MESITYLENE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
1,3,5-TRIMETHYLBENZENE 1,3,5-TRIMETHYL BENZENE BENZENE, 1,3,5-TRIMETHYL- FLEET-X MESITELENE MESITYLENE TMB 1,3,5-TMB TRIMETHYL BENZENE sym-TRIMETHYLBENZENE symmetrical-TRIMETHYLBENZENE SYMMETRICAL TRIMETHYLBENZENE TRIMETHYLBENZOL TRIMETHYL BENZOL
IDENTIFIERS
SYNONYM REFERENCE
- (Bingham et al, 2001)ILO, 1998;(NIOSH , 2002; Pohanish, 2002; Laham, 1987)
USES/FORMS/SOURCES
Mesitylene is used in paint and lacquer thinners, as a solvent in paint and varnish formulations, as a component in motor fuel, as an ultraviolet oxidation stabilizer for plastics, and as an intermediate in the manufacture of organic chemicals. It is also used in the production of plastics and dyes (AAR, 1998; Bingham et al, 2001; Pohanish, 2002; Laham, 1987) .
Mesitylene is one of three isomers of trimethylbenzene and is found in refined petroleum and in coal tars (through fractionation). It can also be produced by the dehydration of acetone with sulfuric acid or by the disproportionation of xylene when in the presence of aluminum chloride (Bingham et al, 2001; Budavari, 2000; HSDB , 2002; Laham, 1987).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Mesitylene is irritating to the eyes, skin, and mucous membranes. Mesitylene can cause CNS depression. Fatigue, drowsiness, headache, dizziness, confusion, incoordination, nervousness, and anxiety may be noted. Pulmonary aspiration may result in chemical pneumonitis with acute lung injury and hemorrhage.
- Thrombocytopenia, leukopenia, mild anemia, and coagulation disorders may also occur. Elevated liver function tests have been noted.
- Chronic exposure may cause asthmatic-like bronchitis. Erythema, drying, and defatting of the skin may occur following dermal exposure to the liquid.
- POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
ACUTE CLINICAL EFFECTS
- Mesitylene is irritating to the eyes, skin, and mucous membranes (Plunkett, 1976; ITI, 1985; Hathaway et al, 1996) RTECS, 1997). Pulmonary aspiration can cause potentially fatal chemical pneumonitis, pulmonary edema, and hemorrhage (Laham, 1987). Neurologic effects may include headache, fatigue, nervousness, anxiety, and central nervous system (CNS) depression (HSDB, 1997; (Hathaway et al, 1996; Laham, 1987). Nausea may also be noted (Plunkett, 1976; ITI, 1985; Finkel, 1983; Hathaway et al, 1996).
- Dermal irritation may occur following direct skin contact (Plunkett, 1976) EPA, 1985). Systemic absorption through intact skin does not occur readily and acute poisoning by this exposure route is unlikely (Laham, 1987).
CHRONIC CLINICAL EFFECTS
- Chronic asthmatic-like bronchitis may be a delayed or chronic hazard (EPA, 1985; (Laham, 1987) HSDB, 1997). Nervousness, tension, and anxiety have been noted in chronically exposed workers with exposure to a mixture of solvents including mesitylene (HSDB, 1997).
- Thrombocytopenia with bleeding from the gums and nose and mild anemia may occur with chronic exposure to mesitylene as a component of the commercial solvent mixture, "Fleet-X-DV-99" (Plunkett, 1976; Finkel, 1983) HSDB, 1997). Hypochromic anemia and coagulation disorders were found in a group of workers exposed for several years to a solvent mixture containing 50 percent pseudocumene and 30 percent mesitylene (Battig et al, 1956) ACGIH, 1992). These hematologic effects may have been due to a contaminant in the remaining 20 percent, probably benzene (Laham, 1987; Hathaway et al, 1996; Gerarde, 1960). Thrombocytosis and thrombocytopenia have been noted in rabbits (Clayton & Clayton, 1994).
- Repeated skin contact may result in cracking and drying (Hathaway et al, 1996).
- Elevated alkaline phosphatase and SGOT (AST) levels have been noted in chronic experimental animal inhalation studies (Clayton & Clayton, 1994). These effects have not been reported in exposed humans.
-MEDICAL TREATMENT
LIFE SUPPORT
- Support respiratory and cardiovascular function.
SUMMARY
- FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
FIRST AID EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Primary eye protection (spectacles or goggles), as defined by the Occupational Safety and Health Administration (OSHA), should be used when working with this chemical. Face shields should only be worn over primary eye protection. DERMAL EXPOSURE - Wash the contaminated skin with soap and water. INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. ORAL EXPOSURE - If this chemical has been swallowed, get medical attention immediately. TARGET ORGANS - Eyes, skin, respiratory system, central nervous system, and blood (National Institute for Occupational Safety and Health, 2007; Chemsoft(R) , 2000).
INHALATION EXPOSURE INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm. If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents. ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.
DERMAL EXPOSURE DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999). Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
EYE EXPOSURE DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
ORAL EXPOSURE Because of the potential for gastrointestinal tract irritation or chemical pneumonitis and acute lung injury from aspiration, DO NOT induce emesis. PREHOSPITAL ACTIVATED CHARCOAL ADMINISTRATION Consider prehospital administration of activated charcoal as an aqueous slurry in patients with a potentially toxic ingestion who are awake and able to protect their airway. Activated charcoal is most effective when administered within one hour of ingestion. Administration in the prehospital setting has the potential to significantly decrease the time from toxin ingestion to activated charcoal administration, although it has not been shown to affect outcome (Alaspaa et al, 2005; Thakore & Murphy, 2002; Spiller & Rogers, 2002). In patients who are at risk for the abrupt onset of seizures or mental status depression, activated charcoal should not be administered in the prehospital setting, due to the risk of aspiration in the event of spontaneous emesis. The addition of flavoring agents (cola drinks, chocolate milk, cherry syrup) to activated charcoal improves the palatability for children and may facilitate successful administration (Guenther Skokan et al, 2001; Dagnone et al, 2002).
ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
-RANGE OF TOXICITY
MINIMUM LETHAL EXPOSURE
In experiments with rats, 4 of 10 animals died following inhalation exposure to an airborne concentration of 2400 ppm for 24 hours. An oral dose of 5 mL/kg caused death in 1 of 10 rats (Laham, 1987). Minimum lethal intraperitoneal doses were 1.5 to 2.0 mL/kg in rats and 1.13 to 12 mL/kg in guinea pigs (Laham, 1987).
MAXIMUM TOLERATED EXPOSURE
10 ppm is the lowest toxic concentration reported in humans. At this concentration, central nervous system effects with somnolence and respiratory tract irritation are observed (EPA, 1985; (RTECS , 2002). A variety of effects on the central nervous system (CNS), respiratory system, and hematopoietic system were observed in a group of workers with chronic exposure to a solvent mixture containing 30 percent mesitylene (Laham, 1987). Mesitylene inhalation at airborne concentrations of 1.5, 3.0, and 6.0 mg/L for 6 hours caused dose-related changes in white blood cell counts in rats (Clayton & Clayton, 1994). CNS depression and ataxia were noted in rats exposed to airborne concentrations of 5100 to 9180 ppm for 2 hours (Laham, 1987).
- Carcinogenicity Ratings for CAS108-67-8 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: 1,3,5-Trimethylbenzene MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS108-67-8 (U.S. Environmental Protection Agency, 2011):
CALCULATIONS
CONVERSION FACTORS: 1 mg/L = 203.4 ppm (Laham, 1987) 1 mg/L = 203.5 ppm (HSDB , 2002) 1 mg/m(3) = 0.20 ppm (Laham, 1987)
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS108-67-8 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS108-67-8 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS108-67-8 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS108-67-8 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS108-67-8 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS108-67-8 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS108-67-8 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS108-67-8 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS108-67-8 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS108-67-8 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS108-67-8 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS108-67-8 (EPA, 2005):
SHIPPING REGULATIONS
- DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 2325 (49 CFR 172.101, 2005):
- ICAO International Shipping Name for UN2325 (ICAO, 2002):
LABELS
- NFPA Hazard Ratings for CAS108-67-8 (NFPA, 2002):
-HANDLING AND STORAGE
SUMMARY
Wear protective clothing including rubber gloves, a protective mask, overalls, and an all-purpose respiratory mask (ITI, 1995; (Pohanish, 2002). For normal handling procedures, ensure that ventilation is adequate and wear protective clothing including chemical goggles, a chemical cartridge respirator, and rubber gloves (Plunkett, 1976).
HANDLING
- When handling mesitylene, rubber gloves, a protective mask, overalls, and an all-purpose respiratory mask should be worn (ITI, 1995).
- Ensure that explosive concentrations do not exist before entering a confined space where mesitylene is stored or may be present (Pohanish, 2002).
STORAGE
Mound storage tanks containing trimethylbenzenes to confine escaping liquid (HSDB , 2002). If possible, liquid should be automatically pumped from drums or other storage containers into process containers (Pohanish, 2002).
- ROOM/CABINET RECOMMENDATIONS
Store tightly-closed containers of mesitylene in cool, well-ventilated areas. Keep far from oxidizers and strong acids (Pohanish, 2002). Use effective ventilation (preferably local exhaust ventilation) to keep the concentration of vapor in the atmosphere below 35-50 ppm; this will help decrease the risk of explosion (HSDB , 2002).
-PERSONAL PROTECTION
SUMMARY
- RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- To prevent contact with mesitylene, protective clothing, including gloves and a face shield, should be used. Clothing should be removed and replaced if it becomes wet or significantly contaminated (NIOSH , 2002; Pohanish, 2002).
- For normal handling procedures, ensure that ventilation is adequate and wear protective clothing including chemical goggles, a chemical cartridge respirator, and rubber gloves (Plunkett, 1976).
EYE/FACE PROTECTION
- Do not wear contact lenses when working with mesitylene (Pohanish, 2002).
RESPIRATORY PROTECTION
- Wear an all-purpose respiratory mask when working with mesitylene (ITI, 1995).
- For normal handling procedures, ensure that ventilation is adequate and wear protective clothing including chemical goggles, a chemical cartridge respirator, and rubber gloves (Plunkett, 1976).
- Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 108-67-8.
ENGINEERING CONTROLS
- Emergency showers and eyewash stations should be provided (Pohanish, 2002).
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS108-67-8 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane.
- LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk.
- TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
- NFPA Extinguishing Methods for CAS108-67-8 (NFPA, 2002):
Listed as: 1,3,5-Trimethylbenzene Extinguishing Method(s): Not Listed
- Mesitylene is a flammable liquid, and poisonous gases may be produced in fires involving this compound. Mesitylene vapors are more dense than air and will collect in low areas; if vapors in confined areas are exposed to fire, explosion is possible. They also may travel to a source of ignition, causing a flashback. Containers may also explode or possible rocket great distances (Pohanish, 2002).
- Fire should be extinguished only if the runoff can be stopped or confined safely. Carbon dioxide, dry chemical, or alcohol or polymer foam extinguishers should be used as water may be ineffective. Water can be used to cool exposed containers from a safe location. In the instance that this is ineffective or if venting sound increases, tank discolors or deforms, withdrawal to a secure position should be immediate. Do not allow runoff to enter sewers or water sources (HSDB , 2002; Pohanish, 2002).
- Water spray, fog, foam, and carbon dioxide are recommended to fight fires involving mesitylene (Lewis, 2000).
Mesitylene forms an explosive mixture with air (Pohanish & Greene, 1997) To decrease the risk of explosion, use local applied exhaust or other effective ventilation to ensure that trimethylbenzene vapors are kept below 35-50 ppm (HSDB , 2002). Mesitylene releases acrid smoke and fumes when heated to decomposition (Lewis, 2000).
EXPLOSION HAZARD
- A vapor explosion hazard is associated with mesitylene indoors, outdoors, or in sewers. Allowing this compound to runoff into sewers may result in the creation of a fire or explosion (Pohanish, 2002).
DUST/VAPOR HAZARD
- Mesitylene releases acrid smoke and fumes when heated to decomposition (Lewis, 2000).
REACTIVITY HAZARD
- Mesitylene emits acrid smoke and fumes when heated to decomposition (Lewis, 2000).
- Heat, sparks, or flames may ignite mesitylene (Sittig, 1991).
- A violent reaction occurs when mesitylene is exposed to nitric acid or oxidizing materials (Lewis, 2000).
- Mesitylene may accumulate static electrical charges, which may cause ignition of its vapors (Pohanish & Greene, 1997).
EVACUATION PROCEDURES
- Editor's Note: This material is not listed in the Table of Initial Isolation and Protective Action Distances.
- LARGE SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
- FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
- PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004)
CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number: MEXICO: SETIQ: 01-800-00-214-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5559-1588; For calls originating elsewhere, call: 011-52-555-559-1588.
CENACOM: 01-800-00-413-00 in the Mexican Republic; For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885; For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.
ARGENTINA: CIQUIME: 0-800-222-2933 in the Republic of Argentina; For calls originating elsewhere, call: +54-11-4613-1100.
BRAZIL: PRÓ-QUÍMICA: 0-800-118270 (Toll-free in Brazil); For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).
COLUMBIA: CISPROQUIM: 01-800-091-6012 in Colombia; For calls originating in Bogotá, Colombia, call: 288-6012; For calls originating elsewhere, call: 011-57-1-288-6012.
CANADA: UNITED STATES:
For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
- FIRE -- When a tank car or truck becomes involved in a fire with mesitylene, isolate the area for one-half mile in all directions. In the event of a rising sound coming from a venting safety device or if any discoloration of a tank due to the fire is observed, withdraw from the scene immediately (Pohanish, 2002).
- SPILL -- Keep people not wearing protective clothing away from the spill by isolating and denying entry to the area (Pohanish, 2002).
- AIHA ERPG Values for CAS108-67-8 (AIHA, 2006):
- DOE TEEL Values for CAS108-67-8 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Mesitylene (1,3,5-Trimethyl benzene) TEEL-0 (units = ppm): 25 TEEL-1 (units = ppm): 140 TEEL-2 (units = ppm): 360 TEEL-3 (units = ppm): 500 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS108-67-8 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
Listed as: 1,3,5-Trimethylbenzene Proposed Value: AEGL-2 10 min exposure: ppm: 460 ppm mg/m3: 2300 mg/m(3)
30 min exposure: ppm: 460 ppm mg/m3: 2300 mg/m(3)
1 hr exposure: ppm: 360 ppm mg/m3: 1800 mg/m(3)
4 hr exposure: ppm: 230 ppm mg/m3: 1100 mg/m(3)
8 hr exposure: ppm: 150 ppm mg/m3: 740 mg/m(3)
Definitions: AEGL-2 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape.
Listed as: 1,3,5-Trimethylbenzene Proposed Value: AEGL-3 10 min exposure: 30 min exposure: 1 hr exposure: 4 hr exposure: 8 hr exposure:
Definitions: AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening health effects or death.
Listed as: 1,3,5-Trimethylbenzene Proposed Value: AEGL-1 10 min exposure: ppm: 180 ppm mg/m3: 890 mg/m(3)
30 min exposure: ppm: 180 ppm mg/m3: 890 mg/m(3)
1 hr exposure: ppm: 140 ppm mg/m3: 690 mg/m(3)
4 hr exposure: ppm: 90 ppm mg/m3: 440 mg/m(3)
8 hr exposure: ppm: 45 ppm mg/m3: 220 mg/m(3)
Definitions: AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling, are transient, and are reversible upon cessation of exposure.
- NIOSH IDLH Values for CAS108-67-8 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 129 (ERG, 2004) All individuals not wearing protective equipment should be evacuated and restricted from the spill or leak area until cleanup is complete. All ignition sources should be removed, and forced ventilation should be established to ensure levels are kept below the explosive limit. The spill can be absorbed in dry sand, earth, peat, vermiculite, carbon or other noncombustible, absorbent material. To lessen the possibility of explosions, do not allow the chemical to enter into confined spaces. If done immediately, sorbent foams and oil-skimming equipment may applied to a slick. If material should enter into a waterway, downstream users must be notified of potential contamination. Contact for specific disposal recommendations. It may need to be treated as if a hazardous waste (Pohanish, 2002) LAND SPILL -- When mesitylene is spilled on land, a holding area should be created to contain the material. Soil, sand bags, foamed polyurethane, or foamed concrete can be used to dike the surface flow, and fly ash, cement powder, or commercial sorbents can then be used to absorb the bulk liquid (NFPA, 1997). WATER SPILL -- To limit the travel of mesitylene that has been spilled in water, natural barrriers or oil spill control booms should be used. The trapped material can then be removed with suction hoses (NFPA, 1997). AIR SPILL -- Water spray or mist should be used to knock down vapors when mesitylene is spilled in air (NFPA, 1997).
-ENVIRONMENTAL HAZARD MANAGEMENT
POLLUTION HAZARD
- Mesitylene is emitted into the atmosphere by gasoline-powered vehicles, coal-fired power stations, and municipal waste-treatment plants. Exposure to this compound for the general population will occur through the ingestion of food or drinking water, the inhalation of ambient air, or dermal contact with vapors, food, or other mesitylene-containing products (HSDB , 2002).
ENVIRONMENTAL FATE AND KINETICS
Based on its vapor pressure of 2.48 mmHg at 25 degrees C, mesitylene released to air will exist entirely in the vapor phase. Vapor-phase mesitylene will be degraded in the atmosphere by its reaction with photochemically-produced hydroxyl radicals. The half-life for this reaction is approximately 7 hours. Mesitylene in the vapor phase may also be degraded by a reaction with nitrate radicals at a half-life of 10-67 days (HSDB , 2002). Mesitylene has a half-life of 0.2 days for its reaction with hydroxyl radicals and of 1,100 days for its reaction with ozone (Verschueren, 2000).
SURFACE WATER Based on its octanol/water partition coefficient, mesitylene may adsorb to sediment or particulate matter in water, and it is expected to volatilize from water surfaces due to its Henry's Law constant of 8.77x10(-3) atm-m(3)/mol. The half-lives for mesitylene in a model river and model lake were estimated at 3 hours and 4 days, respectively (HSDB , 2002).
TERRESTRIAL The mobility of mesitylene in soil is expected to be low based upon a measured Koc value of 660. This compound is also likely to volatilize from both moist and dry soil surfaces according to measured values for its Henry's Law Constant and vapor pressure, respectively. Mesitylene is expected to biodegrade in soil; the rate of biodegradation may be increased by acclimation (HSDB , 2002).
BIOACCUMULATION
CARP: 23-342 (for a mesitylene concentration of 150 mcg/L) (HSDB , 2002) CARP: 42-328 (for a mesitylene concentration of 15 mcg/L) (HSDB , 2002)
ENVIRONMENTAL TOXICITY
EC50 - SCENEDESMUS SUBSPICATUS: 25-53 mg/L for 48H (Verschueren, 2000) EC50 - DAPHNIA MAGNA: 50 mg/L for 24H - increased mortality; reduced reproduction rates (HSDB , 2002) LC50 - GOLDFISH: 13 mg/L for 96H (Verschueren, 2000) TLm96 - UNSPECIFIED FISH SPECIES: 100-1000 ppm (Clayton & Clayton, 1994)
-PHYSICAL/CHEMICAL PROPERTIES
MOLECULAR WEIGHT
DESCRIPTION/PHYSICAL STATE
- Mesitylene is a clear, colorless liquid at room temperature; its odor has been characterized as being peculiar, distinctive, aromatic, and sweet (Budavari, 2000; HSDB , 2002; NIOSH , 2002).
VAPOR PRESSURE
- 1.82 mmHg (at 20 degrees C)(Bingham et al, 2001) Verschueren, 2000)
- 1.86 mmHg (at 20 degrees C) (HSDB , 2002; Laham, 1987)
- 2.48 mmHg (at 25 degrees C) (from experimentally-derived coefficients) (HSDB , 2002)
SPECIFIC GRAVITY
- TEMPERATURE AND/OR PRESSURE NOT LISTED
DENSITY
- TEMPERATURE AND/OR PRESSURE NOT LISTED
4.1 (Bingham et al, 2001; NFPA, 2002a) Verschueren, 2000) 1.006 (at 20 degrees C) (HSDB , 2002; Laham, 1987) 1.006 (ILO, 1998)
FREEZING/MELTING POINT
-49 degrees F (NIOSH , 2002) -52.7 degrees C (Lewis, 2001)
-44.8 degrees C (ITI, 1995; (Lewis, 2000) 44.7 degrees C (Bingham et al, 2001) -44.7 degrees C (ILO, 1998) -52.7 degrees C (Verschueren, 2000)
BOILING POINT
- 329 degrees F (NIOSH , 2002)
- 165 degrees C (Sittig, 1991)
- 163-165 degrees C (Ashford, 2001)
- 328 degrees F; 164 degrees C (NFPA, 2002a)
- 164.7 degrees C (at 760 mmHg)(Budavari, 2000; Clayton & Clayton, 1994; Lewis, 2000) ITI, 1995)
- 164.6 degrees C (Lewis, 2002)
- 164.7 degrees C (ILO, 1998; Verschueren, 2000)
- 98.9 degrees C (at 100 mmHg) (Budavari, 2000)
- 61 degrees C (at 20 mmHg) (Budavari, 2000)
- 47.4 degrees C (at 10 mmHg) (Budavari, 2000)
- 9.6 degrees C (at 1.0 mmHg) (Budavari, 2000)
FLASH POINT
- 122 degrees F; 50 degrees C (closed cup)(HSDB , 1999; NFPA, 2002a; NIOSH , 2002)
- near 123 degrees F (AAR, 2002).
- 50 degrees C (Sittig, 1991; Laham, 1987)
- 47 degrees C; 117 degrees F (Pohanish & Greene, 1997).
AUTOIGNITION TEMPERATURE
- 1022 degrees F (Lewis, 2000)
- 1039 degrees F; 559 degrees C (NFPA, 2002a)
EXPLOSIVE LIMITS
SOLUBILITY
0.002% (Budavari, 2000; NIOSH , 2002; Laham, 1987) 20 mg/l (Verschueren, 2000) Insoluble in water (Ashford, 2001; Bingham et al, 2001; Lewis, 2000) ILO, 1998) 48.2 mg/L (at 25 degrees C) (HSDB , 2002)
Mesitylene is miscible with aromatic and oxygenated solvents (Ashford, 2001). Mesitylene is miscible with ether, petroleum ether, benzene, and alcohol (Budavari, 2000) ITI, 1995; (Lewis, 2000; Laham, 1987) Mesitylene is very soluble in alcohol and ether (Bingham et al, 2001)
OCTANOL/WATER PARTITION COEFFICIENT
- Log Pow = 3.42 (HSDB , 2002) Verschueren, 2000)
HENRY'S CONSTANT
- 8.770x10(-3) atm-m(3)/mol(3) (HSDB , 2002)
SPECTRAL CONSTANTS
OTHER/PHYSICAL
1.49541 (at 18 degrees C) (Budavari, 2000) ITI, 1995; (Laham, 1987) 1.4994 (Bingham et al, 2001)
- NUCLEAR MAGNETIC RESONANCE
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