AMMONIUM PHOSPHATE, MONOBASIC
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
Ammonium acid phosphate Ammonium biphosphate Ammonium dihydrogen phosphate Ammonium orthophosphate, dihydrogen Monoammonium phosphate Primary ammonium phosphate
IDENTIFIERS
USES/FORMS/SOURCES
Ammonium phosphate, monobasic is used as a general purpose food additive, as a baking powder combined with sodium bicarbonate, in yeast culture and other fermentations, for fireproofing of fiberboard, paper, and wood, in some fertilizers, in the manufacturing of toothpaste, fertilizers, and pharmaceuticals (Budavari, 1996) (Lewis, 1996) (Product Info, 1996) (HSDB , 1996), and in dry chemical fire extinguishers (Loschiavo et al, 2015; Senthilkumaran et al, 2012; Lin et al, 2009).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- USES: Ammonium phosphate, monobasic (monoammonium phosphate, ammonium dihydrogen phosphate) is used as a general purpose food additive, as a baking powder combined with sodium bicarbonate, in yeast culture and other fermentations, for fireproofing of fiberboard, paper, and wood, in some fertilizers, and as a component of dry chemical fire extinguishers.
- TOXICOLOGY: Ingestion and inhalation of monoammonium phosphate, as the primary component of dry chemical fire extinguishers, has resulted in acute phosphate toxicity.
- EPIDEMIOLOGY: Exposure has been infrequently reported.
MILD TO MODERATE TOXICITY: Monoammonium phosphate is a mild eye irritant. Concentrated solutions may irritate the skin. Mild respiratory tract irritation, nausea, and vomiting may be seen after inhalation of vapor. Nausea, vomiting and diarrhea may occur following ingestion. SEVERE TOXICITY: Hyperphosphatemia, hypocalcemia, hypomagnesemia, metabolic acidosis, and respiratory distress including airway obstruction have been reported following inhalational and oral exposure to dry chemical fire extinguishers containing monoammonium phosphate. Other effects that may occur include acute renal failure, seizures, QT interval prolongation, and ventricular dysrhythmias progressing to cardiac arrest.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
ACUTE CLINICAL EFFECTS
USES: Ammonium phosphate, monobasic (monoammonium phosphate, ammonium dihydrogen phosphate) is used as a general purpose food additive, as a baking powder combined with sodium bicarbonate, in yeast culture and other fermentations, for fireproofing of fiberboard, paper, and wood, in some fertilizers, and as a component of dry chemical fire extinguishers. TOXICOLOGY: Ingestion and inhalation of monoammonium phosphate, as the primary component of dry chemical fire extinguishers, has resulted in acute phosphate toxicity. EPIDEMIOLOGY: Exposure has been infrequently reported. MILD TO MODERATE TOXICITY: Monoammonium phosphate is a mild eye irritant. Concentrated solutions may irritate the skin. Mild respiratory tract irritation, nausea, and vomiting may be seen after inhalation of vapor. Nausea, vomiting and diarrhea may occur following ingestion. SEVERE TOXICITY: Hyperphosphatemia, hypocalcemia, hypomagnesemia, metabolic acidosis, and respiratory distress including airway obstruction have been reported following inhalational and oral exposure to dry chemical fire extinguishers containing monoammonium phosphate. Other effects that may occur include acute renal failure, seizures, QT interval prolongation, and ventricular dysrhythmias progressing to cardiac arrest.
CASE REPORT: A 25-year-old man presented to the emergency department after intentionally ingesting a large amount of dry fire extinguisher powder containing ammonium dihydrogen phosphate. Laboratory data revealed hyperphosphatemia (peak level 30.6 mg/dL, normal range 2.7 to 4.5 mg/dL), hypokalemia (3.1 mEq/L, normal range 3.5 to 5.1 mEq/L), hypocalcemia (4.3 mg/dL, normal range 8.9 to 10.3 mg/dL), and metabolic acidosis (pH 7.24, HCO3 16.4 mmol/L). Four hours post-presentation, the patient developed cardiac arrest and underwent cardioversion and cardiopulmonary resuscitation. An ECG revealed ventricular tachycardia. He received calcium gluconate and sodium bicarbonate infusions; however, despite aggressive supportive therapy, he subsequently died (Lin et al, 2009). CASE REPORT: A 25-year-old man presented to the emergency department with palpitations, and difficulty in opening his eyes, swallowing, talking, and breathing approximately 4 hours after intentionally inhaling the fumes of a dry chemical fire extinguisher containing monoammonium phosphate. At presentation he was irritable with facial flushing, diaphoresis, stridor, and drooling. His blood pressure, pulse, and respiratory rate were 90/60 mmHg, 110, and 28, respectively. Examination of his oropharynx revealed a swollen, erythematous vocal cord, requiring intubation and mechanical ventilation secondary to airway obstruction. Arterial blood gas analysis revealed metabolic acidosis and laboratory data values indicated hyperphosphatemia (11 mg/dL, normal range 3 to 4.5 mg/dL), hypocalcemia (ionized calcium 1.18 mg/dL, normal range 4.4 to 5.1 mg/dL), and hypomagnesemia (1.2 mg/dL, normal range 1.8 to 2.4 mg/dL). His QTc interval was prolonged at 498 msec. The patient received supportive therapy, including calcium gluconate and magnesium sulfate infusions; however, 2 hours post-presentation, he developed a generalized seizure refractory to IV lorazepam, but responsive to a 100-mg IV bolus of calcium gluconate. Subsequently, 4 episodes of pulseless ventricular tachycardia occurred that were successfully cardioverted. Following several days of aggressive supportive management and 2 cycles of hemodialysis, the patient gradually recovered with normalization of laboratory values and no evidence of pulmonary or renal sequelae at follow-up (Senthilkumaran et al, 2012). CASE REPORT: A 62-year-old man presented to the emergency department, complaining of respiratory distress, approximately 30 minutes after intentionally ingesting/inhaling a dry chemical fire extinguisher powder containing ammonium dihydrogen phosphate. His oxygen saturation was 95% on room air. Laboratory data, obtained 6 hours post presentation, revealed a phosphorus level of 18 mg/dL and a calcium level of 7.6 mg/dL. With supportive therapy, including hemodialysis, the patient's laboratory values improved, and he was discharged 72 hours post-exposure (Loschiavo et al, 2015).
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
- Prehospital gastrointestinal decontamination is not recommended. For inhalational exposures, monitor for respiratory distress. If cough or difficulty breathing develops, administer oxygen and assist ventilation as required. DERMAL EXPOSURE: Remove contaminated clothing and wash exposed area thoroughly with soap and water. EYE EXPOSURE: Irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If present, carefully remove contact lenses.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
- CASE REPORT: A 25-year-old man presented to the emergency department after intentionally ingesting a large amount of dry fire extinguisher powder containing ammonium dihydrogen phosphate. Laboratory data revealed hyperphosphatemia (peak level 30.6 mg/dL, normal range 2.7 to 4.5 mg/dL), hypokalemia (3.1 mEq/L, normal range 3.5 to 5.1 mEq/L), hypocalcemia (4.3 mg/dL, normal range 8.9 to 10.3 mg/dL), and metabolic acidosis (pH 7.24, HCO3 16.4 mmol/L). Four hours post-presentation, the patient developed cardiac arrest and underwent cardioversion and cardiopulmonary resuscitation. An ECG revealed ventricular tachycardia. He received calcium gluconate and sodium bicarbonate infusions; however, despite aggressive supportive therapy, he subsequently died (Lin et al, 2009).
MAXIMUM TOLERATED EXPOSURE
CASE REPORT: A 25-year-old man presented to the emergency department with palpitations, and difficulty in opening his eyes, swallowing, talking, and breathing approximately 4 hours after intentionally inhaling the fumes of a dry chemical fire extinguisher containing monoammonium phosphate. At presentation he was irritable with facial flushing, diaphoresis, stridor, and drooling. His blood pressure, pulse, and respiratory rate were 90/60 mmHg, 110, and 28, respectively. Examination of his oropharynx revealed a swollen, erythematous vocal cord, requiring intubation and mechanical ventilation secondary to airway obstruction. Arterial blood gas analysis revealed metabolic acidosis and laboratory data values indicated hyperphosphatemia, hypocalcemia, and hypomagnesemia. His QTc interval was prolonged at 498 msec. The patient received supportive therapy, including calcium gluconate and magnesium sulfate infusions; however, 2 hours post-presentation, he developed a generalized seizure refractory to IV lorazepam, but responsive to a 100-mg IV bolus of calcium gluconate. Subsequently 4 episodes of pulseless ventricular tachycardia occurred that were successfully cardioverted. Following several days of aggressive supportive management and 2 cycles of hemodialysis, the patient gradually recovered with normalization of laboratory values and no evidence of pulmonary or renal sequelae at follow-up (Senthilkumaran et al, 2012). CASE REPORT: A 62-year-old man presented to the emergency department, complaining of respiratory distress, approximately 30 minutes after intentionally ingesting/inhaling a dry chemical fire extinguisher powder containing ammonium dihydrogen phosphate. His oxygen saturation was 95% on room air. Laboratory data, obtained 6 hours post presentation, revealed a phosphorus level of 18 mg/dL and a calcium level of 7.6 mg/dL. With supportive therapy, including hemodialysis, the patient's laboratory values improved, and he was discharged 72 hours post-exposure (Loschiavo et al, 2015).
- Carcinogenicity Ratings for CAS7722-76-1 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS7722-76-1 (U.S. Environmental Protection Agency, 2011):
LD50- (ORAL)UNASSIGNED: LD50- (SKIN)UNASSIGNED:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS7722-76-1 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS7722-76-1 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS7722-76-1 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS7722-76-1 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS7722-76-1 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS7722-76-1 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS7722-76-1 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS7722-76-1 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS7722-76-1 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS7722-76-1 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS7722-76-1 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS7722-76-1 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS7722-76-1 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 7722-76-1.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS7722-76-1 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS7722-76-1 (NFPA, 2002):
REACTIVITY HAZARD
- Reacts with alkali to liberate ammonia (Prod Info, 1986).
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS7722-76-1 (AIHA, 2006):
- DOE TEEL Values for CAS7722-76-1 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Ammonium dihydrogen phosphate (Monoammonium phosphate) TEEL-0 (units = mg/m3): 15 TEEL-1 (units = mg/m3): 50 TEEL-2 (units = mg/m3): 350 TEEL-3 (units = mg/m3): 500 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS7722-76-1 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS7722-76-1 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Ammonium phosphate, monobasic is a white odorless tetragonal crystalline powder or crystalline solid (Budavari, 1996).
PH
- 4.2 (for a 0.2 molar aqueous solution) (Budavari, 1996)
DENSITY
- TEMPERATURE AND/OR PRESSURE NOT LISTED
FREEZING/MELTING POINT
SOLUBILITY
OTHER/PHYSICAL
- DECOMPOSITION TEMPERATURE
-REFERENCES
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