HEXAFLUOROACETONE

Hexafluoroacetone, which exists as a gas at room temperature, is used in the synthesis of polymer, pharmaceutical, and agricultural chemicals; as a solvent for polyamides, polyesters, polyacrylates, and polyacetals; in the synthesis of hexafluoroisopropanol, polyacrylates used for textile coating, and polyester coatings for textiles; as a polymer adhesive; and as an intermediate in organic synthesis (ACGHI, 1996; Hathaway, 1996; (Lewis, 1993; Sittig, 1991). Hexafluoroacetone is also used as a non-selective herbicide in the control of annual and perennial weeds and woody plants on uncropped ground (HSDB , 1997).
This compound forms various hydrates with water which are also used as solvents for resins and polymers. Its other derivatives can be used in the production of repellent coatings for textiles and polymers (Sittig, 1991).

FORMS

It has a minimum purity of 95 percent and typically has a purity of at least 99.5 percent and commonly exceeds 99.9 percent (HSDB , 1997; Lewis, 1993).

SOURCES

This compound is manufactured by the perchlorination of acetone, followed by a reaction with hydrogen fluoride and a chromium catalyst. The separation of the product from excess hydrogen fluoride demands the use of a hydrogen fluoride acceptor like activated sodium fluoride or acetic anhydride (HSDB , 1997).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

Hexafluoroacetone is irritating to the eyes, skin, and mucous membranes. It is also toxic by ingestion.

Symptoms of exposure may include eye, skin, and respiratory tract irritation, and pulmonary edema. In experimental animals, injury to the liver, kidneys, testes, and thymus, and CNS depression have been reported. Frostbite injury may also occur.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

TOXIC; may be fatal if inhaled, ingested or absorbed through skin.
Vapors are extremely irritating and corrosive.
Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.
Fire will produce irritating, corrosive and/or toxic gases.
Runoff from fire control may cause pollution.

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with liquefied gas, thaw frosted parts with lukewarm water.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
In case of contact with Hydrogen fluoride, anhydrous (UN1052), flush skin and eyes with water for 5 minutes; then, for skin exposures rub on a calcium/jelly combination; for eyes flush with a water/calcium solution for 15 minutes.
Keep victim warm and quiet.
Keep victim under observation.
Effects of contact or inhalation may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID

EYE EXPOSURE - If the eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.
DERMAL EXPOSURE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.
INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
TARGET ORGANS - Eyes, skin, respiratory system, kidneys, and reproductive system (National Institute for Occupational Safety and Health, 2007).

GENERAL

Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Ingestion may result in significant esophageal or gastrointestinal tract irritation or burns, and EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.

INHALATION EXPOSURE

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.

DERMAL EXPOSURE

DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
If frostbite has occurred, do not rub the affected areas, flush them with water, or remove clothing.

EYE EXPOSURE

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
Seek medical attention immediately if eye tissue is frozen.

ORAL EXPOSURE

Because of the potential for gastrointestinal tract irritation or CNS depression, DO NOT induce emesis.
Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.
GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

GENERAL/SUMMARY

The minimum lethal human dose to this agent has not been delineated.

ANIMAL DATA

Hathaway et al (1996) reports that "in dogs, 5000 ppm was lethal to 1 of 2 animals following a 45 minute exposure. Deaths occurred within 3 days of post-exposure; lung hemorrhage and edema were observed, whereas the trachea, spleen, liver, kidney, and urinary bladder appeared normal."
"Inhalation exposures of rats indicated a 4-hour lethal concentration of 300 ppm" (ACGIH, 1996). Rats exposed to 200 ppm or above for 4 hours experienced injuries to the liver, kidneys, testes, and thymus. Their lungs showed signs of pulmonary edema and congestion and males had testicles that were small and showed aspermatogenesis, destruction of the stem cells, and effects on the interstitial tissue (Hathaway et al, 1996). At 100 ppm, only testes showed damage (ACGIH, 1996).
ACGIH (1996) reports that "daily, 6-hour repeated exposures of rats at 60 ppm resulted in decreased spermatogenesis after 10 exposures and decreased bone marrow erythropoiesis after termination of exposure. Testicular regeneration was still incomplete at 57 days following a single, 4-hour exposure at 60 ppm."

MAXIMUM TOLERATED EXPOSURE

GENERAL/SUMMARY

The maximum tolerated human exposure to this agent has not been delineated.

Carcinogenicity Ratings for CAS684-16-2 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Hexafluoroacetone
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Hexafluoroacetone
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS684-16-2 (U.S. Environmental Protection Agency, 2011):

Not Listed

TOXICITY VALUES

References: (Hathaway et al, 1996; Lewis, 1996 RTECS, 1997
- LC50- (INHALATION)RAT:
- LD50- (ORAL)RAT:
- LDLo- (ORAL)RAT:
- TDLo- (SKIN)RAT:

CALCULATIONS

AMBIENT CONVERSIONS

Conversion factor:

1 ppm = 6.90 mg/m(3) (NIOSH, 1997)

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS684-16-2 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Hexafluoroacetone

TLV:

TLV-TWA: 0.1 ppm
TLV-STEL:
TLV-Ceiling:

Notations and Endnotes:

Carcinogenicity Category: Not Listed
Codes: Skin
Definitions:

Skin: This refers to the potential significant contribution to the overall exposure by the cutaneous route, including mucous membranes and the eyes, either by contact with vapors or, of likely greater significance, by direct skin contact with the substance. It should be noted that although some materials are capable of causing irritation, dermatitis, and sensitization in workers, these properties are not considered relevant when assigning a skin notation. Rather, data from acute dermal studies and repeated dose dermal studies in animals or humans, along with the ability of the chemical to be absorbed, are integrated in the decision-making toward assignment of the skin designation. Use of the skin designation provides an alert that air sampling would not be sufficient by itself in quantifying exposure from the substance and that measures to prevent significant cutaneous absorption may be warranted. Please see "Definitions and Notations" (in TLV booklet) for full definition.

TLV Basis - Critical Effect(s): Testicular dam; kidney dam
Molecular Weight: 166.02

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS684-16-2 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS684-16-2 (National Institute for Occupational Safety and Health, 2007):

Listed as: Hexafluoroacetone
REL:

TWA: 0.1 ppm (0.7 mg/m(3))
STEL:
Ceiling:
Carcinogen Listing: (Not Listed) Not Listed
Skin Designation: [skin]

Indicates the potential for dermal absorption; skin exposure should be prevented as necessary through the use of good work practices and gloves, coveralls, goggles, and other appropriate equipment.

Note(s):

IDLH: Not Listed

OSHA PEL Values for CAS684-16-2 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS684-16-2 (U.S. Occupational Safety and Health Administration, 2010):

Threshold Quantity, in pounds:5000

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS684-16-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS684-16-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS684-16-2 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS684-16-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS684-16-2 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS684-16-2 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS684-16-2 (EPA, 2005):

Listed as: 2-Propanone, 1,1,1,3,3,3-hexafluoro-

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 2420 (49 CFR 172.101, 2005):

Hazardous materials descriptions and proper shipping name: Hexafluoroacetone

Symbol(s): Not Listed
Hazard class or Division: 2.3

2.3: Poisonous gas. See 49 CFR section 173.115 for definitions.

Identification Number: UN2420
Packing Group: Not Listed
Label(s) required (if not excepted): 2.3, 8

2.3: Poison Gas.
8: Corrosive.

Special Provisions: 2, B9, B14

2: This material is poisonous by inhalation (see sxn. 171.8 of this subchapter) in Hazard Zone B (see sxn. 173.116(a) or sxn. 173.133(a) of this subchapter), and must be described as an inhalation hazard under the provisions of this subchapter.
B9: Bottom outlets are not authorized.
B14: Each bulk packaging, except a tank car or a multi-unit-tank car tank, must be insulated with an insulating material so that the overall thermal conductance at 15.5 °C (60 °F) is no more than 1.5333 kilojoules per hour per square meter per degree Celsius (0.075 Btu per hour per square foot per degree Fahrenheit) temperature differential. Insulating materials must not promote corrosion to steel when wet.

Packaging Authorizations (refer to 49 CFR 173.***):

Exceptions: None
Non-bulk packaging: 304
Bulk packaging: 314, 315

Quantity Limitations:

Passenger aircraft or railcar: Forbidden
Cargo aircraft only: Forbidden

Vessel Stowage Requirements:

Vessel stowage location: D

D: The material must be stowed "on deck only" on a cargo vessel and on a passenger vessel carrying a number of passengers limited to not more than the larger of 25 passengers or one passenger per each 3 m of overall vessel length, but the material is prohibited on passenger vessels in which the limiting number of passengers is exceeded.

Vessel stowage other: 40

40: Stow "clear of living quarters".

ICAO International Shipping Name for UN2420 (ICAO, 2002):

Proper Shipping Name: Hexafluoroacetone
UN Number: 2420

LABELS

NFPA

NFPA Hazard Ratings for CAS684-16-2 (NFPA, 2002):

Not Listed

-HANDLING AND STORAGE

STORAGE

CONTAINER

Hexafluoroacetone should be stored in tightly closed containers (Sittig, 1991).

ROOM/CABINET RECOMMENDATIONS

Keep containers in a cool, well-ventilated area out of direct sunlight, and away from water, heat, reducing agents, nitrates, and nitric acid (Sittig, 1991).

INCOMPATIBILITIES

Keep away from water, heat, reducing agents, nitrates, and nitric acid (Sittig, 1991).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Vapors from this compound should not be breathed. Personnel should approach from upwind. Use of a self-contained breathing apparatus is recommended. Personnel should avoid bodily contact with hexafluoroacetone and should wear appropriate chemical protective clothing, including solvent-resistant gloves (AAR, 1996; (Sittig, 1991). Frostbite may occur (NIOSH , 1997). Protective clothing should be clean, available each day, and put on before work (Sittig, 1991).

Workers should promptly wash away any material which may have contacted the body with copious amounts of water or soap and water (AAR, 1996).

EYE/FACE PROTECTION

Workers should wear appropriate eye protection to prevent contact or frostbite (NIOSH , 1997).

RESPIRATORY PROTECTION

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 684-16-2.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)
- Some may burn, but none ignite readily.
- Vapors from liquefied gas are initially heavier than air and spread along ground.
- Some of these materials may react violently with water.
- Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices.
- Containers may explode when heated.
- Ruptured cylinders may rocket.
Hexafluoroacetone is non-flammable; it does not burn or burns with difficulty (AAR, 1996; (Ashford, 1994).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS684-16-2 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Dry chemical or CO2.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Water spray, fog or regular foam.
Move containers from fire area if you can do it without risk.
Do not get water inside containers.
Damaged cylinders should be handled only by specialists.

TANK FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.
Do not direct water at source of leak or safety devices; icing may occur.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.

NFPA Extinguishing Methods for CAS684-16-2 (NFPA, 2002):

Not Listed

Alcohol foam, dry chemical, carbon dioxide, water fog, or other agent suitable for the type of surrounding fire, may be used to extinguish fires involving this compound. Affected containers may be cooled with flooding quantities of water. Water should be applied from as far a distance as possible. All run-off water should be kept out of sewers and water sources (AAR, 1996).

Positive pressure self-contained breathing apparatus should be worn when fighting fires involving hexafluoroacetone (AAR, 1996).

COMBUSTION TOXICITY

Hexafluoroacetone, when heated to high temperatures, emits toxic fumes of fluoride (AAR, 1996).

DUST/VAPOR HAZARD

When heated to high temperatures, hexafluoroacetone emits toxic fumes of fluoride. Its high vapor pressure contributes to the generation of considerable amounts of vapor being released at ambient temperatures (AAR, 1996; (Lewis, 1996).

REACTIVITY HAZARD

Hexafluoroacetone reacts vigorously with water and other substances. Reactions with water form hydrates of which the sesquihydrate is the most common (ACGIH, 1996; (Ashford, 1994) Hathaway et al, 1996; (Lewis, 1993). Considerable heat is released during these reactions. This compound, itself, is not flammable (Ashford, 1994) Hathaway et al, 1996; (Lewis, 1993).

EVACUATION PROCEDURES

SUMMARY

Initial Isolation and Protective Action Distances (ERG, 2004)

Data presented from the Emergency Response Guidebook Table of Initial Isolation and Protective Action Distances are for use when a spill has occurred and there is no fire. If there is a fire, or if a fire is involved, evacuation information presented under FIRE - PUBLIC SAFETY EVACUATION DISTANCES should be used.
Generally, a small spill is one that involves a single, small package such as a drum containing up to approximately 200 liters, a small cylinder, or a small leak from a large package. A large spill is one that involves a spill from a large package, or multiple spills from many small packages.
Suggested distances to protect from vapors of toxic-by-inhalation and/or water-reactive materials during the first 30 minutes following the spill.

DOT ID No. 2420 - Hexafluoroacetone

SMALL SPILLS

First isolate in all directions: 30 meters (100 feet).
Note wind direction.
Then protect persons downwind:

during the DAY for: 0.3 kilometers (0.2 miles); or
during the NIGHT for: 1.3 kilometers (0.8 miles).

LARGE SPILLS

First isolate in all directions: 800 meters (2500 feet).
Note wind direction.
Then protect persons downwind:

during the DAY for: 7.2 kilometers (4.5 miles); or
during the NIGHT for: 11.0+ kilometers (7.0+ miles).

SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

Increase, in the downwind direction, as necessary, the isolation distance of at least 100 meters (330 feet) in all directions.

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions.
Keep unauthorized personnel away.
Stay upwind.
Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks).
Keep out of low areas.
Ventilate closed spaces before entering.

If hexafluoroacetone is involved in a leak, evacuation from downwind areas should be considered, based on the amount of material spilled, the location of the spill, and the weather conditions (AAR, 1996).

AIHA ERPG Values for CAS684-16-2 (AIHA, 2006):

Listed as Hexafluoroacetone
ERPG-1 (units = ppm): Not appropriate
ERPG-2 (units = ppm): 1
ERPG-3 (units = ppm): 50
Under Ballot, Review, or Consideration: No
Definitions:

ERPG-1: The ERPG-1 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing more than mild, transient adverse health effects or perceiving a clearly defined objectionable odor.
ERPG-2: The ERPG-2 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing irreversible or other serious health effects or symptoms that could impair an individual's ability to take protective action.
ERPG-3: The ERPG-3 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing life-threatening health effects.

DOE TEEL Values for CAS684-16-2 (U.S. Department of Energy, Office of Emergency Management, 2010):

Listed as Hexafluoroacetone
TEEL-0 (units = ppm): 0.1
TEEL-1 (units = ppm): 0.1
TEEL-2 (units = ppm): 0.2
TEEL-3 (units = ppm): 80
Definitions:

TEEL-0: The threshold concentration below which most people will experience no adverse health effects.
TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure.
TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape.
TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.

AEGL Values for CAS684-16-2 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS684-16-2 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)
- Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire.
- Do not touch or walk through spilled material.
- Stop leak if you can do it without risk.
- If possible, turn leaking containers so that gas escapes rather than liquid.
- Prevent entry into waterways, sewers, basements or confined areas.
- Do not direct water at spill or source of leak.
- Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to conact spilled material.
- Isolate area until gas has dispersed.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 125 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
If this compound is spilled or leaked, restrict persons not wearing protective equipment from the area until clean-up is complete. Vermiculite, dry sand, earth, or a similar material may be used to absorb liquids. This clean-up material should then be deposited in sealed containers (Sittig, 1991).
If hexafluoroacetone gas is leaked, restrict persons not wearing protective equipment from the area until clean-up is complete. Ventilate the area to disperse the gas and stop the flow of gas. If the leak is from a cylinder and the leak cannot be stopped in place, move cylinder to a safe place in open air and repair leak or allow cylinder to empty (Sittig, 1991).
Hexafluoroacetone should be kept out of water sources and sewers. Dikes may be built to contain the flow and water spray may be used to knock down vapors (AAR, 1996).

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

Hexafluoroacetone is released into the environment through its manufacture and use and may also be released through various waste streams (HSDB , 1997).

ENVIRONMENTAL FATE AND KINETICS

In the atmosphere, this compound exists as a vapor and is not expected to significantly react with hydroxyl radicals; it may directly photolyze (HSDB , 1997).

WATER

SURFACE WATER
- Hexafluoroacetone is expected to react vigorously with water, producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol (a stable solid hydrate) as well as liquid hydrates (HSDB , 1997).

SOIL

TERRESTRIAL
- In soil, this compound is moderately mobile. In moist soil, it vigorously reacts with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate, and liquid hydrates. In dry soil, hexafluoroacetone quickly volatilizes, may photolyze, and decomposes under UV irradiation to trifluoromethyl radicals and carbon dioxide (HSDB , 1997).

ABIOTIC DEGRADATION

This compound readily reacts with nucleophilic reagents. It vigorously reacts with water, forming 1,1,1,3,3,3-hexafluoro-2,2-propanediol (a stable solid hydrate). With further addition of water, it produces liquid hydrates. The addition of primary and secondary amines causes hexafluoroacetone to form stable 2,2-amino alcohols. Under UV irradiation, hexafluoroacetone decomposes to trifluoromethyl radicals and carbon monoxide. In the atmosphere, this compound is non-reactive and degradation through hydroxyl radical reaction is not believed to be a major fate process (HSDB , 1997).

BIOACCUMULATION

BIOCONCENTRATION FACTOR

A BCF of 8 has been calculated for hexafluoroacetone. This BCF indicates that this compound will not bioconcentrate in aquatic organisms (HSDB , 1997).

ENVIRONMENTAL TOXICITY

No information found at the time of this review.

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

166.02

DESCRIPTION/PHYSICAL STATE

Hexafluoroacetone exists as a colorless, hygroscopic, highly reactive, non-flammable gas with a musty odor which becomes acrid in the presence of acidic impurities (Ashford, 1994; HSDB , 1997; Lewis, 1996; Lewis, 1993; NIOSH , 1997). It is shipped as a liquefied compressed gas (HSDB , 1997; NIOSH , 1997).

VAPOR PRESSURE

5.8 atm (NIOSH , 1997)

5.0 mmHg (at 25 degrees C) (from experimentally derived coefficients) (HSDB , 1997)

DENSITY

NORMAL TEMPERATURE AND PRESSURE

(25 degrees C; 77 degrees F and 760 mmHg)
1.32 kg/L (at 25 degrees C) (Ashford, 1994)
1.65 g/mL (at 25 degrees C) (Lewis, 1996)
LIQUID: 1.33 g/mL (at 25 degrees C) (Lewis, 1993)

FREEZING/MELTING POINT

FREEZING POINT

-122 degrees C (ACGHI, 1996; (Lewis, 1993)
-129 degrees C (Lewis, 1996)
-188 degrees F (NIOSH , 1997)

MELTING POINT

-125.45 degrees C (at 101.3 kPa) (HSDB , 1997)

BOILING POINT

-26 degrees C (Lewis, 1996)

-27 degrees C (ACGIH, 1996; (Lewis, 1993; Sittig, 1991)

-18 degrees F (NIOSH , 1997)

OCTANOL/WATER PARTITION COEFFICIENT

Log Kow = 1.46 (HSDB , 1997)

HENRY'S CONSTANT

3.07 x 10(-3) atm-m(3)/mol (HSDB , 1997)

OTHER/PHYSICAL

CRITICAL PRESSURE

2.834 MPa (HSDB , 1997)

IONIZATION POTENTIAL

11.81 eV (NIOSH , 1997)

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ethylbenzene (Proposed). United States Environmental Protection Agency. Washington, DC. 2008g. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064809203e7&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

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National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Germane (Proposed). United States Environmental Protection Agency. Washington, DC. 2008j. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=0900006480963906&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Hexafluoropropylene (Proposed). United States Environmental Protection Agency. Washington, DC. 2006. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=09000064801ea1f5&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Ketene (Proposed). United States Environmental Protection Agency. Washington, DC. 2007. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020ee7c&disposition=attachment&contentType=pdf. As accessed 2010-08-15.

National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances: Acute Exposure Guideline Levels (AEGLs) for Magnesium Aluminum Phosphide (Proposed). United States Environmental Protection Agency. Washington, DC. 2005h. Available from URL: http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648020c5ed&disposition=attachment&contentType=pdf. As accessed 2010-08-16.

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Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents