). Following gastric lavage and supportive care, the patient recovered and was discharged (Prakash et al, 2009).

PEDIATRIC

Overdose ingestions up to 195 mg were reported in pediatric patients (ages 12 years and younger) during clinical trials and postmarketing surveillance. All patients recovered (Prod Info ABILIFY(R) oral tablets, oral solution, intramuscular injection solution, 2012).
Prolonged somnolence occurred in a 9-year-old girl following ingestion of a single 15-mg dose of aripiprazole (Davenport et al, 2004).
Persistent tachycardia, lethargy, tremors, and irritability occurred in a 2-year-old child after ingesting two 5-mg (0.92 mg/kg) aripiprazole tablets (Melhem et al, 2009).
A 2-year-old child developed lethargy, ataxia, hypothermia, and an episode of vomiting after a suspected ingestion of 3 15-mg tablets of aripiprazole. With supportive care, the patient recovered uneventfully and was discharged 2 days post-admission (Kaplan et al, 2015).

Carcinogenicity Ratings for CAS129722-12-9 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS129722-12-9 (U.S. Environmental Protection Agency, 2011):

Not Listed

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS129722-12-9 (American Conference of Governmental Industrial Hygienists, 2010):

Not Listed

AIHA WEEL Values for CAS129722-12-9 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS129722-12-9 (National Institute for Occupational Safety and Health, 2007):

Not Listed

OSHA PEL Values for CAS129722-12-9 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS129722-12-9 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS129722-12-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS129722-12-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS129722-12-9 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS129722-12-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS129722-12-9 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS129722-12-9 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS129722-12-9 (EPA, 2005):

Not Listed

LABELS

NFPA

NFPA Hazard Ratings for CAS129722-12-9 (NFPA, 2002):

Not Listed

-PERSONAL PROTECTION

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 129722-12-9.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS129722-12-9 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

Editor's Note: An ERG guide with information appropriate to this material does not exist.

NFPA Extinguishing Methods for CAS129722-12-9 (NFPA, 2002):

Not Listed

EVACUATION PROCEDURES

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

AIHA ERPG Values for CAS129722-12-9 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS129722-12-9 (U.S. Department of Energy, Office of Emergency Management, 2010):

Not Listed

AEGL Values for CAS129722-12-9 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS129722-12-9 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

SMALL LEAK/SPILL

Editor's Note: An ERG guide with information appropriate to this material does not exist.

LARGE LEAK/SPILL

Editor's Note: An ERG guide with information appropriate to this material does not exist.

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

ARIPIPRAZOLE: 448.38 (Prod Info ABILIFY(R) oral tablets, solution, IM injection, 2014; Prod Info ABILIFY DISCMELT(R) oral disintegrating tablets, 2014)

ARIPIPRAZOLE LAUROXIL: 660.7 g/mol (Prod Info ARISTADA(TM) intramuscular extended-release injection, 2015)

DESCRIPTION/PHYSICAL STATE

ARIPIPRAZOLE is a white to off-white, crystalline powder; insoluble in water and in methyl alcohol; freely soluble in dichloromethane; and sparingly soluble in toluene (Sweetman, 2014); melting point is 139 to 139.5 degrees C (Merck & Co., 2003).

ARIPIPRAZOLE injection solution is a clear, colorless, aqueous solution, and the oral solution is clear, colorless to light yellow (Prod Info ABILIFY(R) oral tablets, solution, IM injection, 2014; Prod Info ABILIFY DISCMELT(R) oral disintegrating tablets, 2014).

ARIPIPRAZOLE LAUROXIL is a white to off-white aqueous extended-release suspension (Prod Info ARISTADA(TM) intramuscular extended-release injection, 2015).

ARIPIPRAZOLE: 4.3 (IM injection solution) (Prod Info ABILIFY(R) oral tablets, solution, IM injection, 2014; Prod Info ABILIFY DISCMELT(R) oral disintegrating tablets, 2014)

FREEZING/MELTING POINT

MELTING POINT

139 to 139.5 degrees C (Merck & Co., 2003)

-REFERENCES

GENERAL BIBLIOGRAPHY

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40 CFR 372.65: Environmental Protection Agency - Toxic Chemical Release Reporting, Community Right-To-Know, Chemicals and Chemical Categories to which this part applies. National Archives and Records Association (NARA) and the Government Printing Office (GPO), Washington, DC. Final rules current as of Apr 3, 2006.

49 CFR 172.101 - App. B: Department of Transportation - Table of Hazardous Materials, Appendix B: List of Marine Pollutants. National Archives and Records Administration (NARA) and the Government Printing Office (GPO), Washington, DC. Final rules current as of Aug 29, 2005.

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65 FR 14186: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.

65 FR 39264: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.

65 FR 77866: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.

66 FR 21940: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2001.

67 FR 7164: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2002.

68 FR 42710: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2003.

69 FR 54144: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2004.

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Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents