10,10-OXIDIPHENOXARSINE

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.

MOLECULAR FORMULA

C24-H16-As2-O3

ERG GUIDE NUMBER

152-SUBSTANCES - TOXIC (COMBUSTIBLE)

SYNONYM REFERENCE

(RTECS, 1990;(Budavari, 1989; EPA, 1985)

USES/FORMS/SOURCES

USES

When condensed with epoxidized soybean oil, it functions as both a plasticizer and biocide in vinyl plastics (Sax & Lewis, 1987).

FORMS

10,10'-Oxidiphenoxarsine occurs as colorless, monoclinic prisms which are soluble in methylene chloride, chloroform, and alcohol, and are sparingly soluble in water (HSDB , 1993).
10,10'-Oxidiphenoxarsine is a pentavalent arsenic compound. As such, it is less toxic than the trivalent arsenic on an equivalent dose basis; however, all arsenic compounds, regardless of valence, are capable of producing the same effects (Finkel, 1983; Morgan, 1989).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

10,10'Oxydiphenoxarsine (OBPA) is used as an antimicrobial agent and plasticizer in vinyl plastics. At the time of this review, little information was found on its toxic effects. This review is based on the toxic effects of arsenicals in general.

Acute arsenic poisoning can occur with doses as low as 20 mg in an adult. Symptoms of acute arsenic poisoning include metallic or garlic taste, vomiting, abdominal pain, dysphagia, and watery or bloody diarrhea. Dehydration, intense thirst, fluid-electrolyte disturbances, and hypovolemia are common.

Hypotension, tachycardia, cardiac dysrhythmias, EKG abnormalities, delerium, encephalopathy, peripheral neuropathy, and liver and kidney damage may also occur. Hemolysis, pancytopenia, and anemia have been caused by acute or chronic arsenic poisoning.

Chronic occupational arsenic exposure has been associated with hoarse voice, nasal irritation, possible perforation of the nasal septum, irritation of eyes, skin, and mucous membranes, and rarely, cirrhosis of the liver.

Nausea and vomiting and ulceration of the wrist and scrotal skin, lips, and nostrils may develop with chronic exposure to arsenic dust or vapor. Systemic arsenic poisoning from occupational exposure is uncommon.

Arsenic exposure has been linked with cancers of the lungs, lymph glands, bone marrow, bladder, kidney, prostate, and liver.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin.
Contact with molten substance may cause severe burns to skin and eyes.
Avoid any skin contact.
Effects of contact or inhalation may be delayed.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

ACUTE CLINICAL EFFECTS

10,10'-oxidiphenoxarsine (OBPA) is assumed to have toxic effects similar to other arsenicals. It may be hazardous by the inhalation, dermal, or oral route exposure routes, by analogy with other arsenicals (EPA, 1985).

OBPA was a severe skin irritant in guinea pigs in the Standard Draize Test (RTECS , 1993).

Acute arsenic ingestion generally produces symptoms within 30 to 60 minutes, but symptom onset may be delayed for several hours if ingested with food (Morgan, 1989; Sittig, 1985). Greater than 90% of an ingested dose of inorganic arsenic is systemically absorbed, with the rate of absorption being highly dependent on the solubility of the specific compound and the arsenic valence state. A metallic or garlic taste and garlic-like odor of the breath, vomiting, abdominal pain, dysphagia, and profuse watery (rice-like) and sometimes bloody diarrhea may occur (Sittig, 1985; Finkel, 1983; EPA, 1988).

Dehydration, intense thirst, and fluid-electrolyte disturbances are common (Morgan, 1989). Hypovolemia from capillary leaking ("third spacing" of fluids) is a common early sign (Morgan, 1989; EPA, 1988; HSDB , 1993). Cardiac arrhythmias may occur, but these may be secondary to electrolyte imbalance (Peterson & Rumack, 1977; Goldsmith, 1980; St Peter et al, 1970; Sittig, 1985).

The primary target organs initially are the gastrointestinal tract, heart, brain, and kidneys (Sittig, 1985; Morgan, 1989; Finkel, 1983; HSDB , 1993). Eventually, the skin, bone marrow, and peripheral nervous system may be significantly damaged (Finkel, 1983; Morgan, 1989; Sittig, 1985; HSDB , 1993). Hemolysis, pancytopenia, and anemia may occur after acute arsenic poisoning (Kyle & Pease, 1965; Kjeldsberg & Ward, 1972).

MEE'S LINES, transverse white lines in the nails, may be seen after acute exposure. Mee's lines commonly take 5 weeks to appear above the cuticle and advance 1 mm per week afterwards, allowing an approximation of the time of acute exposure (Heyman et al, 1956).

Permanent encephalopathy may ensue from acute exposure to arsenic compounds. The encephalopathy can result in atrophy of the cortex one to six months after exposure (Fincher & Koerker, 1987), causing loss of many higher functions.

Peripheral neuropathy of both the sensory and motor type can appear in a similar pattern, regardless of the route of exposure to arsenic compounds (Finkel, 1983). It commonly begins one to 3 weeks following exposure (Le Quesne & McLeod, 1977; Heyman et al, 1956). It usually begins as paresthesias of the soles of the feet, then the hands, progressing proximally over the next few days (Heyman et al, 1956).

Severe muscle weakness and wasting then develops, causing disability (Le Quesne & McLeod, 1977). It may initially be confused with Guillain-Barre' syndrome (Donofrio et al, 1987). Paresthesias may be painful and are frequently described as severe burning pain in a "stocking and glove" distribution.

Physical findings of arsenic neuropathy usually include prominently decreased sensation to touch, pinprick, and temperature, frequently in a stocking and glove distribution (Heyman et al, 1956). Loss of vibration sense and profound muscle weakness and wasting, distal more so than proximal, is also observed (Donofrio et al, 1987; Heyman et al, 1956), as are wrist drop, foot drop, and muscle fasciculations (Heyman et al, 1956).

Arsenic inhibits enzymes required for cellular respiration, and has the effect of depleting cellular energy stores, leading to cellular death (Schoolmeester & White, 1980).

CHRONIC CLINICAL EFFECTS

One worker chronically exposed to 10,10'-oxidiphenoxarsine and arsenate developed typical dermatologic signs of chronic arsenic poisoning consisting of eczemoid lesions, hyperkeratosis, warts, increased pigmentation, and mucous membrane irritation (Horiguchi, 1979).

Dichlorophenylarsine, a related compound, has been reported to be an allergen in occupational exposures (Foussereau et al, 1982).

Workers chronically exposed to arsenic by inhalation and dermal contact have mainly developed a hoarse voice, nasal irritation, and, possibly, perforation of the nasal septum, irritation of eyes, skin, and mucous membranes, and rarely, cirrhosis of the liver (ACGIH, 1986; Finkel, 1983; Sittig, 1985; Proctor et al, 1988; Clayton & Clayton, 1981). Nausea and vomiting are infrequent complaints (Clayton & Clayton, 1981). Painful ulceration of the wrist and scrotal skin, lips, and nostrils may develop with dust exposure (Finkel, 1983; Sittig, 1985).

Chronic arsenic poisoning involves alopecia and enlarged liver, in addition to the signs and symptoms mentioned in the ACUTE EXPOSURE section (Finkel, 1983). Aplastic anemia has also been described after chronic arsenic exposure (Kjeldsberg & Ward, 1972).

Arsenic can cause cancer in humans (refer to CARCINOGENIC EFFECTS section for more information).

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
For minor skin contact, avoid spreading material on unaffected skin.
Keep victim warm and quiet.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID MEASURES -

INHALATION EXPOSURE -

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.

DERMAL EXPOSURE -

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).

EYE EXPOSURE -

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

ORAL EXPOSURE -

Do not induce emesis.
DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.
GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

Although arsenic is commonly listed as being effectively adsorbed to charcoal, data are lacking.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.

OTHER -

After acute arsenic exposure, the primary threats to life are from hypovolemia and cardiac toxicity resulting in arrhythmias or cardiogenic shock. Volume status must be monitored carefully by taking frequent vital signs, following hourly urine output (requires catheterization of bladder), and preferably central venous pressure or cardiac output monitoring.
In chronic arsenic poisoning, the most important step is removing the patient from the source of exposure.
Details of the evaluation and treatment of arsenical cancers is beyond the scope of this review. Individuals suspected of having arsenic-induced cancers should be evaluated in consultation with an oncologist, surgeon, or other physicians knowledgeable in the treatment of cancer.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

GENERAL/SUMMARY

The minimum lethal human dose to this agent has not been delineated.
One mg/kg of ingested arsenic may be lethal in a child (Woody & Kometani, 1948).
As little as 20 mg of arsenic may produce life-threatening toxicity (Zaloga et al, 1970; Schoolmeester & White, 1980; Hutton & Christians, 1983).
In general, however, organoarsenicals are less toxic than inorganic arsenic conpounds.

ANIMAL DATA

Published Values (RTECS, 1996) -

LDLo (ORAL) MOUSE - 42 mg/kg
LCLo (INHL) GUINEA PIG - 141 mg/m(3)/2h

MAXIMUM TOLERATED EXPOSURE

GENERAL/SUMMARY

The maximum tolerated human exposure to this agent has not been delineated.
AVERAGE HUMAN ARSENIC INTAKE - 250 to 330 mcg/day (in food and water) (Gilman et al, 1985; Baselt & Cravey, 1989).

Carcinogenicity Ratings for CAS58-36-6 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS58-36-6 (U.S. Environmental Protection Agency, 2011):

Not Listed

TOXICITY VALUES

References: (RTECS, 1996)
- LD50- (ORAL)GUINEA_PIG:
- LD50- (ORAL)RAT:

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS58-36-6 (American Conference of Governmental Industrial Hygienists, 2010):

Not Listed

AIHA WEEL Values for CAS58-36-6 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS58-36-6 (National Institute for Occupational Safety and Health, 2007):

Not Listed

OSHA PEL Values for CAS58-36-6 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS58-36-6 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS58-36-6 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS58-36-6 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS58-36-6 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS58-36-6 (U.S. Environmental Protection Agency, 2010):

Listed as: Phenoxarsine, 10,10'-Oxydi-
Reportable Quantity, in pounds: 500

Only the statutory or final RQ is shown. For more information, see 40 CFR table 302.4.

Threshold Planning Quantity, in pounds:

500/10,000
Amount necessary to be covered by this standard. See 40 CFR 355.30.

Note(s): Not Listed

EPA SARA Title III, Community Right-to-Know for CAS58-36-6 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS58-36-6 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS58-36-6 (EPA, 2005):

Not Listed

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions (49 CFR 172.101, 2005):

Not Listed

ICAO International Shipping Name (ICAO, 2002):

Not Listed

LABELS

NFPA

NFPA Hazard Ratings for CAS58-36-6 (NFPA, 2002):

Not Listed

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Every precaution must be taken to limit exposure to arsenic-containing compounds.

RESPIRATORY PROTECTION

Work time should be monitored for heat stress factors and limited if necessary when wearing chemical protective clothing (NIOSH et al, 1985).

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 58-36-6.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.
POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)
- Combustible material: may burn but does not ignite readily.
- Containers may explode when heated.
- Runoff may pollute waterways.
- Substance may be transported in a molten form.
When heated to decomposition, arsenicals will emit toxic gases containing arsenic (EPA, 1985).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS58-36-6 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Dry chemical, CO2 or water spray.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Water spray, fog or regular foam.
Move containers from fire area if you can do it without risk.
Dike fire control water for later disposal; do not scatter the material.
Use water spray or fog; do not use straight streams.

TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Do not get water inside containers.
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.
For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

NFPA Extinguishing Methods for CAS58-36-6 (NFPA, 2002):

Not Listed

Stay upwind and keep out of low areas (EPA, 1985).

Wear self-contained breathing apparatus in positive pressure mode, and full chemical protective clothing (EPA, 1985).

COMBUSTION TOXICITY

When heated to decomposition, arsenicals will emit toxic gases containing arsenic (EPA, 1985).

DUST/VAPOR HAZARD

When heated to decomposition, arsenicals will emit toxic gases containing arsenic (EPA, 1985).

EVACUATION PROCEDURES

SUMMARY

Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.

SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

Increase, in the downwind direction, as necessary, the isolation distance of at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids in all directions.

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.

Stay upwind and keep out of low areas (EPA, 1985).

AIHA ERPG Values for CAS58-36-6 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS58-36-6 (U.S. Department of Energy, Office of Emergency Management, 2010):

Listed as Oxydiphenoxarsine, 10,10'- (Phenoxyarsine oxide)
TEEL-0 (units = mg/m3): 1.68
TEEL-1 (units = mg/m3): 2
TEEL-2 (units = mg/m3): 14
TEEL-3 (units = mg/m3): 14
Definitions:

TEEL-0: The threshold concentration below which most people will experience no adverse health effects.
TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure.
TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape.
TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.

AEGL Values for CAS58-36-6 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS58-36-6 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.
- Stop leak if you can do it without risk.
- Prevent entry into waterways, sewers, basements or confined areas.
- Cover with plastic sheet to prevent spreading.
- Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
- DO NOT GET WATER INSIDE CONTAINERS.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 152 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
Do not touch spilled material (EPA, 1985).
Stop leak if you can do so without risk (EPA, 1985).
Dike far ahead of liquid spill (EPA, 1985).
Absorb with sand or other noncombustible sorbent material (EPA, 1985).
With clean shovel, place material into clean, dry container and cover for later disposal (EPA, 1985).
Move container from spill area (EPA, 1985).

SMALL LEAK/SPILL

Any quantity above one pound must be disposed as a hazardous waste according to Federal and/or State regulations (EPA, 1990).

LARGE LEAK/SPILL

For a large drum or container of 10,10'-oxidiphenoxarsine waste, trained and skilled hazardous response personnel may be required to remediate the situation.
Any quantity above one pound must be disposed as a hazardous waste according to Federal and/or State regulations (EPA, 1990).

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

No information on the pollution hazard of 10,10'-oxidiphenoxarsine was found in the available literature at the time of this review.

ENVIRONMENTAL FATE AND KINETICS

OTHER

OTHER
- No information on the environmental kinetics of 10,10'-oxidiphenoxarsine was found in the available literature at the time of this review.

ENVIRONMENTAL TOXICITY

No information on the environmental toxicity of 10,10'-oxidiphenoxarsine was found in the available literature at the time of this review.

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

502.23 (Budavari, 1996)

DESCRIPTION/PHYSICAL STATE

This compound exists as a colorless crystalline solid (Budavari, 1996).

SPECIFIC GRAVITY

TEMPERATURE AND/OR PRESSURE NOT LISTED

1.40-1.42 (Budavari, 1996)

FREEZING/MELTING POINT

MELTING POINT

184-185 degrees C; 363-365 degrees F (Budavari, 1989)

SOLUBILITY

IN WATER

Practically insoluble (5 ppm at 20 degrees C) (Budavari, 1996)

IN ORGANIC SOLVENTS

Soluble in alcohol, chloroform, and methylene chloride (Budavari, 1996).

OTHER

ALKALI: Practically insoluble (Budavari, 1996)

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10,10-OXIDIPHENOXARSINE

Classification | Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents