METHYL ISOBUTYL CARBINOL

Methyl isobutyl carbinol is used as a solvent for dyestuffs, oils, gums, waxes, resins, nitrocellulose, and ethylcellulose (Lewis, 1993).
It is used in organic synthesis, froth flotation, and in brake fluids (Lewis, 1993). In addition, it is used in the manufacture of lubricant additives, solvents, lacquers, and plasticizers (HSDB , 1995).

SOURCES

Methyl isobutyl carbinol is derived from methyl isobutyl ketone (Lewis, 1993).
Methyl isobutyl carbinol may be formed naturally, as it was detected in a mixture of volatiles from mountain Beaufort cheese (HSDB , 1995).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

Methyl isobutyl carbinol is irritating to the eyes, skin, and mucous membranes. It is moderately toxic by ingestion, dermal exposure, and intraperitoneal exposure; it is mildly toxic by inhalation.

Exposure to high concentrations causes narcosis in experimental animals and it is expected that severe exposure in humans would produce the same effect. Exposure to the vapors may cause headache, dizziness, or suffocation.

In experimental animals, chloroform-induced hepatotoxicity was potentiated by methyl isobutyl carbinol; this effect was attributed to methyl isobutyl ketone, the metabolite, and not the alcohol.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

May cause toxic effects if inhaled or absorbed through skin.
Inhalation or contact with material may irritate or burn skin and eyes.
Fire will produce irritating, corrosive and/or toxic gases.
Vapors may cause dizziness or suffocation.
Runoff from fire control or dilution water may cause pollution.

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Wash skin with soap and water.
Keep victim warm and quiet.
In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID

EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical.
DERMAL EXPOSURE - Flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.
INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
INGESTION EXPOSURE - If this chemical has been swallowed, get medical attention immediately.
TARGET ORGANS - Eyes, skin, and central nervous system (National Institute for Occupational Safety and Health, 2007).

GENERAL -

Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Because of the potential for rapid onset of CNS depression or seizures with possible aspiration of gastric contents, EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.

INHALATION EXPOSURE -

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.

DERMAL EXPOSURE -

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

EYE EXPOSURE -

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

INGESTION EXPOSURE -

Because of the potential for gastrointestinal tract irritation or CNS depression, do not induce emesis.
Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.
GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

GENERAL/SUMMARY

The minimum lethal human dose to this agent has not been delineated.

ANIMAL DATA

After exposure to 2000 ppm of methyl isobutyl carbinol for 8 hours, 5 out of 6 rats died (Hathaway, 1991).
Groups of 10 mice were exposed to 20 mg/L (4600 ppm) of methyl isobutyl carbinol for 1, 4, 8.5, 10, and 15 hours. Six mice from one group died after 10 hours of exposure and eight from another group died after 15 hours (ACGIH, 1991).

MAXIMUM TOLERATED EXPOSURE

GENERAL/SUMMARY

Acute, chronic, and systemic effects have not been reported in humans (Hathaway, 1991).
Exposure for 15 minutes to 50 ppm of methyl isobutyl carbinol vapor caused throat and nose irritation (Clayton & Clayton, 1994).

ANIMAL DATA

Seven out of 10 mice exposed to 4600 ppm for 4 hours experienced anesthetization. Ten out of 10 in another group also experienced anesthetization after 8.5 hours (ACGIH, 1991).
At high concentrations, methyl isobutyl carbinol causes narcosis in animals (Hathaway, 1991).

Carcinogenicity Ratings for CAS108-11-2 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Methyl isobutyl carbinol
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Methyl isobutyl carbinol
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS108-11-2 (U.S. Environmental Protection Agency, 2011):

Not Listed

TOXICITY VALUES

References: Clayton & Clayton, 1994 Lewis, 1992 RTECS, 1995 Note: All values are from RTECS, 1995, unless otherwise noted.
- LCLo- (INHALATION)RAT:
- LD50- (SKIN)GUINEA_PIG:
- LD50- (INTRAPERITONEAL)MOUSE:
- LD50- (SKIN)RABBIT:
- LD50- (ORAL)RAT:
- LDLo- (ORAL)MOUSE:

CALCULATIONS

AMBIENT CONVERSIONS

CONVERSION FACTORS

1 ppm = 4.25 mg/m(3) (NIOSH, 1995)

1 mg/L = 239.3 ppm (HSDB , 1995)

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS108-11-2 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Methyl isobutyl carbinol

TLV:

TLV-TWA: 25 ppm
TLV-STEL: 40 ppm
TLV-Ceiling:

Notations and Endnotes:

Carcinogenicity Category: Not Listed
Codes: Skin
Definitions:

Skin: This refers to the potential significant contribution to the overall exposure by the cutaneous route, including mucous membranes and the eyes, either by contact with vapors or, of likely greater significance, by direct skin contact with the substance. It should be noted that although some materials are capable of causing irritation, dermatitis, and sensitization in workers, these properties are not considered relevant when assigning a skin notation. Rather, data from acute dermal studies and repeated dose dermal studies in animals or humans, along with the ability of the chemical to be absorbed, are integrated in the decision-making toward assignment of the skin designation. Use of the skin designation provides an alert that air sampling would not be sufficient by itself in quantifying exposure from the substance and that measures to prevent significant cutaneous absorption may be warranted. Please see "Definitions and Notations" (in TLV booklet) for full definition.

TLV Basis - Critical Effect(s): URT and eye irr; CNS impair
Molecular Weight: 102.18

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS108-11-2 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS108-11-2 (National Institute for Occupational Safety and Health, 2007):

Listed as: Methyl isobutyl carbinol
REL:

TWA: 25 ppm (100 mg/m(3))
STEL: 40 ppm (165 mg/m(3))
Ceiling:
Carcinogen Listing: (Not Listed) Not Listed
Skin Designation: [skin]

Indicates the potential for dermal absorption; skin exposure should be prevented as necessary through the use of good work practices and gloves, coveralls, goggles, and other appropriate equipment.

Note(s):

IDLH:

IDLH: 400 ppm
Note(s): Not Listed

OSHA PEL Values for CAS108-11-2 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Listed as: Methyl isobutyl carbinol
Table Z-1 for Methyl isobutyl carbinol:

8-hour TWA:

ppm: 25

Parts of vapor or gas per million parts of contaminated air by volume at 25 degrees C and 760 torr.

mg/m3: 100

Milligrams of substances per cubic meter of air. When entry is in this column only, the value is exact; when listed with a ppm entry, it is approximate.

Ceiling Value:
Skin Designation: Yes
Notation(s): Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS108-11-2 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS108-11-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS108-11-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS108-11-2 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS108-11-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS108-11-2 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS108-11-2 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS108-11-2 (EPA, 2005):

Listed as: 2-Pentanol, 4-methyl-

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 2053 (49 CFR 172.101, 2005):

Hazardous materials descriptions and proper shipping name: Methyl isobutyl carbinol

Symbol(s): Not Listed
Hazard class or Division: 3

3: Flammable and combustible liquid. See 49 CFR section 173.120 for definitions.

Identification Number: UN2053
Packing Group: III

III: Packing Group III - indicates the degree of danger presented by the material is minor.

Label(s) required (if not excepted): 3

3: Flammable Liquid.

Special Provisions: B1, IB3, T2, TP1

B1: If the material has a flash point at or above 38 °C (100 °F) and below 93 °C (200 °F), then the bulk packaging requirements of sxn. 173.241 of this subchapter are applicable. If the material has a flash point of less than 38 °C (100 °F), then the bulk packaging requirements of sxn. 173.242 of this subchapter are applicable.
IB3: Authorized IBCs: Metal (31A, 31B and 31N); Rigid plastics (31H1 and 31H2); Composite (31HZ1 and 31HA2, 31HB2, 31HN2, 31HD2 and 31HH2). Additional Requirement: Only liquids with a vapor pressure less than or equal to 110 kPa at 50 °C (1.1 bar at 122 °F), or 130 kPa at 55 °C (1.3 bar at 131 °F) are authorized, except for UN2672 (also see Special Provision IP8 in Table 3 for UN2672).
T2: Minimum test pressure (bar): 1.5; Minimum shell thickness (in mm-reference steel) (See sxn.178.274(d)): sxn.178.274(d)(2); Pressure-relief requirements (See sxn.178.275(g)): Normal; Bottom opening requirements (See sxn.178.275(d)): sxn.178.275(d)(3).
TP1: The maximum degree of filling must not exceed the degree of filling determined by the following: [Degree of filling = 97/1+alpha(tr - tf)], where tr is the maximum mean bulk temperature during transport, and tf is the temperature in degrees celsius of the liquid during filling.

Packaging Authorizations (refer to 49 CFR 173.***):

Exceptions: 150
Non-bulk packaging: 203
Bulk packaging: 242

Quantity Limitations:

Passenger aircraft or railcar: 60 L
Cargo aircraft only: 220 L

Vessel Stowage Requirements:

Vessel stowage location: A

A: The material may be stowed "on deck" or "under deck" on a cargo vessel and on a passenger vessel.

Vessel stowage other: Not Listed

ICAO International Shipping Name for UN2053 (ICAO, 2002):

Proper Shipping Name: Methyl isobutyl carbinol
UN Number: 2053

LABELS

NFPA

NFPA Hazard Ratings for CAS108-11-2 (NFPA, 2002):

Listed as: 4-Methyl-2-Pentanol
Hazard Ratings:

Health Rating (Blue): 2

(2) Moderately toxic material. Intense or continued exposure could cause temporary incapacitation or possible residual injury unless prompt medical treatment is given.

Flammability Rating (Red): 2

(2) Combustible. Materials that must be moderately heated before ignition can occur. Including liquids having a flash point above 100 degrees F, and solids that readily give off flammable vapors.

Instability Rating (Yellow): 0

(0) Materials which are normally stable, even under fire conditions, and which are not reactive with water.

Oxidizer/Water-Reactive Designation: Not Listed

-HANDLING AND STORAGE

STORAGE

INCOMPATIBILITIES

Keep separate from oxidizing materials (Lewis, 1992).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Structural firefighters' protective clothing will only provide limited protection.

Wear appropriate chemical protective boots, gloves, and goggles (AAR, 1994).

Workers should wash skin as soon as it becomes contaminated (NIOSH, 1995).

Wet or significantly contaminated clothing should be removed and replaced. Workers need not change clothing at the end of the shift unless clothing is contaminated (NIOSH, 1995).

Do not wear contact lenses when working with this material (HSDB , 1995).

Stay upwind and avoid breathing vapors (AAR, 1994).

EYE/FACE PROTECTION

Wear goggles or face shield (CHRIS , 1995).

If chemical contacts eyes, flush with copious amounts of water while holding eyelids open (CHRIS , 1995).

RESPIRATORY PROTECTION

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 108-11-2.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
- Vapors may form explosive mixtures with air.
- Vapors may travel to source of ignition and flash back.
- Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks).
- Vapor explosion hazard indoors, outdoors or in sewers.
- Those substances designated with a "P" may polymerize explosively when heated or involved in a fire.
- Runoff to sewer may create fire or explosion hazard.
- Containers may explode when heated.
- Many liquids are lighter than water.
Methyl isobutyl carbinol is flammable when exposed to heat or flame (Lewis, 1992).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS108-11-2 (NFPA, 2002):

Listed as: 4-Methyl-2-Pentanol
Flammability Rating: 2

(2) Combustible. Materials that must be moderately heated before ignition can occur. Including liquids having a flash point above 100 degrees F, and solids that readily give off flammable vapors.

FIRE CONTROL/EXTINGUISHING AGENTS

FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient.

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Dry chemical, CO2, water spray or alcohol-resistant foam.
Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Water spray, fog or alcohol-resistant foam.
Do not use straight streams.
Move containers from fire area if you can do it without risk.

TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.
For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

NFPA Extinguishing Methods for CAS108-11-2 (NFPA, 2002):

Listed as: 4-Methyl-2-Pentanol
Extinguishing Method(s): 5

5: Flammable liquid fires can be extinguished using carbon dioxide, dry chemical, foam, and vaporizing liquid extinguishers, as long as the fires are small to moderate in size and the flammable liquid reservoir is shallow. Use of foam to form a blanket over a flammable liquid is not effective when the liquid is water-soluble. Certain alcohol resistant foams are effective extinguishing agents for polar, non-polar, and water-soluble liquid fires. These foams are preferred for fighting flammable liquid fires except those that involve water reactive flammable liquids.

COMBUSTION TOXICITY

It emits acrid fumes and smoke when heated to decomposition (Lewis, 1992).

EXPLOSION HAZARD

When exposed to heat or flame, methyl isobutyl carbinol is a moderate explosion hazard (Lewis, 1992).

DUST/VAPOR HAZARD

Anesthesia can result from inhalation of high concentrations (Lewis, 1992).

Vapors will cause moderate, temporary irritation to workers (CHRIS , 1995).

REACTIVITY HAZARD

Methyl isobutyl carbinol can react with oxidizing materials (Lewis, 1992).

EVACUATION PROCEDURES

SUMMARY

Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.

LARGE SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.
Ventilate closed spaces before entering.

AIHA ERPG Values for CAS108-11-2 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS108-11-2 (U.S. Department of Energy, Office of Emergency Management, 2010):

Not Listed

AEGL Values for CAS108-11-2 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS108-11-2 (National Institute for Occupational Safety and Health, 2007):

IDLH: 400 ppm
Note(s): Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- All equipment used when handling the product must be grounded.
- Do not touch or walk through spilled material.
- Stop leak if you can do it without risk.
- Prevent entry into waterways, sewers, basements or confined areas.
- A vapor suppressing foam may be used to reduce vapors.
- Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
- Use clean non-sparking tools to collect absorbed material.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Structural firefighters' protective clothing will only provide limited protection.

LARGE LEAK/SPILL

LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- Dike far ahead of liquid spill for later disposal.
- Water spray may reduce vapor; but may not prevent ignition in closed spaces.

WASTE TREATMENT OPTIONS

CHEMICAL TREATMENT

In screening tests using activated sludge in a medium consisting of approximately 16,000 ppm ethyl alcohol and 100 ppm urea, the rate constant of disappearance of methyl isobutyl carbinol was 0.432/hr. This corresponds to a half-life of 17 hours (HSDB, 2004).
Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

BIOREMEDIATION

Laboratory studies revealed rapid biodegradation of methyl isobutyl in aqueous screening tests using sewage and activated sludge inoculum (HSDB, 2004).
- Percent Theoretical Biological Oxygen Demand (BOD) (HSDB, 2004):

PHYSICAL TREATMENT

Sorbent foams can be applied to a slick and oil skimming equipment can be used. Carbon or peat should be applied to the dissolved portion (OHM/TADS , 1995).
Methyl isobutyl carbinol may be sprayed into an incinerator or burned in paper packaging. If necessary, additional flammable solvent may be added (OHM/TADS , 1995).

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

The compound may be released to the environment from industrial sources that use it in manufacturing processes (HSDB, 2004).

ENVIRONMENTAL FATE AND KINETICS

When released to the atmosphere, it is expected that methyl isobutyl carbinol will exist mainly in the vapor phase. This assumption is based on an experimental vapor pressure of 5.3 mmHg at 25 degrees C (HSDB, 2004).
A rate constant of 7.1 x 10(-12) cm(3)/molecule-sec at 25 degrees C was measured for the vapor-phase reaction of methyl isobutyl carbinol with photochemically produced hydroxyl radicals. This rate constant corresponds to an atmospheric half-life of 2.3 days at an atmospheric concentration of 5 x 10(5) hydroxyl radicals per cm(3) (HSDB, 2004).

WATER

SURFACE WATER
- If released to water, methyl isobutyl carbinol is not expected to adsorb to sediment and suspended particulates or to bioconcentrate in aquatic organisms. This expectation is based on the organic carbon partition coefficient (Koc) and bioconcentration factor, estimated from log octanol-water partition coefficient (log Kow) and water solubility, respectively (HSDB, 2004).
- Methyl isobutyl carbinol is not expected to directly photolyze or hydrolyze (HSDB, 2004).
- Based on volatilization experiments in a model river and model pond, it is probable that methyl isobutyl carbinol will volatilize from surface waters (HSDB, 2004).
GROUND WATER
- It can leach through soil (HSDB, 2004).

SOIL

TERRESTRIAL
- The mobility of methyl isobutyl carbinol in soil is very high based on an estimated Koc values of 143 and 21, estimated from log Kow and water solubility values, respectively. Thus, it can leach through soil (HSDB, 2004).
- It will not hydrolyze in moist soil, but if it is near the soil surface, it may volatilize based on estimated volatilization rates from water (HSDB, 2004).

ABIOTIC DEGRADATION

Methyl isobutyl carbinol exists mainly in the vapor phase in air. In water, it is not expected to adsorb to sediment and suspended particulates or to bioconcentrate in aquatic organisms. In surface water, methyl isobutyl carbinol will more likely volatilize versus directly photolyze or hydrolyze. Its mobility in soil is very high. While it's unlikely to hydrolyze in moist soil, if it is near the soil's surface, it will more likely volatilize. Laboratory studies show methyl isobutyl carbinol will likely biodegrade in soil (HSDB, 2004).

BIODEGRADATION

Methyl isobutyl carbinol may biodegrade in soil. This assumption is based on laboratory studies that revealed rapid biodegradation in aqueous screening tests using sewage and activated sludge inoculum (HSDB, 2004).

BIOACCUMULATION

BIOCONCENTRATION FACTOR

Methyl isobutyl carbinol is not expected to bioconcentrate in aquatic organisms based on published bioconcentration factors (HSDB, 2004).
- A bioconcentration factor of 7.2 was estimated based on an experimental log Kow of 1.43 (HSDB, 2004).
- A bioconcentration factor of 2.6 was estimated based on an experimental water solubility of 1.64 x 10(4) mg/kg(3) (HSDB, 2004).

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

102.20 (Lewis, 1992)

DESCRIPTION/PHYSICAL STATE

Methyl isobutyl carbinol is a clear, stable, oily liquid with a mild alcohol odor (Lewis, 1992; CHRIS , 1995).

VAPOR PRESSURE

2.8 mmHg (at 20 degrees C) (Lewis, 1992)

3.52 mmHg (at 20 degrees C) (ACGIH, 1991)

SPECIFIC GRAVITY

OTHER TEMPERATURE AND/OR PRESSURE

LIQUID: 0.8079 (at 20/20 degrees C) (Lewis, 1993)

DENSITY

OTHER TEMPERATURE AND/OR PRESSURE

LIQUID: 0.8079 g/mL (at 20 degrees C) (ACGIH, 1991)

FREEZING/MELTING POINT

FREEZING POINT

-130 degrees F (NIOSH, 1995)

MELTING POINT

-90 degrees C (ACGIH, 1991)

BOILING POINT

131.8 degrees C (ACGIH, 1991)

FLASH POINT

41.11 degrees C (closed cup) (ACGIH, 1991)

EXPLOSIVE LIMITS

LOWER

1.0% (NIOSH, 1995)

UPPER

5.5% (NIOSH, 1995)

SOLUBILITY

IN WATER

2% (percentage by weight) (NIOSH, 1995)
Methyl isobutyl carbinol is slightly soluble in water (ACGIH, 1991).

IN ORGANIC SOLVENTS

Methyl isobutyl carbinol is miscible with most organic solvents (ACGIH, 1991).
It is soluble in alcohol and ether (HSDB , 1995).

OCTANOL/WATER PARTITION COEFFICIENT

log Kow = 1.43 (HSDB , 1995)

SPECTRAL CONSTANTS

10933 (HSDB , 1995)

MASS

280 (HSDB , 1995)

OTHER/PHYSICAL

INDEX OF REFRACTION

1.4100 (at 20 degrees C/D) (HSDB , 1995)

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METHYL ISOBUTYL CARBINOL

Classification | Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents