SIMAZINE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
SIMAZINE s-TRIAZINE, 2-CHLORO-4,6-BIS(ETHYLAMINO)- A 2079 AKTINIT S AQUAZINE BATAZINA 2,4-BIS(AETHYLAMINO)-6-CHLOR-1,3,5-TRIAZIN (German) 2,4-BIS(ETHYLAMINO)-6-CHLORO-s-TRIAZINE BITEMOL BITEMOL S 50 CAT CAT (herbicide) CDT CEKUSAN CEKUZINA-S CET 1-CHLORO, 3,5-BISETHYLAMINO-2,4,6-TRIAZINE 2-CHLORO-4,6-BIS(ETHYLAMINO)-s-TRIAZINE 2-CHLORO-4,6-BIS(ETHYLAMINO)-1,3,5-TRIAZINE 6-CHLORO-N,N'-DIETHYL-1,3,5-TRIAZINE-2,4-DIYLDIAMINE FRAMED G 27692 GEIGY 27,692 GESARAN GESATOP GESATOP 50 H 1803 HERBAZIN HERBAZIN 50 HERBEX HERBOXY HUNGAZIN DT PREMAZINE PRIMATOL S PRINCEP PRINTOP RADOCON RADOKOR SIMADEX SIMANEX SIMAZIN SIMAZINE 80W SYMAZINE TAFAZINE TAFAZINE 50-W TAPHAZINE TRIAZINE A 384 W 6658 WEEDEX ZEAPUR YRODAZIN
IDENTIFIERS
USES/FORMS/SOURCES
Simazine is a triazine herbicide (Budavari, 1996; Lewis, 1993). It is a white, crystalline solid which is practically insoluble in water and is slightly soluble in methanol, chloroform, droxane, and ethylene glycol ethyl ether (Budavari, 1996; Lewis, 1993; Clayton & Clayton, 1994). It is marketed as 50 and 80 percent wettable powders and as water-dispersible granules of 90 percent purity (Hayes & Laws, 1991).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
ACUTE CLINICAL EFFECTS
- There are no known cases of human poisoning with simazine in the 20-year history of its use (Hayes & Laws, 1991; Clayton & Clayton, 1994). Simazine has low acute oral and dermal toxicity in experimental animals (Clayton & Clayton, 1994). It has been reported to be irritating to the mucous membranes (HSDB , 1997). It was not a skin irritant in patch testing in human volunteers with the 80 percent wettable powder (Hayes & Laws, 1991).
- Sheep appear to be more sensitive to simazine than other species (Clayton & Clayton, 1994).
- Simazine had estrogen and dioxin-like activity in an in vitro recombinant receptor-reporter gene assay which used a human estrogen receptor and a luciferase reporter gene (Balaguer et al, 1996).
CHRONIC CLINICAL EFFECTS
- Simazine has been reported not to be a dermal sensitizer (Clayton & Clayton, 1982). There have been some cases of dermatitis in Russia (Elizarov & Sharonova, 1972), possibly due to impurities not present in the product available in the USA.
- Skin rash and blisters were reported in one case after years of use (Hayes & Laws, 1991).
- A group of 2683 men with definite or probable exposure to triazine herbicides in a manufacturing setting had less overall mortality than expected during the period 1960 to 1986 (Sathiakumar et al, 1996).
-RANGE OF TOXICITY
MAXIMUM TOLERATED EXPOSURE
- Carcinogenicity Ratings for CAS122-34-9 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Simazine EPA (U.S. Environmental Protection Agency, 2011): Not Assessed under the IRIS program. ; Listed as: Simazine IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 3 ; Listed as: Simazine 3 : The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS122-34-9 (U.S. Environmental Protection Agency, 2011):
Oral: Slope Factor: RfD: 5x10(-3) mg/kg-day
Inhalation: Drinking Water:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS122-34-9 (American Conference of Governmental Industrial Hygienists, 2010):
Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.
- AIHA WEEL Values for CAS122-34-9 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS122-34-9 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS122-34-9 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS122-34-9 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS122-34-9 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS122-34-9 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS122-34-9 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS122-34-9 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS122-34-9 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS122-34-9 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS122-34-9 (EPA, 2005):
Listed as: 1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-diethyl-
LABELS
- NFPA Hazard Ratings for CAS122-34-9 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 122-34-9.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS122-34-9 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS122-34-9 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS122-34-9 (AIHA, 2006):
- DOE TEEL Values for CAS122-34-9 (U.S. Department of Energy, Office of Emergency Management, 2010):
- AEGL Values for CAS122-34-9 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS122-34-9 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
-REFERENCES
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