ADIPONITRILE

Classification | Detailed evidence-based information

Substances Included Synonyms

Therapeutic Toxic Class

Specific Substances

1.2.1) MOLECULAR FORMULA
1) C6-H8-N2

Available Forms Sources

1) Adiponitrile is a water-white to yellowish colored, nearly odorless combustible liquid which floats on water (Sax & Lewis, 1989; Sax & Lewis, 1987; CHRIS , 1990; EPA, 1985; OHM/TADS , 1990).
2) Its low vapor pressure makes it unlikely that exposure to harmful concentrations of vapor will occur when the chemical is handled properly with adequate ventilation under ambient conditions (Sax & Lewis, 1989).

1) It is used as an extractant for aromatic hydrocarbons, in organic synthesis for corrosion inhibitors, rubber accelerators, and adipoguanine, and as a chemical intermediate for hexamethylene diamine in the manufacture of Nylon 66 (Sax & Lewis, 1987; HSDB , 1990; EPA, 1985; Hartung, 1982).

Overview

Life Support

Clinical Effects

0.2.1)

A) Adiponitrile is a cyanogenic aliphatic nitrile compound. It is irritating to the skin and eyes, and direct dermal contact causes irritation and inflammation. In one case, serious skin destruction on a foot occurred.
B) The toxicity of adiponitrile is due to metabolic release of cyanide following absorption. A patient who ingested a few milliliters of adiponitrile developed chest tightness, headache, weakness, unsteady gait, vertigo, cyanosis, hypotension, tachycardia, mydriasis, confusion, tonic- clonic muscular contractions, and vomiting, with onset about 20 minutes after ingestion and worsening of the condition about 2 hours later. Treatment with sodium thiosulfate brought about slow recovery.
C) Rats exposed by inhalation for 10 4-hour periods to adiponitrile concentrations of 0.1 or 0.3 mg/Liter developed salivation, irregular respirations, increased blood glucose, BUN, and creatinine levels, and decreased erythrocyte and leukocyte counts and hemoglobin. These effects had normalized by 14 days following the last exposure, and have not been reported in exposed humans.
D) In poisoning with most nitrile compounds, the onset of symptoms is generally delayed for up to several hours after exposure, thus making a PROLONGED PERIOD OF OBSERVATION in a CONTROLLED SETTING NECESSARY.
E) The remainder of this discussion relates to CYANIDE POISONING and TREATMENT. The possibility of DELAYED ONSET of SYMPTOMS, up to SEVERAL HOURS AFTER ADIPONITRILE EXPOSURE must be kept in mind. PROLONGED OBSERVATION is usually required for initially asymptomatic individuals with aliphatic nitrile exposure.
F) Lesser cyanide exposures may produce nausea, vomiting, palpitations, confusion, hyperventilation, anxiety, and vertigo. Severe hypoxic signs in the absence of cyanosis suggest the diagnosis. Patients have survived potentially lethal cyanide exposures with supportive care only, and the absence of a rapidly deteriorating course does not exclude the diagnosis.
G) Cyanosis is generally a late finding and does not occur until the stage of circulatory collapse and apnea. Initially the patient may experience flushing, tachycardia, tachypnea, headache, and dizziness. This may progress to agitation, stupor, coma, apnea, generalized convulsions, pulmonary edema, bradycardia, hypotension, and death.
H) Severe hypoxic signs in the absence of cyanosis should suggest the diagnosis of cyanide poisoning.
I) If systemic CYANIDE POISONING is suspected, IMMEDIATELY BEGIN ADMINISTERING 100% OXYGEN. OBTAIN THE CYANIDE ANTIDOTE KIT AND PREPARE IT FOR USE.

0.2.3)

A) Part of the initial presentation of cyanide poisoning may be hyperpnea and tachypnea. Hypoventilation progressing to apnea may be seen in the later phases of cyanide poisoning and is a major cause of death.
B) Tachycardia and hypertension may be seen in the initial phases of cyanide poisoning. Bradycardia and hypotension are seen in the late phases of cyanide poisoning.
C) A patient who ingested a few milliliters of adiponitrile developed hypotension and tachycardia.

0.2.4)

A) Dilated pupils are common. Corneal edema may be seen. Retinal arteries and veins that appear equally red on funduscopic examination suggest the diagnosis.
B) Accidental eye contamination with cyanide compounds may produce systemic symptoms.
C) Adiponitrile is irritating to the eyes. Rats exposed by inhalation for 10 4-hour periods to adiponitrile concentrations of 0.1 or 0.3 mg/Liter developed salivation, an effect not been reported in exposed humans.

0.2.5)

A) Tachycardia and hypertension may be seen in the initial phases of cyanide poisoning. Bradycardia and hypotension are seen in the late phases of cyanide poisoning.
B) Erratic atrial and ventricular cardiac rhythms with varying degrees of atrioventricular block followed by asystole may be seen; ST-T segment elevation or depression may be noted.
C) A patient who ingested a few milliliters of adiponitrile developed hypotension and tachycardia.

0.2.6)

A) Hyperpnea and tachypnea may be noted initially. Hypoventilation progressing to apnea may be seen in the later phases and is a major cause of death.
B) Noncardiogenic pulmonary edema has been reported in cases of acute cyanide poisoning, even following ingestion. Cyanosis is a late finding and does not occur until the stage of apnea and circulatory collapse.
C) A patient who ingested a few milliliters of adiponitrile developed chest tightness and became cyanotic.

0.2.7)

A) Headache, CNS stimulation with anxiety, agitation, and combative behavior, coma, and seizures may be seen. Opisthotonos, trismus, and paralysis were reported in one case of cyanide poisoning.
B) Most victims of acute poisoning either die acutely or fully recover, but rare cases of neurological sequelae such as personality changes, memory deficits, and extrapyramidal (Parkinsonian-like) syndromes have been reported.
C) A patient who ingested a few milliliters of adiponitrile developed vertigo, headache, confusion, weakness, unsteady gait and tonic-clonic muscular contractions

0.2.8)

A) Nausea, vomiting, and abdominal pain may occur, especially after ingestion.
B) A patient who ingested a few milliliters of adiponitrile developed vomiting.

0.2.11)

A) Elevated anion gap metabolic acidosis and elevated serum lactate levels may be found.

0.2.12)

A) An elevated anion gap metabolic acidosis is seen in cyanide poisoning, largely from excess production of lactic acid.

0.2.14)

A) Direct dermal contact with adiponitrile causes irritation and inflammation, and in one case resulted in serious skin destruction on a foot.

0.2.15)

A) A patient who ingested a few milliliters of adiponitrile developed unsteady gait and tonic-clonic muscular contractions.

0.2.16)

A) Insulin resistance was noted in a severely cyanide poisoned patient.

0.2.17)

A) The systemic toxicity of adiponitrile is due to metabolic release of cyanide by hepatic metabolism following absorption.

0.2.20)

A) No studies of the possible reproductive effects of adiponitrile in humans were found at the time of this review.
B) ANIMAL STUDIES

1) No teratogenic effects were seen at maternal doses of 20, 40, or 80 mg/kg daily on gestation days 6 through 19 in rats, although slight fetotoxicity was observed at the highest dose.
2) Adiponitrile has caused fetotoxicity in the offspring of pregnant rats exposed by the oral route on days 6 through 19 of pregnancy. Slight fetotoxicity was seen with maternal doses of 80 mg/kg adiponitrile daily on gestation days 6 through 19 in rats.
3) Pregnant rats exposed to 10, 100, and 500 ppm adiponitrile in drinking water had no changes in fertility, gestation, or viability of offspring.
4) A 13 week inhalation study found minor toxicity but no reduction in fertility or alteration of litter parameters with male or female rat exposures at 99 mg/cubic meter (Short et al, 1990).

C) RELATED COMPOUNDS -

1) Sodium cyanide, acetonitrile, acrylonitrile, propionitrile, and laetrile caused resorptions or malformations in the offspring of hamsters. Cassava was teratogenic in rats.

0.2.21)

A) ADIPONITRILE -

1) There are no reports of carcinogenicity in humans or experimental animals due to adiponitrile itself.

B) RELATED COMPOUNDS -

0.2.22)

A) Patients with cyanide poisoning characteristically have an odor of bitter almonds in gastric contents or expired breath, although up to 50% of the population cannot detect its presence.

Laboratory Monitoring

1) Cyanide can be measured chemically by several methods, but this should never be allowed to delay treatment. Initial therapy should be based on clinical examination.

1) A REDUCED ARTERIO-CENTRAL VENOUS MEASURED %O2 SATURATION DIFFERENCE may be seen due to cellular inability to extract oxygen.

Treatment Overview

0.4.2)

A) In symptomatic patients, skip these steps until other major emergency measures including use of cyanide antidote kit and other life support measures have been instituted.
B) Perform gastric lavage with a large bore tube after endotracheal intubation.

1) GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.

a) CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.

C) ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
D) Administer 100% oxygen. Hyperbaric oxygen may be useful in severe cases not responsive to supportive and antidotal therapy.
E) Establish a secure large-bore IV access.
F) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
G) HYDROXOCOBALAMIN: ADULT DOSE: 5 g (two 2.5 g vials each reconstituted with 100 mL sterile 0.9% saline) administered as an intravenous infusion over 15 minutes. For severe poisoning, a second dose of 5 g may be infused intravenously over 15 minutes to 2 hours, depending on the patient's condition. CHILDREN: Limited experience; a dose of 70 mg/kg has been used in pediatric patients.
H) Prepare the CYANIDE ANTIDOTE KIT for use in symptomatic patients.

1) SODIUM NITRITE: Adult: 10 mL (300 mg) of a 3% solution IV at a rate of 2.5 to 5 mL/minute; Child (with normal hemoglobin concentration): 0.2 mL/kg (6 mg/kg) of a 3% solution IV at a rate of 2.5 to 5 mL/minute, not to exceed 10 mL (300 mg).
2) Repeat one-half of initial sodium nitrite dose one-half hour later if there is inadequate clinical response. Calculate pediatric doses precisely to avoid potentially life-threatening methemoglobinemia. Use with caution if carbon monoxide poisoning is also suspected. Monitor blood pressure carefully. Reduce nitrite administration rate if hypotension occurs.
3) SODIUM THIOSULFATE: Administer sodium thiosulfate IV immediately following sodium nitrite. DOSE: ADULT: 50 mL (12.5 g) of a 25% solution; CHILD: 1 mL/kg (250 mg/kg) of a 25% solution, not to exceed 50 mL (12.5 g) total dose. A second dose, one-half of the first dose, may be administered if signs of cyanide toxicity reappear.

I) SODIUM BICARBONATE: Administer 1 mEq/kg IV to acidotic patients. Monitor arterial blood gases to guide further bicarbonate therapy.
J) SEIZURES: Administer a benzodiazepine; DIAZEPAM (ADULT: 5 to 10 mg IV initially; repeat every 5 to 20 minutes as needed. CHILD: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed) or LORAZEPAM (ADULT: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist. CHILD: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue).

1) Consider phenobarbital or propofol if seizures recur after diazepam 30 mg (adults) or 10 mg (children greater than 5 years).
2) Monitor for hypotension, dysrhythmias, respiratory depression, and need for endotracheal intubation. Evaluate for hypoglycemia, electrolyte disturbances, and hypoxia.

K) METHEMOGLOBINEMIA

1) If excessive methemoglobinemia occurs, some authors have suggested that methylene blue should not be used because it could cause release of cyanide from the cyanmethemoglobin complex. Such authors have suggested that emergency exchange transfusion is the treatment of choice. Hyperbaric oxygen therapy could be used to support the patient while preparations for exchange transfusion are being made.
2) However, methylene or toluidine blue have been used successfully in this setting without worsening the course of the cyanide poisoning. There is some controversy over whether or not the induction of methemoglobinemia is the sodium nitrite mechanism of action in cyanide poisoning. As long as intensive care monitoring and further antidote doses (if required) are available, methylene blue can most likely be safely administered in this setting.
3) METHEMOGLOBINEMIA: Determine the methemoglobin concentration and evaluate the patient for clinical effects of methemoglobinemia (ie, dyspnea, headache, fatigue, CNS depression, tachycardia, metabolic acidosis). Treat patients with symptomatic methemoglobinemia with methylene blue (this usually occurs at methemoglobin concentrations above 20% to 30%, but may occur at lower methemoglobin concentrations in patients with anemia, or underlying pulmonary or cardiovascular disorders). Administer oxygen while preparing for methylene blue therapy.
4) METHYLENE BLUE: INITIAL DOSE/ADULT OR CHILD: 1 mg/kg IV over 5 to 30 minutes; a repeat dose of up to 1 mg/kg may be given 1 hour after the first dose if methemoglobin levels remain greater than 30% or if signs and symptoms persist. NOTE: Methylene blue is available as follows: 50 mg/10 mL (5 mg/mL or 0.5% solution) single-dose ampules and 10 mg/1 mL (1% solution) vials. Additional doses may sometimes be required. Improvement is usually noted shortly after administration if diagnosis is correct. Consider other diagnoses or treatment options if no improvement has been observed after several doses. If intravenous access cannot be established, methylene blue may also be given by intraosseous infusion. Methylene blue should not be given by subcutaneous or intrathecal injection. NEONATES: DOSE: 0.3 to 1 mg/kg.
5) Concomitant use of methylene blue with serotonergic drugs, including serotonin reuptake inhibitors (SRIs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), norepinephrine-dopamine reuptake inhibitors (NDRIs), triptans, and ergot alkaloids may increase the risk of potentially fatal serotonin syndrome.

L) HYPOTENSION: Infuse 10 to 20 mL/kg isotonic fluid. If hypotension persists, administer dopamine (5 to 20 mcg/kg/min) or norepinephrine (ADULT: begin infusion at 0.5 to 1 mcg/min; CHILD: begin infusion at 0.1 mcg/kg/min); titrate to desired response.
M) ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.
N) HEMODIALYSIS and HEMOPERFUSION do not seem to be indicated or efficacious in most cases of cyanide poisoning.
O) Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.
P) NOTE: See treatment of oral exposure in the main body of this document for complete information.

0.4.3)

A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
B) Respiratory tract irritation, if severe, can progress to pulmonary edema which may be delayed in onset up to 24 to 72 hours after exposure in some cases.
C) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.
D) ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.
E) If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
F) All patients with significant inhalation exposure should be carefully observed for signs of systemic cyanide poisoning. The following recommendations should be followed if significant cyanide poisoning is present.
G) Administer 100% oxygen. Hyperbaric oxygen may be useful in severe cases not responsive to supportive and antidotal therapy.
H) Establish secure large bore IV.
I) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
J) HYDROXOCOBALAMIN: ADULT DOSE: 5 g (two 2.5 g vials each reconstituted with 100 mL sterile 0.9% saline) administered as an intravenous infusion over 15 minutes. For severe poisoning, a second dose of 5 g may be infused intravenously over 15 minutes to 2 hours, depending on the patient's condition. CHILDREN: Limited experience; a dose of 70 mg/kg has been used in pediatric patients.
K) Prepare the CYANIDE ANTIDOTE KIT for use in symptomatic patients:

L) SODIUM BICARBONATE: Administer 1 mEq/kg IV to acidotic patients. Monitor arterial blood gases to guide further bicarbonate therapy.
M) SEIZURES: Administer a benzodiazepine; DIAZEPAM (ADULT: 5 to 10 mg IV initially; repeat every 5 to 20 minutes as needed. CHILD: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed) or LORAZEPAM (ADULT: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist. CHILD: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue).

N) METHEMOGLOBINEMIA

O) HYPOTENSION: Infuse 10 to 20 mL/kg isotonic fluid. If hypotension persists, administer dopamine (5 to 20 mcg/kg/min) or norepinephrine (ADULT: begin infusion at 0.5 to 1 mcg/min; CHILD: begin infusion at 0.1 mcg/kg/min); titrate to desired response.
P) HEMODIALYSIS and HEMOPERFUSION do not seem to be indicated or efficacious in most cases of cyanide poisoning.
Q) NOTE: See treatment of inhalation exposure in the main body of this document for complete information.

0.4.4)

1) No cases of systemic cyanide in humans exposed to adiponitrile by the ocular route have been reported. Patients exposed by this route should be observed for several hours in a controlled setting for the possible development of symptoms of cyanide poisoning.
2) Treatment should include recommendations listed in the INHALATION EXPOSURE section when appropriate.

0.4.5)

A) OVERVIEW

1) DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
2) Adiponitrile can be absorbed and cause systemic cyanide poisoning by the dermal route.
3) SYSTEMIC CYANIDE POISONING

a) It is possible that systemic cyanide poisoning may occur following significant dermal exposure. The following recommendations should be followed if significant cyanide poisoning is present.

4) Administer 100% oxygen. Hyperbaric oxygen may be useful in severe cases not responsive to supportive and antidotal therapy.
5) Establish a secure large-bore IV access.
6) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
7) HYDROXOCOBALAMIN: ADULT DOSE: 5 g (two 2.5 g vials each reconstituted with 100 mL sterile 0.9% saline) administered as an intravenous infusion over 15 minutes. For severe poisoning, a second dose of 5 g may be infused intravenously over 15 minutes to 2 hours, depending on the patient's condition. CHILDREN: Limited experience; a dose of 70 mg/kg has been used in pediatric patients.
8) Prepare the CYANIDE ANTIDOTE KIT for use in symptomatic patients. See Main Document under TREATMENT section by appropriate route of exposure for alternate antidotes not available in the USA.

a) SODIUM NITRITE: Adult: 10 mL (300 mg) of a 3% solution IV at a rate of 2.5 to 5 mL/minute; Child (with normal hemoglobin concentration): 0.2 mL/kg (6 mg/kg) of a 3% solution IV at a rate of 2.5 to 5 mL/minute, not to exceed 10 mL (300 mg).
b) Repeat one-half of initial sodium nitrite dose one-half hour later if there is inadequate clinical response. Calculate pediatric doses precisely to avoid potentially life-threatening methemoglobinemia. Use with caution if carbon monoxide poisoning is also suspected. Monitor blood pressure carefully. Reduce nitrite administration rate if hypotension occurs.
c) SODIUM THIOSULFATE: Administer sodium thiosulfate IV immediately following sodium nitrite. DOSE: ADULT: 50 mL (12.5 g) of a 25% solution; CHILD: 1 mL/kg (250 mg/kg) of a 25% solution, not to exceed 50 mL (12.5 g) total dose. A second dose, one-half of the first dose, may be administered if signs of cyanide toxicity reappear.

9) SODIUM BICARBONATE: Administer 1 mEq/kg IV to acidotic patients. Monitor arterial blood gases to guide further bicarbonate therapy.
10) SEIZURES: Administer a benzodiazepine; DIAZEPAM (ADULT: 5 to 10 mg IV initially; repeat every 5 to 20 minutes as needed. CHILD: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed) or LORAZEPAM (ADULT: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist. CHILD: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue).

a) Consider phenobarbital or propofol if seizures recur after diazepam 30 mg (adults) or 10 mg (children greater than 5 years).
b) Monitor for hypotension, dysrhythmias, respiratory depression, and need for endotracheal intubation. Evaluate for hypoglycemia, electrolyte disturbances, and hypoxia.

11) METHEMOGLOBINEMIA

a) If excessive methemoglobinemia occurs, some authors have suggested that methylene blue should not be used because it could cause release of cyanide from the cyanmethemoglobin complex. Such authors have suggested that emergency exchange transfusion is the treatment of choice. Hyperbaric oxygen therapy could be used to support the patient while preparations for exchange transfusion are being made.
b) However, methylene or toluidine blue have been used successfully in this setting without worsening the course of the cyanide poisoning. There is some controversy over whether or not the induction of methemoglobinemia is the sodium nitrite mechanism of action in cyanide poisoning. As long as intensive care monitoring and further antidote doses (if required) are available, methylene blue can most likely be safely administered in this setting.
c) METHEMOGLOBINEMIA: Determine the methemoglobin concentration and evaluate the patient for clinical effects of methemoglobinemia (ie, dyspnea, headache, fatigue, CNS depression, tachycardia, metabolic acidosis). Treat patients with symptomatic methemoglobinemia with methylene blue (this usually occurs at methemoglobin concentrations above 20% to 30%, but may occur at lower methemoglobin concentrations in patients with anemia, or underlying pulmonary or cardiovascular disorders). Administer oxygen while preparing for methylene blue therapy.
d) METHYLENE BLUE: INITIAL DOSE/ADULT OR CHILD: 1 mg/kg IV over 5 to 30 minutes; a repeat dose of up to 1 mg/kg may be given 1 hour after the first dose if methemoglobin levels remain greater than 30% or if signs and symptoms persist. NOTE: Methylene blue is available as follows: 50 mg/10 mL (5 mg/mL or 0.5% solution) single-dose ampules and 10 mg/1 mL (1% solution) vials. Additional doses may sometimes be required. Improvement is usually noted shortly after administration if diagnosis is correct. Consider other diagnoses or treatment options if no improvement has been observed after several doses. If intravenous access cannot be established, methylene blue may also be given by intraosseous infusion. Methylene blue should not be given by subcutaneous or intrathecal injection. NEONATES: DOSE: 0.3 to 1 mg/kg.
e) Concomitant use of methylene blue with serotonergic drugs, including serotonin reuptake inhibitors (SRIs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), norepinephrine-dopamine reuptake inhibitors (NDRIs), triptans, and ergot alkaloids may increase the risk of potentially fatal serotonin syndrome.

12) HYPOTENSION: Infuse 10 to 20 mL/kg isotonic fluid. If hypotension persists, administer dopamine (5 to 20 mcg/kg/min) or norepinephrine (ADULT: begin infusion at 0.5 to 1 mcg/min; CHILD: begin infusion at 0.1 mcg/kg/min); titrate to desired response.
13) ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.
14) HEMODIALYSIS and HEMOPERFUSION do NOT seem to be indicated or efficacious in most cases of cyanide poisoning.
15) Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
16) NOTE: See treatment of dermal exposure in the main body of this document for complete information.

Range Of Toxicity

1) Dogs fed 10, 100, 500, or 1000 ppm adiponitrile in the diet had decreased food consumption and vomiting at the highest dose; no hematological changes were noted and liver and kidney function tests remained normal at 500 ppm and below.
2) In these experiments, no effects were seen in rats exposed to 0.03 mg/Liter of adiponitrile. No irreversible pathological tissue changes were noted with exposures as high as 0.3 mg/Liter (about 62 ppm).

Clinical Effects

Summary Of Exposure

Vital Signs

3.3.1)

3.3.2)

A) HYPERPNEA - Part of the initial presentation of cyanide poisoning may be hyperpnea and tachypnea (Hall & Rumack, 1986).
B) APNEA - Hypoventilation progressing to apnea may be seen in the later phases of cyanide poisoning and is a major cause of death (Vogel et al, 1981).

3.3.4)

A) HYPOTENSION - A patient who ingested a few milliliters of adiponitrile developed hypotension (Hartung, 1982; Smith & Kennedy, 1982).

1) Bradycardia and hypotension are seen in the late phases of cyanide poisoning (Hall & Rumack, 1986).

B) HYPERTENSION - Tachycardia and hypertension may be seen in the initial phases of cyanide poisoning (Vogel et al, 1981).

3.3.5)

A) TACHYCARDIA - A patient who ingested a few milliliters of adiponitrile developed tachycardia (Hartung, 1982; Smith & Kennedy, 1982).

1) Tachycardia and hypertension may be seen in the initial phases of cyanide poisoning (Vogel et al, 1981).

B) BRADYCARDIA - Bradycardia and hypotension are seen in the late phases of cyanide poisoning (Hall & Rumack, 1986).

Heent

3.4.1)

3.4.3)

A) IRRITATION - Adiponitrile is irritating to the eyes (EPA, 1985).
B) MYDRIASIS - A patient who ingested a few milliliters of adiponitrile developed dilated, poorly reactive pupils (Hartung, 1982; Smith & Kennedy, 1982).

1) Dilated pupils are common in severe cyanide poisoning (Vogel et al, 1981).

C) FUNDUSCOPIC EXAMINATION - Retinal arteries and veins that appear equally red on funduscopic examination suggest the diagnosis (Buchanan et al, 1976).

3.4.6)

A) SALIVATION - Rats exposed by inhalation for 10 4-hour periods to adiponitrile concentrations of 0.1 or 0.3 mg/Liter developed salivation (Smith & Kennedy, 1982). This effect has not been reported in exposed humans.

Cardiovascular

3.5.1)

3.5.2)

A) TACHYARRHYTHMIA

1) A patient who ingested a few milliliters of adiponitrile developed tachycardia (Hartung, 1982; Smith & Kennedy, 1982).
2) Tachycardia and hypertension may be seen in the initial phases of cyanide poisoning (Vogel et al, 1981).

B) HYPOTENSIVE EPISODE

1) A patient who ingested a few milliliters of adiponitrile developed hypotension (Hartung, 1982; Smith & Kennedy, 1982).
2) Bradycardia and hypotension are seen in the late phases of cyanide poisoning (Hall & Rumack, 1986).

C) ELECTROCARDIOGRAM ABNORMAL

1) Erratic atrial and ventricular cardiac rhythms with varying degrees of atrioventricular block followed by asystole may be seen in severe cyanide poisoning (Hall & Rumack, 1986). ST-T segment elevation or depression may be noted (Cope, 1961).

Respiratory

3.6.1)

3.6.2)

A) CHEST PAIN

1) CHEST TIGHTNESS - A patient who ingested a few milliliters of adiponitrile developed chest tightness (Hartung, 1982; Smith & Kennedy, 1982).

B) CYANOSIS

1) A patient who ingested a few milliliters of adiponitrile became cyanotic (Hartung, 1982; Smith & Kennedy, 1982).
2) Cyanosis is a late finding in cyanide poisoning and does not occur until the stage of apnea and circulatory collapse (Hall & Rumack, 1986).

C) HYPERVENTILATION

1) HYPERPNEA - Part of the initial presentation of cyanide poisoning may be hyperpnea and tachypnea (Hall & Rumack, 1986).

D) APNEA

1) Hypoventilation progressing to apnea may be seen in the later phases of cyanide poisoning and is a major cause of death (Vogel et al, 1981).

E) ACUTE LUNG INJURY

1) Noncardiogenic pulmonary edema has been reported in cases of acute cyanide poisoning, even following ingestion (Graham et al, 1977).

3.6.3)

A) ANIMAL STUDIES

a) IRREGULAR RESPIRATIONS - Rats exposed by inhalation to adiponitrile concentrations of 0.1 or 0.3 mg/Liter for 10 4-hour periods developed irregular respirations (Smith & Kennedy, 1982). This effect has not been reported in exposed humans.

Neurologic

3.7.1)

3.7.2)

A) HEADACHE

1) A patient who ingested a few milliliters of adiponitrile developed headache and weakness (Hartung, 1982; Smith & Kennedy, 1982).
2) Headache may be an early sign of cyanide poisoning (Vogel et al, 1981).

B) DIZZINESS

1) A patient who ingested a few milliliters of adiponitrile developed unsteady gait and vertigo (Hartung, 1982; Smith & Kennedy, 1982).

C) CLOUDED CONSCIOUSNESS

1) A patient who ingested a few milliliters of adiponitrile became confused (Hartung, 1982; Smith & Kennedy, 1982).

D) SPASMODIC MOVEMENT

1) MUSCULAR CONTRACTIONS - A patient who ingested a few milliliters of adiponitrile developed unsteady gait and tonic-clonic muscular contractions (Hartung, 1982; Smith & Kennedy, 1982).

E) PSYCHOMOTOR AGITATION

1) CNS STIMULATION - CNS stimulation with varied presentations from anxiety to agitation and combative behavior may be seen in the early stages of cyanide poisoning (Vogel et al, 1981).

F) COMA

1) Coma is common in severe poisoning (Hall & Rumack, 1986; Vogel et al, 1981).

G) SEIZURE

1) Seizures are common in severe cyanide poisoning (Hall & Rumack, 1986).

H) PARALYSIS

1) Opisthotonos, trismus, and paralysis were reported in one case of cyanide poisoning (De Busk & Seidl, 1969).

I) SEQUELA

1) An 18-year-old patient who ingested between 975 and 1,300 mg of potassium cyanide developed a Parkinsonian syndrome with rigidity and akinesis (Uitti et al, 1985).
2) Parkinsonism developed progressively over 3 weeks after acute ingestion of 1,500 mg of potassium cyanide. Slowed gait, masked facies, hypophonia, mild rigidity, and minimal tremor were noted. Damage was permanent, and although not evident on CT or MRI scan at 6 months, was noted on MRI at 12 months postingestion. There was no improvement with levodopa therapy (Rosenberg et al, 1989).
3) Progressive parkinsonism was reported after acute cyanide poisoning over a five-year period in a 46-year-old woman. Drooling and dysphagia increased over this time, and marked tongue and mouth dystonia developed. Apraxia of eyelid opening was also marked (Carella et al, 1988). Some improvement was noted with trihexyphenidyl treatment.
4) Most victims of acute poisoning either die acutely or fully recover, but rare cases of neurological sequelae such as personality changes, memory deficits, and extrapyramidal syndromes have been reported (Jouglard et al, 1971; Jouglard et al, 1974).

Gastrointestinal

3.8.1)

A) Nausea, vomiting, and abdominal pain may occur, especially after ingestion.
B) A patient who ingested a few milliliters of adiponitrile developed vomiting.

3.8.2)

A) VOMITING

1) A patient who ingested a few milliliters of adiponitrile developed vomiting (Smith & Kennedy, 1982).

3.8.3)

A) ANIMAL STUDIES

a) Dogs chronically exposed to 1000 ppm adiponitrile in drinking water developed vomiting and a decreased food intake (HSDB , 1990).

Genitourinary

3.10.3)

A) ANIMAL STUDIES

a) RENAL FUNCTION TESTS - Rats exposed by inhalation for 10 4-hour periods to adiponitrile concentrations of 0.1 or 0.3 mg/Liter developed increased BUN and creatinine levels (Smith & Kennedy, 1982). These effects have not been reported in exposed humans.

Acid-Base

3.11.1)

A) Elevated anion gap metabolic acidosis and elevated serum lactate levels may be found.

3.11.2)

A) LACTIC ACIDOSIS

1) METABOLIC ACIDOSIS - Elevated anion gap metabolic acidosis and elevated serum lactate levels are frequently found cyanide poisoning (Hall & Rumack, 1986; Vogel et al, 1981; Singh et al, 1989).

Dermatologic

3.14.1)

A) Direct dermal contact with adiponitrile causes irritation and inflammation, and in one case resulted in serious skin destruction on a foot.

3.14.2)

A) SKIN IRRITATION

1) Direct dermal contact with adiponitrile causes irritation and inflammation, and in one case resulted in serious skin destruction on a foot (Hartung, 1982; Smith & Kennedy, 1982).

Musculoskeletal

3.15.1)

A) A patient who ingested a few milliliters of adiponitrile developed unsteady gait and tonic-clonic muscular contractions.

3.15.2)

A) SPASMODIC MOVEMENT

1) MUSCULAR CONTRACTIONS - A patient who ingested a few milliliters of adiponitrile developed unsteady gait and tonic-clonic muscular contractions (Hartung, 1982; Smith & Kennedy, 1982).

Endocrine

3.16.1)

A) Insulin resistance was noted in a severely cyanide poisoned patient.

3.16.2)

A) HYPERGLYCEMIA

1) INSULIN RESISTANCE - Was noted in a severely cyanide poisoned patient (Singh et al, 1989).

Reproductive

3.20.1)

A) No studies of the possible reproductive effects of adiponitrile in humans were found at the time of this review.
B) ANIMAL STUDIES

C) RELATED COMPOUNDS -

1) Sodium cyanide, acetonitrile, acrylonitrile, propionitrile, and laetrile caused resorptions or malformations in the offspring of hamsters. Cassava was teratogenic in rats.

3.20.2)

A) ANIMAL STUDIES

1) CONGENITAL ANOMALY

a) No teratogenic effects of adiponitrile were seen at maternal doses of 20, 40, or 80 mg/kg daily on gestation days 6 through 19 in rats, although slight fetotoxicity was observed at the highest dose (Johannsen & Levinskas, 1986).
b) Adiponitrile has caused fetotoxicity in the offspring of pregnant rats exposed by the oral route on days 6 through 19 of pregnancy. Slight fetotoxicity was seen with maternal doses of 80 mg/kg adiponitrile daily on gestation days 6 through 19 in rats.
c) Pregnant rats exposed to 10, 100, and 500 ppm adiponitrile in drinking water had no changes in fertility, gestation, or viability of offspring.
d) A 13 week inhalation study found minor toxicity but no reduction in fertility or alteration of litter parameters with male or female rat exposures at 99 mg/cubic meter (Short et al, 1990).

2) RELATED COMPOUNDS

a) SODIUM CYANIDE -

1) Sodium cyanide solution delivered by constant infusion to pregnant Golden Hamsters at doses from 0.126 to 0.1295 mmol/kg/hour between days 6 and 9 of gestation caused a high incidence of both resorptions and malformations in the offspring (Doherty et al, 1982).
2) Neural tube defects (exencephaly, encephalocele) were the most common malformations. Hydropericardium and crooked tails were also noted (Doherty et al, 1982).
3) Concomitant infusion of sodium thiosulfate prevented both maternal signs of toxicity and the teratogenic effects of the sodium cyanide infusion (Doherty et al, 1982).

b) ACETONITRILE -

1) Pregnant hamsters exposed by either inhalation of 5000 to 8000 ppm or given 100 to 400 mg/kg oral or intraperitoneal doses of acetonitrile delivered offspring with severe axial skeletal disorders (Willhite, 1983).
2) Injections of sodium thiosulfate antagonized the teratogenic effects (Willhite, 1983). Elevated cyanide and thiocyanate levels were found in all tissues studied 2.5 hours after oral or intraperitoneal dosing, and suggested that the in vivo liberation of cyanide from acetonitrile was responsible for the observed teratogenic effects (Willhite, 1983).

c) ACRYLONITRILE/PROPIONITRILE -

1) Intraperitoneal injections of acrylonitrile or propionitrile to hamsters on day 8 of gestation resulted in exencephaly, encephaloceles, and rib abnormalities in the offspring (Willhite et al, 1981).
2) Sodium thiosulfate injections protected the fetus from these effects, except at larger nitrile doses where thiosulfate protected the dam against overt poisoning but did not protect the fetus against malformations (Willhite et al, 1981). The teratogenic effects of both nitriles may be related to the metabolic release of cyanide after absorption (Willhite et al, 1981).

d) LAETRILE -

1) Laetrile given orally to pregnant hamsters produced skeletal malformations in the offspring and increased levels of tissue cyanide (Willhite, 1982). Intravenous administration of laetrile (which does not result in cyanide release) produced neither effect (Willhite, 1982).
2) Sodium thiosulfate administration protected the fetus from teratogenic effects (Willhite, 1982). These data suggested that the teratogenic effects were due to cyanide released in vivo from oral laetrile dosing (Willhite, 1982).

e) CASSAVA -

1) Rats fed cassava powder (containing high concentrations of a cyanogenic glycoside) as 50 to 80% of their diet during the first 5 days of pregnancy showed a low incidence of limb defects, open eye defects, microcephaly, and fetal growth retardation in fetuses collected on day 20 of pregnancy (Singh, 1981).
2) Cyanide is a possible human teratogen, based on endemic cretinism in areas where the diet is composed largely of cyanogenic substances, such as cassava.

3.20.3)

A) ANIMAL STUDIES

1) FETOTOXICITY

a) Adiponitrile has caused fetotoxicity in the offspring of pregnant rats exposed by the oral route on days 6 through 19 of pregnancy (RTECS, 1997).
b) Slight fetotoxicity was seen with maternal doses of 80 mg/kg adiponitrile daily on gestation days 6 through 19 in rats (Johannsen & Levinskas, 1986).
c) The NOEL (No Observable Effect Level) for both maternal and fetal effects was 30 mg/kg (Johannsen & Levinskas, 1986).
d) Pregnant rats exposed to 10, 100, and 500 ppm adiponitrile in drinking water had no changes in fertility, gestation, or viability of offspring (Hartung, 1982).

Carcinogenicity

3.21.1)

A) IARC Carcinogenicity Ratings for CAS111-69-3 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):

1) Not Listed

3.21.2)

A) ADIPONITRILE -

1) There are no reports of carcinogenicity in humans or experimental animals due to adiponitrile itself.

B) RELATED COMPOUNDS -

3.21.3)

A) LACK OF INFORMATION

1) ADIPONITRILE -

a) There are no reports of carcinogenicity in humans due to adiponitrile itself.

B) RELATED COMPOUNDS

1) Acrylonitrile has carcinogenic properties in some species of experimental animals and has been suggested to be associated with a slight increase in deaths from lung cancer and other malignancies in humans (Buchter & Peter, 1984; Geiger et al, 1983).
2) Whether the metabolic release of cyanide after acrylonitrile absorption plays any role in this carcinogenesis is unknown. In isolated cell preparations, the release of cyanide from acrylonitrile does not appear to play a role in cell death (Geiger et al, 1983).

3.21.4)

A) LACK OF INFORMATION

1) At the time of this review, no studies were found on the possible carcinogenic effects of adiponitrile in experimental animals.

Genotoxicity

Laboratory Monitoring

Monitoring Parameters Levels

4.1.1)

A) No methods for measurement of adiponitrile in biological samples were listed in available references at the time of this review.

1) Cyanide can be measured chemically by several methods, but this should never be allowed to delay treatment. Initial therapy should be based on clinical examination.

B) Arterial blood gases and serum electrolytes are useful in the assessment of patients poisoned with cyanide.

1) A REDUCED ARTERIO-CENTRAL VENOUS MEASURED %O2 SATURATION DIFFERENCE may be seen due to cellular inability to extract oxygen.

C) Monitor methemoglobin levels during nitrite administration, especially if more than one dose is needed. Maintain methemoglobin levels below 30%.
D) Monitor arterial blood gases and/or pulse oximetry, pulmonary function tests, and chest x-ray in patients with significant exposure.
E) If respiratory tract irritation is present, it may be useful to monitor pulmonary function tests.
F) Monitor the chest x-ray in patients with significant exposure.
G) If respiratory tract irritation is present, monitor chest x-ray.
H) MRI studies may be useful in identifying the location and extent of injury in patients with cyanide-induced Parkinsonian syndrome.

4.1.2)

A) BLOOD/SERUM CHEMISTRY

1) Blood cyanide levels and associated symptoms in untreated patients (Graham et al, 1977)

No symptoms:  less than 0.2 mg/L (mcg/mL)
                       (0.02 mg%)
                       (SI = 7.7 mcmol/L)
Flushing and tachycardia:  0.5-1.0 mg/L (mcg/mL)
                           (0.05-0.1 mg%)
                           (SI = 19.2 to
                                 38.5 mcmol/L)
Obtundation:  1.0-2.5 mg/L (mcg/mL)
             (0.1-0.25 mg%)
             (SI = 38.5 to
                   96.1 mcmol/L)
Coma/Respiratory Depression:  greater than
                              2.5 mg/L (mcg/mL)
                             (0.25 mg%)
                             (SI = 96.1 mcmol/L)
Death:  greater than 3 mg/L (mcg/mL)
                    (0.3 mg%)
                    (SI = 115.4 mcmol/L)

B) OTHER

1) SCREENING LABORATORY TESTS - Arterial blood gases and serum electrolytes are useful in the assessment of potential elevated anion gap metabolic acidosis in patients poisoned with cyanide (Hall & Rumack, 1986; Vogel et al, 1981).
2) A REDUCED ARTERIO-CENTRAL VENOUS MEASURED %O2 SATURATION DIFFERENCE may be seen due to cellular inability to extract oxygen (Graham et al, 1977; Paulet, 1955).
3) Serum lactate levels may be useful in monitoring the severity of poisoning and the efficacy of treatment (Vogel et al, 1981).
4) Monitor methemoglobin levels during nitrite administration, especially if more than one dose is needed. Maintain methemoglobin levels below 30% (Hall & Rumack, 1986).
5) A number of chemicals produce abnormalities of the hematopoietic system, liver, and kidneys. Monitoring complete blood count, urinalysis, and liver and kidney function tests is suggested for patients with significant exposure.

4.1.4)

A) OTHER

1) MONITORING

a) Monitor arterial blood gases and/or pulse oximetry, pulmonary function tests, and chest x-ray in patients with significant exposure.

Radiographic Studies

1) Monitor the chest x-ray in patients with significant exposure.

1) MRI studies may be useful in identifying the location and extent of injury in patients with cyanide-induced parkinsonian syndrome (Rosenberg et al, 1989; Carella et al, 1988).

Treatment

Life Support

Monitoring

1) Cyanide can be measured chemically by several methods, but this should never be allowed to delay treatment. Initial therapy should be based on clinical examination.

1) A REDUCED ARTERIO-CENTRAL VENOUS MEASURED %O2 SATURATION DIFFERENCE may be seen due to cellular inability to extract oxygen.

Oral Exposure

6.5.2)

A) MEDICAL FACILITY MANAGEMENT

1) EMERGENCY MEASURES: In symptomatic patients, skip these steps until other major emergency measures including oxygen administration, use of the cyanide antidote kit, and other life support measures have been instituted.

B) GASTRIC LAVAGE/PRECAUTIONS

1) Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.

C) GASTRIC LAVAGE

1) INDICATIONS: Consider gastric lavage with a large-bore orogastric tube (ADULT: 36 to 40 French or 30 English gauge tube {external diameter 12 to 13.3 mm}; CHILD: 24 to 28 French {diameter 7.8 to 9.3 mm}) after a potentially life threatening ingestion if it can be performed soon after ingestion (generally within 60 minutes).

a) Consider lavage more than 60 minutes after ingestion of sustained-release formulations and substances known to form bezoars or concretions.

2) PRECAUTIONS:

a) SEIZURE CONTROL: Is mandatory prior to gastric lavage.
b) AIRWAY PROTECTION: Place patients in the head down left lateral decubitus position, with suction available. Patients with depressed mental status should be intubated with a cuffed endotracheal tube prior to lavage.

3) LAVAGE FLUID:

a) Use small aliquots of liquid. Lavage with 200 to 300 milliliters warm tap water (preferably 38 degrees Celsius) or saline per wash (in older children or adults) and 10 milliliters/kilogram body weight of normal saline in young children(Vale et al, 2004) and repeat until lavage return is clear.
b) The volume of lavage return should approximate amount of fluid given to avoid fluid-electrolyte imbalance.
c) CAUTION: Water should be avoided in young children because of the risk of electrolyte imbalance and water intoxication. Warm fluids avoid the risk of hypothermia in very young children and the elderly.

4) COMPLICATIONS:

a) Complications of gastric lavage have included: aspiration pneumonia, hypoxia, hypercapnia, mechanical injury to the throat, esophagus, or stomach, fluid and electrolyte imbalance (Vale, 1997). Combative patients may be at greater risk for complications (Caravati et al, 2001).
b) Gastric lavage can cause significant morbidity; it should NOT be performed routinely in all poisoned patients (Vale, 1997).

5) CONTRAINDICATIONS:

a) Loss of airway protective reflexes or decreased level of consciousness if patient is not intubated, following ingestion of corrosive substances, hydrocarbons (high aspiration potential), patients at risk of hemorrhage or gastrointestinal perforation, or trivial or non-toxic ingestion.

D) ACTIVATED CHARCOAL

1) The usefulness of activated charcoal is questionable. One gram of activated charcoal can adsorb 35 mg of potassium cyanide (Anderson, 1946) but this may be only a small percentage of the ingested dose. The absorption of cyanide is so rapid that charcoal may be of little use unless administered immediately after ingestion of cyanide.

a) Immediate administration of a large dose of superactivated charcoal (4 g/kg) to rats given an oral lethal dose of potassium cyanide (35 to 40 mg/kg) prevented lethality; 8 of 26 charcoal treated animals died compared to 25 of 26 untreated animals (Lambert et al, 1988).

2) CHARCOAL ADMINISTRATION

a) Consider administration of activated charcoal after a potentially toxic ingestion (Chyka et al, 2005). Administer charcoal as an aqueous slurry; most effective when administered within one hour of ingestion.

3) CHARCOAL DOSE

a) Use a minimum of 240 milliliters of water per 30 grams charcoal (FDA, 1985). Optimum dose not established; usual dose is 25 to 100 grams in adults and adolescents; 25 to 50 grams in children aged 1 to 12 years (or 0.5 to 1 gram/kilogram body weight) ; and 0.5 to 1 gram/kilogram in infants up to 1 year old (Chyka et al, 2005).

1) Routine use of a cathartic with activated charcoal is NOT recommended as there is no evidence that cathartics reduce drug absorption and cathartics are known to cause adverse effects such as nausea, vomiting, abdominal cramps, electrolyte imbalances and occasionally hypotension (None Listed, 2004).

b) ADVERSE EFFECTS/CONTRAINDICATIONS

1) Complications: emesis, aspiration (Chyka et al, 2005). Aspiration may be complicated by acute respiratory failure, ARDS, bronchiolitis obliterans or chronic lung disease (Golej et al, 2001; Graff et al, 2002; Pollack et al, 1981; Harris & Filandrinos, 1993; Elliot et al, 1989; Rau et al, 1988; Golej et al, 2001; Graff et al, 2002). Refer to the ACTIVATED CHARCOAL/TREATMENT management for further information.
2) Contraindications: unprotected airway (increases risk/severity of aspiration) , nonfunctioning gastrointestinal tract, uncontrolled vomiting, and ingestion of most hydrocarbons (Chyka et al, 2005).

6.5.3)

A) DILUTION

1) DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting (Caravati, 2004).

B) OXYGEN

1) Administer 100% oxygen to maintain an elevated pO2. Oxygen may reverse the cyanide-cytochrome oxidase complex and facilitate the conversion to thiocyanate following thiosulfate administration (Graham et al, 1977). There is fairly good evidence that 100% oxygen, combined with traditional nitrite/thiosulfate therapy is better than thiosulfate alone (Litovitz et al, 1983; Way et al, 1972).
2) HYPERBARIC OXYGEN (HBO) THERAPY is approved for cyanide poisoning as a category one condition (approved for third party reimbursement and known effective as treatment) by the Hyperbaric and Undersea Medical Society (Myers & Schnitzer, 1984). Hyperbaric oxygen has been suggested to improve clinical outcome, especially in those patients with CNS toxicity not responding to more traditional therapy. Animal studies have both confirmed and refuted this (Skene et al, 1966; Way et al, 1972; Takano et al, 1980).

a) Case reports suggest that HBO may be of value (Carden, 1970; Trapp, 1970). However, one patient treated with supportive therapy, antidotes, and HBO did not survive a serious poisoning (Litovitz et al, 1983). Hyperbaric oxygen should be reserved for those patients with significant symptoms (ie, coma, seizures, unstable vital signs) who do not respond to normal supportive and antidotal therapy, and for those poisoned with both cyanide and carbon monoxide secondary to smoke inhalation (Hart et al, 1985).

C) CYANIDE ANTIDOTE

1) IV ACCESS: Establish secure large bore IV line.
2) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
3) HYDROXOCOBALAMIN - CYANOKIT(R)

a) ADULT DOSE: 5 g (two 2.5 g vials each reconstituted with 100 mL sterile 0.9% saline) administered as an intravenous infusion over 15 minutes. For severe poisoning, a second dose of 5 g may be infused intravenously over 15 minutes to 2 hours, depending on the patient's condition (Prod Info CYANOKIT(R) 2.5g IV injection, 2006).
b) PEDIATRIC DOSE: A dose of 70 mg/kg has been used in pediatric patients, based on limited post-marketing experience outside the US (Prod Info CYANOKIT(R) 2.5g IV injection, 2006).
c) INDICATIONS: Known or suspected cyanide poisoning.
d) ADVERSE EFFECTS: Transient hypertension, allergic reactions (including anaphylaxis), nausea, headache, rash. Hydroxocobalamin's deep red color causes red-colored urine in all patients, and erythema of the skin in most (Prod Info CYANOKIT(R) 2.5g IV injection, 2006).
e) LABORATORY INTERFERENCE: Because of its' color, hydroxocobalamin interferes with colorimetric determination of various laboratory parameters. It may artificially increase serum creatinine, bilirubin, triglycerides, cholesterol, total protein, glucose, albumin , alkaline phosphatase and hemoglobin. It may artificially decrease serum ALT and amylase. It may artificially increase urinary pH, glucose, protein, erythrocytes, leukocytes, ketones, bilirubin, urobilinogen, and nitrate (Prod Info CYANOKIT(R) 2.5g IV injection, 2006).
f) HEMODIALYSIS INTERFERENCE: Dialysis machines have a spectrophotometric safety measure that can shut down after detecting blood leaking across the dialysis membrane. Hydroxocobalamin has a deep red color and can permeate the dialysis membrane, coloring the dialysate and causing the hemodialysis machine to shut down erroneously. In one case report, a patient with cyanide poisoning underwent dialysis after receiving 5 g of IV hydroxocobalamin because of refractory acidemia, reduced kidney function and hyperkalemia. A blood leak alarm caused the dialysis machine to shut down erroneously, delaying therapy, and resulting in the death of the patient (Stellpflug et al, 2013).

4) CYANIDE ANTIDOTE KIT

a) Obtain and prepare for administration. Antidotes should be used only in significantly symptomatic patients (ie, impaired consciousness, convulsions, significant acidosis, or unstable vital signs).
b) SODIUM NITRITE

1) INDICATION

a) Sodium nitrite should be given initially and administered as soon as vascular access is established.
b) Further administration of sodium nitrite is dictated only by the clinical situation, provided no significant complications (hypotension, excessive methemoglobinemia) are present. Use with caution if carbon monoxide poisoning is also suspected.
c) The goal of nitrite therapy is to achieve a methemoglobin level of 20% to 30%. This level is not based on clinical data, but represents the tolerated concentration without significant adverse symptoms from methemoglobin in an otherwise healthy individual. Clinical response has been reported to occur with methemoglobin levels in the range of 3.6% to 9.2% (DiNapoli et al, 1989; Johnson et al, 1989; Johnson & Mellors, 1988).

2) ADULT DOSE

a) 10 mL of a 3% solution (300 mg) administered intravenously at a rate of 2.5 to 5 mL/minute (Prod Info NITHIODOTE intravenous injection solution, 2011). Frequent blood pressure monitoring must accompany sodium nitrite injection and the rate slowed if hypotension occurs.
b) If there is inadequate clinical response, an additional dose of sodium nitrite at half the amount of the initial dose may be administered 30 minutes following the first dose (Prod Info NITHIODOTE intravenous injection solution, 2011).

3) PEDIATRIC DOSE

a) The recommended pediatric sodium nitrite dose is 0.2 mL/kg of a 3% solution (6 mg/kg) administered intravenously at a rate of 2.5 to 5 mL/minute, not to exceed 10 mL (300 mg) (Prod Info NITHIODOTE intravenous injection solution, 2011).
b) If there is inadequate clinical response, an additional dose of sodium nitrite at half the amount of the initial dose may be administered 30 minutes following the first dose (Prod Info NITHIODOTE intravenous injection solution, 2011; Berlin, 1970a).
c) PRESENCE OF ANEMIA: If there is a reason to suspect the presence of anemia, the following initial sodium nitrite doses should be given, depending on the child's hemoglobin (sodium nitrite should not exceed the doses listed below; fatal methemoglobinemia may result) (Berlin, 1970a):

1) Hemoglobin: 8 g/dL - Initial 3% sodium nitrite dose: 0.22 mL/kg (6.6 mg/kg)
2) Hemoglobin: 10 g/dL - Initial 3% sodium nitrite dose: 0.27 mL/kg (8.7 mg/kg)
3) Hemoglobin: 12 g/dL (average child) - Initial 3% sodium nitrite dose: 0.33 mL/kg (10 mg/kg)
4) Hemoglobin: 14 g/dL - Initial 3% sodium nitrite dose: 0.39 mL/kg (11.6 mg/kg)

4) It is highly recommended that total hemoglobin and methemoglobin concentrations be rapidly measured (30 minutes after dose), when possible, before repeating a dose of sodium nitrite to be sure that dangerous methemoglobinemia will not occur, especially in the pediatric patient.
5) Monitor blood pressure frequently and treat hypotension by slowing infusion rate and giving crystalloids and vasopressors. Consider possible excessive methemoglobin formation if patient deteriorates during therapy.
6) Excessive methemoglobinemia and hypotension are potential complications of nitrite therapy.
7) In individuals with G6PD deficiency, therapy with methemoglobin-inducing agents is contraindicated because of the likelihood of serious hemolysis.

c) SODIUM THIOSULFATE

1) Sodium thiosulfate is the second component of the cyanide antidote kit. It is supplied as 50 mL of a 25% solution and it is administered intravenously. There are no adverse reactions to thiosulfate itself. The pediatric dose is adjusted for weight and not hemoglobin concentration.
2) Sodium thiosulfate supplies sulfur for the rhodanese reaction, and is recommended after sodium nitrite, hydroxocobalamin, or 4-DMAP (4-dimethylaminophenol) administration (Marrs, 1988; Hall & Rumack, 1987).
3) DOSE

a) Follow sodium nitrite with IV sodium thiosulfate. ADULT: Administer 50 mL (12.5 g) of a 25% solution IV; PEDIATRIC: 1 mL/kg of a 25% solution (250 mg/kg), not to exceed 50 mL (12.5 g) total dose (Prod Info NITHIODOTE intravenous injection solution, 2011).
b) A second dose, one-half of the first dose, may be administered if signs of cyanide toxicity reappear (Prod Info NITHIODOTE intravenous injection solution, 2011).
c) Sodium thiosulfate is usually used in combination with sodium nitrite but may be used alone (Prod Info sodium thiosulfate IV injection, 2003).
d) Sodium thiosulfate can be administered without sodium nitrite in patients at risk to develop further methemoglobinemia (ie excessive methemoglobinemia or hypotension after initial sodium nitrite administration or in the presence of methemoglobinemia or carboxyhemoglobin in patients with smoke inhalation due to fire). Sodium thiosulfate can also be used in combination with hydroxocobalamin to treat cyanide poisoning (Howland, 2011)
e) CONTINUOUS INFUSION: It has been suggested that a continuous infusion of sodium thiosulfate be given after the initial bolus to maintain high thiosulfate levels. Low sodium intravenous fluids are required to avoid sodium overload. If large amounts of sodium thiosulfate are required, hemodialysis may be necessary to maintain a physiologic serum sodium level (Turchen et al, 1991).
f) ADVERSE EVENTS: Sodium thiosulfate does not usually produce significant toxicity. Possible adverse events include hypotension, headache, nausea, vomiting, disorientation, and prolonged bleeding time (Prod Info NITHIODOTE intravenous injection solution, 2011).

D) ACIDOSIS

1) Administer sodium bicarbonate, 1 mEq/kg IV to acidotic patients. Base further sodium bicarbonate administration on serial arterial blood gas determinations.
2) Acidosis may be difficult to correct prior to administration of antidotes in serious cyanide poisoning cases (Hall & Rumack, 1986).

E) MONITORING OF PATIENT

1) LABORATORY: Obtain blood for arterial blood gases, serum electrolytes, serum lactate, and whole blood cyanide.
2) A number of chemicals produce abnormalities of the hematopoietic system, liver, and kidneys. Monitoring complete blood count, urinalysis, and liver and kidney function tests is suggested for patients with significant exposure.
3) INTERPRETATION OF LABORATORY VALUES

a) Arterial pO2: Usually normal until the stage of hypoventilation or apnea. Usually remains normal until terminal stages of the poisoning if supplemental oxygen and assisted ventilation are provided.
b) Serum electrolytes: Elevated anion gap (Na - (Cl + CO2)) (normals 12 to 16 milliequivalents/liter (12 to 16 millimoles/liter) or less) is present from the presence of unmeasured organic anions (usually lactate).
c) Serum Lactate: Elevated (normals 0.6 to 1.8 milliequivalents/liter) (0.6 to 1.8 millimoles/liter) due to anaerobic metabolism with excessive production of lactic acid.
d) Arterio-Central Venous Measured %O2 Saturation Difference: Due to cellular inability to extract and use oxygen, more is present on the venous side. The MEASURED values of arterial and central venous %O2 saturation approach each other with MEASURED central venous %O2 saturation greater than 70%.

F) SEIZURE

1) SUMMARY

a) Attempt initial control with a benzodiazepine (eg, diazepam, lorazepam). If seizures persist or recur, administer phenobarbital or propofol.
b) Monitor for respiratory depression, hypotension, and dysrhythmias. Endotracheal intubation should be performed in patients with persistent seizures.
c) Evaluate for hypoxia, electrolyte disturbances, and hypoglycemia (or, if immediate bedside glucose testing is not available, treat with intravenous dextrose).

2) DIAZEPAM

a) ADULT DOSE: Initially 5 to 10 mg IV, OR 0.15 mg/kg IV up to 10 mg per dose up to a rate of 5 mg/minute; may be repeated every 5 to 20 minutes as needed (Brophy et al, 2012; Prod Info diazepam IM, IV injection, 2008; Manno, 2003).
b) PEDIATRIC DOSE: 0.1 to 0.5 mg/kg IV over 2 to 5 minutes; up to a maximum of 10 mg/dose. May repeat dose every 5 to 10 minutes as needed (Loddenkemper & Goodkin, 2011; Hegenbarth & American Academy of Pediatrics Committee on Drugs, 2008).
c) Monitor for hypotension, respiratory depression, and the need for endotracheal intubation. Consider a second agent if seizures persist or recur after repeated doses of diazepam .

3) NO INTRAVENOUS ACCESS

a) DIAZEPAM may be given rectally or intramuscularly (Manno, 2003). RECTAL DOSE: CHILD: Greater than 12 years: 0.2 mg/kg; 6 to 11 years: 0.3 mg/kg; 2 to 5 years: 0.5 mg/kg (Brophy et al, 2012).
b) MIDAZOLAM has been used intramuscularly and intranasally, particularly in children when intravenous access has not been established. ADULT DOSE: 0.2 mg/kg IM, up to a maximum dose of 10 mg (Brophy et al, 2012). PEDIATRIC DOSE: INTRAMUSCULAR: 0.2 mg/kg IM, up to a maximum dose of 7 mg (Chamberlain et al, 1997) OR 10 mg IM (weight greater than 40 kg); 5 mg IM (weight 13 to 40 kg); INTRANASAL: 0.2 to 0.5 mg/kg up to a maximum of 10 mg/dose (Loddenkemper & Goodkin, 2011; Brophy et al, 2012). BUCCAL midazolam, 10 mg, has been used in adolescents and older children (5-years-old or more) to control seizures when intravenous access was not established (Scott et al, 1999).

4) LORAZEPAM

a) MAXIMUM RATE: The rate of intravenous administration of lorazepam should not exceed 2 mg/min (Brophy et al, 2012; Prod Info lorazepam IM, IV injection, 2008).
b) ADULT DOSE: 2 to 4 mg IV initially; repeat every 5 to 10 minutes as needed, if seizures persist (Manno, 2003; Brophy et al, 2012).
c) PEDIATRIC DOSE: 0.05 to 0.1 mg/kg IV over 2 to 5 minutes, up to a maximum of 4 mg/dose; may repeat in 5 to 15 minutes as needed, if seizures continue (Brophy et al, 2012; Loddenkemper & Goodkin, 2011; Hegenbarth & American Academy of Pediatrics Committee on Drugs, 2008; Sreenath et al, 2009; Chin et al, 2008).

5) PHENOBARBITAL

a) ADULT LOADING DOSE: 20 mg/kg IV at an infusion rate of 50 to 100 mg/minute IV. An additional 5 to 10 mg/kg dose may be given 10 minutes after loading infusion if seizures persist or recur (Brophy et al, 2012).
b) Patients receiving high doses will require endotracheal intubation and may require vasopressor support (Brophy et al, 2012).
c) PEDIATRIC LOADING DOSE: 20 mg/kg may be given as single or divided application (2 mg/kg/minute in children weighing less than 40 kg up to 100 mg/min in children weighing greater than 40 kg). A plasma concentration of about 20 mg/L will be achieved by this dose (Loddenkemper & Goodkin, 2011).
d) REPEAT PEDIATRIC DOSE: Repeat doses of 5 to 20 mg/kg may be given every 15 to 20 minutes if seizures persist, with cardiorespiratory monitoring (Loddenkemper & Goodkin, 2011).
e) MONITOR: For hypotension, respiratory depression, and the need for endotracheal intubation (Loddenkemper & Goodkin, 2011; Manno, 2003).
f) SERUM CONCENTRATION MONITORING: Monitor serum concentrations over the next 12 to 24 hours. Therapeutic serum concentrations of phenobarbital range from 10 to 40 mcg/mL, although the optimal plasma concentration for some individuals may vary outside this range (Hvidberg & Dam, 1976; Choonara & Rane, 1990; AMA Department of Drugs, 1992).

6) OTHER AGENTS

a) If seizures persist after phenobarbital, propofol or pentobarbital infusion, or neuromuscular paralysis with general anesthesia (isoflurane) and continuous EEG monitoring should be considered (Manno, 2003). Other anticonvulsants can be considered (eg, valproate sodium, levetiracetam, lacosamide, topiramate) if seizures persist or recur; however, there is very little data regarding their use in toxin induced seizures, controlled trials are not available to define the optimal dosage ranges for these agents in status epilepticus (Brophy et al, 2012):

1) VALPROATE SODIUM: ADULT DOSE: An initial dose of 20 to 40 mg/kg IV, at a rate of 3 to 6 mg/kg/minute; may give an additional dose of 20 mg/kg 10 minutes after loading infusion. PEDIATRIC DOSE: 1.5 to 3 mg/kg/minute (Brophy et al, 2012).
2) LEVETIRACETAM: ADULT DOSE: 1000 to 3000 mg IV, at a rate of 2 to 5 mg/kg/min IV. PEDIATRIC DOSE: 20 to 60 mg/kg IV (Brophy et al, 2012; Loddenkemper & Goodkin, 2011).
3) LACOSAMIDE: ADULT DOSE: 200 to 400 mg IV; 200 mg IV over 15 minutes (Brophy et al, 2012). PEDIATRIC DOSE: In one study, median starting doses of 1.3 mg/kg/day and maintenance doses of 4.7 mg/kg/day were used in children 8 years and older (Loddenkemper & Goodkin, 2011).
4) TOPIRAMATE: ADULT DOSE: 200 to 400 mg nasogastric/orally OR 300 to 1600 mg/day orally divided in 2 to 4 times daily (Brophy et al, 2012).

G) METHEMOGLOBINEMIA

1) While clinically significant excessive methemoglobinemia has occurred following sodium nitrite therapy for cyanide poisoning, such instances are rare and usually occur only in children receiving excessive nitrite doses.
2) If excessive methemoglobinemia occurs, some authors have suggested that methylene blue should not be used because it could cause release of cyanide from the cyanmethemoglobin complex. Such authors have suggested that emergency exchange transfusion is the treatment of choice (Berlin, 1970). Hyperbaric oxygen therapy could be used to support the patient while preparations for exchange transfusion are being made.
3) However, methylene or toluidine blue have been used successfully in this setting without worsening the course of the cyanide poisoning (van Heijst et al, 1987). There is some controversy over whether or not the induction of methemoglobinemia is the sodium nitrite mechanism of action in cyanide poisoning. As long as intensive care monitoring and further antidote doses (if required) are available, methylene blue can most likely be safely administered in this setting.
4) SUMMARY

a) Determine the methemoglobin concentration and evaluate the patient for clinical effects of methemoglobinemia (ie, dyspnea, headache, fatigue, CNS depression, tachycardia, metabolic acidosis). Treat patients with symptomatic methemoglobinemia with methylene blue (this usually occurs at methemoglobin concentrations above 20% to 30%, but may occur at lower methemoglobin concentrations in patients with anemia, or underlying pulmonary or cardiovascular disorders). Administer oxygen while preparing for methylene blue therapy.

5) METHYLENE BLUE

a) INITIAL DOSE/ADULT OR CHILD: 1 mg/kg IV over 5 to 30 minutes; a repeat dose of up to 1 mg/kg may be given 1 hour after the first dose if methemoglobin levels remain greater than 30% or if signs and symptoms persist. NOTE: Methylene blue is available as follows: 50 mg/10 mL (5 mg/mL or 0.5% solution) single-dose ampules (Prod Info PROVAYBLUE(TM) intravenous injection, 2016) and 10 mg/1 mL (1% solution) vials (Prod Info methylene blue 1% intravenous injection, 2011). REPEAT DOSES: Additional doses may be required, especially for substances with prolonged absorption, slow elimination, or those that form metabolites that produce methemoglobin. NOTE: Large doses of methylene blue may cause methemoglobinemia or hemolysis (Howland, 2006). Improvement is usually noted shortly after administration if diagnosis is correct. Consider other diagnoses or treatment options if no improvement has been observed after several doses. If intravenous access cannot be established, methylene blue may also be given by intraosseous infusion. Methylene blue should not be given by subcutaneous or intrathecal injection (Prod Info methylene blue 1% intravenous injection, 2011; Herman et al, 1999). NEONATES: DOSE: 0.3 to 1 mg/kg (Hjelt et al, 1995).
b) CONTRAINDICATIONS: G-6-PD deficiency (methylene blue may cause hemolysis), known hypersensitivity to methylene blue, methemoglobin reductase deficiency (Shepherd & Keyes, 2004)
c) FAILURE: Failure of methylene blue therapy suggests: inadequate dose of methylene blue, inadequate decontamination, NADPH dependent methemoglobin reductase deficiency, hemoglobin M disease, sulfhemoglobinemia, or G-6-PD deficiency. Methylene blue is reduced by methemoglobin reductase and nicotinamide adenosine dinucleotide phosphate (NADPH) to leukomethylene blue. This in turn reduces methemoglobin. Red blood cells of patients with G-6-PD deficiency do not produce enough NADPH to convert methylene blue to leukomethylene blue (do Nascimento et al, 2008).
d) DRUG INTERACTION: Concomitant use of methylene blue with serotonergic drugs, including serotonin reuptake inhibitors (SRIs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), norepinephrine-dopamine reuptake inhibitors (NDRIs), triptans, and ergot alkaloids may increase the risk of potentially fatal serotonin syndrome (U.S. Food and Drug Administration, 2011; Stanford et al, 2010; Prod Info methylene blue 1% IV injection, 2011).

6) TOLUIDINE BLUE OR TOLONIUM CHLORIDE (GERMANY)

a) DOSE: 2 to 4 mg/kg intravenously over 5 minutes. Dose may be repeated in 30 minutes (Nemec, 2011; Lindenmann et al, 2006; Kiese et al, 1972).
b) SIDE EFFECTS: Hypotension with rapid intravenous administration. Vomiting, diarrhea, excessive sweating, hypotension, dysrhythmias, hemolysis, agranulocytosis and acute renal insufficiency after overdose (Dunipace et al, 1992; Hix & Wilson, 1987; Winek et al, 1969; Teunis et al, 1970; Marquez & Todd, 1959).
c) CONTRAINDICATIONS: G-6-PD deficiency; may cause hemolysis.

H) GENERAL TREATMENT

1) ALTERNATE ANTIDOTES

a) DICOBALT-EDTA (KELOCYANOR(R))

1) Dicobalt-EDTA (Kelocyanor(R)) is a highly effective cyanide chelating agent currently used in Europe and Australia. Significant toxicity from the antidote (severe hypertension or hypotension, cardiac ischemia or arrhythmias) may be seen in patients incorrectly diagnosed as being poisoned by cyanide and administered this antidote (Pronczuk de Garbino & Bismuth, 1981). Severe anaphylactoid reactions with airway compromise may also occur (Dodds & McKnight, 1985). Dicobalt-EDTA is not available in America.

b) 4-DIMETHYLAMINOPHENOL (4-DMAP)

1) 4-DMAP - is a methemoglobin inducing agent used in some European countries for the treatment of acute cyanide poisoning. Excessive methemoglobinemia may be a major complication following the use of this agent (van Dijk et al, 1986).

c) STROMA-FREE METHEMOGLOBIN SOLUTION

1) Stroma-free methemoglobin solution prepared from outdated human red blood cells by oxidation of the ferrous iron of hemoglobin to the ferric form in vitro has been studied in experimental animals and shows promise as a cyanide antidote (Ten Eyck et al, 1985). It has not been studied in human poisoning cases and is not available for human administration.

d) ALPHA-KETOGLUTARIC ACID

1) Alpha-ketoglutaric acid is also being tested as a replacement for sodium nitrite in combination with sodium thiosulfate in animal models where it has been efficacious in experimental cyanide poisoning (Moore et al, 1986). It has not been studied in human poisoning cases and is not available for human administration.

e) CHLORPROMAZINE

1) Chlorpromazine has been studied in various animal models as a possible cyanide antidote. Conflicting reports of efficacy have been published (Pettersen & Cohen, 1986). It has not been studied in human poisoning cases.

I) HYPOTENSIVE EPISODE

1) SUMMARY

a) Infuse 10 to 20 milliliters/kilogram of isotonic fluid and keep the patient supine. If hypotension persists, administer dopamine or norepinephrine. Consider central venous pressure monitoring to guide further fluid therapy.

2) DOPAMINE

a) DOSE: Begin at 5 micrograms per kilogram per minute progressing in 5 micrograms per kilogram per minute increments as needed (Prod Info dopamine hcl, 5% dextrose IV injection, 2004). If hypotension persists, dopamine may need to be discontinued and a more potent vasoconstrictor (eg, norepinephrine) should be considered (Prod Info dopamine hcl, 5% dextrose IV injection, 2004).
b) CAUTION: If ventricular dysrhythmias occur, decrease rate of administration (Prod Info dopamine hcl, 5% dextrose IV injection, 2004). Extravasation may cause local tissue necrosis, administration through a central venous catheter is preferred (Prod Info dopamine hcl, 5% dextrose IV injection, 2004).

3) NOREPINEPHRINE

a) PREPARATION: 4 milligrams (1 amp) added to 1000 milliliters of diluent provides a concentration of 4 micrograms/milliliter of norepinephrine base. Norepinephrine bitartrate should be mixed in dextrose solutions (dextrose 5% in water, dextrose 5% in saline) since dextrose-containing solutions protect against excessive oxidation and subsequent potency loss. Administration in saline alone is not recommended (Prod Info norepinephrine bitartrate injection, 2005).
b) DOSE

1) ADULT: Dose range: 0.1 to 0.5 microgram/kilogram/minute (eg, 70 kg adult 7 to 35 mcg/min); titrate to maintain adequate blood pressure (Peberdy et al, 2010).
2) CHILD: Dose range: 0.1 to 2 micrograms/kilogram/minute; titrate to maintain adequate blood pressure (Kleinman et al, 2010).
3) CAUTION: Extravasation may cause local tissue ischemia, administration by central venous catheter is advised (Peberdy et al, 2010).

J) ACUTE LUNG INJURY

1) ONSET: Onset of acute lung injury after toxic exposure may be delayed up to 24 to 72 hours after exposure in some cases.
2) NON-PHARMACOLOGIC TREATMENT: The treatment of acute lung injury is primarily supportive (Cataletto, 2012). Maintain adequate ventilation and oxygenation with frequent monitoring of arterial blood gases and/or pulse oximetry. If a high FIO2 is required to maintain adequate oxygenation, mechanical ventilation and positive-end-expiratory pressure (PEEP) may be required; ventilation with small tidal volumes (6 mL/kg) is preferred if ARDS develops (Haas, 2011; Stolbach & Hoffman, 2011).

a) To minimize barotrauma and other complications, use the lowest amount of PEEP possible while maintaining adequate oxygenation. Use of smaller tidal volumes (6 mL/kg) and lower plateau pressures (30 cm water or less) has been associated with decreased mortality and more rapid weaning from mechanical ventilation in patients with ARDS (Brower et al, 2000). More treatment information may be obtained from ARDS Clinical Network website, NIH NHLBI ARDS Clinical Network Mechanical Ventilation Protocol Summary, http://www.ardsnet.org/node/77791 (NHLBI ARDS Network, 2008)

3) FLUIDS: Crystalloid solutions must be administered judiciously. Pulmonary artery monitoring may help. In general the pulmonary artery wedge pressure should be kept relatively low while still maintaining adequate cardiac output, blood pressure and urine output (Stolbach & Hoffman, 2011).
4) ANTIBIOTICS: Indicated only when there is evidence of infection (Artigas et al, 1998).
5) EXPERIMENTAL THERAPY: Partial liquid ventilation has shown promise in preliminary studies (Kollef & Schuster, 1995).
6) CALFACTANT: In a multicenter, randomized, blinded trial, endotracheal instillation of 2 doses of 80 mL/m(2) calfactant (35 mg/mL of phospholipid suspension in saline) in infants, children, and adolescents with acute lung injury resulted in acute improvement in oxygenation and lower mortality; however, no significant decrease in the course of respiratory failure measured by duration of ventilator therapy, intensive care unit, or hospital stay was noted. Adverse effects (transient hypoxia and hypotension) were more frequent in calfactant patients, but these effects were mild and did not require withdrawal from the study (Wilson et al, 2005).
7) However, in a multicenter, randomized, controlled, and masked trial, endotracheal instillation of up to 3 doses of calfactant (30 mg) in adults only with acute lung injury/ARDS due to direct lung injury was not associated with improved oxygenation and longer term benefits compared to the placebo group. It was also associated with significant increases in hypoxia and hypotension (Willson et al, 2015).

K) HOSPITAL ADMISSION

1) All patients with cyanide exposure resulting in symptoms should be admitted to the hospital. Whenever the cyanide antidote kit is used, the patient should be admitted to the intensive care unit.

L) OBSERVATION REGIMES

1) Patients with a history of significant cyanide exposure but who are asymptomatic should be observed closely in the hospital with an IV in place and the drugs drawn up ready at the bedside. If they remain asymptomatic for a period of two hours, they may be released from the hospital.

Inhalation Exposure

6.7.1)

A) Move patient from the toxic environment to fresh air. Monitor for respiratory distress. If cough or difficulty in breathing develops, evaluate for hypoxia, respiratory tract irritation, bronchitis, or pneumonitis.
B) OBSERVATION: Carefully observe patients with inhalation exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
C) INITIAL TREATMENT: Administer 100% humidified supplemental oxygen, perform endotracheal intubation and provide assisted ventilation as required. Administer inhaled beta-2 adrenergic agonists, if bronchospasm develops. Consider systemic corticosteroids in patients with significant bronchospasm (National Heart,Lung,and Blood Institute, 2007). Exposed skin and eyes should be flushed with copious amounts of water.

6.7.2)

A) IRRITATION SYMPTOM

1) Respiratory tract irritation, if severe, can progress to noncardiogenic pulmonary edema which may be delayed in onset up to 24 to 72 hours after exposure in some cases.
2) There are no controlled studies indicating that early administration of corticosteroids can prevent the development of noncardiogenic pulmonary edema in patients with inhalation exposure to respiratory irritant substances, and long-term use may cause adverse effects (Boysen & Modell, 1989).

a) However, based on anecdotal experience, some clinicians do recommend early administration of corticosteroids (such as methylprednisolone 1 gram intravenously as a single dose) in an attempt to prevent the later development of pulmonary edema.

1) Anecdotal experience with dimethyl sulfate inhalation showed possible benefit of methylprednisolone in the TREATMENT of noncardiogenic pulmonary edema (Ip et al, 1989).

3) Anecdotal experience also indicated that systemic corticosteroids may have possible efficacy in the TREATMENT of drug-induced noncardiogenic pulmonary edema (Zitnik & Cooper, 1990; Stentoft, 1990; Chudnofsky & Otten, 1989) or noncardiogenic pulmonary edema developing after cardiopulmonary bypass (Maggart & Stewart, 1987).
4) It is not clear from the published literature that administration of systemic corticosteroids early following inhalation exposure to respiratory irritant substances can PREVENT the development of noncardiogenic pulmonary edema. The decision to administer or withhold corticosteroids in this setting must currently be made on clinical grounds.
5) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.

B) MONITORING OF PATIENT

1) Monitor arterial blood gases and/or pulse oximetry, pulmonary function tests, and chest x-ray in patients with significant exposure.
2) A number of chemicals produce abnormalities of the hematopoietic system, liver, and kidneys. Monitoring complete blood count, urinalysis, and liver and kidney function tests is suggested for patients with significant exposure.
3) LABORATORY: Obtain blood for arterial blood gases, serum electrolytes, serum lactate, and whole blood cyanide.
4) Arterial pO2: Usually normal until the stage of hypoventilation or apnea. Usually remains normal until terminal stages of the poisoning if supplemental oxygen and assisted ventilation are provided.
5) Serum electrolytes: Elevated anion gap (Na - (Cl + CO2)) (normals 12 to 16 milliequivalents/liter (12 to 16 millimoles/liter) or less) is present from the presence of unmeasured organic anions (usually lactate).
6) Serum Lactate: Elevated (normals 0.6 to 1.8 milliequivalents/liter) (0.6 to 1.8 millimoles/liter) due to anaerobic metabolism with excessive production of lactic acid.
7) Arterio-Central Venous Measured %O2 Saturation Difference: Due to cellular inability to extract and use oxygen, more is present on the venous side. The MEASURED values of arterial and central venous %O2 saturation approach each other with MEASURED central venous %O2 saturation greater than 70%.

C) ACUTE LUNG INJURY

D) CYANIDE ANTIDOTE

1) SYSTEMIC CYANIDE POISONING: All patients with significant inhalation exposure should be carefully observed for signs of systemic cyanide poisoning. The following recommendations should be followed if significant cyanide poisoning is present.
2) IV ACCESS: Establish secure large bore IV line.
3) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
4) HYDROXOCOBALAMIN - CYANOKIT(R)

5) CYANIDE ANTIDOTE KIT

a) OBTAIN AND PREPARE for administration a CYANIDE ANTIDOTE KIT.KIT, consisting of sodium nitrite and sodium thiosulfate.
b) Antidotes should be used only in significantly symptomatic patients (ie, impaired consciousness, convulsions, significant acidosis, or unstable vital signs). Antidote therapy may be effective as long as the heart still beats (Chen & Rose, 1952).
c) SODIUM NITRITE

1) INDICATION

2) ADULT DOSE

3) PEDIATRIC DOSE

d) SODIUM THIOSULFATE

E) OXYGEN

F) ACIDOSIS

G) SEIZURE

1) SUMMARY

2) DIAZEPAM

3) NO INTRAVENOUS ACCESS

4) LORAZEPAM

5) PHENOBARBITAL

6) OTHER AGENTS

H) METHEMOGLOBINEMIA

5) METHYLENE BLUE

6) TOLUIDINE BLUE OR TOLONIUM CHLORIDE (GERMANY)

I) GENERAL TREATMENT

1) ALTERNATE ANTIDOTES

a) DICOBALT-EDTA (KELOCYANOR(R))

b) 4-DIMETHYLAMINOPHENOL (4-DMAP)

1) 4-DMAP is a methemoglobin inducing agent used in some European countries for the treatment of acute cyanide poisoning. Excessive methemoglobinemia may be a major complication following the use of this agent (van Dijk et al, 1986).

c) STROMA-FREE METHEMOGLOBIN SOLUTION

d) ALPHA-KETOGLUTARIC ACID

e) CHLORPROMAZINE

J) HYPOTENSIVE EPISODE

1) SUMMARY

2) DOPAMINE

3) NOREPINEPHRINE

K) HOSPITAL ADMISSION

1) All patients with cyanide exposure resulting in symptoms should be admitted to the hospital. Whenever the cyanide antidote kit is used, the patient should be admitted to the intensive care unit.

L) OBSERVATION REGIMES

M) Treatment should include recommendations listed in the ORAL EXPOSURE section when appropriate.

Eye Exposure

6.8.1)

A) EYE IRRIGATION, ROUTINE: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, an ophthalmologic examination should be performed (Peate, 2007; Naradzay & Barish, 2006).

6.8.2)

A) MONITORING OF PATIENT

1) SYSTEMIC CYANIDE POISONING: No cases of systemic cyanide in humans exposed to adiponitrile by the ocular route have been reported. Patients exposed by this route should be observed for several hours in a controlled setting for the possible development of symptoms of cyanide poisoning.
2) Treatment should include recommendations listed in the INHALATION EXPOSURE section when appropriate.

B) Treatment should include recommendations listed in the ORAL EXPOSURE section when appropriate.

Dermal Exposure

6.9.1)

A) DERMAL DECONTAMINATION

1) DECONTAMINATION: Remove contaminated clothing and wash exposed area thoroughly with soap and water for 10 to 15 minutes. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).

6.9.2)

A) IRRITATION SYMPTOM

1) Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

B) SKIN ABSORPTION

1) Adiponitrile can be absorbed and cause systemic cyanide poisoning by the dermal route (EPA, 1985; Lewis, 1996).

C) CYANIDE ANTIDOTE

1) SYSTEMIC CYANIDE POISONING: It is possible that systemic cyanide poisoning may occur following significant dermal exposure. The following recommendations should be followed if significant cyanide poisoning is present.
2) IV ACCESS: Establish secure large bore IV line.
3) A cyanide antidote, either hydroxocobalamin OR the sodium nitrite/sodium thiosulfate kit, should be administered to patients with symptomatic poisoning.
4) HYDROXOCOBALAMIN - CYANOKIT(R)

5) CYANIDE ANTIDOTE KIT

a) OBTAIN AND PREPARE for administration a CYANIDE ANTIDOTE KIT consisting of sodium nitrite and sodium thiosulfate.

1) Antidotes should be used only in significantly symptomatic patients (ie, impaired consciousness, convulsions, acidosis, or unstable vital signs).
2) Even when patients are rendered comatose by the inhalation of hydrogen cyanide gas, antidotes may not be necessary if the exposure is rapidly terminated, the patient has regained consciousness on arrival at the medical facility, and there is no acidosis or abnormality of the vital signs (Peden et al, 1986).

b) SODIUM NITRITE

1) INDICATION

2) ADULT DOSE

3) PEDIATRIC DOSE

c) SODIUM THIOSULFATE

D) OXYGEN

E) ACIDOSIS

F) MONITORING OF PATIENT

1) LABORATORY: Obtain blood for arterial blood gases, serum electrolytes, serum lactate, and whole blood cyanide.
2) INTERPRETATION OF LABORATORY VALUES

G) SEIZURE

1) SUMMARY

2) DIAZEPAM

3) NO INTRAVENOUS ACCESS

4) LORAZEPAM

5) PHENOBARBITAL

6) OTHER AGENTS

H) METHEMOGLOBINEMIA

5) METHYLENE BLUE

6) TOLUIDINE BLUE OR TOLONIUM CHLORIDE (GERMANY)

I) GENERAL TREATMENT

1) ALTERNATE ANTIDOTES

a) DICOBALT-EDTA (KELOCYANOR(R))

b) 4-DIMETHYLAMINOPHENOL (4-DMAP)

c) STROMA-FREE METHEMOGLOBIN SOLUTION

d) ALPHA-KETOGLUTARIC ACID

e) CHLORPROMAZINE

J) HYPOTENSIVE EPISODE

1) SUMMARY

2) DOPAMINE

3) NOREPINEPHRINE

K) ACUTE LUNG INJURY

L) HOSPITAL ADMISSION

1) All patients with cyanide exposure resulting in symptoms should be admitted to the hospital. Whenever the cyanide antidote kit is used, the patient should be admitted to the intensive care unit.

M) OBSERVATION REGIMES

N) Treatment should include recommendations listed in the ORAL EXPOSURE section when appropriate.

Enhanced Elimination

1) HEMODIALYSIS: Could potentially be an effective adjunct by correcting resistant acidemia and by increasing thiocyanate clearance, thereby favoring thiosulfate-cyanide reaction to thiocyanate (Wesson et al, 1985). It has, however, been used in only one reported case, where antidote therapy with sodium nitrite and sodium thiosulfate were also administered (Wesson et al, 1985).

a) The outcome in this case was no different from that of other patients treated similarly without hemodialysis. Hemodialysis cannot be considered standard therapy for cyanide poisoning at this time.

2) CHARCOAL HEMOPERFUSION: Charcoal hemoperfusion has also been used in one reported case of cyanide poisoning (Kreig & Saxena, 1987). This patient also received supportive measures and sodium nitrite/thiosulfate antidotes.

a) The outcome in this case was no different from that of other patients treated similarly without hemoperfusion. Hemoperfusion cannot be considered standard therapy for cyanide poisoning at this time.

Abstracts

Range Of Toxicity

Summary

Minimum Lethal Exposure

1) The minimum lethal human dose to this agent has not been delineated.
2) The minimal adult lethal dose for hydrocyanic acid, a potential combustion product of adiponitrile, has been estimated as 100 milligrams (Baselt & Cravey, 1989).

Maximum Tolerated Exposure

1) A patient who ingested a few milliliters of adiponitrile developed chest tightness, headache, weakness, unsteady gait, vertigo, cyanosis, hypotension, tachycardia, mydriasis, confusion, tonic-clonic muscular contractions, and vomiting, with onset about 20 minutes after ingestion and worsening of the condition about 2 hours later (Hartung, 1982; Smith & Kennedy, 1982).
2) Direct dermal contact with adiponitrile causes irritation and inflammation, and in one case resulted in serious skin destruction on a foot (Hartung, 1982; Smith & Kennedy, 1982).

1) GUINEA PIGS - No hematologic effects were noted in guinea pigs administered between 3 and 30 milligrams/kilogram subcutaneously, 6 days weekly for 40 to 70 days (Hartung, 1982).
2) RATS - A two-year drinking water study in rats with adiponitrile concentrations of 0.5, 5, and 50 parts per million showed that adrenal degeneration developed (Hartung, 1982).

a) Pregnant rats exposed to 10, 100, and 500 parts per million adiponitrile in drinking water had no changes in fertility, gestation, or viability of offspring (Hartung, 1982).

3) DOGS - Dogs fed 10, 100, 500, or 1000 parts per million adiponitrile in the diet had decreased food consumption and vomiting at the highest dose; no hematological changes were noted and liver and kidney function tests remained normal at 500 parts per million and below (Hartung, 1982).
4) RATS - Rats exposed by inhalation for 10 4-hour periods to adiponitrile concentrations of 0.1 or 0.3 milligrams/Liter developed salivation, irregular respirations, increased blood glucose, BUN, and creatinine levels, and decreased erythrocyte and leukocyte counts and hemoglobin (Smith & Kennedy, 1982). These effects had normalized by 14 days following the last exposure (Smith & Kennedy, 1982).

a) In these experiments, no effects were seen in rats exposed to 0.03 milligrams/Liter of adiponitrile (Smith & Kennedy, 1982). No irreversible pathological tissue changes were noted with exposures as high as 0.3 milligrams/Liter (about 62 parts per million) (Smith & Kennedy, 1982).

Serum Plasma Blood Concentrations

7.5.2)

A) TOXIC CONCENTRATION LEVELS

1) ANIMAL DATA

a) Rats exposed to inhalation of adiponitrile 6 hours/day, 5 days per week, for either 4 or 13 weeks showed reduced weight gain at 1 week at 493 mg/cubic meter. At 99 mg/cubic meter for 13 weeks slight anemia was present, but histopathological examination and basic reproductive parameters were normal (Short et al, 1990).

Workplace Standards

1) Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

a) Adopted Value

1) Adiponitrile

a) TLV:

1) TLV-TWA: 2 ppm
2) TLV-STEL:
3) TLV-Ceiling:

b) Notations and Endnotes:

1) Carcinogenicity Category: Not Listed
2) Codes: Skin
3) Definitions:

a) Skin: This refers to the potential significant contribution to the overall exposure by the cutaneous route, including mucous membranes and the eyes, either by contact with vapors or, of likely greater significance, by direct skin contact with the substance. It should be noted that although some materials are capable of causing irritation, dermatitis, and sensitization in workers, these properties are not considered relevant when assigning a skin notation. Rather, data from acute dermal studies and repeated dose dermal studies in animals or humans, along with the ability of the chemical to be absorbed, are integrated in the decision-making toward assignment of the skin designation. Use of the skin designation provides an alert that air sampling would not be sufficient by itself in quantifying exposure from the substance and that measures to prevent significant cutaneous absorption may be warranted. Please see "Definitions and Notations" (in TLV booklet) for full definition.

c) TLV Basis - Critical Effect(s): URT and LRT irr
d) Molecular Weight: 108.1

1) For gases and vapors, to convert the TLV from ppm to mg/m(3):

a) [(TLV in ppm)(gram molecular weight of substance)]/24.45

2) For gases and vapors, to convert the TLV from mg/m(3) to ppm:

a) [(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

e) Additional information:

B) NIOSH REL and IDLH Values for CAS111-69-3 (National Institute for Occupational Safety and Health, 2007):

1) Listed as: Adiponitrile
2) REL:

a) TWA: 4 ppm (18 mg/m(3))
b) STEL:
c) Ceiling:
d) Carcinogen Listing: (Not Listed) Not Listed
e) Skin Designation: Not Listed
f) Note(s):

3) IDLH: Not Listed

C) Carcinogenicity Ratings for CAS111-69-3 :

1) ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Adiponitrile
2) EPA (U.S. Environmental Protection Agency, 2011): D ; Listed as: Adiponitrile

a) D : Not classifiable as to human carcinogenicity.

3) IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
4) NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed ; Listed as: Adiponitrile
5) MAK (DFG, 2002): Not Listed
6) NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

D) OSHA PEL Values for CAS111-69-3 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

1) Not Listed

Toxicity Information

7.7.1)

A) References: (RTECS, 1997; EPA, 1985 Hartung, 1982

1) LD50- (INTRAPERITONEAL)MOUSE:

a) 40 mg/kg

2) LD50- (ORAL)MOUSE:

a) 172 mg/kg

3) LD50- (ORAL)RAT:

a) 155 mg/kg
b) 300 mg/kg

Pharmacology Toxicology

Physicochemical

Physical Characteristics

Ph

1) No information found at the time of this review.

Molecular Weight

Animal Toxicology

References

General Bibliography

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