TANNIC ACID
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
Acide gallotannique (French) Acide tannique (French) Acido galotanico (Spanish) Acido tanico (Spanish) Acido tannico (Italian) Acidum Gallotannicum Acidum Tannicum Digallic acid (Incorrectly) Gallotannic acid Gallusgerosaure (German) Gerbsaure (German) Glycerite Tanin officinal (French) Tannin Tannino (Italian) ACID, TANNIC D'ACIDE TANNIQUE (FRENCH) GALLOTANNIN
IDENTIFIERS
USES/FORMS/SOURCES
Tannic acid is used as a mordant in dyeing, as a coagulant in rubber manufacture, and as a boiler feedwater additive; used in manufacturing gallic acid, pyrogallol, and ink; used for sizing paper and silk and printing fabrics; used in tanning and photography; used to treat wastewater; used to clarify beer and wine (Budavari, 1996; HSDB , 2000). Suppositories have been used in the treatment of hemorrhoids (JEF Reynolds , 2000). Tannic acid was formerly used locally for sore throat and stomatitis and to harden nipples during nursing (Osol & Hoover, 1975). It was also formerly used in the treatment of extensive burns, orally as a antidiarrheal agent, and as an additive to barium sulfate enemas to improved radiological imaging of the colon (JEF Reynolds , 2000; HSDB , 2000). It has historically been used internally as an astringent, hemostatic, and heavy metal antidote in veterinary medicine (Budavari, 1996).
Tannic acid is available medicinally as 5% tannic acid in a jelly base (Amertan - Lilly). Also known as Tannin, gallotannin and gallotannic acid, it is included in Universal Antidote, a preparation which should NOT be used. Acorns & beech nuts containing tannic acid may be dangerous when eaten in large quantities. Martinek & Wolman (1955) investigated the average amount of tannins in coffee, tea and cocoa. A summary of their data is below. ACORNS Contain various polyhydroxyphenolic compounds known as tannins. The primary chemicals involved are tannic acid, gallic acid, and pyrogallol (Sandusky et al, 1977; Dollahite et al, 1962). Concentration of total phenolics found in Arkansas plants of the following species (Basden & Dalvi, 1987):
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Acute ingestion of tannic acid may result in nausea, vomiting, abdominal pain, and hepatic necrosis if large amounts are absorbed. The minimal toxic or lethal dose is not well established in the literature. Severity of intoxication should be based on clinical findings.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
SUMMARY - Tannic acid was formerly used in the treatment of large burns and added to barium sulfate enemas (to improve radiological imaging) (JEF Reynolds , 2000). Tannic acid has also been included in barium enemas in concentrations of 0.25 to 3 percent; however, there have been human deaths (5 children, 3 adults) reported from its therapeutic use in barium enemas. Death was due to hepatic necrosis (Arena, 1974). This procedure (tannic acid in barium enema) is NOT recommended and absolutely should not be used in children or adults with hepatic disease.
LDLo (ORAL) RAT - 200 mg/kg (Lewis, 1996) LDLo (Subcutaneous) RAT - 200 mg/kg (RTECS, 2000) LDLo (PARENTERAL) RAT - 1400 mg/kg (RTECS, 2000) LDLo (ORAL) MOUSE - 2,000 mg/kg (RTECS, 2000) LDLo (Subcutaneous) MOUSE - 75 mg/kg (RTECS, 2000) LDLo (IV) MOUSE - 10 mg/kg (RTECS, 2000) LDLo (IV) GUINEA PIG - 40 mg/kg (RTECS, 2000)
MAXIMUM TOLERATED EXPOSURE
Humans may ingest up to 1 gram/day in foods and drinks (Gosselin et al, 1984). Very little is known about the concentration or orally administered amount of tannic acid needed to cause liver cell death (Janower et al, 1965).
- Carcinogenicity Ratings for CAS1401-55-4 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 3 ; Listed as: Tannic acid and tannins 3 : The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS1401-55-4 (U.S. Environmental Protection Agency, 2011):
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS1401-55-4 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS1401-55-4 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS1401-55-4 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS1401-55-4 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS1401-55-4 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS1401-55-4 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS1401-55-4 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS1401-55-4 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS1401-55-4 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS1401-55-4 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS1401-55-4 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS1401-55-4 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS1401-55-4 (NFPA, 2002):
Listed as: Tannic Acid Hazard Ratings: Health Rating (Blue): 1 Flammability Rating (Red): 1 Instability Rating (Yellow): 0 Oxidizer/Water-Reactive Designation: Not Listed
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 1401-55-4.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS1401-55-4 (NFPA, 2002):
Listed as: Tannic Acid Flammability Rating: 1
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS1401-55-4 (NFPA, 2002):
REACTIVITY HAZARD
- Aqueous solutions of tannic acid are unstable, decomposition occurs due to oxidation and mold and bacterial growth. Physical changes include precipitation, darkening in color and a disagreeable odor (Osol & Farrar, 1955).
- Will produce insoluble precipitates with albumin, starch, gelatin, most alkaloidal and metallic salts. Tannins produce a bluish-black color or a precipitate with ferric salt (Budavari, 1989).
- It is easily hydrolyzed by esterases (Harris et al, 1966).
- Combustible when exposed to heat or flame (Sax & Lewis, 1989)
- Decomposes at 210 to 215 degrees F mostly into pyrogallol and carbon dioxide (Budavari, 1989)
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS1401-55-4 (AIHA, 2006):
- DOE TEEL Values for CAS1401-55-4 (U.S. Department of Energy, Office of Emergency Management, 2010):
- AEGL Values for CAS1401-55-4 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS1401-55-4 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
- 1500-2000 (Gosselin et al, 1984)
DESCRIPTION/PHYSICAL STATE
- An amorphous, yellowish-white to brown powder or flakes with faint characteristic odor and astringent taste (Budavari, 1996; HSDB , 2000).
- Tannic acid of commerce usually contains about 10% water (Budavari, 1996).
FREEZING/MELTING POINT
FLASH POINT
- 390 degrees F (open cup) (Lewis, 1996)
AUTOIGNITION TEMPERATURE
- 980 degrees F (Lewis, 1996)
SOLUBILITY
Very soluble in alcohol, acetone; almost insoluble in benzene, chloroform, ether, petroleum ether, carbon disulfide (Lewis, 1996).
OTHER/PHYSICAL
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