AMMONIUM PERFLUOROOCTANOATE

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.

MOLECULAR FORMULA

C8-F15-O2-H4-N

ERG GUIDE NUMBER

154-SUBSTANCES - TOXIC and/or CORROSIVE (NON-COMBUSTIBLE)

SYNONYM REFERENCE

(EPA OPPT, 2003; GIST, 2003; LOLI, 2003; RTECS, 2003; ACGIH, 2001; Lewis, 2000)

USES/FORMS/SOURCES

USES

Ammonium perfluorooctanoate is used commercially in the polymerization of fluorinated monomers, generally for emulsifier and surfactant applications (Pohanish, 2002; Lewis, 2001).

FORMS

Ammonium perfluorooctanoate exists as a free-flowing, white powder, which is highly soluble in water (Pohanish, 2002; Lewis, 2001).

SOURCES

Ammonium perfluorooctanoate is a synthetic compound that does not occur naturally in the environment. It is produced from perfluorooctanoic acid (PFOA), also a man-made chemical (68 FR 18626, 2003).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

WITH POISONING/EXPOSURE

There is little human data regarding adverse health effects from acute exposure to ammonium perfluorooctanoate (APFO). Based on animal studies, APFO is considered moderately toxic following acute exposure and is an ocular irritant. APFO may cause cough, sneezing, nasal discharge, headache, hoarseness, nasal and throat pain and other signs of upper respiratory tract irritation if inhaled. Mild skin irritation may occur following dermal contact.
In biologic media, APFO quickly dissociates to perfluorooctanoate which is the anion of perfluorooctanoic acid (PFOA). This management will address APFO when possible, but because of lack of data will also include information regarding PFOA. Perfluorooctanoic acid and its salts (APFO) are commonly referred to collectively.
Occupational studies in humans have found higher organic fluoride concentrations in workers exposed to ammonium perfluorooctanoate, but no adverse health effects attributable to exposure have been seen. It is thought that the general population may be exposed to low levels of APFO, but it has not yet been determined how exposure occurs.
In animal studies, chronic exposure by dermal, oral or inhalation primarily affects the liver. Increased liver weights and hepatocellular changes have been observed. Leydig cell tumors, mammary fibroadenomas and pancreatic acinar cell tumors have been reported in rats, but this is thought to be related to hepatic peroxisome proliferation. Peroxisome proliferation is thought to be species specific with humans predominantly nonresponsive.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death.
Contact with molten substance may cause severe burns to skin and eyes.
Avoid any skin contact.
Effects of contact or inhalation may be delayed.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

-FIRST AID

FIRST AID AND PREHOSPITAL TREATMENT

At the time of this review, no data exists on acute exposure to ammonium perfluorooctanoate (APFO) in humans. Animal studies have shown that APFO is moderately toxic following acute exposure.

Observe patients with large exposures for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.

DILUTION

DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.

ACTIVATED CHARCOAL

CHARCOAL DOSE

Use a minimum of 240 milliliters of water per 30 grams charcoal (FDA, 1985). Optimum dose not established; usual dose is 25 to 100 grams in adults and adolescents; 25 to 50 grams in children aged 1 to 12 years (or 0.5 to 1 gram/kilogram body weight) ; and 0.5 to 1 gram/kilogram in infants up to 1 year old (Chyka et al, 2005).

Routine use of a cathartic with activated charcoal is NOT recommended as there is no evidence that cathartics reduce drug absorption and cathartics are known to cause adverse effects such as nausea, vomiting, abdominal cramps, electrolyte imbalances and occasionally hypotension (None Listed, 2004).

ADVERSE EFFECTS/CONTRAINDICATIONS

Complications: emesis, aspiration (Chyka et al, 2005). Aspiration may be complicated by acute respiratory failure, ARDS, bronchiolitis obliterans or chronic lung disease (Golej et al, 2001; Graff et al, 2002; Pollack et al, 1981; Harris & Filandrinos, 1993; Elliot et al, 1989; Rau et al, 1988; Golej et al, 2001; Graff et al, 2002). Refer to the ACTIVATED CHARCOAL/TREATMENT management for further information.
Contraindications: unprotected airway (increases risk/severity of aspiration) , nonfunctioning gastrointestinal tract, uncontrolled vomiting, and ingestion of most hydrocarbons (Chyka et al, 2005).

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
For minor skin contact, avoid spreading material on unaffected skin.
Keep victim warm and quiet.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

INHALATION EXPOSURE

If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.

DERMAL EXPOSURE

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).

EYE EXPOSURE

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

ORAL EXPOSURE

Do not induce vomiting.
DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.
ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

GENERAL/SUMMARY

The minimum lethal human dose to this agent has not been delineated.

ANIMAL DATA

A single 4-hour inhalation exposure was lethal to rats at a concentration of 800 mg/m3 (ACGIH, 2001).
In a rat inhalation study, the median lethal concentration was 980+ mg/m(3)(Kennedy et al, 1986).

MAXIMUM TOLERATED EXPOSURE

GENERAL/SUMMARY

The maximum tolerated human exposure to this agent has not been delineated.

ANIMAL DATA

Rats tolerated oral doses of ammonium perfluorooctanoate of up to 3000 ppm for 28 days, although doses of 1000 ppm and greater resulted in reduced body weight gain (ACGIH, 2001).

Carcinogenicity Ratings for CAS3825-26-1 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): A3 ; Listed as: Ammonium perfluorooctanoate

A3 :Confirmed Animal Carcinogen with Unknown Relevance to Humans: The agent is carcinogenic in experimental animals at a relatively high dose, by route(s) of administration, at site(s), of histologic type(s), or by mechanism(s) that may not be relevant to worker exposure. Available epidemiologic studies do not confirm an increased risk of cancer in exposed humans. Available evidence does not suggest that the agent is likely to cause cancer in humans except under uncommon or unlikely routes or levels of exposure.

EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS3825-26-1 (U.S. Environmental Protection Agency, 2011):

Not Listed

RISK ASSESSMENT VALUES

LOAEL- (ORAL)PRIMATE:
- 3 to 10 mg/kg-day for 26W -- 30% increase in absolute liver weight (DEP, 2002)
LOAEL- (GAVAGE)RAT:
- 1 mg/kg-day -- male rats; statistically-significant increases in relative liver and kidney weights (DEP, 2002)
LOAEL- (GAVAGE)RAT:
- 1.6 mg/kg-day for 2Y -- female rats; ovarian stromal tubular hyperplasia (DEP, 2002)
LOAEL- (GAVAGE)RAT:
- 14 mg/kg-day for 2Y -- male rats; increased liver weight; hepatic cystoid degeneration; increased ALT enzyme activity; testicular vascular mineralization (DEP, 2002)
LOAEL- (GAVAGE)RAT:
- 30 mg/kg-day -- female rats; increased mortality and decreased body weight (DEP, 2002)
LOAEL- (INHALATION)RAT:
- 84 mg/m(3) for 6H/D, 5D/W for 2W -- male rats (DEP, 2002)
LOAEL- (ORAL)RAT:
- 1.44 mg/kg-day for 90D -- male rats; statistically-significant increases in relative liver weight and CoA oxidase activity (DEP, 2002)
NOAEL- (INHALATION)RAT:
- 1 mg/m(3) for 6H/D, 5D/W for 2W -- male rats; for liver effects (DEP, 2002)
NOAEL- (INHALATION)RAT:
- 7.6 mg/m(3) for 6H/D, 5D/W for 2W -- male rats; for pulmonary effects (DEP, 2002)
NOAEL- (ORAL)RAT:
- 0.47 mg/kg-day for 90D -- male rats (DEP, 2002)
NOAEL- (ORAL)RAT:
- 1.3 mg/kg-day for 2Y -- male rats (DEP, 2002)
NOAEL- (ORAL)RAT:
- 10 mg/kg-day -- female rats (DEP, 2002)
NOEL- (INHALATION)RAT:
- 1 mg/m(3) -- repeated inhalation by male rats (ACGIH, 2001)
NOEL- (ORAL)RAT:
- 1 ppm for 13W (ACGIH, 2001)

TOXICITY VALUES

LC- (INHALATION)RAT:
- 800 mg/m(3) for 4H (ACGIH, 2001)
LC50- (INHALATION)RAT:
- 980 mg/m(3) for 4H -- corneal damage; acute pulmonary edema; dyspnea (RTECS, 2003)
LD50- (ORAL)MOUSE:
- 457 mg/kg -- tremor; changes to hair; weight loss or decreased weight gain (RTECS, 2003)
LD50- (SKIN)RABBIT:
- 4300 mg/kg -- dyspnea; gastrointestinal hypermotility, diarrhea; weight loss or decreased weight gain (RTECS, 2003)
LD50- (ORAL)RAT:
- 430 mg/kg -- ptosis; ataxia; changes to hair (RTECS, 2003)
LD50- (ORAL)RAT:
- 540 mg/kg (ACGIH, 2001)
LD50- (SKIN)RAT:
- 7 g/kg -- somnolence (general depressed activity) (RTECS, 2003)
LD50- (SKIN)RAT:
- 7000 mg/kg -- male rats(ACGIH, 2001)
LD50- (SKIN)RAT:
- >7500 mg/kg -- female rats(ACGIH, 2001)
TCLo- (INHALATION)RAT:
- 25 mg/m(3) for 6H, female, days 6-15 of pregnancy -- fetotoxicity; affected growth statistics (RTECS, 2003)
TCLo- (INHALATION)RAT:
- 84 mg/m(3) for 6H/2W, intermittent -- changes in liver weight; affected biochemistry, including phosphatases (RTECS, 2003)
TCLo- (INHALATION)RAT:
- 800 mg/m(3) for 6H/12D, intermittent -- fatty liver degeneration; liver function tests impaired; changes in liver weight (RTECS, 2003)
TDLo- (ORAL)MOUSE:
- 101 mg/kg for 28D, continuous -- changes in liver weight; death (RTECS, 2003)
TDLo- (ORAL)MOUSE:
- 7560 mcg/kg for 21D, continuous -- changes in liver weight (RTECS, 2003)
TDLo- (ORAL)PRIMATE:
- 2700 mg/kg for 90D, continuous -- affected food intake; changes to the endocrine system; death (RTECS, 2003)
TDLo- (ORAL)RAT:
- 140 mg/kg, for 14D, intermittent -- changes in liver weight; endocrine/estrogenic changes; weight loss or decreased weight gain (RTECS, 2003)
TDLo- (ORAL)RAT:
- 150 mg/kg for 3D, intermittent -- changes in liver weight; affected biochemistry, including hepatic microsomal mixed function oxidases (dealkylation, hydroxylation, etc.) and other transferases (RTECS, 2003)
TDLo- (ORAL)RAT:
- 350 mg/kg for 14D, intermittent -- changes in testicular weight (RTECS, 2003)
TDLo- (ORAL)RAT:
- 700 mg/kg for 14D, intermittent -- changes in prostate weight (RTECS, 2003)
TDLo- (ORAL)RAT:
- 1680 mg/kg for 28D, continuous -- diffuse hepatitis (hepatocellular necrosis); changes in liver weight; weight loss or decreased weight gain (RTECS, 2003)
TDLo- (ORAL)RAT:
- 5400 mg/kg for 90D, continuous -- multiple effects on the liver; changes in liver weight; weight loss or decreased weight gain (RTECS, 2003)
TDLo- (SKIN)RAT:
- 20 g/kg for 2W, intermittent -- changes in liver weight; affected biochemistry, including phosphatases; changes in testicular weight (RTECS, 2003)

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS3825-26-1 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Ammonium perfluorooctanoate

TLV:

TLV-TWA: 0.01 mg/m(3)
TLV-STEL:
TLV-Ceiling:

Notations and Endnotes:

Carcinogenicity Category: A3
Codes: Skin
Definitions:

A3: Confirmed Animal Carcinogen with Unknown Relevance to Humans: The agent is carcinogenic in experimental animals at a relatively high dose, by route(s) of administration, at site(s), of histologic type(s), or by mechanism(s) that may not be relevant to worker exposure. Available epidemiologic studies do not confirm an increased risk of cancer in exposed humans. Available evidence does not suggest that the agent is likely to cause cancer in humans except under uncommon or unlikely routes or levels of exposure.
Skin: This refers to the potential significant contribution to the overall exposure by the cutaneous route, including mucous membranes and the eyes, either by contact with vapors or, of likely greater significance, by direct skin contact with the substance. It should be noted that although some materials are capable of causing irritation, dermatitis, and sensitization in workers, these properties are not considered relevant when assigning a skin notation. Rather, data from acute dermal studies and repeated dose dermal studies in animals or humans, along with the ability of the chemical to be absorbed, are integrated in the decision-making toward assignment of the skin designation. Use of the skin designation provides an alert that air sampling would not be sufficient by itself in quantifying exposure from the substance and that measures to prevent significant cutaneous absorption may be warranted. Please see "Definitions and Notations" (in TLV booklet) for full definition.

TLV Basis - Critical Effect(s): Liver dam
Molecular Weight: 431.0

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS3825-26-1 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS3825-26-1 (National Institute for Occupational Safety and Health, 2007):

Not Listed

OSHA PEL Values for CAS3825-26-1 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS3825-26-1 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS3825-26-1 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS3825-26-1 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS3825-26-1 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS3825-26-1 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS3825-26-1 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS3825-26-1 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS3825-26-1 (EPA, 2005):

Listed as: Octanoic acid, pentadecafluoro-, ammonium salt

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions (49 CFR 172.101, 2005):

Not Listed

ICAO International Shipping Name (ICAO, 2002):

Not Listed

LABELS

NFPA

NFPA Hazard Ratings for CAS3825-26-1 (NFPA, 2002):

Not Listed

-HANDLING AND STORAGE

HANDLING

Wear eye and face protection, protective gloves, and chemical resistant clothing when working with or around ammonium perfluorooctanoate. Respiratory protection may also be recommended depending on airborne levels and OSHA requirements (Pohanish, 2002; Dyneon, 2002; DuPont, 2001).

Persons handling and working with this material should be trained on its safe handling and storage (Pohanish, 2002).

Do not eat, drink, or smoke when working with ammonium perfluorooctanoate (Dyneon, 2002; DuPont, 2001).

STORAGE

CONTAINER

Store ammonium perfluorooctanoate in tightly closed containers (Pohanish, 2002; DuPont, 2001).

ROOM/CABINET RECOMMENDATIONS

Store ammonium perfluorooctanoate in a cool, well-ventilated area (Pohanish, 2002; DuPont, 2001).

INCOMPATIBILITIES

Store ammonium perfluorooctanoate away from heat and oxidizing agents, and out of direct sunlight (Dyneon, 2002).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Ammonium perfluorooctanoate is an inhalation, ingestion, and direct contact hazard. Wear appropriate eye protection, protective gloves, and chemical resistant clothing to prevent eye and skin contact with this chemical. Respiratory protection may be recommended (Pohanish, 2002; DuPont, 2001).

EYE/FACE PROTECTION

Wear safety glasses or chemical splash goggles when working with solutions. Dust-proof chemical goggles and a face shield should be used when working with or around ammonium perfluorooctanoate powder. Alternatively, a full facepiece respirator will protect the eyes and face(Pohanish, 2002; DuPont, 2001).

Avoid eye contact with ammonium perfluorooctanoate vapors, mist, or spray. Indirect vented goggles are recommended for protection when working with solutions (Dyneon, 2002).

Do not wear contact lenses when working with ammonium perfluorooctanoate (Pohanish, 2002).

RESPIRATORY PROTECTION

When working with solutions of the material, avoid breathing ammonium perfluorooctanoate vapors, mists, or spray. Wear a NIOSH-approved respiratory protection, such as a half-facepiece or fullface supplied-air respirator, based on airborne levels and OSHA requirements(Dyneon, 2002; DuPont, 2001).

Respiratory protection should be implemented at any detectable concentration (Pohanish, 2002).

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 3825-26-1.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

ENGINEERING CONTROLS

Ammonium perfluorooctanoate should only be used in areas with adequate ventilation. Do not use the material in confined areas or places with little or no air movement (Dyneon, 2002; DuPont, 2001).

Use general dilution ventilation and/or local exhaust ventilation (Dyneon, 2002; DuPont, 2001).
Vent heated dryer or extruder fumes outside of the work area (DuPont, 2001).

During spray applications, use airless-type pressure spray equipment at less than 60 psi (DuPont, 2001).

Minimize worker exposure to mists and overspray by using exhaust ducts, drip pans, and other design elements (DuPont, 2001).

OTHER

INDUSTRIAL DECONTAMINATION

An eyewash and emergency safety shower should be provided in the area(s) where ammonium perfluorooctanoate is used (Pohanish, 2002).
If ammonium perfluorooctanoate contacts the skin, immediately wash affected area(s) with soap and water. Remove any contaminated clothing, shoes, or equipment. Seek medical attention right away (Dyneon, 2002; Pohanish, 2002; DuPont, 2001).
In case of chemical contact with the eye(s), first remove contact lenses if present, then immediately flush the eye(s) with water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Seek medical attention right away (Dyneon, 2002; Pohanish, 2002; DuPont, 2001).
If ammonium perfluorooctanoate is inhaled, move the victim to fresh air, and seek medical attention (Dyneon, 2002; Pohanish, 2002; DuPont, 2001).

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.
POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)
- Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
- Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.).
- Contact with metals may evolve flammable hydrogen gas.
- Containers may explode when heated.
Wear self-contained breathing apparatus (SCBA) and full protective gear when fighting a fire involving this material (DuPont, 2001).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS3825-26-1 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Dry chemical, CO2 or water spray.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Dry chemical, CO2, alcohol-resistant foam or water spray.
Move containers from fire area if you can do it without risk.
Dike fire control water for later disposal; do not scatter the material.

TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Do not get water inside containers.
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

NFPA Extinguishing Methods for CAS3825-26-1 (NFPA, 2002):

Not Listed

Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers to fight fires involving ammonium perfluorooctanoate (Pohanish, 2002; DuPont, 2001).

Notify downstream users and local health, fire, and pollution control officials if ammonium perfluorooctanoate or runoff contaminated with it enters the waterways (Pohanish, 2002).

COMBUSTION TOXICITY

When heated to decomposition, ammonium perfluorooctanoate emits toxic fumes of fluorine and ammonia (Lewis, 2000).
Hazardous decomposition products of the solution include carbon dioxide, carbon monoxide, and hydrogen fluoride (Dyneon, 2002; DuPont, 2001).

REACTIVITY HAZARD

Ammonium perfluorooctanoate solution will evolve ammonia under the influence of alkalies (Dyneon, 2002).

For solutions of the material, hazardous polymerization will not occur (Dyneon, 2002; DuPont, 2001).

The 20% solution is stable at normal temperature (DuPont, 2001).

EVACUATION PROCEDURES

SUMMARY

Initial Isolation and Protective Action Distances (ERG, 2004)

Data presented from the Emergency Response Guidebook Table of Initial Isolation and Protective Action Distances are for use when a spill has occurred and there is no fire. If there is a fire, or if a fire is involved, evacuation information presented under FIRE - PUBLIC SAFETY EVACUATION DISTANCES should be used.
Generally, a small spill is one that involves a single, small package such as a drum containing up to approximately 200 liters, a small cylinder, or a small leak from a large package. A large spill is one that involves a spill from a large package, or multiple spills from many small packages.
Suggested distances to protect from vapors of toxic-by-inhalation and/or water-reactive materials during the first 30 minutes following the spill.

SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

Increase, in the downwind direction, as necessary, the isolation distance of at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids in all directions.

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.
Ventilate enclosed areas.

Evacuate unprotected workers from the area of the spill (Dyneon, 2002).

Remove persons from area of inhalation exposure (Pohanish, 2002).

AIHA ERPG Values for CAS3825-26-1 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS3825-26-1 (U.S. Department of Energy, Office of Emergency Management, 2010):

Not Listed

AEGL Values for CAS3825-26-1 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS3825-26-1 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.
- Stop leak if you can do it without risk.
- Prevent entry into waterways, sewers, basements or confined areas.
- Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
- DO NOT GET WATER INSIDE CONTAINERS.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 154 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
Spills of ammonium perfluorooctanoate solution should be handled by trained personnel. Evacuate other unprotected workers from the area of the spill and ventilate the area (Dyneon, 2002; DuPont, 2001).
Initial containment of liquid spills can be accomplished with dikes (DuPont, 2001).
Cover spills of ammonium perfluorooctanoate solution with bentonite, vermiculite, or other absorbent material until the spill area appears dry. Collect material and place in approved metal container for disposal. Decontaminate area of spill with water (Dyneon, 2002).
Soak up spills of ammonium perfluorooctanoate with sawdust, sand, "oil dry," or other absorbent material (DuPont, 2001).

LARGE LEAK/SPILL

Provide mechanical ventilation for large spills or spills in confined spaces to disperse vapors (Dyneon, 2002).
Dike spilled material and cover drains to prevent the chemical from entering sewers or waterways (Dyneon, 2002; DuPont, 2001).

WASTE TREATMENT OPTIONS

INCINERATION

Incinerate solutions of ammonium perfluorooctanoate in the presence of a combustible material at an approved facility that can adequately handle halogenated materials (Dyneon, 2002).
Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

Occupational exposure to ammonium perfluorooctanoate occurs through its use as a processing aid in the production of fluoropolymers and fluoroelastomers. Low levels of exposure to the general public may occur, but specific pathways of exposure for the general population are currently unknown (EPA OPPT, 2003; 68 FR 18626, 2003; ACGIH, 2001).

Ammonium perfluorooctanoate is potentially released to the environment via air emissions and wastewater discharge from manufacturing facilities and possibly in leachate from ammonium perfluorooctanoate-containing landfill wastes (GIST, 2003).

There are very limited data on the presence of ammonium perfluorooctanoate in the general environment (EPA OPPT, 2003).

Salts of perfluorooctanoate acid (PFOA), including ammonium perfluorooctanoate, can be formed from degradation or metabolism of certain other manmade fluorochemical products (68 FR 18626, 2003).

ENVIRONMENTAL FATE AND KINETICS

Ammonium perfluorooctanoate may be removed from the atmosphere through deposition and may subsequently migrate to surface and/or groundwater (GIST, 2003).

SOIL

TERRESTRIAL
- Based on groundwater sampling in the vicinity of several known ammonium perfluorooctanoate waste disposal sites, ammonium perfluorooctanoate is thought to be migrating from landfill wastes through the soil as leachate into surface and ground water (GIST, 2003).

ABIOTIC DEGRADATION

Ammonium perfluorooctanoate may migrate from the atmosphere and landfill wastes into surface and ground water (GIST, 2003).

In biologic media, ammonium perfluorooctanoate readily disassociates to perfluorooctanoate, the anion of perfluorooctanoic acid (DEP, 2002).

Data indicate that ammonium perfluorooctanoate persists in the environment for long periods of time (DuPont, 2001).

BIODEGRADATION

When tested in a ready biodegradation test, ammonium perfluorooctanoate did not undergo significant biodegradation (Dyneon, 2002).

EC50 - MICROBES (ACTIVATED SLUDGE) - >1000 mg/L for 3H, static -- 38% inhibition of respiration rate (DEP, 2002)

EC50 - MICROBES (ACTIVATED SLUDGE) - >3320 mg/L for 3H, static -- inhibition of respiration rate (DEP, 2002)

ENVIRONMENTAL TOXICITY

EC50 - DAPHNIA MAGNA (Water flea) - 33 mg/L for 14D with renewal every 2D, semi-static -- reproduction impaired (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 38 mg/L for 21D with renewal every 2D, semi-static -- reproduction impaired (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 40 mg/L for 21D with renewal every 2D, semi-static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - >60 mg/L for 14D with renewal every 2D, semi-static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 126 mg/L for 48H (Dyneon, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 126 - >1000 mg/L for 48H, static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 221 mg/L for 48H, static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 266 mg/L for 48H, static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 360 mg/L for 48H, static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 416 mg/L for 24H, static (DEP, 2002)

EC50 - DAPHNIA MAGNA (Water flea) - 632 mg/L for 48H (DuPont, 2001)

EC50 - PHOTOBACTERIUM PHOSHOREUM (Marine bacteria) - 730 mg/L for 30M, static (DEP, 2002)

EC50 - PHOTOBACTERIUM PHOSHOREUM (Marine bacteria) - 870 mg/L for 30M, static (DEP, 2002)

EC50 - PHOTOBACTERIUM PHOSHOREUM (Marine bacteria) - 1950 mg/L for 30M, static (DEP, 2002)

EC50 - PHOTOBACTERIUM PHOSHOREUM (Marine bacteria) - 3150 mg/L for 30M, static (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 27 mg/L for 240H, static -- cell count affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 30 mg/L for 168H, static -- cell count affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 43 mg/L for 336H, static -- cell count affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 49 mg/L for 96H, static -- cell count affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 49 mg/L for 240H, static -- cell dry weight affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 70 mg/L for 168H, static -- cell dry weight affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 73 mg/L for 336H, static -- cell dry weight affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 149 mg/L for 96H, static -- cell dry weight affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 1980 mg/L for 96H, static -- cell counts affected (DEP, 2002)

EC50 - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - >3330 mg/L for 96H, static -- growth rate affected (DEP, 2002)

LC50 - DAPHNIA MAGNA (Water flea) - 632 mg/L for 48H, static (DEP, 2002)

LC50 - DAPHNIA MAGNA (Water flea) - 720 mg/L for 48H, static (DEP, 2002)

LC50 - LEPOMIS MACROCHIRUS (Bluegill sunfish) - >420 mg/L for 96H, static (DEP, 2002)

LC50 - LEPOMIS MACROCHIRUS (Bluegill sunfish) - 569 mg/L for 96H, static (DEP, 2002)

LC50 - LEPOMIS MACROCHIRUS (Bluegill sunfish) - 634 mg/L for 96H, static (DEP, 2002; DuPont, 2001)

LC50 - LEPOMIS MACROCHIRUS (Bluegill sunfish) - 1550 mg/L for 48H, static (DEP, 2002)

LC50 - ONCORHYNCHUS MYKISS (Rainbow trout) - 800 mg/L for 96H, static (DEP, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 70 mg/L for 96H, static (DEP, 2002; Dyneon, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 301 mg/L for 96H, static (DEP, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 440 mg/L for 96H, static (DEP, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 740 mg/L for 96H, static (DEP, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 741 mg/L for 96H, static (DEP, 2002)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 766 mg/L for 96H, static (DEP, 2002; DuPont, 2001)

LC50 - PIMEPHALES PROMELAS (Fathead minnow) - 843 mg/L for 96H, static (DEP, 2002)

LC50 - SNAILS - 820 mg/L for 48H (DEP, 2002)

LOEC - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 430 mg/L for 96H, static -- cell counts affected (DEP, 2002)

LOEC - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 830 mg/L for 96H, static -- growth rate affected (DEP, 2002)

NOAEL - PIMEPHALES PROMELAS (Fathead minnow) - 100 mg/L from 48H post-fertilization to 30D post-hatch -- no observed reductions in hatchability, percent survival, and growth (DEP, 2002)

NOEC - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 210 mg/L for 96H, static -- cell counts affected (DEP, 2002)

NOEC - SELENESTRUM CAPRICORNUTUM (Freshwater green algae) - 430 mg/L for 96H, static -- growth rate affected (DEP, 2002)

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

431.1

VAPOR PRESSURE

7 x 10(-5) torr (at 20 degrees C) (ACGIH, 2001)

DENSITY

TEMPERATURE AND/OR PRESSURE NOT LISTED

0.6 - 0.7 g/cc (ACGIH, 2001; Lewis, 2001)

BOILING POINT

125 degrees C (sublimes) (Lewis, 2001; Pohanish, 2002)

Sublimes at >125 degrees C (ACGIH, 2001)

SOLUBILITY

IN WATER

Highly soluble in water (ACGIH, 2001; Lewis, 2001; Pohanish, 2002)

HENRY'S CONSTANT

10(-11) (DEP, 2002)

-REFERENCES

GENERAL BIBLIOGRAPHY

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65 FR 39264: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.

65 FR 77866: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2000.

66 FR 21940: Notice of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances - Proposed AEGL Values, Environmental Protection Agency, NAC/AEGL Committee. National Archives and Records Administration (NARA) and the Government Publishing Office (GPO), Washington, DC, 2001.

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ICAO: Technical Instructions for the Safe Transport of Dangerous Goods by Air, 2003-2004. International Civil Aviation Organization, Montreal, Quebec, Canada, 2002.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Phosgene Oxime (Proposed). United States Environmental Protection Agency. Washington, DC. 2009f. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480a7e26d&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Propargyl Alcohol (Proposed). United States Environmental Protection Agency. Washington, DC. 2006e. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020ec91&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Selenium Hexafluoride (Proposed). United States Environmental Protection Agency. Washington, DC. 2006f. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020ec55&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Silane (Proposed). United States Environmental Protection Agency. Washington, DC. 2006g. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020d523&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

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AMMONIUM PERFLUOROOCTANOATE

Classification | Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents