N-PROPANOL
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
AI3-16115 ALBACOL ALCOHOL PROPYL ALCOHOL, PROPYL ALCOOL PROPILICO (Italian) ALCOOL PROPYLIQUE (French) ETHYLCARBINOL ETHYL CARBINOL 1-HYDROXYPROPANE NORMAL PROPANOL OPTAL OSMOSOL EXTRA PROPANOL 1-PROPANOL n-PROPANOL PROPANOL-1 PROPAN-1-OL n-PROPAN-1-OL PROPANOLE (German) PROPANOLEN (Dutch) PROPANOLI (Italian) PROPYL ALCOHOL 1-PROPYL ALCOHOL n-PROPYL ALCOHOL n-PROPYL ALKOHOL (German) PROPYLIC ALCOHOL PROPYLOWY ALKOHOL (Polish)
IDENTIFIERS
SYNONYM REFERENCE
- ACGIH; 1991; HSDB, 1999; RTECS, 1999; Snyder, 1992
USES/FORMS/SOURCES
Propyl alcohol is used as a solvent for waxes, vegetable oils, resins, cellulose esters, ethers, paints, printing inks, cosmetics, perfumes, polishing compounds, lacquer formulations, pharmaceuticals, polymers production, and contact lenses manufacturing (ACGIH, 1991; Ashford, 1994; HSDB , 1999; Snyder, 1992). Propyl alcohol is used as a food additive (for synthetic flavoring) in non-alcoholic beverages, ice cream, candy, and baked goods (ACGIH, 1991; Ashford, 1994; HSDB , 1999; Snyder, 1992). Propyl alcohol is used as a antiseptic/disinfecting agent in skin care products, hair care products, dye solutions, antifreezes, brake fluids, degreasing agents, soaps, rubbing alcohols, and window cleaners (AAR, 1998; (Harbison, 1998; HSDB , 1999). Propyl alcohol has been identified in commercial fermentation brine, Cahors wine, Corbiers wine, Jamaican Run, beer, cistern room whiskey, kefir, yogurt, and fermented eggs (Howard, 1990).
Propyl alcohol is a colorless liquid (AAR, 1998; (Ashford, 1994). It has a sharp musty and slightly stupefying odor like rubbing alcohol (AAR, 1998; (Budavari, 1996).
Propyl alcohol occurs naturally in plant volatiles, forest fires, volcanos, and insects. It is released during microbial degradation of animal wastes. The various natural sources are expected to release significant amounts of propyl alcohol (Harbison, 1998; Howard, 1990). Propyl alcohol is emitted from diesel exhaust, plastic combustion, printing, whiskey production, wood pulping, sewage treatment, fermentation, and factories that use propyl alcohol (Howard, 1990). Propyl alcohol is manufactured by hydrogenation of propinoaldehyde following hydroformulation of ethylene, by oxidation of propane, and by hydrogenation of propylene oxide over nickel (Ashford, 1994; HSDB , 1999; Snyder, 1992). It can also be obtained from crude fuel oil by fractionation, from the synthesis of methyl alcohol by high pressure, from the oxidation process of propane/butane, and from the reaction between carbon monoxide and hydrogen as a byproduct (Budavari, 1996; HSDB , 1999). It can be isolated from head fractions during distillation of wine and tail fractions during rectification of spirits (HSDB , 1999).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Propyl alcohol may be irritating to the eyes, skin, and mucous membranes. Exposure may occur via inhalation, ingestion, and dermal and eye contact.
- Signs and symptoms of exposure may include headache, lethargy, dizziness, ataxia, incoordination, confusion, CNS depression, stupor, persistent coma with hypothermia, prostration, gastroenteritis (with or without vomiting and diarrhea), hypotension, bradycardia, circulatory collapse, muscular edema, and death from respiratory arrest.
- POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
ACUTE CLINICAL EFFECTS
- N-propanol is absorbed through the skin, lungs and GI tract. Symptoms of intoxication include mucous membrane irritation, loss of coordination, lethargy, hypotension, sleepiness, headache, weakness, dizziness, coma, and (occasionally) death (ILO, 1983; NIOSH/OSHA; (p 38). Exposure to an airborne concentration of 400 ppm for 3 to 5 minutes caused mild eye, nose, and throat irritation (Clayton & Clayton, 1982). It caused positional nystagmus in rabbits (Oedkvisi, 1979).
CHRONIC CLINICAL EFFECTS
- N-propanol has produced positive skin patch test reactions in humans (HSDB), indicating potential allergic sensitization. No other adverse effects from long-term human exposure have been reported (Clayton & Clayton, 1982).
- In mice, n-propanol inhalation caused no EEG changes (pp 16-22). When given to neonatal rats, it interfered with normal brain development (Grant & Samson, 1984). In rats, the highest concentration of n-propanol was in the adrenals following inhalation exposure (Babanov, 1984). Rats had cross-tolerance between ethanol and n-propanol (Leblanc & Kalant, 1975). N-propanol produced no greater liver toxicity than ethanol in rats (Hillbom, 1974), but did cause changes in internal organs and the CNS (Cameron, 1985).
-MEDICAL TREATMENT
LIFE SUPPORT
- Support respiratory and cardiovascular function.
SUMMARY
- FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
FIRST AID EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. DERMAL EXPOSURE - Flush the contaminated skin with water. Where there is evidence of skin irritation, get medical attention. INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. ORAL EXPOSURE - If this chemical has been swallowed, get medical attention immediately. TARGET ORGANS - Eyes, skin, respiratory system, gastrointestinal tract, and central nervous system (National Institute for Occupational Safety and Health, 2007).
GENERAL - Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Because of the potential for rapid onset of CNS depression or seizures with possible aspiration of gastric contents, EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.
INHALATION EXPOSURE - INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm. If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
DERMAL EXPOSURE - DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999). Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
EYE EXPOSURE - DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
ORAL EXPOSURE - Because of the potential for gastrointestinal tract irritation and CNS depression, DO NOT induce emesis. Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first. ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
Exposure to 13,120 ppm for 160 minutes or 19,680 ppm for 120 minutes was lethal to mice (Clayton & Clayton, 1982).
MAXIMUM TOLERATED EXPOSURE
Mice exposed for 480 minutes to 2050 ppm (5 mg/L) exhibited no signs of adverse effects (Clayton & Clayton, 1982). Four successive daily doses of 2160 mg/kg/day in rats produced no macroscopic liver lesions (Clayton & Clayton, 1982). Mice survived intermittent exposures for a total of 95 hours to 7874 ppm (19.3 mg/L) (Clayton & Clayton, 1982).
- Carcinogenicity Ratings for CAS71-23-8 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): A4 ; Listed as: N-Propanol (n-Propyl alcohol) EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: n-Propyl alcohol MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS71-23-8 (U.S. Environmental Protection Agency, 2011):
CALCULATIONS
CONVERSION FACTORS 1 ppm = 2.46 mg/m(3) (at 68 degrees F, 760 mmHg) (NIOSH , 1999) 1 mg/L = 408 ppm (at 25 degrees C, 760 mmHg) (Snyder, 1992)
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS71-23-8 (American Conference of Governmental Industrial Hygienists, 2010):
Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.
- AIHA WEEL Values for CAS71-23-8 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS71-23-8 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS71-23-8 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS71-23-8 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS71-23-8 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS71-23-8 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS71-23-8 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS71-23-8 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS71-23-8 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS71-23-8 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS71-23-8 (EPA, 2005):
SHIPPING REGULATIONS
- DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 1274 (49 CFR 172.101, 2005):
Hazardous materials descriptions and proper shipping name: n-Propanol or Propyl alcohol, normal Symbol(s): Not Listed Hazard class or Division: 3 Identification Number: UN1274 Packing Group: II Label(s) required (if not excepted): 3 Special Provisions: B1, IB2, T4, TP1 B1: If the material has a flash point at or above 38 °C (100 °F) and below 93 °C (200 °F), then the bulk packaging requirements of sxn. 173.241 of this subchapter are applicable. If the material has a flash point of less than 38 °C (100 °F), then the bulk packaging requirements of sxn. 173.242 of this subchapter are applicable. IB2: Authorized IBCs: Metal (31A, 31B and 31N); Rigid plastics (31H1 and 31H2); Composite (31HZ1). Additional Requirement: Only liquids with a vapor pressure less than or equal to 110 kPa at 50 °C (1.1 bar at 122 °F), or 130kPa at 55 °C (1.3 bar at 131 °F) are authorized. T4: Minimum test pressure (bar): 2.65; Minimum shell thickness (in mm-reference steel) (See sxn.178.274(d)): sxn.178.274(d)(2); Pressure-relief requirements (See sxn.178.275(g)): Normal; Bottom opening requirements (See sxn.178.275(d)): sxn.178.275(d)(3). TP1: The maximum degree of filling must not exceed the degree of filling determined by the following: [Degree of filling = 97/1+alpha(tr - tf)], where tr is the maximum mean bulk temperature during transport, and tf is the temperature in degrees celsius of the liquid during filling.
Packaging Authorizations (refer to 49 CFR 173.***): Exceptions: 150 Non-bulk packaging: 202 Bulk packaging: 242
Quantity Limitations: Vessel Stowage Requirements:
Hazardous materials descriptions and proper shipping name: n-Propanol or Propyl alcohol, normal Symbol(s): Not Listed Hazard class or Division: 3 Identification Number: UN1274 Packing Group: III Label(s) required (if not excepted): 3 Special Provisions: B1, IB3, T2, TP1 B1: If the material has a flash point at or above 38 °C (100 °F) and below 93 °C (200 °F), then the bulk packaging requirements of sxn. 173.241 of this subchapter are applicable. If the material has a flash point of less than 38 °C (100 °F), then the bulk packaging requirements of sxn. 173.242 of this subchapter are applicable. IB3: Authorized IBCs: Metal (31A, 31B and 31N); Rigid plastics (31H1 and 31H2); Composite (31HZ1 and 31HA2, 31HB2, 31HN2, 31HD2 and 31HH2). Additional Requirement: Only liquids with a vapor pressure less than or equal to 110 kPa at 50 °C (1.1 bar at 122 °F), or 130 kPa at 55 °C (1.3 bar at 131 °F) are authorized, except for UN2672 (also see Special Provision IP8 in Table 3 for UN2672). T2: Minimum test pressure (bar): 1.5; Minimum shell thickness (in mm-reference steel) (See sxn.178.274(d)): sxn.178.274(d)(2); Pressure-relief requirements (See sxn.178.275(g)): Normal; Bottom opening requirements (See sxn.178.275(d)): sxn.178.275(d)(3). TP1: The maximum degree of filling must not exceed the degree of filling determined by the following: [Degree of filling = 97/1+alpha(tr - tf)], where tr is the maximum mean bulk temperature during transport, and tf is the temperature in degrees celsius of the liquid during filling.
Packaging Authorizations (refer to 49 CFR 173.***): Exceptions: 150 Non-bulk packaging: 203 Bulk packaging: 242
Quantity Limitations: Vessel Stowage Requirements:
- ICAO International Shipping Name for UN1274 (ICAO, 2002):
LABELS
- NFPA Hazard Ratings for CAS71-23-8 (NFPA, 2002):
-HANDLING AND STORAGE
SUMMARY
HANDLING
- Broken packages should not be handled without wearing appropriate personal protective equipment (AAR, 1998).
STORAGE
Containers with propyl alcohol should be kept tightly closed. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters (Sittig, 1991).
- ROOM/CABINET RECOMMENDATIONS
Keep sparks, flames, and other source of ignition away (AAR, 1998). Keep away form strong oxidizers (Sittig, 1991). Attacks some plastics, rubber, and coatings (Pohanish & Greene, 1997).
-PERSONAL PROTECTION
SUMMARY
- RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- Wear appropriate protective rubber glove, goggles (or face shield), overalls, all-purpose gas mask, and avoid breath vapors (AAR, 1998; (ITI, 1995). Wash away any material which may have contacted skin or eyes with copious amounts of running water or soap and water for at least 15 minutes (AAR, 1998). Change immediately when work clothing becomes contaminated due to the low flash point (flammability hazard) (NIOSH , 1999).
EYE/FACE PROTECTION
- Vapors are mildly irritating to the eyes (AAR, 1998). Goggles (or face shields) should be worn for protection (AAR, 1998; (ITI, 1995).
RESPIRATORY PROTECTION
- Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.
- Vapors are mildly irritating to the nose and throat. Personnel should keep upwind from propyl alcohol (AAR, 1998). All-purpose gas mask should be worn (ITI, 1995).
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 71-23-8.
-PHYSICAL HAZARDS
FIRE HAZARD
POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Propyl alcohol is flammable (Harbison, 1998). It can be easily ignited by heat, sparks, or flames. Attempts to extinguish fire should not be made unless flow can be stopped. Dikes should be built to contain flow as necessary. Water spray can be used to disperse vapors; water can be used to dilute standing pools of liquid (AAR, 1998). It can ignite on contact with potassium-tert-butoxide (Lewis, 1996). Vapors may travel to source of ignition and flash back (CHRIS , 1999). Toxic gases and fumes may be released in a fire (HSDB , 1999; Lewis, 1996). It has an electrical hazard rating of Class I Group D (CHRIS , 1999).
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS71-23-8 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane.
- LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk.
- TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
- NFPA Extinguishing Methods for CAS71-23-8 (NFPA, 2002):
- Use alcohol-resistant foam, dry chemical, or carbon dioxide extinguish agents (solid streams of water may be ineffective). Do not extinguish fire unless flow can be stopped. Build dikes to contain flow as necessary. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible (AAR, 1998; (Lewis, 1996).
EXPLOSION HAZARD
- Propyl alcohol can react with strong oxidizers to form an explosive mixture (Harbison, 1998).
- Vapors can be explosive when exposed to heat or flame (CHRIS , 1999; HSDB , 1999; Lewis, 1996).
DUST/VAPOR HAZARD
- Propyl alcohol emits acrid smoke and irritating fumes when heated to decomposition (Lewis, 1996).
- Toxic gases and vapors (such as carbon monoxide) may be released in a fire (HSDB , 1999).
- Propyl alcohol vapors are heavier than, and mix well with, air (AAR, 1998; (ILO, 1998). Vapors can be explosive when exposed to heat or flame (CHRIS , 1999; Lewis, 1996). Vapors may form explosive mixtures with air creating hazards indoors, outdoors, or in sewers. Vapors may travel to source of ignition and flash back (CHRIS , 1999).
REACTIVITY HAZARD
- It reacts with strong oxidants such as perchlorates and nitrates (ILO, 1998). Reacts also with strong acids, caustics, aliphatic amines, and isocyanates (NIOSH , 1999) Pohanish & Greene, 1997).
- Attacks some plastics, rubber, and coatings (NIOSH , 1999) Pohanish & Greene, 1997).
- Propyl alcohol is classified with a reactivity group value of 20 (CHRIS , 1999).
- Contact of solid potassium tert-butoxide with drops of liquid propyl alcohol can cause ignition after 1 minute (Urben, 1995).
EVACUATION PROCEDURES
- Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.
- LARGE SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
- PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number: MEXICO: SETIQ: 01-800-00-214-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5559-1588; For calls originating elsewhere, call: 011-52-555-559-1588.
CENACOM: 01-800-00-413-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885; For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.
ARGENTINA: CIQUIME: 0-800-222-2933 in the Republic of Argentina; For calls originating elsewhere, call: +54-11-4613-1100.
BRAZIL: PRÓ-QUÍMICA: 0-800-118270 (Toll-free in Brazil); For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).
COLUMBIA: CISPROQUIM: 01-800-091-6012 in Colombia; For calls originating in Bogotá, Colombia, call: 288-6012; For calls originating elsewhere, call: 011-57-1-288-6012.
CANADA: UNITED STATES:
For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
- AIHA ERPG Values for CAS71-23-8 (AIHA, 2006):
- DOE TEEL Values for CAS71-23-8 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Propyl alcohol, n- TEEL-0 (units = ppm): 200 TEEL-1 (units = ppm): 250 TEEL-2 (units = ppm): 250 TEEL-3 (units = ppm): 800 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS71-23-8 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS71-23-8 (National Institute for Occupational Safety and Health, 2007):
IDLH: 800 ppm Note(s): Not Listed
CONTAINMENT/WASTE TREATMENT OPTIONS
SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) Keep sparks, flames, flares, and other sources of ignition away. Keep material out of water sources, sewers, and low areas. Absorb or cover with dry soil, sand, or other non-combustible material. Stop leak if safe to do so. Use water to dilute standing pools of liquid. Use water spray or vapor suppressing foam to disperse vapors (AAR, 1998; (CHRIS , 1999).
LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) Build dikes to contain flow as necessary (AAR, 1998).
Incineration is recommended for disposal (Sittig, 1991). This can be done by spraying into a furnace. Incineration can be aided by mixing with a more flammable solvent (ITI, 1995). Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.
-ENVIRONMENTAL HAZARD MANAGEMENT
POLLUTION HAZARD
- Propyl alcohol is dangerous to aquatic life in high concentrations, and it may be dangerous if it enters water intakes (CHRIS , 1999).
ENVIRONMENTAL FATE AND KINETICS
Propyl alcohol released into air is apt to photodegrade (with estimated half-life of 6.7 days) primarily by reaction with hydroxyl radicals. Rainout may be a significant process based on water solubility. The estimated half-life for propyl alcohol in the atmosphere is 2.6 days based on a rate constant of 3.8x10(-12) cm(3)/mol-sec for the reaction with hydroxyl radicals and an estimated hydroxyl radical concentration of 8x10(5) molecules/cm(3) (Howard, 1990).
SURFACE WATER Because alcohols are resistant to hydrolysis, reaction with hydroxyl radicals will not likely to be a significant process in aquatic media. Propyl alcohol released into surface waterways is apt to volatilize (with estimated half-life of 6.5 days) and biodegrade. It is not expected to adsorb to sediment. The release into ground water has unknown fate but is likely to biodegrade (Howard, 1990).
TERRESTRIAL Propyl alcohol released into soil is apt to volatilize, leach into ground water, and biodegrade. Propyl alcohol released into ground water has unknown fate but is likely to biodegrade. The estimated half-life for evaporation of propyl alcohol from water 1 meter deep with a 1 m/sec current and 3 m/sec wind is 4.3 days. The adsorption to soil will be low due to the low octanol/water partition coefficient (Howard, 1990).
ABIOTIC DEGRADATION
- Propyl alcohol is very volatile. Once in air, it degrades by reaction with hydroxyl radicals (Howard, 1990; HSDB , 1999).
BIODEGRADATION
- Propyl alcohol is readily degraded in laboratory tests using activated sludges, sewage seed, and wastewater inocula; it is also degraded in soil and anaerobic environment (Howard, 1990).
BIOACCUMULATION
Human exposure will be in occupational settings and by ingestion of contaminated drinking water/foods (Howard, 1990). Propyl alcohol is more toxic to humans than ethanol, probably because it is absorbed more rapidly and metabolized slower than ethanol (Harbison, 1998; Snyder, 1992). Once absorbed, propyl alcohol is converted to proponaldehylde by alcohol dehydrogenase. No chronic effects have been reported in humans, perhaps because propyl alcohol is oxidized to propionic acid and excreted (Harbison, 1998) Hathaway, 1996).
ENVIRONMENTAL TOXICITY
- Propyl alcohol is dangerous to aquatic life in high concentrations, and it may be dangerous if it enters water intakes (CHRIS , 1999). The biological oxygen demand is rated as 0.47 lb/lb to 1.5 lb/lb for 5 days (CHRIS , 1999).
Freshwater toxicity (OHM/TADS , 1999) EC50 - FATHEAD MINNOWS, 29 days old: 4.63 g/L for 96H -- water hardness 47.0 mg/L of CaCO3, temperature 26.7 degrees C, pH 7.45, dissolved oxygen 4.5 mg/L, alkalinity 43.3 mg/L of CaCO3, tank volume 1 L, additions 36 volumes per day in flow-through bioassay (HSDB, 1999) LC50 - FATHEAD MINNOWS, 30 days old: 4.48 g/L for 96H -- water hardness 47.0 mg/L of CaCO3, temperature 27.7 degrees C, pH 7.40, dissolved oxygen 5.4 mg/L, alkalinity 43.0 mg/L of CaCO3, tank volume 1.0 L, additons 36 volumes per day in flow-through bioassay (HSDB, 1999) LC50 - MEXICAN AXOLOTL, 3-4 weeks after hatching: 4000 mg/L for 48H (HSDB, 1999) LC50 - CLAWED TOADS, 3-4 weeks after hatching: 4000 mg/L for 48H (HSDB, 1999) LD - CREEK CHUB: 500 mg/L for 24H -- in Detroit river water (HSDB, 1999) LD - GUDGEON: 200 ppm for 24H LD - FISH: 500 ppm for 24H LD - CREEK CHUB: 350-500 ppm for 24H LD - GOLDFISH: 500 ppm for 24H
Saltwater toxicity (OHM/TADS , 1999)
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Propyl alcohol is a clear, colorless, volatile liquid which has been described as having both a ripe fruity flavor and a burning taste (Budavari, 1989; (HSDB , 1992).
- It has an ethanol like odor (Budavari, 1989)
VAPOR PRESSURE
- 10 mmHg (at 14.7 degrees C) (Lewis, 1996; OHM/TADS , 1999)
- 15 mmHg (at 20 degrees C) (ACGIH, 1991)
- 20.8 mmHg (at 25 degrees C) (ILO, 1998; Snyder, 1992)
- 20.99 mmHg (at 25 degrees C) (Howard, 1990)
- 21 mm Hg (at 25 degrees C) (Clayton & Clayton, 1994)
SPECIFIC GRAVITY
- NORMAL TEMPERATURE AND PRESSURE
- OTHER TEMPERATURE AND/OR PRESSURE
0.8053 (at 20/4 degrees C) (Ashford, 1991; (Budavari, 1996; ILO, 1998; Snyder, 1992) 0.804 (at 20/4 degrees C) (Lewis, 1997) 0.8044 (at 20/4 degrees C) (Lewis, 1996)
- TEMPERATURE AND/OR PRESSURE NOT LISTED
DENSITY
- OTHER TEMPERATURE AND/OR PRESSURE
0.803 kg/L (at 20 degrees C) (CHRIS , 1999) 6.7 lb/gal (at 20 degrees C) (HSDB , 1999)
- TEMPERATURE AND/OR PRESSURE NOT LISTED
2.1 (Harbison, 1998; ILO, 1998) 2.07 (ITI, 1995; Lewis, 1996; OHM/TADS , 1999)
FREEZING/MELTING POINT
-126 degrees C (Ashford, 1994) -196 degrees F (NIOSH , 1999) -126.2 degrees C; -195.2 degrees F; 147 degrees K (CHRIS , 1999; Clayton & Clayton, 1994)
-127 degrees C (ACGIH, 1991; Budavari, 1996; OHM/TADS , 1999) -126.5 degrees C (Howard, 1990; Snyder, 1992)
BOILING POINT
- 82.5 degrees C (Snyder, 1992)
- 97 degrees C (Ashford, 1994; Clayton & Clayton, 1994; OHM/TADS , 1999)
- 97.2 degrees C; 207 degrees F; 370.4 degrees K (ACGIH, 1991; Budavari, 1996; CHRIS , 1999; Howard, 1990)
FLASH POINT
- 15 degrees C (closed cup) (ACGIH, 1991)
- 23 degrees C (closed cup) (Ashford, 1994; HSDB , 1999; ILO, 1998)
- 59 degrees F (closed cup) (Lewis, 1996)
- 74 degrees F (closed cup) (HSDB , 1999)
- 77 degrees F (closed cup) (CHRIS , 1999)
- 22 degrees C (open cup) (Budavari, 1996; HSDB , 1999; ITI, 1995; Snyder, 1992)
- 25 degrees C (open cup) (Lewis, 1997)
- 77 degrees F (open cup) (Lewis, 1997)
- 81 degrees F (open cup) (CHRIS , 1999)
- 25 degrees C (OHM/TADS , 1999)
- 72 degrees F (NIOSH , 1999)
- 53-77 degrees F (AAR, 1998)
AUTOIGNITION TEMPERATURE
- 404 degrees C (ITI, 1995)
- 412 degrees C (HSDB , 1999; ILO, 1998; Snyder, 1992)
- 371 degrees C (OHM/TADS , 1999)
- 824 degrees F (Lewis, 1996)
- 775 degrees F (HSDB , 1999)
- 700 degrees F; 371 degrees C (AAR, 1998; (Lewis, 1997)
EXPLOSIVE LIMITS
2.1% (ACGIH, 1991; CHRIS , 1999; Lewis, 1996; OHM/TADS , 1999) 2.2% (NIOSH , 1999; Sittig, 1991) 2% (ITI, 1995; Lewis, 1997) 2.29% (HSDB , 1999)
13.5% (ACGIH, 1991; CHRIS , 1999; Lewis, 1996; OHM/TADS , 1999) 13.7% (NIOSH , 1999; Sittig, 1991) 13% (ITI, 1995; Lewis, 1997)
SOLUBILITY
Propyl alcohol is miscible with water (Ashford, 1994; Budavari, 1996; Howard, 1990). Propyl alcohol is fully soluble in water (AAR, 1998; (ACGIH, 1991).
Propyl alcohol is miscible with oxygenated solvents such as alcohol and ether (ACGIH, 1991; Ashford, 1994; Budavari, 1996; Snyder, 1992). It is soluble in benzene and acetone (ACGIH, 1991; Budavari, 1996; Snyder, 1992).
OCTANOL/WATER PARTITION COEFFICIENT
- log Kow = 0.25 (Howard, 1990; HSDB , 1999)
HENRY'S CONSTANT
- 6.85x10(-6) atm-m(3)/mol (at 25 degrees C) (Howard, 1990)
SPECTRAL CONSTANTS
OTHER/PHYSICAL
2.6-40 ppm (ACGIH, 1991) 30 ppm (75 mg/m(3)) (Harbison, 1998) 0.075-150 mg/m(3) (HSDB , 1999) 75-500 mg/m(3) (HSDB , 1999) LIQUID GAS 9.00X10(-3) mg/L (HSDB , 1999) 2.80X10(-6) g/L (HSDB , 1999) 3.86X10(-5) g/L (HSDB , 1999)
25.9 dynes/cm (at -5 degrees C) (HSDB , 1999) 23.8 dynes/cm (at 20 degrees C) (HSDB , 1999) 20.5 dynes/cm (at 60 degrees C) (HSDB , 1999)
263.6 degrees C; 506.5 degrees F; 536.8 degrees K (CHRIS , 1999) 263.7 degrees C (HSDB , 1999)
22.2 (at 20 degrees C) (HSDB , 1999) 20.33 (at 25 degrees C) (HSDB , 1999)
-13130 Btu/lb; -7296 cal/g; -305.5x10(5) J/kg (CHRIS , 1999) 482.75 kg cal/g mol wt (at 25 degrees C) (HSDB , 1999)
- NUCLEAR MAGNETIC RESONANCE
2.256 cP (at 20 degrees C) (Lewis, 1997) 3.883 cP (at 0 degrees C) (HSDB , 1999) 1.405 cP (at 40 degrees C) (HSDB , 1999) 0.5310 cP (at 90 degrees C) (HSDB , 1999)
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