DICARBOXIMIDE FUNGICIDES

Ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-5-oxazolidine carboxylate
Oxazolidine-5-carboxylic acid, 3-(3,5-dichlorophenyl)-2,4-dioxo-5-methyl-, ethyl ester
Dichlozolinate
M 8164
1-Imidazolidinecarboxamide, 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-
3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1- imidazolidinecarboxamide
FA 2071
Glycophen
Glycophene
Kidan
LFA 2043
MRC 910
NRC 910
Promidione
ROP 500 F
Rovral
RP 26019
N-(3,5-Dichlorophenyl)succinimide
1,2-Cyclopropanedicarboximide,N-(3,5-dichlorophenyl)-1,2-dimethyl-
Dicyclidine
S 7131
SP 751011
Sumilex
Sumisclex
2,4-Oxazolidinedione,3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-
BAS 352 F
Ornalin
Ronilan
Vinchlozoline
Vinclozoline
Vorlan
FUNGICIDES, DICARBOXIMIDE

CHLOZOLINATE

Ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-5-oxazolidine carboxylate
Oxazolidine-5-carboxylic acid, 3-(3,5-dichlorophenyl)-2,4-dioxo-5-methyl-, ethyl ester
Dichlozolinate
M 8164

1-Imidazolidinecarboxamide, 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-
3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1- imidazolidinecarboxamide
FA 2071
Glycophen
Glycophene
Kidan
LFA 2043
MRC 910
NRC 910
Promidione
ROP 500 F
Rovral
RP 26019

N-(3,5-Dichlorophenyl)succinimide

1,2-Cyclopropanedicarboximide,N-(3,5-dichlorophenyl)-1,2-dimethyl-
Dicyclidine
S 7131
SP 751011
Sumilex
Sumisclex

2,4-Oxazolidinedione,3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-
BAS 352 F
Ornalin
Ronilan
Vinchlozoline
Vinclozoline
Vorlan
FUNGICIDES, DICARBOXIMIDE

IDENTIFIERS

CAS REGISTRY NUMBER

72391-46-9(Chlozolinate)
36734-19-7(Iprodione)

MOLECULAR FORMULA

Chlozolinate: C13-H11-Cl2-N-O5
Iprodione: C13-H13-Cl2-N3-O3
Procymidone: C13-H11-Cl2-N-O2
Vinclozolin: C12-H9-Cl2-N-O3

ERG GUIDE NUMBER

Editor's Note: An ERG guide with information appropriate to this material does not exist.

USES/FORMS/SOURCES

USES

These chemicals are agricultural, non-systemic fungicides with protective actions. They have been used for the control of several types of fungi in vines, strawberries, vegetables, fruit, ornamentals, and turf grass. They act by preventing spore germination. They have been used as a post-harvest dip, as a seed treatment, or as a dip or spray at planting (HSDB, 2003). Vinclozolin is registered in the United States and Europe for use on agricultural crops (Wong et al, 1995).
Vinclozolin was originally developed to inhibit the production of a fungal steroid, ergosterol (Flynn et al, 2001). This group of fungicides is active against zygomycetes, deuteromycetes, ascomycetes and basidiomycetes; low toxicity is shown against oomycetes and yeasts. Dicarboximides have been used in the control of gray mold of grape and protected vegetable and ornamental crops caused by Botrytis cinerea, and the control of brown rot of fruit due to Monilinia spp. The mechanism of action of these fungicides includes inhibition of spore germination and mycelial growth, inducing leakage of pool metabolites, and causing distortion, bursting, and lysis of cells (Cabral & Cabral, 2000).

FORMS

These fungicides are available as a wettable powder, suspension concentrate, dustable powder, smoke tablet, dry flowable, water dispersible granular, and flowable, wettable powder in water soluble bags (HSDB, 2003). Vinclozolin is a colorless or white crystalline solid with a slight aromatic odor. Iprodione is a colorless or white crystal which is odorless (HSDB, 2003).

SOURCES

Vinclozolin is formed synthetically by the reaction of 3,5-dichlorophenyl isocyanate with an alkyl ester of 2-hydroxy-2-vinylpropionic acid; an elevated temperature results in ring closure of the finished chemical(HSDB, 2003).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

USES: Dicarboximide fungicides are used as seed treatments and as protectants against mildew, late blight, and other plant diseases. They are endocrine-disrupting pesticides which bind to the androgen receptor in mammals.

TOXICOLOGY: Unknown.

EPIDEMIOLOGY: This is a very uncommon poison with only a handful of cases reported in the literature. Large overdoses produce mild to moderate symptoms with no confirmed fatalities reported in the literature.

WITH POISONING/EXPOSURE

OVERDOSE: Acute toxicity is low or unlikely following acute ingestion and inhalation exposure. Chronic exposure to high doses may result in anti-androgenic effects, similar to those caused by flutamide, although no human cases have yet been reported. All information about overdose is based on a few case reports. One reported dermal exposure produced symptoms of vomiting and diarrhea. In animal studies, in utero exposure to large doses of dicarboximide fungicides is associated with hypospadias and alterations in sexual differentiation of androgen-dependent tissues. The relevance of this finding to human exposure is unknown.

Editor's Note: An ERG guide with information appropriate to this material does not exist.

-FIRST AID

FIRST AID AND PREHOSPITAL TREATMENT

SUMMARY

Exposure to dicarboximide fungicides is generally NOT expected to result in significant toxicity. Gastrointestinal decontamination should only be needed after large ingestions. For accidental ingestions in children rinsing the mouth and dilution with a few sips of water should be sufficient.

-RANGE OF TOXICITY

MAXIMUM TOLERATED EXPOSURE

SUMMARY

Dicarboximides are considered one of the safest pesticides (Meister, 2012).

ADULT

IPRODIONE

The ADI (acceptable daily intake), reported by WHO, is 0.2 mg/kg body weight for iprodione (Lu, 1995).

PROCYMIDONE

The ADI (acceptable daily intake), reported by WHO, is 0.1 mg/kg body weight for procymidone (Lu, 1995).

VINCLOZOLIN

Exposure guidelines: RfD: 25 mg/kg/day. This is approximately equivalent to 260 mcg/L in urine of 3,5-dichloroaniline (3,5-DCA).
The ADI (acceptable daily intake), reported by WHO, is 0.07 mg/kg body weight for vinclozolin (Lu, 1995).
In developmental toxicity studies, a no observable adverse effects level (NOAEL) in rats given oral doses is reported as 2.5 mg/kg body weight/day (Zober et al, 1995).
In developmental toxicity studies, the lowest observable adverse effect level (LOAEL) in rats given oral doses is reported as 50 mg/kg of body weight/day. Antiandrogenic effects were the most sensitive changes seen in these studies (Zober et al, 1995).
When vinclozolin is used on food crops with human exposure, it is estimated that approximately 2 mcg/kg/day may be ingested (Flynn et al, 2001). Occupational exposure is expected to be much greater.

Carcinogenicity Ratings for CAS72391-46-9 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed
EPA (U.S. Environmental Protection Agency, 2011): Not Listed
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

Carcinogenicity Ratings for CAS36734-19-7 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed
EPA (U.S. Environmental Protection Agency, 2011): Not Assessed under the IRIS program. ; Listed as: Iprodione
IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed
MAK (DFG, 2002): Not Listed
NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS72391-46-9 (U.S. Environmental Protection Agency, 2011):

Not Listed

EPA Risk Assessment Values for CAS36734-19-7 (U.S. Environmental Protection Agency, 2011):

Oral:

Slope Factor:
RfD: 4x10(-2) mg/kg-day

Inhalation:

Unit Risk:
RfC:

Drinking Water:

Unit Risk:

TOXICITY VALUES

CHLOZOLINATE
- LD50- (ORAL)MOUSE:
- LD50- (ORAL)RAT:
- LD50- (SKIN)RAT:
IPRODIONE
- LC50- (INHALATION)RAT:
- LD50- (ORAL)MOUSE:
- LD50- (SKIN)RABBIT:
- LD50- (ORAL)RAT:
PROCYMIDONE
- LD50- (ORAL)MOUSE:
- LD50- (SKIN)MOUSE:
- LD50- (ORAL)RABBIT:
- LD50- (ORAL)RAT:
- LD50- (SKIN)RAT:
VINCLOZOLIN
- LC50- (INHALATION)RABBIT:
- LC50- (INHALATION)RAT:
- LD50- (ORAL)GUINEA_PIG:
- LD50- (ORAL)MOUSE:
- LD50- (SKIN)RABBIT:
- LD50- (ORAL)RAT:
- LD50- (SKIN)RAT:

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS72391-46-9 (American Conference of Governmental Industrial Hygienists, 2010):

Not Listed

ACGIH TLV Values for CAS36734-19-7 (American Conference of Governmental Industrial Hygienists, 2010):

Not Listed

AIHA WEEL Values for CAS72391-46-9 (AIHA, 2006):

Not Listed

AIHA WEEL Values for CAS36734-19-7 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS72391-46-9 (National Institute for Occupational Safety and Health, 2007):

Not Listed

NIOSH REL and IDLH Values for CAS36734-19-7 (National Institute for Occupational Safety and Health, 2007):

Not Listed

OSHA PEL Values for CAS72391-46-9 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA PEL Values for CAS36734-19-7 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS72391-46-9 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS36734-19-7 (U.S. Occupational Safety and Health Administration, 2010):

Not Listed

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS72391-46-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS36734-19-7 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS72391-46-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS36734-19-7 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS72391-46-9 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA RCRA Hazardous Waste Number for CAS36734-19-7 (U.S. Environmental Protection Agency, 2010b):

Not Listed
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS72391-46-9 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Extremely Hazardous Substance List for CAS36734-19-7 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS72391-46-9 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

EPA SARA Title III, Community Right-to-Know for CAS36734-19-7 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Not Listed

DOT List of Marine Pollutants for CAS72391-46-9 (49 CFR 172.101 - App. B, 2005):

Not Listed

DOT List of Marine Pollutants for CAS36734-19-7 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS72391-46-9 (EPA, 2005):

Not Listed

EPA TSCA Inventory for CAS36734-19-7 (EPA, 2005):

Not Listed

LABELS

NFPA

NFPA Hazard Ratings for CAS72391-46-9 (NFPA, 2002):

Not Listed

NFPA Hazard Ratings for CAS36734-19-7 (NFPA, 2002):

Not Listed

-HANDLING AND STORAGE

SUMMARY

PUBLIC HEALTH CONSIDERATIONS

PROTECTIVE CLOTHING

Potential for exposure (dermal and inhalation) exists for persons involved in the manufacture, formulation, or application of the dicarboximide fungicides. When handling undiluted product or applying product to horticultural crops, wear goggles, impermeable gloves and apron, protective clothing and boots (Capri et al, 1999).

SPILL CONTROL/CLEANUP

For solid spillage of the dicarboximide fungicides, pick up with an industrial vacuum cleaner and dispose of in accordance with local regulations. A large liquid spillage should be dammed-off and pumped into containers. Soak up remaining spillage with absorbent material and dispose of in accordance with local regulation

-PERSONAL PROTECTION

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 72391-46-9.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 36734-19-7.

Specific recommendations and test data for this chemical were not found in the available manufacturers' product literature. A complete list of consulted manufacturers and references is presented below.

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS72391-46-9 (NFPA, 2002):

Not Listed

NFPA Flammability Rating for CAS36734-19-7 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

Editor's Note: An ERG guide with information appropriate to this material does not exist.

NFPA Extinguishing Methods for CAS72391-46-9 (NFPA, 2002):

Not Listed

NFPA Extinguishing Methods for CAS36734-19-7 (NFPA, 2002):

Not Listed

EVACUATION PROCEDURES

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

AIHA ERPG Values for CAS72391-46-9 (AIHA, 2006):

Not Listed

AIHA ERPG Values for CAS36734-19-7 (AIHA, 2006):

Not Listed

DOE TEEL Values for CAS72391-46-9 (U.S. Department of Energy, Office of Emergency Management, 2010):

Not Listed

DOE TEEL Values for CAS36734-19-7 (U.S. Department of Energy, Office of Emergency Management, 2010):

Not Listed

AEGL Values for CAS72391-46-9 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

AEGL Values for CAS36734-19-7 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Not Listed

NIOSH IDLH Values for CAS72391-46-9 (National Institute for Occupational Safety and Health, 2007):

Not Listed

NIOSH IDLH Values for CAS36734-19-7 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

Editor's Note: An ERG guide with information appropriate to this material does not exist.

SMALL LEAK/SPILL

Editor's Note: An ERG guide with information appropriate to this material does not exist.

LARGE LEAK/SPILL

Editor's Note: An ERG guide with information appropriate to this material does not exist.

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

Chlozolinate: 332.15

Iprodione: 330.17

Procymidone: 284.15

Vinclozolin: 286.12

DESCRIPTION/PHYSICAL STATE

Iprodione is a colorless or white crystalline solid, which is odorless. It is soluble in water (13.9 mg/liter at 25 degrees C), ethanol, methanol, acetone, dichloromethane and dimethylformamide (HSDB, 2003).

Vinclozolin is a colorless or white crystalline solid at room temperature, with a slight aromatic odor. It is almost insoluble in water, but is readily soluble in most organic solvents (HSDB, 2003; Zober et al, 1995).

Vinclozolin: pH 6.5 in water at 22 degrees Centigrade (Zober et al, 1995)

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Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents