PHENYLHYDRAZINE

Phenylhydrazine is useful in analytical chemistry as a reagent to characterize sugars, aldehydes, and ketones since it reacts readily with carbonyl compounds (Clayton & Clayton, 1994).
It is also used in the manufacture of dyes and pharmaceuticals, in the organic synthesis of indoles, antipyrine, and pyrazole derivatives, and in the manufacture of nitron, an explosive stabilizer (Clayton & Clayton, 1994; Budavari, 1989; HSDB , 1996).
Phenylhydrazine was formerly used in the treatment of polycythemia vera, but less toxic and more effective treatments are now used (ACGIH, 1991).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

Phenylhydrazine may be toxic by inhalation, ingestion, and skin or eye exposure. Hydrazines are local irritants, mucous membrane irritants, convulsants, hepatotoxins, and hemolytic agents.

Exposure may cause nausea; anorexia; jaundice; dermatitis; vascular thrombosis; liver and kidney damage; and hematologic effects including cyanosis, hemolytic anemia, methemoglobinemia, and leukocytosis. NIOSH has recommended that phenylhydrazine be regulated as a carcinogen. It has also demonstrated mutagenic activity.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death.
Contact with molten substance may cause severe burns to skin and eyes.
Avoid any skin contact.
Effects of contact or inhalation may be delayed.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
For minor skin contact, avoid spreading material on unaffected skin.
Keep victim warm and quiet.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID

EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical.
DERMAL EXPOSURE - Immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.
INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
ORAL EXPOSURE - If this chemical has been swallowed, get medical attention immediately.
TARGET ORGANS - Blood, respiratory system, liver, kidneys, and skin (National Institute for Occupational Safety and Health, 2007).

GENERAL

Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Because of the potential for rapid onset of CNS depression or seizures with possible aspiration of gastric contents, EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.

INHALATION EXPOSURE

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
SEIZURES: Administer a benzodiazepine; DIAZEPAM (ADULT: 5 to 10 mg IV initially; repeat every 5 to 20 minutes as needed. CHILD: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed) or LORAZEPAM (ADULT: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist. CHILD: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue).

Consider phenobarbital or propofol if seizures recur after diazepam 30 mg (adults) or 10 mg (children greater than 5 years).
Monitor for hypotension, dysrhythmias, respiratory depression, and need for endotracheal intubation. Evaluate for hypoglycemia, electrolyte disturbances, and hypoxia.

DERMAL EXPOSURE

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

EYE EXPOSURE

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

INGESTION EXPOSURE

Because of the potential for gastrointestinal tract irritation or CNS depression, do not induce emesis.
Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.
GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.
SEIZURES: Administer a benzodiazepine; DIAZEPAM (ADULT: 5 to 10 mg IV initially; repeat every 5 to 20 minutes as needed. CHILD: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed) or LORAZEPAM (ADULT: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist. CHILD: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue).

Consider phenobarbital or propofol if seizures recur after diazepam 30 mg (adults) or 10 mg (children greater than 5 years).
Monitor for hypotension, dysrhythmias, respiratory depression, and need for endotracheal intubation. Evaluate for hypoglycemia, electrolyte disturbances, and hypoxia.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

GENERAL/SUMMARY

The minimum lethal human dose to this agent has not been delineated.

ANIMAL DATA

The lowest published lethal doses were 170 mg/kg in mice by the subcutaneous route, 200 mg/kg orally in dogs, 120 mg/kg intravenously in dogs, and 300 mg/kg in frogs by an unreported route (RTECS , 1996).

MAXIMUM TOLERATED EXPOSURE

GENERAL/SUMMARY

The maximum tolerated human exposure to this agent has not been delineated.

Carcinogenicity Ratings for CAS100-63-0 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): A3 ; Listed as: Phenylhydrazine

A3 :Confirmed Animal Carcinogen with Unknown Relevance to Humans: The agent is carcinogenic in experimental animals at a relatively high dose, by route(s) of administration, at site(s), of histologic type(s), or by mechanism(s) that may not be relevant to worker exposure. Available epidemiologic studies do not confirm an increased risk of cancer in exposed humans. Available evidence does not suggest that the agent is likely to cause cancer in humans except under uncommon or unlikely routes or levels of exposure.

EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Ca ; Listed as: Phenylhydrazine

Ca : NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A in the NIOSH Pocket Guide to Chemical Hazards).

MAK (DFG, 2002): Category 3B ; Listed as: Phenylhydrazine

Category 3B : Substances for which in vitro or animal studies have yielded evidence of carcinogenic effects that is not sufficient for classification of the substance in one of the other categories. Further studies are required before a final decision can be made. A MAK value can be established provided no genotoxic effects have been detected. (Footnote: In the past, when a substance was classified as Category 3 it was given a MAK value provided that it had no detectable genotoxic effects. When all such substances have been examined for whether or not they may be classified in Category 4, this sentence may be omitted.)

NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS100-63-0 (U.S. Environmental Protection Agency, 2011):

Not Listed

TOXICITY VALUES

References: RTECS, 1996 Lewis, 1992 Clayton & Clayton, 1994 (Hathaway, 1991; ITI, 1988 Note: All values are from RTECS (1996) unless otherwise noted.
- LC50- (INHALATION)MOUSE:
- LC50- (INHALATION)RAT:
- LD50- (INTRAVENOUS)DOG:
- LD50- (ORAL)DOG:
- LD50- (ORAL)GUINEA_PIG:
- LD50- (INTRAPERITONEAL)MOUSE:
- LD50- (ORAL)MOUSE:
- LD50- (ORAL)RABBIT:
- LD50- (SKIN)RABBIT:
- LD50- (SUBCUTANEOUS)RABBIT:
- LD50- (ORAL)RAT:
- LD50- (SUBCUTANEOUS)RAT:
- LDLo- (INTRAVENOUS)DOG:
- LDLo- (ORAL)DOG:
- LDLo- (ORAL)MOUSE:
- LDLo- (SUBCUTANEOUS)MOUSE:
- LDLo- (SUBCUTANEOUS)RAT:
- TDLo- (INTRAPERITONEAL)RAT:
- TDLo- (SUBCUTANEOUS)RAT:

CALCULATIONS

AMBIENT CONVERSIONS

CONVERSION FACTORS

1 ppm = 4.49 mg/m(3)

Conversion factor at 68 degrees F and 760 mmHg -

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS100-63-0 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Phenylhydrazine

TLV:

TLV-TWA: 0.1 ppm
TLV-STEL:
TLV-Ceiling:

Notations and Endnotes:

Carcinogenicity Category: A3
Codes: Skin
Definitions:

A3: Confirmed Animal Carcinogen with Unknown Relevance to Humans: The agent is carcinogenic in experimental animals at a relatively high dose, by route(s) of administration, at site(s), of histologic type(s), or by mechanism(s) that may not be relevant to worker exposure. Available epidemiologic studies do not confirm an increased risk of cancer in exposed humans. Available evidence does not suggest that the agent is likely to cause cancer in humans except under uncommon or unlikely routes or levels of exposure.
Skin: This refers to the potential significant contribution to the overall exposure by the cutaneous route, including mucous membranes and the eyes, either by contact with vapors or, of likely greater significance, by direct skin contact with the substance. It should be noted that although some materials are capable of causing irritation, dermatitis, and sensitization in workers, these properties are not considered relevant when assigning a skin notation. Rather, data from acute dermal studies and repeated dose dermal studies in animals or humans, along with the ability of the chemical to be absorbed, are integrated in the decision-making toward assignment of the skin designation. Use of the skin designation provides an alert that air sampling would not be sufficient by itself in quantifying exposure from the substance and that measures to prevent significant cutaneous absorption may be warranted. Please see "Definitions and Notations" (in TLV booklet) for full definition.

TLV Basis - Critical Effect(s): Anemia; URT and skin irr
Molecular Weight: 108.14

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS100-63-0 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS100-63-0 (National Institute for Occupational Safety and Health, 2007):

Listed as: Phenylhydrazine
REL:

TWA:
STEL:
Ceiling: 0.14 ppm (0.6 mg/m(3)) [2-hr]
Carcinogen Listing: (Ca) NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A in the NIOSH Pocket Guide to Chemical Hazards).
Skin Designation: [skin]

Indicates the potential for dermal absorption; skin exposure should be prevented as necessary through the use of good work practices and gloves, coveralls, goggles, and other appropriate equipment.

Note(s): See Appendix A

IDLH:

IDLH: 15 ppm
Note(s): Ca

Ca: NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A).

OSHA PEL Values for CAS100-63-0 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Listed as: Phenylhydrazine
Table Z-1 for Phenylhydrazine:

8-hour TWA:

ppm: 5

Parts of vapor or gas per million parts of contaminated air by volume at 25 degrees C and 760 torr.

mg/m3: 22

Milligrams of substances per cubic meter of air. When entry is in this column only, the value is exact; when listed with a ppm entry, it is approximate.

Ceiling Value:
Skin Designation: Yes
Notation(s): Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS100-63-0 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS100-63-0 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS100-63-0 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS100-63-0 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS100-63-0 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS100-63-0 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS100-63-0 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS100-63-0 (EPA, 2005):

Listed as: Hydrazine, phenyl-

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 2572 (49 CFR 172.101, 2005):

Hazardous materials descriptions and proper shipping name: Phenylhydrazine

Symbol(s): Not Listed
Hazard class or Division: 6.1

6.1: Poisonous materials. See 49 CFR section 173.132 for definitions.

Identification Number: UN2572
Packing Group: II

II: Packing Group II - indicates the degree of danger presented by the material is medium.

Label(s) required (if not excepted): 6.1

6.1: Poison Inhalation Hazard (inhalation hazard, Zone A or B) or Poison (other than inhalation hazard, Zone A or B; the packing group for a material is indicated in column 5 of the table.).

Special Provisions: IB2, T7, TP2

IB2: Authorized IBCs: Metal (31A, 31B and 31N); Rigid plastics (31H1 and 31H2); Composite (31HZ1). Additional Requirement: Only liquids with a vapor pressure less than or equal to 110 kPa at 50 °C (1.1 bar at 122 °F), or 130kPa at 55 °C (1.3 bar at 131 °F) are authorized.
T7: Minimum test pressure (bar): 4; Minimum shell thickness (in mm-reference steel) (See sxn.178.274(d)): sxn.178.274(d)(2); Pressure-relief requirements (See sxn.178.275(g)): Normal; Bottom opening requirements (See sxn.178.275(d)): sxn.178.275(d)(3).
TP2: a. The maximum degree of filling must not exceed the degree of filling determined by the following: [Degree of filling = 95/1+alpha(tr - tf)], where tr is the maximum mean bulk temperature during transport, tf is the temperature in degrees celsius of the liquid during filling, and alpha is the mean coefficient of cubical expansion of the liquid between the mean temperature of the liquid during filling (tf) and the maximum mean bulk temperature during transportation (tr) both in degrees celsius; and b. For liquids transported under ambient conditions a may be calculated using the formula: [alpha = (d15-d50)/(35 x d50)], where d15 and d50 are the densities (in units of mass per unit volume) of the liquid at 15 degrees C (59 degrees F) and 50 degrees C (122 degrees F), respectively.

Packaging Authorizations (refer to 49 CFR 173.***):

Exceptions: 153
Non-bulk packaging: 202
Bulk packaging: 243

Quantity Limitations:

Passenger aircraft or railcar: 5 L
Cargo aircraft only: 60 L

Vessel Stowage Requirements:

Vessel stowage location: A

A: The material may be stowed "on deck" or "under deck" on a cargo vessel and on a passenger vessel.

Vessel stowage other: 40

40: Stow "clear of living quarters".

ICAO International Shipping Name for UN2572 (ICAO, 2002):

Proper Shipping Name: Phenylhydrazine
UN Number: 2572

LABELS

NFPA

NFPA Hazard Ratings for CAS100-63-0 (NFPA, 2002):

Listed as: Phenylhydrazine
Hazard Ratings:

Health Rating (Blue): 3

(3) Seriously toxic material. Short term exposure could cause serious temporary or residual injury even though prompt medical treatment is given. Includes known or suspect small animal carcinogens, mutagens, or teratogens.

Flammability Rating (Red): 2

(2) Combustible. Materials that must be moderately heated before ignition can occur. Including liquids having a flash point above 100 degrees F, and solids that readily give off flammable vapors.

Instability Rating (Yellow): 0

(0) Materials which are normally stable, even under fire conditions, and which are not reactive with water.

Oxidizer/Water-Reactive Designation: Not Listed

-HANDLING AND STORAGE

STORAGE

CONTAINER

Phenylhydrazine containers should be kept tightly closed and protected from light (Budavari, 1989).
It should be stored in an electrically grounded container (HSDB , 1996).

ROOM/CABINET RECOMMENDATIONS

Phenylhydrazine should be stored in a cool, ventilated location at a temperature well below its boiling point. It should be stored away from all ignition sources and oxidizers (HSDB , 1996).

INCOMPATIBILITIES

Phenylhydrazine is incompatible with strong oxidizers and lead dioxide (NIOSH , 1996).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing provides limited protection. fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Personnel should stay upwind and avoid breathing phenylhydrazine vapors. All bodily contact with the material should be avoided by wearing appropriate chemical protective clothing including rubber gloves, penetration-resistant coveralls, full body shield, and positive pressure self-contained breathing apparatus. Broken packages should not be handled unless wearing appropriate protective clothing, and any phenylhydrazine which has contacted the skin should be washed away with abundant amounts of water (AAR, 1994; (ITI, 1988).

Workers should wear sufficiently long, tight-fitting gloves (HSDB , 1996).

RESPIRATORY PROTECTION

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 100-63-0.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

ENGINEERING CONTROLS

Process enclosure, local exhaust ventilation, or other engineering controls should be used to keep airborne concentrations of phenylhydrazine within acceptable limits. Ventilation systems must prevent accumulation or recirculation of phenylhydrazine vapors (HSDB , 1996).

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)
- Combustible material: may burn but does not ignite readily.
- When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards.
- Those substances designated with a "P" may polymerize explosively when heated or involved in a fire.
- Contact with metals may evolve flammable hydrogen gas.
- Containers may explode when heated.
- Runoff may pollute waterways.
- Substance may be transported in a molten form.
Phenylhydrazine is combustible when exposed to heat, flame, or oxidizers (Lewis, 1992).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS100-63-0 (NFPA, 2002):

Listed as: Phenylhydrazine
Flammability Rating: 2

(2) Combustible. Materials that must be moderately heated before ignition can occur. Including liquids having a flash point above 100 degrees F, and solids that readily give off flammable vapors.

FIRE CONTROL/EXTINGUISHING AGENTS

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Dry chemical, CO2 or water spray.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Dry chemical, CO2, alcohol-resistant foam or water spray.
Move containers from fire area if you can do it without risk.
Dike fire control water for later disposal; do not scatter the material.

TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Do not get water inside containers.
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

NFPA Extinguishing Methods for CAS100-63-0 (NFPA, 2002):

Listed as: Phenylhydrazine
Extinguishing Method(s): 5

5: Flammable liquid fires can be extinguished using carbon dioxide, dry chemical, foam, and vaporizing liquid extinguishers, as long as the fires are small to moderate in size and the flammable liquid reservoir is shallow. Use of foam to form a blanket over a flammable liquid is not effective when the liquid is water-soluble. Certain alcohol resistant foams are effective extinguishing agents for polar, non-polar, and water-soluble liquid fires. These foams are preferred for fighting flammable liquid fires except those that involve water reactive flammable liquids.

Alcohol foam, dry chemical, or carbon dioxide should be used to fight fires involving phenylhydrazine. Attempts to extinguish the fire should not be made unless the flow of material can be stopped. Solid streams of water may be ineffective, but flooding quantities of water applied from as far away as possible may be used to cool affected containers (AAR, 1994).

COMBUSTION TOXICITY

Highly toxic fumes of nitrogen oxides are emitted when phenylhydrazine is heated to decomposition (Lewis, 1992).

EXPLOSION HAZARD

Phenylhydrazine and perchloryl fluoride may react explosively (Lewis, 1992).

Phenylhydrazine interacts with isopropylamine or isobutylamine in the presence of a diluent below 0 degrees C, causing separation of explosive liquids. The reaction with phenylhydrazine and 1,2-diphenylhydrazine causes separation of explosive solids (HSDB , 1996).

REACTIVITY HAZARD

Phenylhydrazine and perchloryl fluoride may react explosively (Lewis, 1992).

Phenylhydrazine interacts with isopropylamine or isobutylamine in the presence of a diluent below 0 degrees C, causing separation of explosive liquids. The reaction with phenylhydrazine and 1,2-diphenylhydrazine causes separation of explosive solids (HSDB , 1996).

Highly toxic fumes of nitrogen oxides are emitted when phenylhydrazine is heated to decomposition (Lewis, 1992).

Phenylhydrazine will react violently with 2-phenylamino-3-phenyloxazirane and vigorously with lead (IV) oxide (Lewis, 1992).

Phenylhydrazine is incompatible with strong oxidizers and lead dioxide (NIOSH , 1996).

EVACUATION PROCEDURES

SUMMARY

Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.

SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

Increase, in the downwind direction, as necessary, the isolation distance of at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids in all directions.

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.
Ventilate enclosed areas.

AIHA ERPG Values for CAS100-63-0 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS100-63-0 (U.S. Department of Energy, Office of Emergency Management, 2010):

Listed as Phenylhydrazine
TEEL-0 (units = ppm): 0.1
TEEL-1 (units = ppm): 0.3
TEEL-2 (units = ppm): 2
TEEL-3 (units = ppm): 15
Definitions:

TEEL-0: The threshold concentration below which most people will experience no adverse health effects.
TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure.
TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape.
TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.

AEGL Values for CAS100-63-0 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS100-63-0 (National Institute for Occupational Safety and Health, 2007):

IDLH: 15 ppm
Note(s): Ca

(Ca) NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A).

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.
- Stop leak if you can do it without risk.
- Prevent entry into waterways, sewers, basements or confined areas.
- Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
- DO NOT GET WATER INSIDE CONTAINERS.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 153 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing provides limited protection. fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
If phenylhydrazine is not on fire or involved in fire, all ignition sources and sparks should be kept away. Attempt should be made to stop the leak if it can be done without undue hazard to personnel. Dikes should be constructed around the spill to ensure that material is kept out of sewers and water sources. A water spray may be used to knock down vapors (AAR, 1994).
For land spills, a pit, pond, lagoon, or other holding area should be constructed to contain the liquid or solid material. Any surface flow should be diked with soil, sand bags, foamed polyurethane, or foamed concrete and bulk liquid should be absorbed with fly ash or cement powder (AAR, 1994).
For water spills, natural barriers or oil spill control booms should be employed to limit the spill travel, and trapped material should be removed with suction hoses (AAR, 1994).

WASTE TREATMENT OPTIONS

CHEMICAL TREATMENT

Spilled phenylhydrazine should be recovered with an aspirator and diluted with enough water to form at least a 40% solution. It may then be neutralized with dilute sulfuric acid (ITI, 1988).
Environmental regulatory agencies should be consulted prior to land disposal of waste residue or sludge (HSDB , 1996).
Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

PHYSICAL TREATMENT

Phenylhydrazine may be dissolved in a flammable solvent such as alcohols or benzene, then carefully incinerated in an open pit after igniting the mixture from a safe distance (ITI, 1988).

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

Phenylhydrazine may be released to the environment through manufacturing processes, transport, or disposal (HSDB, 2004).

ENVIRONMENTAL FATE AND KINETICS

Phenylhydrazine is expected to exist almost entirely in the vapor phase in the atmosphere, based on its estimated vapor pressure of 3.3 mmHg at 25 degrees C. Photolysis and reaction with photochemically-produced hydroxyl radicals may be important fate processes (HSDB, 2004).
Half-lives for the reaction of phenylhydrazine with photochemically-produced hydroxyl radicals in the atmosphere have been estimated at 2.16 to 9 hours. The rate constant for this reaction has been estimated as 4.3 x 10(-11) cm(3)/molecule-sec at 25 degrees C (HSDB, 2004; Verschueren, 2001).
Phenylhydrazine in a methanol solution has been shown to strongly absorb ultraviolet radiation with wavelengths >290 nm, which indicates that it may be susceptible to photolysis when exposed to sunlight (HSDB , 1996).

WATER

SURFACE WATER
- Data are inadequate to determine the primary removal process for phenylhydrazine in water, however, it is expected to undergo photolysis under sunlight conditions. It is not expected to volatilize from water surfaces or bioaccumulate significantly, nor is adsorption to suspended solids and sediments in water predicted (HSDB, 2004).

SOIL

TERRESTRIAL
- Phenylhydrazine released to soil is predicted to be highly mobile, based on its estimated organic carbon partition coefficient (Koc) value of 114. It may undergo photolysis on soil surfaces under sunlit conditions. Volatilization may occur from dry soil surfaces, but is not expected to be significant (HSDB, 2004).

ABIOTIC DEGRADATION

Phenylhydrazine will exist almost entirely in vapor phase in the atmosphere, where is expected to degrade through reaction with photochemically-produced hydroxyl radicals and photolysis. In aquatic environments, it may photolyze in surface waters, but is not expected to volatilize. Phenylhydrazine in soils is highly mobile and may photolyze at soil surfaces or biodegrade (HSDB, 2004).

BIODEGRADATION

Biodegradation of phenylhydrazine under aerobic conditions may occur in soil and water (HSDB, 2004).

Phenylhydrazine has been shown to be significantly more resistant to biological oxidation than aniline (HSDB, 2004).

BIOACCUMULATION

BIOCONCENTRATION FACTOR

An estimated bioconcentration factor (BCF) of 5 indicates phenylhydrazine will not bioconcentrate significantly in aquatic organisms (HSDB, 2004).

ENVIRONMENTAL TOXICITY

BACTERIA

EC50 - Photobacterium phosphoreum: 175 mg/L for 1H (Verschueren, 2001)

CRUSTACEAN

EC50 - WATER FLEA (Daphnia magna): 2 - 5 mg/L for 24H (Verschueren, 2001)

FISH

IC50 - RICEFISH (Oryzias latipes): 16 mg/L for 48H (Verschueren, 2001)
IC50 - RICEFISH (Oryzias latipes): 21 mg/L for 24H (Verschueren, 2001)
LC0 - ZEBRA DANIO (Brachydanio rerio): 0.1 mg/L for 96H (Verschueren, 2001)
LC50 - ZEBRA DANIO (Brachydanio rerio): 0.16 - 0.25 mg/L for 96H (Verschueren, 2001)
LC60 - CARP (Cyprinus carpio): 1 mg/L for 24H (Verschueren, 2001)
LC100 - BLUEGILL (Lepomis macrochirus): 0.01 mg/L for 96H (Verschueren, 2001)
LC100 - BLUEGILL (Lepomis macrochirus): 0.1 mg/L for 48H (Verschueren, 2001)
LC100 - CARP (Cyprinus carpio): 1 mg/L for 24H (Verschueren, 2001)
LC100 - ZEBRA DANIO (Brachydanio rerio): 0.25 mg/L for 96H (Verschueren, 2001)
NOEC - CARP (Cyprinus carpio): 0.1 mg/L for 96H (Verschueren, 2001)

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

108.14

DESCRIPTION/PHYSICAL STATE

Phenylhydrazine occurs in the form of pale yellow monoclinic prisms below 67 degrees F or as an oily liquid which darkens to red when exposed to air and light. It has a faint, aromatic odor (Clayton & Clayton, 1994; Budavari, 1989; NIOSH , 1996).

Phenylhydrazine is a weakly basic reducing agent with a pkb of 8.79 at 15 degrees C (Budavari, 1989; Clayton & Clayton, 1994).

VAPOR PRESSURE

<0.1 mmHg (at 20 degrees C) (Clayton & Clayton, 1994)

0.04 mmHg (at 25 degrees C) (ACGIH, 1991)

3.3 mmHg (at 25 degrees C) (estimated) (HSDB , 1996)

SPECIFIC GRAVITY

OTHER TEMPERATURE AND/OR PRESSURE

1.0978 at 20/4 degrees C (Budavari, 1989)

FREEZING/MELTING POINT

MELTING POINT

19.5 degrees C (Budavari, 1989)

BOILING POINT

243.5 degrees C (at 760 mmHg) (decomposes) (Budavari, 1989)

173.5 degrees C (at 100 mmHg) (Budavari, 1989)

148.2 degrees C (at 40 mmHg) (Budavari, 1989)

131.5 degrees C (at 20 mmHg) (Budavari, 1989)

115.8 degrees C (at 10 mmHg) (Budavari, 1989)

101.6 degrees C (at 5 mmHg) (Budavari, 1989)

71.8 degrees C (at 1.0 mmHg) (Budavari, 1989)

FLASH POINT

88 degrees C; 190 degrees F (closed cup) (NFPA, 1994; ACGIH, 1991)

AUTOIGNITION TEMPERATURE

173 degrees C; 345 degrees F (Lewis, 1993)

EXPLOSIVE LIMITS

LOWER

Unknown (NIOSH , 1996)

UPPER

Unknown (NIOSH , 1996)

SOLUBILITY

IN WATER

Phenylhydrazine is slightly soluble in hot water (Lewis, 1992).
The solubility in water has been experimentally determined to be 837,000 mg/L at 24.2 degrees C (HSDB , 1996).

IN ORGANIC SOLVENTS

It is soluble in alcohol, chloroform, ether, benzene, acetone, and dilute acids (Lewis, 1993) ACGIH, 1991).
Phenylhydrazine has a solubility of greater than 10% in benzene, ethyl ether, and ethanol (HSDB , 1996).
It is sparingly soluble in petroleum ether (Budavari, 1989).

OCTANOL/WATER PARTITION COEFFICIENT

Log Kow = 1.25 (HSDB , 1996)

HENRY'S CONSTANT

5.56 X 10(-9) atm-m(3)/mol (estimated) (HSDB , 1996)

SPECTRAL CONSTANTS

3670 (Sadtler Research Laboratories Prism Collection ) (HSDB , 1996)
2:661F (Aldrich Library of Infrared Spectra) (HSDB , 1996)

MASS

341 (Atlas of Mass Spectral Data) (HSDB , 1996)

OTHER/PHYSICAL

INDEX OF REFRACTION

1.60813 (at 20.3 degrees C/D) (Budavari, 1989)

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Arsenic Trioxide (Proposed). United States Environmental Protection Agency. Washington, DC. 2007m. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480220305&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Bis-Chloromethyl Ether (BCME) (Proposed). United States Environmental Protection Agency. Washington, DC. 2006n. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648022db11&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Boron Tribromide (Proposed). United States Environmental Protection Agency. Washington, DC. 2008a. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064803ae1d3&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Bromine Chloride (Proposed). United States Environmental Protection Agency. Washington, DC. 2007d. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648039732a&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Bromoacetone (Proposed). United States Environmental Protection Agency. Washington, DC. 2008e. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064809187bf&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Calcium Phosphide (Proposed). United States Environmental Protection Agency. Washington, DC. 2005d. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020c5ed&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Carbonyl Fluoride (Proposed). United States Environmental Protection Agency. Washington, DC. 2008b. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064803ae328&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Carbonyl Sulfide (Proposed). United States Environmental Protection Agency. Washington, DC. 2007e. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648037ff26&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Chlorobenzene (Proposed). United States Environmental Protection Agency. Washington, DC. 2008c. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064803a52bb&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Cyanogen (Proposed). United States Environmental Protection Agency. Washington, DC. 2008f. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064809187fe&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Dimethyl Phosphite (Proposed). United States Environmental Protection Agency. Washington, DC. 2009. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480a7cbf3&disposition=attachment&contentType=pdf. As accessed 2010-08-12.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Diphenylchloroarsine (Proposed). United States Environmental Protection Agency. Washington, DC. 2007l. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020fd29&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ethyl Isocyanate (Proposed). United States Environmental Protection Agency. Washington, DC. 2008h. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648091884e&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ethyl Phosphorodichloridate (Proposed). United States Environmental Protection Agency. Washington, DC. 2008i. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480920347&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ethylbenzene (Proposed). United States Environmental Protection Agency. Washington, DC. 2008g. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064809203e7&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ethyldichloroarsine (Proposed). United States Environmental Protection Agency. Washington, DC. 2007j. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020fd29&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Germane (Proposed). United States Environmental Protection Agency. Washington, DC. 2008j. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480963906&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Hexafluoropropylene (Proposed). United States Environmental Protection Agency. Washington, DC. 2006. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064801ea1f5&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ketene (Proposed). United States Environmental Protection Agency. Washington, DC. 2007. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020ee7c&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Magnesium Aluminum Phosphide (Proposed). United States Environmental Protection Agency. Washington, DC. 2005h. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020c5ed&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Methyl Isothiocyanate (Proposed). United States Environmental Protection Agency. Washington, DC. 2008k. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480963a03&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Methyl tertiary-butyl ether (Proposed). United States Environmental Protection Agency. Washington, DC. 2007a. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064802a4985&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

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