AMINOGLUTETHIMIDE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
IDENTIFIERS
USES/FORMS/SOURCES
Aminoglutethimide is aromatase inhibitor used in the treatment of breast cancer and prostate cancer. It is also used to suppress adrenal function in selected patients with Cushing's syndrome, primarily as an interim measurement prior to definitive treatment such as surgery, or as long term treatment in rare cases where surgery is not appropriate (Prod Info CYTADREN(R) tablets, 2002). Aminoglutethimide was marketed previously as an anticonvulsant, but was withdrawn for that indication in 1966 because of its effects on the adrenal gland(Prod Info CYTADREN(R) tablets, 2002).
Aminoglutethimide is available as white, round, 250 mg tablets that are scored into quarters (Prod Info CYTADREN(R) tablets, 2002).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
Limited data available. Somnolence, lethargy, fatigue, weakness, and coma have been reported. Anticipated effects after overdose include hypotension, hypovolemia, nausea, vomiting, ataxia, respiratory depression, hyponatremia, hypochloremia, hyperkalemia, hypoglycemia. Manifestations may be similar to acute adrenal insufficiency.
Drowsiness, morbilliform rash, nausea, anorexia, dizziness and headache are common. Leukopenia, thrombocytopenia, adrenal insufficiency, hypothyroidism, masculinization and hirsutism in females, precocious sexual development in males, hypotension (particularly orthostatic), tachycardia, vomiting, and cholestatic jaundice have been reported.
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
-FIRST AID
FIRST AID AND PREHOSPITAL TREATMENT
- Because of the risk of significant CNS depression, prehospital administration of activated charcoal is not advised.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
- No deaths have been reported from aminoglutethimide overdose.
MAXIMUM TOLERATED EXPOSURE
- A 33-year-old woman ingested 7 grams, a 16-year-old girl ingested 7.5 to 10 grams, and a 10-year-old boy ingested 10 grams; all survived with supportive care (Prod Info CYTADREN(R) tablets, 2002). Coma was reported after ingestion of 3 to 4 grams in one patient; mental status was normal after about 40 hours (Prod Info CYTADREN(R) tablets, 2002).
- Carcinogenicity Ratings for CAS125-84-8 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS125-84-8 (U.S. Environmental Protection Agency, 2011):
LD50- (INTRAVENOUS)DOG: LD50- (ORAL)DOG: LD50- (INTRAVENOUS)RAT: LD50- (ORAL)RAT:
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS125-84-8 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS125-84-8 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS125-84-8 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS125-84-8 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS125-84-8 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS125-84-8 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS125-84-8 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS125-84-8 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS125-84-8 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS125-84-8 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS125-84-8 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS125-84-8 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS125-84-8 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 125-84-8.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS125-84-8 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS125-84-8 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS125-84-8 (AIHA, 2006):
- DOE TEEL Values for CAS125-84-8 (U.S. Department of Energy, Office of Emergency Management, 2010):
- AEGL Values for CAS125-84-8 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS125-84-8 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Fine white or creamy white crystalline powder (Prod Info CYTADREN(R) tablets, 2002).
SOLUBILITY
-REFERENCES
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