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DIMETHYL SULFIDE

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Classification   |    Detailed evidence-based information

Substances Included Synonyms

Therapeutic Toxic Class

    A) Dimethyl sulfide is an alkyl sulfide compound.

Specific Substances

    A) No Synonyms were found in group or single elements
    1.2.1) MOLECULAR FORMULA
    1) C2-H6-S

Available Forms Sources

    A) FORMS
    1) Dimethyl sulfide is an alkyl sulfide compound. It occurs as a colorless liquid or gas (boiling point = 37.3 degrees C) with an unpleasant, cabbage- or radish-like odor ((HSDB, 1993)); (AAR, 1987; NFPA, 1986; Budavari, 1989; EPA, 1985; Sax & Lewis, 1987; ITI, 1988). It is soluble in ether, ethanol, and methanol, and is insoluble in water ((HSDB, 1993)); (Sax & Lewis, 1989). It is a FIRE AND EXPLOSION HAZARD (Sax & Lewis, 1987) 1989). Dimethyl sulfide may occur in the wood pulp industry at airborne concentrations of up to 15 ppm ((HSDB, 1993)); (Kangas et al, 1984).
    2) A Maximum Allowable Concentration of dimethyl sulfide in the air in working areas of pulp and paper plants of 0.75 mg/m(3) has been suggested (approximately 0.27 ppm) (Seliuzhitskii, 1972). With an odor threshold of 1 ppb in air (Clayton & Clayton, 1981; CHRIS , 1993; (HSDB, 1993)), dimethyl sulfide has good warning properties. However, odor alone should never be used to determine if an environment is safe.
    3) This review is based on the properties of alkyl sulfide compounds in general. Effects attributed specifically to dimethyl sulfide are identified.

Overview

Life Support

    A) This overview assumes that basic life support measures have been instituted.

Clinical Effects

    0.2.1) SUMMARY OF EXPOSURE
    A) Dimethyl sulfide is a liquid with a disagreeable odor; the vapors are heavier than air. It is a fire and vapor explosion hazard. Inhalation exposure generally results in little systemic toxicity.
    B) Vapor inhalation causes moderate eye, nose, and throat irritation, making it unlikely that individuals will tolerate moderate to high concentrations. Headache and decreased ability to concentrate may occur.
    C) The liquid is a mild skin irritant and a moderate to severe eye irritant. Repeated skin exposure to the liquid results in defatting dermatitis and irritation; burns may occur. Dermal exposure generally results in little systemic toxicity.
    D) Ingestion may cause irritation of the mouth, throat, esophagus, and gastrointestinal tract.
    E) In experimental animals, absorption of large quantities can lower body temperature and inhibit certain enzymes.
    F) Clinically insignificant disturbances in iron metabolism (elevated serum iron and transferrin with decreased ferritin levels) have been noted with chronic exposure.
    G) Highly irritating sulfur dioxide may be released in a fires, and would be predicted to cause respiratory tract irritation, chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema.
    0.2.4) HEENT
    A) The liquid is a moderate to severe eye irritant. Vapor exposure can cause irritation of the nose and throat mucosa.
    0.2.6) RESPIRATORY
    A) Vapor exposure can cause moderate nose and throat irritation.
    B) Highly irritating oxides of sulfur may be released in a fire, and would be predicted to cause respiratory tract irritation, chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema.
    0.2.8) GASTROINTESTINAL
    A) Ingestion may cause irritation of the mouth, throat, esophagus, and gastrointestinal tract.
    0.2.14) DERMATOLOGIC
    A) The liquid is a mild skin irritant.
    0.2.20) REPRODUCTIVE
    A) At the time of this review, no data were available to assess the teratogenic potential of this agent.
    B) At the time of this review, no data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
    C) At the time of this review, no information about possible male reproductive effects of dimethyl sulfide in humans or experimental animals.
    0.2.21) CARCINOGENICITY
    A) At the time of this review, no studies were found on the possible carcinogenic activity of dimethyl sulfide in humans.

Laboratory Monitoring

    A) No biological monitoring parameters for exposed humans were established at the time of this review.
    B) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.

Treatment Overview

    0.4.2) ORAL/PARENTERAL EXPOSURE
    A) DO NOT INDUCE VOMITING - Gastric lavage and administration of activated charcoal are not likely to be beneficial.
    B) DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting.
    C) Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.
    D) Carefully observe patients with ingestion exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
    0.4.3) INHALATION EXPOSURE
    A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
    B) If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
    C) ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.
    D) Carefully observe patients with inhalation exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
    0.4.4) EYE EXPOSURE
    A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
    0.4.5) DERMAL EXPOSURE
    A) OVERVIEW
    1) DECONTAMINATION: Remove contaminated clothing and jewelry and irrigate exposed areas with copious amounts of water. A physician may need to examine the area if irritation or pain persists.
    2) Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.

Range Of Toxicity

    A) Minimum lethal human exposure is unknown.
    B) Rats died following a 15 minute exposure to an airborne concentration of 5 percent by volume.
    C) Rats exposed to airborne concentrations of 3 to 140 mg/Liter for 30 to 35 minutes developed mucous membrane irritation.
    D) Dimethyl sulfide is less toxic than hydrogen sulfide, dimethyl disulfide, and methyl mercaptan.

Clinical Effects

Summary Of Exposure

    A) Dimethyl sulfide is a liquid with a disagreeable odor; the vapors are heavier than air. It is a fire and vapor explosion hazard. Inhalation exposure generally results in little systemic toxicity.
    B) Vapor inhalation causes moderate eye, nose, and throat irritation, making it unlikely that individuals will tolerate moderate to high concentrations. Headache and decreased ability to concentrate may occur.
    C) The liquid is a mild skin irritant and a moderate to severe eye irritant. Repeated skin exposure to the liquid results in defatting dermatitis and irritation; burns may occur. Dermal exposure generally results in little systemic toxicity.
    D) Ingestion may cause irritation of the mouth, throat, esophagus, and gastrointestinal tract.
    E) In experimental animals, absorption of large quantities can lower body temperature and inhibit certain enzymes.
    F) Clinically insignificant disturbances in iron metabolism (elevated serum iron and transferrin with decreased ferritin levels) have been noted with chronic exposure.
    G) Highly irritating sulfur dioxide may be released in a fires, and would be predicted to cause respiratory tract irritation, chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema.

Heent

    3.4.1) SUMMARY
    A) The liquid is a moderate to severe eye irritant. Vapor exposure can cause irritation of the nose and throat mucosa.
    3.4.3) EYES
    A) IRRITATION - The liquid is a moderate to severe eye irritant (Lewis, 1996; RTECS , 1996; EPA, 1985; Clayton & Clayton, 1994).
    3.4.5) NOSE
    A) IRRITATION - Vapor exposure can cause irritation of nose and throat mucosa (EPA, 1985; CHRIS , 1996; Sittig, 1991)1990).
    3.4.6) THROAT
    A) IRRITATION - Vapor exposure can cause irritation of nose and throat mucosa (EPA, 1985; CHRIS , 1996; Sittig, 1991).

Respiratory

    3.6.1) SUMMARY
    A) Vapor exposure can cause moderate nose and throat irritation.
    B) Highly irritating oxides of sulfur may be released in a fire, and would be predicted to cause respiratory tract irritation, chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema.
    3.6.2) CLINICAL EFFECTS
    A) IRRITATION SYMPTOM
    1) Vapor exposure causes moderate irritation of the upper respiratory tract (NFPA, 1986; EPA, 1985; CHRIS , 1996).
    2) The irritating nature of the vapors makes it unlikely that individuals will tolerate moderate to high concentrations (CHRIS , 1996).
    B) TOXIC INHALATION INJURY
    1) LITTLE TOXICITY - Inhalation exposure generally results in little systemic toxicity (HSDB , 1996).
    2) PRODUCTS OF COMBUSTION - Highly irritating sulfur oxides may be released in a fire (NFPA, 1986; Lewis, 1996).
    a) This product of combustion would be predicted to cause respiratory tract irritation, chemical pneumonitis, bronchospasm or noncardiogenic pulmonary edema.

Gastrointestinal

    3.8.1) SUMMARY
    A) Ingestion may cause irritation of the mouth, throat, esophagus, and gastrointestinal tract.
    3.8.2) CLINICAL EFFECTS
    A) GASTROINTESTINAL IRRITATION
    1) Ingestion may cause irritation of the mouth, throat, esophagus, or gastrointestinal tract (EPA, 1985; CHRIS , 1996).

Dermatologic

    3.14.1) SUMMARY
    A) The liquid is a mild skin irritant.
    3.14.2) CLINICAL EFFECTS
    A) SKIN IRRITATION
    1) The liquid material is a mild skin irritant (Lewis, 1996; RTECS , 1996; EPA, 1985; Clayton & Clayton, 1994; CHRIS , 1996).

Reproductive

    3.20.1) SUMMARY
    A) At the time of this review, no data were available to assess the teratogenic potential of this agent.
    B) At the time of this review, no data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
    C) At the time of this review, no information about possible male reproductive effects of dimethyl sulfide in humans or experimental animals.
    3.20.2) TERATOGENICITY
    A) LACK OF INFORMATION
    1) At the time of this review, no data were available to assess the teratogenic potential of this agent.
    3.20.3) EFFECTS IN PREGNANCY
    A) LACK OF INFORMATION
    1) At the time of this review, no data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
    3.20.4) EFFECTS DURING BREAST-FEEDING
    A) LACK OF INFORMATION
    1) At the time of this review, no data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.

Carcinogenicity

    3.21.1) IARC CATEGORY
    A) IARC Carcinogenicity Ratings for CAS75-18-3 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
    1) Not Listed
    3.21.2) SUMMARY/HUMAN
    A) At the time of this review, no studies were found on the possible carcinogenic activity of dimethyl sulfide in humans.
    3.21.3) HUMAN STUDIES
    A) SUMMARY
    1) At the time of this review, no data were available to assess the carcinogenic potential of this agent.

Genotoxicity

    A) Dimethyl sulfide was NOT mutagenic in a variety of bacterial test strains.

Laboratory Monitoring

Monitoring Parameters Levels

    4.1.1) SUMMARY
    A) No biological monitoring parameters for exposed humans were established at the time of this review.
    B) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.

Radiographic Studies

    A) CHEST RADIOGRAPH
    1) If respiratory tract irritation is present, monitor chest x-ray.

Treatment

Life Support

    A) Support respiratory and cardiovascular function.

Monitoring

    A) No biological monitoring parameters for exposed humans were established at the time of this review.
    B) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.

Oral Exposure

    6.5.2) PREVENTION OF ABSORPTION
    A) SUMMARY
    1) Because of the irritant nature of this agent, EMESIS should NOT BE INDUCED. Gastric lavage and administration of activated charcoal are NOT LIKELY TO BE OF BENEFIT.
    B) DILUTION
    1) Immediate dilution with milk or water might be beneficial.
    2) DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting (Caravati, 2004).
    6.5.3) TREATMENT
    A) DILUTION
    1) DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting (Caravati, 2004).
    B) IRRITATION SYMPTOM
    1) Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.
    C) OBSERVATION REGIMES
    1) Carefully observe patients with ingestion exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.

Inhalation Exposure

    6.7.1) DECONTAMINATION
    A) Move patient from the toxic environment to fresh air. Monitor for respiratory distress. If cough or difficulty in breathing develops, evaluate for hypoxia, respiratory tract irritation, bronchitis, or pneumonitis.
    B) OBSERVATION: Carefully observe patients with inhalation exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
    C) INITIAL TREATMENT: Administer 100% humidified supplemental oxygen, perform endotracheal intubation and provide assisted ventilation as required. Administer inhaled beta-2 adrenergic agonists, if bronchospasm develops. Consider systemic corticosteroids in patients with significant bronchospasm (National Heart,Lung,and Blood Institute, 2007). Exposed skin and eyes should be flushed with copious amounts of water.
    6.7.2) TREATMENT
    A) IRRITATION SYMPTOM
    1) Respiratory tract irritation, if severe, can progress to noncardiogenic pulmonary edema which may be delayed in onset up to 24 to 72 hours after exposure in some cases.
    2) There are no controlled studies indicating that early administration of corticosteroids can prevent the development of noncardiogenic pulmonary edema in patients with inhalation exposure to respiratory irritant substances, and long-term use may cause adverse effects (Boysen & Modell, 1989).
    a) However, based on anecdotal experience, some clinicians do recommend early administration of corticosteroids (such as methylprednisolone 1 gram intravenously as a single dose) in an attempt to prevent the later development of pulmonary edema.
    1) Anecdotal experience with dimethyl sulfate inhalation showed possible benefit of methylprednisolone in the TREATMENT of noncardiogenic pulmonary edema (Ip et al, 1989).
    3) Anecdotal experience also indicated that systemic corticosteroids may have possible efficacy in the TREATMENT of drug-induced noncardiogenic pulmonary edema (Zitnik & Cooper, 1990; Stentoft, 1990; Chudnofsky & Otten, 1989) or noncardiogenic pulmonary edema developing after cardiopulmonary bypass (Maggart & Stewart, 1987).
    4) It is not clear from the published literature that administration of systemic corticosteroids early following inhalation exposure to respiratory irritant substances can PREVENT the development of noncardiogenic pulmonary edema. The decision to administer or withhold corticosteroids in this setting must currently be made on clinical grounds.
    B) BRONCHOSPASM
    1) If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
    C) ACUTE LUNG INJURY
    1) ONSET: Onset of acute lung injury after toxic exposure may be delayed up to 24 to 72 hours after exposure in some cases.
    2) NON-PHARMACOLOGIC TREATMENT: The treatment of acute lung injury is primarily supportive (Cataletto, 2012). Maintain adequate ventilation and oxygenation with frequent monitoring of arterial blood gases and/or pulse oximetry. If a high FIO2 is required to maintain adequate oxygenation, mechanical ventilation and positive-end-expiratory pressure (PEEP) may be required; ventilation with small tidal volumes (6 mL/kg) is preferred if ARDS develops (Haas, 2011; Stolbach & Hoffman, 2011).
    a) To minimize barotrauma and other complications, use the lowest amount of PEEP possible while maintaining adequate oxygenation. Use of smaller tidal volumes (6 mL/kg) and lower plateau pressures (30 cm water or less) has been associated with decreased mortality and more rapid weaning from mechanical ventilation in patients with ARDS (Brower et al, 2000). More treatment information may be obtained from ARDS Clinical Network website, NIH NHLBI ARDS Clinical Network Mechanical Ventilation Protocol Summary, http://www.ardsnet.org/node/77791 (NHLBI ARDS Network, 2008)
    3) FLUIDS: Crystalloid solutions must be administered judiciously. Pulmonary artery monitoring may help. In general the pulmonary artery wedge pressure should be kept relatively low while still maintaining adequate cardiac output, blood pressure and urine output (Stolbach & Hoffman, 2011).
    4) ANTIBIOTICS: Indicated only when there is evidence of infection (Artigas et al, 1998).
    5) EXPERIMENTAL THERAPY: Partial liquid ventilation has shown promise in preliminary studies (Kollef & Schuster, 1995).
    6) CALFACTANT: In a multicenter, randomized, blinded trial, endotracheal instillation of 2 doses of 80 mL/m(2) calfactant (35 mg/mL of phospholipid suspension in saline) in infants, children, and adolescents with acute lung injury resulted in acute improvement in oxygenation and lower mortality; however, no significant decrease in the course of respiratory failure measured by duration of ventilator therapy, intensive care unit, or hospital stay was noted. Adverse effects (transient hypoxia and hypotension) were more frequent in calfactant patients, but these effects were mild and did not require withdrawal from the study (Wilson et al, 2005).
    7) However, in a multicenter, randomized, controlled, and masked trial, endotracheal instillation of up to 3 doses of calfactant (30 mg) in adults only with acute lung injury/ARDS due to direct lung injury was not associated with improved oxygenation and longer term benefits compared to the placebo group. It was also associated with significant increases in hypoxia and hypotension (Willson et al, 2015).
    D) MONITORING OF PATIENT
    1) If respiratory tract irritation or respiratory depression is evident, monitor arterial blood gases, chest x-ray, and pulmonary function tests.
    E) OBSERVATION REGIMES
    1) Carefully observe patients with inhalation exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
    F) Treatment should include recommendations listed in the ORAL EXPOSURE section when appropriate.

Eye Exposure

    6.8.1) DECONTAMINATION
    A) EYE IRRIGATION, ROUTINE: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, an ophthalmologic examination should be performed (Peate, 2007; Naradzay & Barish, 2006).

Dermal Exposure

    6.9.1) DECONTAMINATION
    A) DERMAL DECONTAMINATION
    1) DECONTAMINATION: Remove contaminated clothing and wash exposed area thoroughly with soap and water for 10 to 15 minutes. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
    6.9.2) TREATMENT
    A) IRRITATION SYMPTOM
    1) Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
    B) Treatment should include recommendations listed in the ORAL EXPOSURE section when appropriate.

Range Of Toxicity

Summary

    A) Minimum lethal human exposure is unknown.
    B) Rats died following a 15 minute exposure to an airborne concentration of 5 percent by volume.
    C) Rats exposed to airborne concentrations of 3 to 140 mg/Liter for 30 to 35 minutes developed mucous membrane irritation.
    D) Dimethyl sulfide is less toxic than hydrogen sulfide, dimethyl disulfide, and methyl mercaptan.

Minimum Lethal Exposure

    A) GENERAL/SUMMARY
    1) The minimum lethal human dose to this agent has not been delineated.

Maximum Tolerated Exposure

    A) GENERAL/SUMMARY
    1) The maximum tolerated human exposure to this agent has not been delineated.
    B) ANIMAL DATA
    1) Rats exposed to airborne concentrations of 3 to 140 milligrams/Liter for 30 to 35 minutes developed mucous membrane irritation (Ljunggren & Norberg, 1943).

Workplace Standards

    A) ACGIH TLV Values for CAS75-18-3 (American Conference of Governmental Industrial Hygienists, 2010):
    1) Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.
    a) Adopted Value
    1) Dimethyl sulfide
    a) TLV:
    1) TLV-TWA: 10 ppm
    2) TLV-STEL:
    3) TLV-Ceiling:
    b) Notations and Endnotes:
    1) Carcinogenicity Category: Not Listed
    2) Codes: Not Listed
    3) Definitions: Not Listed
    c) TLV Basis - Critical Effect(s): URT irr
    d) Molecular Weight: 62.14
    1) For gases and vapors, to convert the TLV from ppm to mg/m(3):
    a) [(TLV in ppm)(gram molecular weight of substance)]/24.45
    2) For gases and vapors, to convert the TLV from mg/m(3) to ppm:
    a) [(TLV in mg/m(3))(24.45)]/gram molecular weight of substance
    e) Additional information:

    B) NIOSH REL and IDLH Values for CAS75-18-3 (National Institute for Occupational Safety and Health, 2007):
    1) Not Listed

    C) Carcinogenicity Ratings for CAS75-18-3 :
    1) ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed ; Listed as: Dimethyl sulfide
    2) EPA (U.S. Environmental Protection Agency, 2011): Not Listed
    3) IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
    4) NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
    5) MAK (DFG, 2002): Not Listed
    6) NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

    D) OSHA PEL Values for CAS75-18-3 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
    1) Not Listed

Toxicity Information

    7.7.1) TOXICITY VALUES
    A) References: RTECS, 1996
    1) LD50- (INTRAPERITONEAL)MOUSE:
    a) 8 g/kg
    2) LD50- (ORAL)MOUSE:
    a) 3700 mg/kg
    3) LD50- (ORAL)RAT:
    a) 330 mg/kg

Physicochemical

Physical Characteristics

    A) Dimethyl sulfide a colorless to pale yellow liquid with an unpleasant, wild radish, cabbage-like odor (EPA, 1985; Lewis, 1996; Budavari, 1996).
    B) floats on water surface and mixes slowly with water (CHRIS , 1996)

Molecular Weight

    A) 62.13 (Lewis, 1996)

References

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