SODIUM SELENATE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
IDENTIFIERS
SYNONYM REFERENCE
USES/FORMS/SOURCES
It is used as a chemical reagent and an insecticide for certain horticultural applications on nonedible plants (Clayton & Clayton, 1981; Budavari, 1989; Sax & Lewis, 1987; Sax & Lewis, 1989; EPA, 1985).
Sodium selenate is a colorless, rhombic crystalline solid, water-soluble selenium salt. Little is known about the toxicity of sodium selenate. This review is based on the toxicity of SELENIUM. Effects attributed specifically to sodium selenate are identified. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption (Proctor et al, 1988; Ellenhorn & Barceloux, 1988; Clayton & Clayton, 1981; Sax & Lewis, 1989), although specific information on the possible dermal absorption of sodium selenate was not found (EPA, 1985). Elemental selenium has a relatively low order of toxicity; indeed, selenium is an ESSENTIAL TRACE METAL, and CHRONIC DEFICIENCY can lead to fatal cardiomyopathies (Ellenhorn & Barceloux, 1988; Baselt & Cravey, 1989). Sodium selenate can release toxic and irritating fumes of selenium and sodium oxide when heated to decomposition (Sax & Lewis, 1989; EPA, 1985).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Elemental selenium has a relatively low order of toxicity; selenium is an ESSENTIAL TRACE METAL, and CHRONIC DEFICIENCY can lead to fatal cardiomyopathies. Industrial workers exposed for up to 26 years had a normal death pattern. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption, although specific information on the possible dermal absorption of sodium selenate was not found.
- Chronic selenium poisoning resembles chronic arsenic poisoning. Nausea, vomiting, white streaks of the nails, pallor, upper respiratory irritation, paronychiae, hair loss, skin rashes, irritability, fatigue, hyperreflexia, EKG changes, a garlic odor on the breath, and a metallic taste in the mouth may be noted with chronic selenium exposure.
- Acute poisonings with selenium metal and its salts are rare. SELENITE toxicity may include facial flushing, a lightheaded sensation, and muscle tenderness and tremors.
Inhalation of selenium dusts may cause headache, cough, nasal discharge, upper respiratory tract irritation, epistaxis, and olfactory fatigue. Transient dyspnea has been seen. Severe eye irritation may be seen with selenium dust exposure.
- While chronic occupational selenium exposure has not been reported to result in disabling disease, paralysis and hemiplegia were noted in an endemic outbreak of dietary hyperselenosis in China.
- Acute ingestion of 2000 mg of sodium selenate by an adolescent caused a garlic odor of the breath, diarrhea, EKG changes indicating possible anterolateral myocardial damage, elevated liver function tests, muscle aches and pains, and irritability.
- Anemia and marked hepatic necrosis, hemorrhage, and cirrhosis were found in experimental animals fed 5 to 15 ppm of selenium chronically in the diet. These effects have not been reported in exposed humans.
- Sodium selenate releases toxic and irritating fumes of selenium and sodium oxide when heated to decomposition.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
ACUTE CLINICAL EFFECTS
- Acute ingestion of 2000 mg of sodium selenate by an adolescent caused a garlic odor of the breath, diarrhea, EKG changes indicating possible anterolateral myocardial damage, elevated liver function tests, muscle aches and pains, and irritability (Civil & McDonald, 1978).
- Acute poisonings with selenium metal and its salts are rare. SELENITE toxicity may include nausea, vomiting, facial flushing, a lightheaded sensation, and muscle tenderness, tremors, CNS depression, and coma (Diskin et al, 1979; Lombeck et al, 1987; Ellenhorn & Barceloux, 1988).
- Inhalation of selenium dusts can cause headache, cough, nasal discharge, upper respiratory tract irritation, pulmonary edema, epistaxis, and olfactory fatigue (Alderman & Bergin, 1986; Ellenhorn & Barceloux, 1988; Proctor et al, 1988). Transient dyspnea has been seen (Proctor et al, 1988).
- Workers exposed to an undetermined concentration of selenium oxide developed bronchospasm and dyspnea followed within 12 hours by metal fume fever (chills, fever, headache) and bronchitis, leading to pneumonitis. All symptoms resolved within one week (Wilson, 1962).
- Severe eye irritation may be seen with selenium dust exposure (Proctor et al, 1988).
CHRONIC CLINICAL EFFECTS
- Sodium selenate in drinking water at a dose of 0.28 mg/kg/day for 1 year did not increase the mortality of male or female rats. However, the same dose of sodium selenite did increase the mortality of male rats. Therefore, some gender differences exist in rat susceptibility (Schroeder, 1967; Schroeder et al, 1971).
- Chronic selenium poisoning resembles chronic arsenic poisoning (Ellenhorn & Barceloux, 1988; Sax & Lewis, 1989; EPA, 1985). Nausea, vomiting, leukocytosis, white streaks in the nails (Mee's lines), pallor, upper respiratory tract irritation, paronychiae, loss of hair, skin rashes, irritability, fatigue, hyperreflexia, EKG changes, a garlic odor on the breath, and a metallic taste in the mouth may be noted with chronic selenium exposure (Wilson, 1962; Ellenhorn & Barceloux, 1988; Proctor et al, 1988; Clayton & Clayton, 1981; Sax & Lewis, 1989).
- While chronic occupational selenium exposure has not been reported to result in disabling disease, paralysis and hemiplegia were noted in an endemic outbreak of dietary hyperselenosis in China (Proctor et al, 1988).
- Anemia, marked hepatic necrosis, hemorrhage, and cirrhosis were found in experimental animals fed 5 to 15 ppm of selenium chronically in the diet (Proctor et al, 1988). These effects have not been reported in exposed humans.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
MAXIMUM TOLERATED EXPOSURE
The insoluble selenium sulfide is less toxic than the highly toxic soluble selenites, selenates, and organic selenium compounds (Henschler & Kirschner, 1969).
An adolescent patient ingested 400 mL of a 5 mg/mL sodium selenate-containing sheep dip preparation (2000 mg; 22.3 mg Se/kg) but survived (Civil & McDonald, 1978). A report by Yang et al (1983) from the Republic of China described a major outbreak of apparent selenium toxicity. The disease was characterized by the loss of hair and nails and skin lesions on the back of the hands and feet, and outer side of the legs. In regions of China with the most intense exposure, the residents had symptoms of a toxic polyneuritis. Individual daily selenium intake in the area ranged from 3.2 mg to 6.69 mg (average 4.99 mg), and whole blood levels of selenium ranged from 1.33 mcg/mL to 7.5 mcg/mL (average 3.2 mcg/mL) (Yang et al, 1983). An average daily intake of 0.1 milligram of selenium was noted for persons who were unaffected (Proctor et al, 1988).
Anemia and marked hepatic necrosis, hemorrhage, and cirrhosis were found in experimental animals fed 5 to 15 ppm of selenium chronically in the diet (Proctor et al, 1988).
- Carcinogenicity Ratings for CAS13410-01-0 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS13410-01-0 (U.S. Environmental Protection Agency, 2011):
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS13410-01-0 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS13410-01-0 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS13410-01-0 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS13410-01-0 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS13410-01-0 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS13410-01-0 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS13410-01-0 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS13410-01-0 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS13410-01-0 (U.S. Environmental Protection Agency, 2010):
Listed as: Sodium Selenate Reportable Quantity, in pounds: 100 Threshold Planning Quantity, in pounds: Note(s): Not Listed
- EPA SARA Title III, Community Right-to-Know for CAS13410-01-0 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS13410-01-0 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS13410-01-0 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS13410-01-0 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 13410-01-0.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS13410-01-0 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS13410-01-0 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS13410-01-0 (AIHA, 2006):
- DOE TEEL Values for CAS13410-01-0 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Sodium selenate (Disodium selenate) TEEL-0 (units = mg/m3): 0.479 TEEL-1 (units = mg/m3): 1.44 TEEL-2 (units = mg/m3): 2.4 TEEL-3 (units = mg/m3): 2.4 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS13410-01-0 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS13410-01-0 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Sodium selenate exists as white crystals (Budavari, 1996).
-REFERENCES
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- 69 FR 54144: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2004.
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