METHYL ETHYL KETONE PEROXIDE

2-BUTANONE PEROXIDE
2-BUTANONE, PEROXIDE
BUTANOX LPT
BUTANOX M 105
BUTANOX M 50
CADOX
CHALOXYD MEKP-HA 1
CHALOXYD MEKP-LA 1
ESPERFOAM FR
ETHYL METHYL KETONE PEROXIDE
FR 222
HI-POINT 180
HI-POINT 90
HI-POINT PD-1
KAYAMEK A
KAYAMEK M
KETONOX
LUCIDOL DDM 9
LUCIDOL DELTA X
LUCIDOL DELTAX
LUPERSOL
LUPERSOL DDA 30
LUPERSOL DDM
LUPERSOL DEL
LUPERSOL DELTA-X
LUPERSOL DNF
LUPERSOL DSW
MEK PEROXIDE
MEKP
MEKPO
MEPOX
METHYL ETHYL KETONE HYDROPEROXIDE
METHYLETHYLKETONHYDROPEROXIDE
METHYL ETHYL KETONE PEROXIDE
METHYL ETHYL KETONE PEROXIDE, in solution with >9% by
weight active oxygen
PERMEK G
PERMEK N
QUICKSET EXTRA
QUICKSET SUPER
SPRAYSET MEKP
SUPEROX 46-710
THERMACURE
TRIGONOX M 50
CHALOXYD MEPK-LA 1
MEKP (MEK PEROXIDE)
METHYL ETHYL KETONE PEROXIDE, IN SOLUTION WITH MORE THAN 9% BY WEIGHT ACTIVE OXYGEN

IDENTIFIERS

CAS REGISTRY NUMBER

1338-23-4(Methyl ethyl ketone peroxide)

NIOSH/RTECS NUMBER

EL 9450000

UN/NA NUMBER

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.

STCC NUMBER

4919178 (in solution with not more than 9% by weight active oxygen)

MOLECULAR FORMULA

C8-H16-O4

ERG GUIDE NUMBER

146-ORGANIC PEROXIDES (HEAT, CONTAMINATION AND FRICTION SENSITIVE)

SYNONYM REFERENCE

(HSDB , 1999; Lewis, 1996; RTECS , 1999)

USES/FORMS/SOURCES

USES

Methyl ethyl ketone peroxide is used in the manufacture of acrylic resins, as a curing agent for thermosetting polyester resins, to initiate polymerization of plastic monomers, in fiberglass-reinforced plastics, as a cross-linking agent and catalyst in the production of other polymers, and as a hardening agent (ACGIH, 1991; Lewis, 1997; Sittig, 1991).

FORMS

It is produced commercially as a colorless, liquid mixture with approximately 40% diluent (consisting of any combination of cyclohexanone peroxide, diallyl phthalate, or dimethyl phthalate) to reduce the explosion potential (ACGIH, 1991; NIOSH , 1999).

SOURCES

It is produced by the peroxidation of methyl ethyl ketone and hydrogen peroxide (Ashford, 1994).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

Methyl ethyl ketone peroxide is irritating to the eyes, skin, and mucous membranes. Dermal exposure can cause irritant dermatitis; allergic contact dermatitis has only occurred rarely from occupational exposure. Massive peripheral zonal hepatic necrosis, GI tract burns, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis, respiratory insufficiency, and death have been reported in a case of accidental ingestion.

Eye contact has been reported to cause lacrimation, photophobia, corneal epithelial damage, perilimbal hyperemia, epithelial and stromal edema, recurrent erosions, loss of corneal epithelium, full-thickness corneal edema and vascularization, corneal irregularity, and recurrent erosions with exacerbations and a deteriorating 1 to 3 year course to a useless eye.

Other signs and symptoms methyl ethyl ketone peroxide exposure may include cough, dyspnea, pulmonary edema, abdominal pain, vomiting, diarrhea, and kidney damage.

Repeated dosing in experimental animals caused fatty degeneration of the liver, renal granular precipitates or casts in the lumina of the convoluted tubules, and desquamation of the epithelium of the proximal tubules.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Fire may produce irritating, corrosive and/or toxic gases.
Ingestion or contact (skin, eyes) with substance may cause severe injury or burns.
Runoff from fire control or dilution water may cause pollution.

ACUTE CLINICAL EFFECTS

MEKP is CORROSIVE to the skin, eyes, and gastrointestinal tract. Its action is similar to that of alkaline corrosives (HSDB). If ingested, it can cause severe gastritis, vomiting, necrosis, esophageal strictures (Wojkyla, 1979), fatal kidney and liver failure, and pneumonitis (Burger & Chandor, 1971).

In rats exposed by the inhalation route, MEKP caused bleeding in the lungs (HSDB). It also caused hemolysis in acutely exposed mice and rats (Smirnova, 1966).

CHRONIC CLINICAL EFFECTS

MEKP is a skin sensitizer and can cause eczema (Malten, 1957). It had cumulative toxicity in rats (HSDB).

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
Contaminated clothing may be a fire risk when dry.
Remove material from skin immediately.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Keep victim warm and quiet.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID

EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical.
DERMAL EXPOSURE - Immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.
INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
ORAL EXPOSURE - If this chemical has been swallowed, get medical attention immediately.
TARGET ORGANS - Eyes, skin, respiratory system, liver, and kidneys (National Institute for Occupational Safety and Health, 2007).

GENERAL -

Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Ingestion may result in significant esophageal or gastrointestinal tract irritation or burns, and EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.

INHALATION EXPOSURE -

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.

DERMAL EXPOSURE -

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

EYE EXPOSURE -

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

ORAL EXPOSURE -

Because of the potential for gastrointestinal tract irritation or burns, DO NOT induce emesis.
DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.
Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.
GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

The minimum lethal human dose to this agent has not been delineated.

Clayton & Clayton (1993) report that "an oral dose of 50 to 100 mL is toxic and potentially lethal to adults."

ANIMALS

Oral administration of approximately 96 mg/kg 3 times per week for 7 weeks was lethal to rats (Hathaway et al, 1996).

MAXIMUM TOLERATED EXPOSURE

The maximum tolerated human exposure to this agent has not been delineated.

ANIMALS

A maximum non-irritating strength of 1.5 percent has been determined for dermal exposure in rabbits (Hathaway et al, 1996).

Carcinogenicity Ratings for CAS1338-23-4 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Methyl ethyl ketone peroxide
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Methyl ethyl ketone peroxide
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS1338-23-4 (U.S. Environmental Protection Agency, 2011):

Not Listed

TOXICITY VALUES

References: HSDB, 1999 Lewis, 1996 RTECS, 1999
- LC50- (INHALATION)MOUSE:
- LC50- (INHALATION)RAT:
- LD50- (ORAL)MOUSE:
- LD50- (INTRAPERITONEAL)RAT:
- LD50- (ORAL)RAT:
- TDLo- (ORAL)HUMAN:
Toxicity values for specific methyl ethyl ketone peroxide mixtures Clayton & Clayton, 1993:
- LC50- (INHALATION)RAT:
- LD50- (ORAL)RAT:
- LD50- (SKIN)RAT:

CALCULATIONS

AMBIENT CONVERSIONS

1 ppm = 7.21 mg/m(3) (at 68 degrees F and 760 mmHg) (NIOSH , 1999)

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS1338-23-4 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Methyl ethyl ketone peroxide

TLV:

TLV-TWA:
TLV-STEL:
TLV-Ceiling: 0.2 ppm

Notations and Endnotes:

Carcinogenicity Category: Not Listed
Codes: Not Listed
Definitions: Not Listed

TLV Basis - Critical Effect(s): Eye and skin irr; liver and kidney dam
Molecular Weight: 176.24

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS1338-23-4 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS1338-23-4 (National Institute for Occupational Safety and Health, 2007):

Listed as: Methyl ethyl ketone peroxide
REL:

TWA:
STEL:
Ceiling: 0.2 ppm (1.5 mg/m(3))
Carcinogen Listing: (Not Listed) Not Listed
Skin Designation: Not Listed
Note(s):

IDLH: Not Listed

OSHA PEL Values for CAS1338-23-4 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS1338-23-4 (U.S. Occupational Safety and Health Administration, 2010):

Threshold Quantity, in pounds:5000
Threshold Quantity, in pounds:5000

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS1338-23-4 (U.S. Environmental Protection Agency, 2010):

Listed as: Methyl ethyl ketone peroxide
Final Reportable Quantity, in pounds (kilograms):

10 (4.54)

Additional Information:
Listed as: 2-Butanone peroxide
Final Reportable Quantity, in pounds (kilograms):

10 (4.54)

Additional Information:

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS1338-23-4 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS1338-23-4 (U.S. Environmental Protection Agency, 2010b):

Listed as: 2-Butanone, peroxide
P or U series number: U160
Footnote:
Listed as: Methyl ethyl ketone peroxide
P or U series number: U160
Footnote:
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS1338-23-4 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS1338-23-4 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS1338-23-4 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS1338-23-4 (EPA, 2005):

Not Listed

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions (49 CFR 172.101, 2005):

Not Listed

DOT -- Table of Hazardous Materials and Special Provisions (49 CFR 172.101, 2005):

Not Listed

ICAO International Shipping Name (ICAO, 2002):

Not Listed

LABELS

NFPA

NFPA Hazard Ratings for CAS1338-23-4 (NFPA, 2002):

Not Listed

-HANDLING AND STORAGE

SUMMARY

INDUSTRIAL CHEMICALS

Methyl ethyl ketone peroxide is an explosion hazard in its pure form. It should be stored in tightly closed containers in a cool, well-ventilated area away from organic materials, sources of ignition, and sunlight. Explosion-proof electrical equipment and fittings and non-sparking tools and equipment should be used when handling or storing this compound (NIOSH , 1999; Sittig, 1991).

HANDLING

This compound is an explosion hazard in its pure form and can become an explosion hazard if it is separated from the diluents it is generally mixed with; under ordinary handling and at room temperature, the MEKP-diluent mixture is stable and will not detonate (ACGIH, 1991; Lewis, 1996; NIOSH , 1999).

When opening and closing containers of methyl ethyl ketone peroxide, only non-sparking tools and equipment should be used. Use explosion-proof electrical equipment and fittings wherever this compound is stored, used, manufactured, or otherwise handled (Sittig, 1991).

See the Standards and Labels section of this document for shipping regulations.

STORAGE

CONTAINER

Store this compound in tightly closed containers (Sittig, 1991).

ROOM/CABINET RECOMMENDATIONS

Methyl ethyl ketone peroxide is an unstable agent which releases oxygen (HSDB , 1999).
This compound must be stored in a cool, well-ventilated area away from organic materials and smoking, open flames, and other sources of ignition. Explosion-proof electrical equipment and fittings should be used wherever this compound is stored (Sittig, 1991).

INCOMPATIBILITIES

This compound must be stored and handled in such a manner to avoid contact with heat, sunlight, flames, and organic materials (NIOSH , 1999; Sittig, 1991).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing will only provide limited protection.

Contact with methyl ethyl ketone peroxide can cause irritation to skin and tissue and can burn and permanently damage the eyes (Grant, 1993; Lewis, 1997; Sittig, 1991). It can also irritate the throat and cause lung injury (CHRIS , 1999).

Solvent-resistant clothing and gloves and appropriate eye protection should be worn to prevent skin and eye contact with the compound. Clean protective clothing should be available each day and should be put on before work. Appropriate respiratory protection should be worn to prevent inhalation of methyl ethyl ketone peroxide vapors (CHRIS , 1999; NIOSH , 1999; Sittig, 1991).
Contaminated clothing should be promptly removed and replaced; contaminated skin should be immediately washed with large amounts of soap and water (NIOSH , 1999; Sittig, 1991).

EYE/FACE PROTECTION

Contact with methyl ethyl ketone peroxide can burn and permanently damage the eyes (Grant, 1993; Lewis, 1997; Sittig, 1991).

Unless personnel wear full facepiece respiratory protection, splash-proof chemical goggles and a face shield should be worn when working with liquid methyl ethyl ketone peroxide to prevent eye contact with the liquid (HSDB , 1999; Sittig, 1991).

When working with methyl ethyl ketone peroxide, contact lenses should not be worn (NIOSH , 1999).

Eyewash fountains should be placed where there is any possibility of workers being exposed to this compound, whether or not eye protection is worn (NIOSH , 1999).

RESPIRATORY PROTECTION

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

Methyl ethyl ketone peroxide vapors can cause lung injury. A positive pressure self-contained breathing apparatus should be worn when working with this compound (CHRIS , 1999).

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 1338-23-4.

All data are compiled from published sources and are NOT recommended specifically by Truven Health Analytics. The appearance of specific manufacturers or products in this section does not represent an endorsement by Truven Health Analytics. No attempt has been made to verify the data presented. All product recommendations should be confirmed with the specific manufacturer for verification of product performance.
CLOTHING

Specific recommendations and test data for this product type were not found in the available manufacturers' product literature.

FOOTWEAR

Specific recommendations and test data for this product type were not found in the available manufacturers' product literature.

GLOVES

Butyl

North Safety Products

Butyl Series

Degradation Rating: Excellent
Breakthrough Time (minutes): >240
Permeation Rate (mcg/cm2/min): None Detected
Notes: 50%
Citation: (North, 2002)

Viton

North Safety Products

Viton Series

Degradation Rating: Excellent
Breakthrough Time (minutes): >240
Permeation Rate (mcg/cm2/min): None Detected
Notes: 50%
Citation: (North, 2002)

GENERAL INFORMATION

This section provides a compilation of chemical resistance information and test data for specific protective clothing products. Chemical resistance information includes both degradation resistance ratings and permeation resistance data. This information is designed to assist in the selection of appropriate protective clothing. Only data on specific products and manufacturers are included. Generic information or recommendations are not provided since significant differences can exist in the chemical resistance for apparent similar product types.
Specific product information is organized by general product type (gloves, garments, and footwear), material type, and manufacturer. The category 'garments' may include totally encapsulating suits, splash suits, as well as other items (e.g., coveralls, jackets, and aprons). Specific manufacturers should be contacted to determine the features of available styles/models.
In addition to chemical resistance information, there are many critical variables in the selection of protective clothing which cannot be represented in this summary of the literature. Some factors to be considered in choosing protective clothing include, but are not limited to: overall clothing integrity, physical hazard resistance, durability, human factors, ease of decontamination, and cost. Overall clothing integrity refers to a specific design's ability to offer consistent protection for all clothing-covered areas of the body. Physical hazards include resisting the effects of abrasion, cuts, tears, and punctures. Human factors entail effects on wearer mobility, visibility, and hearing for garments; dexterity, tactility, and grip for gloves; ankle support and weight for footwear; and, any effect of the clothing on the function of the wearer. There are several variations in the design for gloves, garments, and footwear that affect these factors. Protective clothing must properly be sized and correctly fit the wearer to ensure its proper use and function.
As required in the U.S.A., protective clothing should be selected based on a risk assessment of the workplace. This risk assessment must account for the identification of existing as well as potential hazards and involve the recommendation of protective clothing appropriate for the identified hazards. Therefore, the recommendations in this section should not be used as the sole basis for decisions on choice of protective clothing, but rather should be used as a tool by qualified occupational health and safety professionals or other technically qualified persons in conjunction with a review of all mitigating factors. Consult the OSHA PPE Standard (29 CFR 1910.132 - 1910.138) for regulations and additional guidance regarding the selection and use of protective clothing and equipment. For general information on protective clothing selection, refer to the "PERSONAL PROTECTIVE EQUIPMENT - OSHA PUB 3077" document.
PROTECTIVE CLOTHING SELECTION

Determine the type of protective clothing item needed based on a risk assessment (e.g., gloves, garments, footwear).
For high risk situations, choose clothing that covers all parts of the body that may be exposed. In many cases, multiple clothing items will be required. Low risk situations may permit partial body protective clothing. Select protective clothing products that have reported chemical resistance data. High risk situations involving full body clothing or extended chemical contact often require permeation resistance data to determine the barrier effectiveness of materials used in the construction of clothing. Relatively low risk situations, where only splash or incidental exposure occur, may allow use of protective clothing based on degradation or penetration resistance data. Specifics on the interpretation of chemical resistance data are presented below.
Other factors must be considered in addition to chemical resistance. The selected chemical protective clothing item should offer the optimal combination of protection against identified hazards while allowing maximum function and comfort.

INTERPRETATION OF DEGRADATION RATINGS

Degradation refers to physical changes in a material as the result of chemical exposure. Degradation may become evident in visible changes, such as discoloration, swelling, delamination, deterioration, or disintegration. Degradation effects may also be measured by weight change or other changes in a material's physical properties (e.g., strength, elasticity, hardness).
Degradation resistance ratings are provided by manufacturers to rate the amount of degradation that occurs for a particular protective clothing material when contacted by a chemical. All degradation ratings are qualitative and include ratings, such as "EXCELLENT," "GOOD," "FAIR," "POOR," and "NOT RECOMMENDED." There is no standard test method for the measurement of chemical degradation resistance; therefore, manufacturer ratings may be based on different testing approaches. This makes comparison of degradation ratings between manufacturers unreliable.
The use of degradation resistance ratings alone to recommend protective clothing, particularly for high hazard situations, should be avoided. Degradation resistance testing does not directly assess the barrier quality of protective clothing, since materials can show relatively little degradation but still allow either permeation or penetration by a chemical. Degradation resistance ratings can be used to exclude protective clothing materials from consideration. Protective clothing materials with a "NOT RECOMMENDED" degradation resistance rating should never be used.
For some products, the rating "NO PENETRATION" is provided. This refers to penetration resistance test results that are based on a different procedure (American Society for Testing and Materials (ASTM) Standard Test Method F 903). Penetration resistance testing involves placing a material sample in a test cell, exposing the exterior side of the material to a chemical, and then observing the interior side of the material for visible signs of liquid penetration. Part of the test is conducted at an elevated pressure. Test results are reported as pass (no penetration) or fail (penetration detected). Unlike degradation testing, penetration testing provides an assessment of protective clothing material barrier performance. Since penetration resistance testing examines only observable amounts of liquid penetration, permeation may still occur. The use of penetration resistance data must be restricted to liquid chemicals, and should be limited to scenarios where there is no reasonable vapor exposure hazard under the conditions of exposure.

INTERPRETATION OF PERMEATION DATA

Permeation is the process of chemical movement through a material on a molecular level. Permeation resistance refers to the ability of a material to retard or prevent chemical movement through it. Permeation may occur without any visible signs of degradation.
Permeation resistance is measured using a test cell which is divided into two halves by a protective clothing specimen. Chemical is placed on the challenge side, while the collection side is periodically monitored for permeating chemical. Permeation data were obtained in accordance with the American Society for Testing and Materials (ASTM) Standard Test Method F 739 (Resistance of Materials Used in Protective Clothing to Permeation by Liquids and Gases), unless stated otherwise. In the case of chemicals that are classified as warfare agents, the data were obtained in accordance with the Military Standard 282 (MIL-STD-282) (Military Standard, Filter Units, Protective Clothing, Gas-Mask Components, and Related Products: Performance Test Methods).
Permeation rate is the amount of chemical that passes through a material for a measured surface area per unit time. In this section, permeation rate is expressed in micrograms per square centimeter per minute (mcg/cm(2)/min). The reported permeation rate is either the steady-state rate or the maximum rate observed during testing. In some cases, very large permeation rates exceed measurement techniques and are reported as ">" (greater than) or "HIGH."
Breakthrough time is the elapsed time, in minutes, from the time the chemical comes in contact with the material exterior surface, to the time that chemical is detected on the interior surface. When no breakthrough is detected, the breakthrough time is report as ">" the testing period. If permeation breakthrough is rapid, results are reported as "<" (less than) the earlier sampling time or as "IMMEDIATELY" (which usually means breakthrough in less than 4 minutes).
The breakthrough time should exceed the expected use period of the selected protective clothing. Additionally, there are several other factors that must be taken into account to provide appropriate protection.
Permeation testing is usually conducted with full strength, undiluted chemical for the duration of the test period. Actual exposures may involve diluted chemical for short or intermittent exposure periods.
Permeation testing is usually conducted at room temperature. Permeation occurs faster at elevated temperatures (short breakthrough times and higher permeation rates) and slower at reduced temperatures (long breakthrough times and lower permeation rates).
Permeation resistance of mixtures cannot usually be determined on the basis of the individual chemicals making up the mixture. Synergistic effects may occur and result in more rapid permeation than accounted for by the individual mixture chemicals.
Permeation rates may be used to calculate potential wearer exposure; however, several assumptions must be made about the extent of exposure and condition of clothing wear. Furthermore, there are few chemicals with dermal exposure limits, making it difficult to determine an acceptable skin exposure level.

COMPANY INFORMATION

North Safety Products 2000 Plainfield Pike Cranston, RI 02921 USA Phone: (800) 430-4110 Fax: (800) 572-6346 Toll-Free: (800) 430-4110 Website: http://www.northsafety.com Email: marketing@northsafety.com

REFERENCES

CHEMICAL PROTECTIVE CLOTHING CITATIONS

The following sources were consulted for chemical protective clothing data:

(Ansell-Edmont, 2001)
(Bata Shoe Company, 1995)
(Best Manufacturing, 2002)
(Best Manufacturing, 2004)
(Boss Manufacturing Company, 1998)
(ChemFab Corporation, 1993)
(Comasec Safety, Inc., 2003)
(Comasec Safety, Inc., 2003a)
(DuPont, 2002)
(DuPont, 2002)
(DuPont, 2003)
(Guardian Manufacturing Group, 2001)
(ILC Dover, Inc., 1998)
(Kappler Inc., 2001)
(Kimberly-Clark, 2002)
(LaCrosse-Rainfair, 1997)
(MAPA Professional, 2003)
(MAPA Professional, 2004)
(Mar-Mac Manufacturing, Inc, 1995)
(Marigold Industrial, 2003)
(Memphis Glove Company, 2001)
(Montgomery Safety Products, 1995)
(Nat-Wear, 2001)
(Neese Industries, Inc., 2003)
(North, 2002)
(North, 2002)
(Playtex, 1995)
(River City, 1995)
(Safety 4, 2002)
(Servus, 1995)
(Standard Safety Equipment, 1995)
(Tingley, 2002)
(Trelleborg-Viking, Inc., 2001)
(Trelleborg-Viking, Inc., 2002)
(Wells Lamont Industrial, 2002)
(Workrite, 1997)

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.
POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)
- May explode from heat, shock, friction or contamination.
- May ignite combustibles (wood, paper, oil, clothing, etc.).
- May be ignited by heat, sparks or flames.
- May burn rapidly with flare-burning effect.
- Containers may explode when heated.
- Runoff may create fire or explosion hazard.
Methyl ethyl ketone peroxide is a combustible liquid. Dry chemical, carbon dioxide, water spray, or alcohol foam should be used to extinguish fires involving this compound. Irritating fumes and acrid smoke may be emitted when this compound is involved in a fire (Lewis, 1996; NIOSH , 1999; Sittig, 1991).
Methyl ethyl ketone peroxide is a strong oxidizing agent and may become a fire hazard when in contact with organic materials (HSDB , 1999; Lewis, 1997).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS1338-23-4 (NFPA, 2002):

Not Listed

INITIATING OR CONTRIBUTING PROPERTIES

Methyl ethyl ketone peroxide vapor may ignite due to accumulation of static electrical charges (Pohanish & Greene, 1997).
Heat, sparks, or flames may cause this compound to ignite (CHRIS , 1999).

FIRE CONTROL/EXTINGUISHING AGENTS

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Water spray or fog is preferred; if water not available use dry chemical, CO2 or regular foam.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Flood fire area with water from a distance.
Use water spray or fog; do not use straight streams.
Move containers from fire area if you can do it without risk.
Do not move cargo or vehicle if cargo has been exposed to heat.
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.
ALWAYS stay away from tanks engulfed in fire.
For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

NFPA Extinguishing Methods for CAS1338-23-4 (NFPA, 2002):

Not Listed

When this compound is involved in a fire, irritating or poisonous gases may be emitted. Appropriate respiratory protection and protective clothing should be worn when fighting fires involving this compound (CHRIS , 1999; Lewis, 1996; NIOSH , 1999).

Dry chemical, carbon dioxide, water spray, or alcohol foam should be used to extinguish fires involving methyl ethyl ketone peroxide. Fire may cause containers of this compound to explode (CHRIS , 1999; Sittig, 1991).

COMBUSTION TOXICITY

Irritating fumes and acrid smoke are emitted when this compound is heated to decomposition (Lewis, 1996).

EXPLOSION HAZARD

Methyl ethyl ketone peroxide is a shock-sensitive explosive that may become a hazard if it is separated from the diluents it is generally mixed with (ACGIH, 1991; Lewis, 1996; NIOSH , 1999; Pohanish & Greene, 1997).

NIOSH (1999) reports that "explosive decomposition occurs at 230 degrees F." Pohanish & Greene (1997) report that "explosive decomposition occurs above 80 degrees C (176 degrees F)."

Violent detonation occurs upon rapid heating or contact with hot surfaces above 140 degrees C (HSDB , 1999).

Methyl ethyl ketone peroxide contaminated with acetone may form shock-sensitive peroxide precipitates (HSDB , 1999).

DUST/VAPOR HAZARD

Irritating fumes and acrid smoke are emitted when this compound is heated to decomposition (Lewis, 1996).

REACTIVITY HAZARD

This compound may react violently with combustible substances, organic materials, strong acids, strong bases, reducing agents, amines, oxides of heavy metals, salts, and trace contaminants (HSDB , 1999; Pohanish & Greene, 1997).

Methyl ethyl ketone peroxide is decomposed by normal heating at approximately 120 degrees C (HSDB , 1999).

It will decompose violently when in contact with concentrated sulfuric acid (HSDB , 1999).

Methyl ethyl ketone peroxide, a strong oxidizing agent, may become a fire hazard when in contact with organic materials (HSDB , 1999; Lewis, 1997).

EVACUATION PROCEDURES

SUMMARY

Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.

LARGE SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

Consider initial evacuation for at least 250 meters (800 feet).

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.

AIHA ERPG Values for CAS1338-23-4 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS1338-23-4 (U.S. Department of Energy, Office of Emergency Management, 2010):

Listed as Methyl ethyl ketone peroxide
TEEL-0 (units = ppm): 1
TEEL-1 (units = ppm): 3
TEEL-2 (units = ppm): 20
TEEL-3 (units = ppm): 20
Definitions:

TEEL-0: The threshold concentration below which most people will experience no adverse health effects.
TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure.
TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape.
TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.

AEGL Values for CAS1338-23-4 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS1338-23-4 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- Keep combustibles (wood, paper, oil, etc.) away from spilled material.
- Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.
- Keep substance wet using water spray.
- Stop leak if you can do it without risk.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing will only provide limited protection.
Only persons wearing protective clothing, including eye protection, solvent-resistant clothing and gloves, and respiratory protection, should be allowed in the contaminated area (CHRIS , 1999; Sittig, 1991).
The contaminated area should be ventilated after all ignition sources have been removed (Sittig, 1991).
If it is not a hazard to personnel, attempt to stop or control any leaks and prevent the compound from entering water supplies (CHRIS , 1999).
Due to the explosive properties of this compound, keep it from entering sewers or other confined spaces, unless the design of the space will prevent the build-up of explosive concentrations (CHRIS , 1999; Sittig, 1991).
Sittig (1991) reports that liquids should be absorbed in materials such as dry sand, earth, or vermiculite and deposited in sealed containers.

SMALL LEAK/SPILL

SMALL SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)
- Take up with inert, damp, non-combustible material using clean non-sparking tools and place into loosely covered plastic containers for later disposal.

LARGE LEAK/SPILL

LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 146 (ERG, 2004)
- Wet down with water and dike for later disposal.
- Prevent entry into waterways, sewers, basements or confined areas.
- DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST.

WASTE TREATMENT OPTIONS

PHYSICAL TREATMENT

The following may be used for incineration of methyl ethyl ketone peroxide (HSDB , 1999):

	TEMPERATURE RANGE	RESIDENCE TIME
Liquid Injection Incineration	650-1600 degrees C	0.1-2 seconds
Rotary Kiln Incineration	820-1600 degrees C	seconds for liquids and gases; hours for solids
Fluidized Bed Incineration	450-980 degrees C	seconds for liquids and gases; longer for solids

Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

Methyl ethyl ketone peroxide may be released to the atmosphere from its production or from its use in the production of polymers (HSDB , 1999).

ENVIRONMENTAL FATE AND KINETICS

The primary removal process for vapor-phase methyl ethyl ketone peroxide is a reaction with photochemically produced hydroxyl radicals, with an estimated half-life of approximately 1.7 days (HSDB , 1999).
Howard et al (1991) reports an estimated half-life in air of 0.913 to 9.13 hours.

WATER

SURFACE WATER
- If methyl ethyl ketone peroxide is released to water, bioconcentration in aquatic organisms, adsorption to sediment, and volatilization should not be significant removal processes. It is a strong oxidizing agent and may react with organic materials (HSDB , 1999).
- Howard et al (1991) reports an estimated half-life in surface water of 7 days to 4 weeks; the half-life in ground water is estimated to be 14 days to 8 weeks.

SOIL

TERRESTRIAL
- Methyl ethyl ketone peroxide may be rapidly oxidized by a reaction with organic materials since it is a strong oxidizing agent. If it is not rapidly oxidized or degraded by other processes, it may leach in soil, based on an estimated Koc of 74 (HSDB , 1999).
- Howard et al (1991) reports an estimated half-life in soil of 7 days to 4 weeks.

ABIOTIC DEGRADATION

The atmospheric half-life for methyl ethyl ketone peroxide is estimated to be approximately 1.7 days at an atmospheric concentration of 5 x 10(5) hydroxyl radicals/cm(3) based on an estimated rate constant for the vapor-phase reaction of this compound with photochemically produced hydroxyl radicals of 9.25 x 10(-12) cm(3)/mol-sec at 25 degrees C. Methyl ethyl ketone peroxide is decomposed by normal heating at approximately 120 degrees C (HSDB , 1999).

BIODEGRADATION

The estimated anaerobic half-life in an unacclimated, aqueous environment ranges from 4 to 16 weeks (Howard et al, 1991).

The estimated aerobic half-life in an unacclimated, aqueous environment ranges from 1 to 4 weeks (Howard et al, 1991).

BIOACCUMULATION

BIOCONCENTRATION FACTOR

The estimated bioconcentration factor for this compound is 2.9 (HSDB , 1999).

ENVIRONMENTAL TOXICITY

No information found at the time of this review.

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

176.21

DESCRIPTION/PHYSICAL STATE

Methyl ethyl ketone peroxide is a colorless liquid that has a characteristic, mint-like, moderately sharp odor; it is a strong oxidizing agent (Clayton & Clayton, 1993; Lewis, 1997; NIOSH , 1999).

VAPOR PRESSURE

Unknown (NIOSH , 1999)

SPECIFIC GRAVITY

OTHER TEMPERATURE AND/OR PRESSURE

1.12 (at 59/39.2 degrees F) (NIOSH , 1999)

DENSITY

OTHER TEMPERATURE AND/OR PRESSURE

1.12 g/mL (at 15 degrees C) (ACGIH, 1991)
1.170 g/mL (at 20 degrees C) (CHRIS , 1999)

FREEZING/MELTING POINT

FREEZING POINT

Unknown (NIOSH , 1999)

MELTING POINT

60 degrees C (ACGIH, 1991; Sittig, 1991)

BOILING POINT

118 degrees C (decomposes) (ACGIH, 1991; Sittig, 1991)

244 degrees F (decomposes) (NIOSH , 1999)

FLASH POINT

52-93 degrees C (Sittig, 1991)

125-200 degrees F (open cup) (60% MEKP) (NIOSH , 1999)

52 degrees C; 125 degrees F (Pohanish & Greene, 1997)

180 degrees F (closed cup) (CHRIS , 1999)

EXPLOSIVE LIMITS

LOWER

Unknown (NIOSH , 1999)

UPPER

Unknown (NIOSH , 1999)

SOLUBILITY

IN WATER

This compound is soluble in water (NIOSH , 1999).

OCTANOL/WATER PARTITION COEFFICIENT

log Kow = 0.914 (estimated) (HSDB , 1999)

HENRY'S CONSTANT

1.6x10(-8) atm-m(3)/mol (HSDB , 1999)

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METHYL ETHYL KETONE PEROXIDE

Classification | Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents