NORBORMIDE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
NORBORMIDE COMPOUND S-6,999 5-(alpha-HYDROXY-alpha-2-PYRIDYLBENZYL)-1- (alpha-2-PYRIDYLBENZYLIDENE)-5-NORBORNENE -2,3-DICARBOXIMIDE MCN 1025 McNEIL 1025 4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE 5-NORBORNENE-2,3-DICARBOXIMIDE, 5-(alpha- HYDROXY-alpha-2-PYRIDYLBENZYL)-7-(alpha- 2PYRIDYLBENZYLIDENE)-4. NOBORMIDE RATICATE RATICIDE S 6999 S-6,999 SHOXIN 3a,4,7,7a-TETRAHYDRO-5-(HYDROXY-PHENYL-2- PYRIDINYLMETHYL)-8-(PHENYL-2-PYRIDINYLMETHYLENE)-
IDENTIFIERS
SYNONYM REFERENCE
- (Budavari, 1996; EPA, 1985; HSDB , 2001; RTECS , 2001; Sax & Lewis, 1987)
USES/FORMS/SOURCES
Norbormide is a selective rodenticide which is effective against most species of rats. It produces extreme irreversible peripheral vasoconstriction in the rats, resulting in death. Toxicity to other rodents is minimal (S Sweetman , 2001). Norbormide is apparently a unique agent. Many different analogs of norbormide have been evaluated, but none are as toxic to rats (Poos et al, 1966).
Norbormide is a white crystalline powder. It is stable at room temperature and to boiling. It is hydrolyzed by alkali; it is noncorrosive (Pelfrene, 1991). Brand names include Shoxin(R) and Raticate(R) (Pelfrene, 1991; Hayes, 1982).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Human poisoning by norbormide is unlikely due to specificity for rats. Doses of 20 to 300 mg have been given to human volunteers with only minimal hypotensive effects. A dose of 300 mg corresponds to 60 grams of the 0.5% bait and 30 grams of the 1% bait.
- RATS given norbormide first present with a hunched position, followed by development of locomotor difficulties and weakness, but not paralysis of the hindlegs. Struggling, dyspnea, and mild seizures precede death which occurs within 15 minutes to 4 hours as a result of intense vasoconstriction.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
MAXIMUM TOLERATED EXPOSURE
Doses up to 300 milligrams have been given to human volunteers with only mild reduction in systolic blood pressure (Hayes, 1982). No ill effects were noted in 3 adult male volunteers who received 15 milligrams/kilogram daily for 3 days (Worthing & Walker, 1983).
Dogs tolerated the equivalent of 1,000 parts per million for 60 days without ill effect. When given a dose corresponding to 10,000 parts per million for 15 to 60 days they looked "sick" and lost weight (Roszkowski et al, 1964). Animals receiving intravenous injections of 40 milligrams/kilogram showed no detectable responses (Hayes, 1982). At a dose of 1 gram/kilogram there was no detectable effect in cats, dogs, monkeys, sheep, and pigs (Roszkowski, et al, 1964; (Niu, 1970). A single oral dose of 1,000 milligrams/kilogram had no effect on monkeys or turkeys nor was it lethal to any of 40 other animal species tested (Worthing & Walker, 1983).
- Carcinogenicity Ratings for CAS991-42-4 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS991-42-4 (U.S. Environmental Protection Agency, 2011):
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS991-42-4 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS991-42-4 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS991-42-4 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS991-42-4 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS991-42-4 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS991-42-4 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS991-42-4 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS991-42-4 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS991-42-4 (U.S. Environmental Protection Agency, 2010):
Listed as: Norbormide Reportable Quantity, in pounds: 100 Threshold Planning Quantity, in pounds: Note(s): Not Listed
- EPA SARA Title III, Community Right-to-Know for CAS991-42-4 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS991-42-4 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS991-42-4 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS991-42-4 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 991-42-4.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS991-42-4 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS991-42-4 (NFPA, 2002):
REACTIVITY HAZARD
- Stable at room temperature (Hayes, 1982)
- Is hydrolyzed by alkali (Hayes, 1982)
- Is not corrosive (Hayes, 1982)
- When heated to decomposition, it emits toxic fumes of NOx (Sax & Lewis, 1989)
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS991-42-4 (AIHA, 2006):
- DOE TEEL Values for CAS991-42-4 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Norbormide TEEL-0 (units = mg/m3): 0.75 TEEL-1 (units = mg/m3): 2 TEEL-2 (units = mg/m3): 3.8 TEEL-3 (units = mg/m3): 3.8 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS991-42-4 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS991-42-4 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
- NORBORMIDE: 511.6 (S Sweetman , 2001)
- NORBORMIDE HYDROCHLORIDE: 547.06
DESCRIPTION/PHYSICAL STATE
- Norbormide is a white crystalline powder. It is stable at room temperature and to boiling. It is hydrolyzed by alkali; it is noncorrosive (Pelfrene, 1991; Hayes, 1982).
FREEZING/MELTING POINT
SOLUBILITY
CHLOROFORM: > 150 mg/L (Hayes, 1982) DIETHYL ETHER: 1 mg/L (Hayes, 1982) ETHANOL: 14 mg/L (Hayes, 1982)
-REFERENCES
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