PROPARGYL BROMIDE

gamma-BROMOALLYLENE

1-BROM-2-PROPIN (Czech)

1-BROMO-2-PROPYNE

3-BROMOPROPYNE

3-BROMO-1-PROPYNE

3-BROMOPROPYNE

PROPYNE, 3-BROMO-

1-PROPYNE, 3-BROMO-

106-96-7(3-bromopropyne)

UK 4375000

2345-3-Bromopropyne

C3-H3-Br

130-FLAMMABLE LIQUIDS (NON-POLAR / WATER-IMMISCIBLE / NOXIOUS)(for UN/NA Number2345)

Propargyl bromide is used as a chemical intermediate, alkylating agent, soil fumigant, and agricultural chemical (ITI, 1985; EPA, 1985; Lewis, 1993; Gosselin et al, 1984; HSDB , 1996).

Propargyl bromide is shipped as a liquid; as such, it is sensitive to mechanical or thermal shock (HSDB , 1996).

Propargyl bromide may contain 20% to 30% TOLUENE by weight to eliminate its explosive potential (NFPA, 1986). The possible contribution of toluene to the overall toxicity of a given exposure should be taken into account.

Propargyl bromide is derived from acetylene by a high-pressure synthetic process (Lewis, 1993).

May cause toxic effects if inhaled or absorbed through skin.

Inhalation or contact with material may irritate or burn skin and eyes.

Fire will produce irritating, corrosive and/or toxic gases.

Vapors may cause dizziness or suffocation.

Runoff from fire control or dilution water may cause pollution.

Move victims of inhalation exposure from the toxic environment and administer 100 percent humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water.

In ingestion exposures, emesis should not be induced. Immediate dilution might be beneficial.

DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.

Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.

Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.

Carefully observe patients with ingestion exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.

A number of chemicals produce abnormalities of the hematopoietic system, liver, and kidneys. Monitoring complete blood count, urinalysis, and liver and kidney function tests is suggested for patients with significant exposure.

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.

ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.

If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.

If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

Because of the potential for severe eye irritation, prolonged initial flushing and early ophthalmologic consultation are advisable.

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).

Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

Move victim to fresh air.

Call 911 or emergency medical service.

Give artificial respiration if victim is not breathing.

Administer oxygen if breathing is difficult.

Remove and isolate contaminated clothing and shoes.

In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.

Wash skin with soap and water.

Keep victim warm and quiet.

In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.

Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

The minimum lethal human dose to this agent has not been delineated.

Rats died when exposed to vapor concentrations of 200 ppm for 4 hours (Gosselin et al, 1984).

The maximum tolerated human exposure to this agent has not been delineated.

Eye and pulmonary irritation and liver and kidney injury were seen in experimental animals with single or multiple exposures to vapor concentrations as low as 10 ppm (Gosselin et al, 1984).

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed

EPA (U.S. Environmental Protection Agency, 2011): Not Listed

IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed

NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed

MAK (DFG, 2002): Not Listed

NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

Not Listed

References: ITI, 1985 RTECS, 1996

Not Listed

Listed as Propargyl Bromide

0.1 ppm

Ceiling or Short-term TWA:

Skin Notation: Yes

Dermal Sensitizer: No

Candidate WEEL: No

WEEL Under Review: No

Not Listed

Not Listed

Threshold Quantity, in pounds:100

Threshold Quantity, in pounds:100

Not Listed

Not Listed

Not Listed

Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

Listed as: Propargyl Bromide

Reportable Quantity, in pounds: 10

Threshold Planning Quantity, in pounds:

Note(s): Not Listed

Not Listed

Not Listed

Listed as: 1-Propyne, 3-bromo-

Hazardous materials descriptions and proper shipping name: 3-Bromopropyne

Proper Shipping Name: 3-Bromopropyne

UN Number: 2345

Listed as: 3-Bromopropyne

Hazard Ratings:

Protective clothing should be worn when fighting fires involving this material (NFPA, 1986). Fires should be fought from a safe location protected from explosions (ITI, 1985). The area should be evacuated if a massive or advanced fire occurs (ITI, 1985).

Wear positive pressure self-contained breathing apparatus (SCBA).

Structural firefighters' protective clothing will only provide limited protection.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 130 (ERG, 2004)

Propargyl bromide is flammable and carries a dangerous explosion and fire risk (Sax & Lewis, 1987). It is dangerous when exposed to flames, heat, or oxidizing materials (Sax, 1989).

Fires should be fought from a location providing protection against explosions (NFPA, 1986). The area should be evacuated if a massive or advanced fire occurs (NFPA, 1986).

Water should be used to cool containers that are exposed to heat or flames until well after the fire is extinguished (NFPA, 1986).

Do not directly approach tanks or containers that have been involved in a fire or heated by fire exposure (NFPA, 1986).

Listed as: 3-Bromopropyne

Flammability Rating: 3

CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient.

Dry chemical, CO2, water spray or regular foam.

Water spray, fog or regular foam.

Do not use straight streams.

Move containers from fire area if you can do it without risk.

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.

Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Listed as: 3-Bromopropyne

Extinguishing Method(s): 4

Toxic fumes of bromides and hydrogen bromide are released when this material is heated to decomposition (Sax, 1989; Gosselin et al, 1984).

Consider initial downwind evacuation for at least 300 meters (1000 feet).

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.

As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.

Keep unauthorized personnel away.

Stay upwind.

Keep out of low areas.

Ventilate closed spaces before entering.

Not Listed

Listed as Propargyl bromide

TEEL-0 (units = mg/m3): 0.03

TEEL-1 (units = mg/m3): 0.03

TEEL-2 (units = mg/m3): 0.03

TEEL-3 (units = mg/m3): 20

Definitions:

Not Listed

Not Listed

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 130 (ERG, 2004)

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 130 (ERG, 2004)

DO NOT ATTEMPT SALVAGE or CLEANUP OPERATIONS UNTIL THIS MATERIAL HAS THOROUGHLY COOLED (NFPA, 1986).

LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 130 (ERG, 2004)

LIQUID: 1.57 (NFPA, 1986)

LIQUID: 1.520 g/mL (Lewis, 1993)

LIQUID: 1.564-1.570 g/mL (Lewis, 1992)

-61.07 degrees C (Lewis, 1992)

76 degrees F (NFPA, 1986)

10 degrees C; 50 degrees F (closed cup) (NFPA, 1986)

3.0% (NFPA, 1986)