2,4-DIHYDROXY-2-METHYLPENTANE

DIOLANE

1,2-HEXANEDIOL

HEXYLENE GLYCOL

ISOL

2-METHYL-2,4-PENTANDIOL

2-METHYL-2,4-PENTANEDIOL

4-METHYL-2,4-PENTANEDIOL

2-METHYL PENTANE-2,4-DIOL

2,4-PENTANEDIOL, 2-METHYL-

PINAKON

ALPHA,ALPHA,ALPHA-TRIMETHYLTRIMETHYLENE GLYCOL

TRIMETHYLTRIMETHYLENE GLYCOL

1,1,3-TRIMETHYLTRIMETHYLENEDIOL

107-41-5(Hexylene glycol)

SA 0810000

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.

C6H14O2 (CH3)2COHCH2CHOHCH3 (CH3)2COHCH2CH2OCH3 (H3C)2C(OH)CH2CH(OH)CH3 (CH3)2C(OH)CH2CHOHCH3 CH3CH2CH2(HO)C(CH3)CH2OH (CH(3))(2)C9OH0CH(2)CH(OH)CH(3)

131-FLAMMABLE LIQUIDS - TOXIC

Hexylene glycol is used in cosmetics, water-based paints, printing inks, detergents, agrochemicals, hydraulic brake fluids, and petroleum refining. It is also used as a chemical intermediate, a coupling agent and penetrant for textiles, a fuel and lubricant additive, an emulsifying agent, an inhibitor of ice formation in carburetors, a cement additive, and an unsaturated polyester resin comonomer (Budavari, 1996) Hathaway, 1996; (ITI, 1995; Ashford, 1994; Clayton & Clayton, 1994; Lewis, 1993).

It is commercially prepared by the catalytic hydrogenation of diacetone alcohol (Ashford, 1994; Clayton & Clayton, 1994; ACGIH, 1991).

TOXIC; may be fatal if inhaled, ingested or absorbed through skin.

Inhalation or contact with some of these materials will irritate or burn skin and eyes.

Fire will produce irritating, corrosive and/or toxic gases.

Vapors may cause dizziness or suffocation.

Runoff from fire control or dilution water may cause pollution.

Move victim to fresh air.

Call 911 or emergency medical service.

Give artificial respiration if victim is not breathing.

Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Administer oxygen if breathing is difficult.

Remove and isolate contaminated clothing and shoes.

In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.

Wash skin with soap and water.

Keep victim warm and quiet.

In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.

Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

GENERAL -

INHALATION EXPOSURE -

DERMAL EXPOSURE -

EYE EXPOSURE -

ORAL EXPOSURE -

The probable oral lethal dose ranges from 0.5 to 15 g/kg, or 1 oz to 1 qt for a 70 kg (150 lb) person (HSDB , 1997). .ARA 10.5.1.A GENERAL/SUMMARY

Rats exposed to 590 mg/kg/day for 8 months experienced no adverse effects (Hathaway, 1996; (Clayton & Clayton, 1994).

Rabbits exposed for 90 days by inunction of 0.92 g/kg/day to the skin experienced no effects (Clayton & Clayton, 1994).

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Hexylene glycol

EPA (U.S. Environmental Protection Agency, 2011): Not Listed

IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed

NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Hexylene glycol

MAK (DFG, 2002): Not Listed

NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

Not Listed

References: HSDB, 1997 OHM/TADS, 1997 RTECS, 1997 Budavari, 1996 (Hathaway, 1996; Lewis, 1996 ITI, 1995 Clayton & Clayton, 1994

1 ppm = 4.83 mg/m(3) (at 68 degrees F and 760 mmHg) (NIOSH , 1997)

1 mg/L = 206.0 ppm (at 25 degrees C and 760 mmHg) (Clayton & Clayton, 1994)

1 ppm = 4.84 mg/m(3) (at 25 degrees C and 760 mmHg) (Clayton & Clayton, 1994)

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Not Listed

Listed as: Hexylene glycol

REL:

IDLH: Not Listed

Not Listed

Not Listed

Not Listed

Not Listed

Not Listed

Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

Not Listed

Not Listed

Not Listed

Listed as: 2,4-Pentanediol, 2-methyl-

Not Listed

Not Listed

Not Listed

This compound should be stored in tightly closed containers in a cool, well-ventilated area away from strong oxidizers and sources of ignition (HSDB , 1997; ITI, 1995; Sittig, 1991).

Hexylene glycol should be stored in tightly closed containers (ITI, 1995; Sittig, 1991).

Store hexylene glycol in a cool, well-ventilated area. Keep it away from direct sunlight, sources of ignition, and oxidizing materials (such as chlorates, nitrates, perchlorates, permanganates, and peroxides). Periodically inspect stored hexylene glycol (HSDB , 1997; ITI, 1995; Sittig, 1991).

Keep this compound away from strong oxidizing materials and strong acids (NIOSH , 1997; Sittig, 1991).

Wear positive pressure self-contained breathing apparatus (SCBA).

Wear chemical protective that is specifically recommended by the manufacturer. It may provide little or no thermal protection.

Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

Editor's Note: This material is not listed in the Emergency Response Guidebook. Based on the material's physical and chemical properties, toxicity, or chemical group, a guide has been assigned. For additional technical information, contact one of the emergency response telephone numbers listed under Public Safety Measures.

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Hexylene glycol is a combustible liquid which may react with oxidizing materials. Foam, alcohol foam, water spray, carbon dioxide, or dry chemicals should be used for fire control (NIOSH , 1997; Lewis, 1996; ITI, 1995; Sittig, 1991).

ITI (1995) states that there is a "moderate fire risk" and that "no dangerous reaction takes place on fire."

Not Listed

CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient.

Dry chemical, CO2, water spray or alcohol-resistant foam.

Water spray, fog or alcohol-resistant foam.

Move containers from fire area if you can do it without risk.

Dike fire control water for later disposal; do not scatter the material.

Use water spray or fog; do not use straight streams.

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.

Cool containers with flooding quantities of water until well after fire is out.

Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

ALWAYS stay away from tanks engulfed in fire.

For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Not Listed

Hexylene glycol is combustible when exposed to heat or flame (Lewis, 1996).

Data presented from the Emergency Response Guidebook Table of Initial Isolation and Protective Action Distances are for use when a spill has occurred and there is no fire. If there is a fire, or if a fire is involved, evacuation information presented under FIRE - PUBLIC SAFETY EVACUATION DISTANCES should be used.

Generally, a small spill is one that involves a single, small package such as a drum containing up to approximately 200 liters, a small cylinder, or a small leak from a large package. A large spill is one that involves a spill from a large package, or multiple spills from many small packages.

Suggested distances to protect from vapors of toxic-by-inhalation and/or water-reactive materials during the first 30 minutes following the spill.

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Only persons wearing protective equipment should be allowed in the contaminated area (Sittig, 1991).

If possible, stop discharge before isolating and removing spilled material (CHRIS , 1997).

Any exposed containers should be cooled with water (CHRIS , 1997).

Liquids should be absorbed in materials such as dry sand, earth, or vermiculite and deposited in sealed containers (Sittig, 1991).

SMALL SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

A flammable solvent may be added to facilitate incineration (ITI, 1995).

Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

Hexylene glycol has a vapor pressure of 0.013 mmHg at 25 degrees C and thus exists in air almost entirely as a vapor. Degradation in air occurs through a reaction with photochemically produced hydroxyl radicals with an atmospheric half-life of approximately 1.6 days. Since it is miscible with water, this compound may also be removed from the atmosphere by rainfall, washout, dissolution into clouds, or other forms of wet deposition (HSDB , 1997).

SURFACE WATER

TERRESTRIAL

95% (samples from a sanitary waste treatment facility using standard BOD dilution test)

56% (acclimated mixed microbial cultures)

2% (5 days in non-acclimated medium)

55% (5 days in acclimated medium)

29% (10 days in non-acclimated medium)

85% (10 days in acclimated medium)

47% (15 days in non-acclimated medium)

88% (15 days in acclimated medium)

48-49% (20 days in non-acclimated medium)

90% (20 days in acclimated medium)

0% (length of time not reported)

7% (length of time not reported)

9% (length of time not reported)

63% (length of time not reported)

Bioconcentration in aquatic organisms should not be significant (HSDB , 1997).

LC50 - PIMEPHALES PROMELAS (FATHEAD MINNOW): 10,700 mg/L for 96 H -- flow-through bioassay

LC50 - ATLANTIC SILVERSIDE: 10,000 ppm for 96H -- Static test environment in saltwater, mg/L added

TL50 - BLUEGILL: >10,000 ppm for 96H -- Static test environment in freshwater, mg/L added

TLM - BRINE SHRIMP: 5900 ppm for 24H -- Static test environment in saltwater

0.924 (at 15/15 degrees C) (Budavari, 1996)

0.9216 (at 20/4 degrees C) (Clayton & Clayton, 1994; Lewis, 1993)

0.9234 (at 20/20 degrees C) (Lewis, 1996)

0.9254 (at 17/4 degrees C) (HSDB , 1997)

0.92 (NIOSH , 1997)

0.9 (NFPA, 1994)

(25 degrees C; 77 degrees F and 760 mmHg)

0.9181 g/mL (at 25 degrees C) (HSDB , 1997)

0.92 kg/L (at 20 degrees C) (Ashford, 1994)

0.9216 g/mL (at 20 degrees C) (ACGIH, 1991)

0.92109 g/mL (at 20 degrees C) (HSDB , 1997)

LIQUID: 0.923 g/mL (at 20 degrees C) (CHRIS , 1997)

-50.0 degrees C; -58 degrees F; 223 degrees K (sets to glass) (Lewis, 1996; Ashford, 1994; Clayton & Clayton, 1994)

1.2 % (Sittig, 1991)

1.3 % (calculated) (HSDB , 1997; NIOSH , 1997)

8.1 % (Sittig, 1991)

7.4 % (estimated) (NIOSH , 1997)

9% (HSDB , 1997)

Hexylene glycol is soluble in water (Budavari, 1996; Lewis, 1996; Ashford, 1994).

Hexylene glycol is miscible with water (HSDB , 1997; NIOSH , 1997; Lewis, 1993).

Hexylene glycol is soluble in alcohol, ether, and lower aliphatic hydrocarbons (Budavari, 1996; Ashford, 1994; ACGIH, 1991).

Hexylene glycol is miscible with ethanol, ether, hydrocarbons, and fatty acids (ITI, 1995; Lewis, 1993).

4809 (Coblentz Society Spectral Collection) (HSDB , 1997)

5-79 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons) (HSDB , 1997)

464 (Atlas of Mass Spectral Data, John Wiley & Sons) (HSDB , 1997)

181 (National Bureau of Standards EPA-NIH, Mass Spectra Data Base, NSRDS-NBS-63) (HSDB , 1997)

50 ppm (ACGIH, 1991; Sittig, 1991)

33.1 dyne/cm (at 20 degrees C) (HSDB , 1997)

497 psia; 33.8 atm; 3.42 MN/m(2) (CHRIS , 1997)

4.01 x 10(6) Pa (HSDB , 1997)

400 degrees C; 752 degrees F; 673 degrees K (CHRIS , 1997)

621 degrees K (HSDB , 1997)

2.8 (Budavari, 1996)

-13,600 Btu/lb; -7550 cal/g; -316 x 10(5) J/kg (estimated) (CHRIS , 1997)

-3.4356 x 10(9) J/kmol (HSDB , 1997)

1.48 x 10(7) J/kmol (at melting point) (HSDB , 1997)

1.4276 (at 20 degrees C) (Budavari, 1996; Lewis, 1993)

1.426 (at 20 degrees C) (Clayton & Clayton, 1994)

7315 (Sadtler Research Laboratories Prism Collection) (HSDB , 1997)

34 cP (at 20 degrees C) (Budavari, 1996)