COBALT (II) CHLORIDE
HAZARDTEXT ®
Information to help in the initial response for evaluating chemical incidents
-IDENTIFICATION
SYNONYMS
COBALT (II) CHLORIDE COBALT CHLORIDE COBALT DICHLORIDE COBALT MURIATE COBALTOUS CHLORIDE COBALTOUS DICHLORIDE KOBALT CHLORID (German) COBALT(II) CHLORIDE, HEXAHYDRATE COBALT CHLORIDE, HEXAHYDRATE COBALT DICHLORIDE HEXAHYDRATE COBALTOUS CHLORIDE, HEXAHYDRATE
IDENTIFIERS
USES/FORMS/SOURCES
It is used in invisible inks, humidity indicators, hygrometers, electroplating, for painting on glass and porcelain, in preparation of catalysts, as a fertilizer and feed additive, and was formerly used as an antifoaming agent in beer (HSDB). It was formerly used medicinally to treat iron-refractory anemia (Breidahl & Fraser, 1955).
COBALT (II) CHLORIDE, also called COBALTOUS CHLORIDE, occurs in both the anhydrous (CAS 7646-79-9) and hexahydrate (CAS 7781-13-1) forms. Because the anhydrous form becomes the hexahydrate upon exposure to moisture (HSDB), both forms are included in this review. The anhydrous form is a colorless crystalline solid which turns pink (hexahydrate) when exposed to moist air (or presumably to moisture in the body) (HSDB). Cobaltous chloride is soluble in water, alcohols, acetone, ether, and glycerol (HSDB).
The anhydrous form of cobaltous chloride is prepared from cobalt powder and chlorine or from cobalt acetate and acetyl chloride. The action of hydrochloric acid on cobalt, or its oxide, hydroxide, or carbonate will yield cobaltous chloride hexahydrate. This can be dehydrated with sulfur oxychloride to obtain cobaltous chloride (HSDB, 2003).
-CLINICAL EFFECTS
GENERAL CLINICAL EFFECTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
ACUTE CLINICAL EFFECTS
- At the time of this review, little information was available on acute exposure to cobaltous chloride in humans. One manufacturer's product information states that the dust is a skin, eye, and respiratory tract irritant, and that ingestion may produce nausea and vomiting.
- When inhaled by rats, it produced fatal pulmonary edema (Hoebel, 1972). It produced permanent corneal opacity and degeneration of the optic nerve when applied to the eyes of rabbits whose corneal epithelium had been removed (HSDB).
- When injected into rabbits, cobaltous chloride damaged the alpha-cells of the Islets of Langerhans in the pancreas (Clayton & Clayton, 1982), a possible mechanism for elevating blood glucose by preventing the synthesis of insulin.
CHRONIC CLINICAL EFFECTS
- A major concern with chronic exposure to metallic cobalt is hard-metal lung disease, but this does not seem to occur with exposure to the soluble salts of cobalt. However, the soluble salts do share the property with metallic cobalt of being potent skin SENSITIZERS. Dermatitis (Camarasa, 1967) and photosensitization of the skin (Romaguera, 1982) have been reported in individuals exposed to cobaltous chloride. Many patients with CEMENT DERMATITIS reacted to cobaltous chloride in skin patch testing (Camarasa, 1967). Cobaltous chloride was one of the most frequently reacting topical allergens in male patients at an allergy clinic (Magnusson, 1966).
- One of the most serious effects of chronic ingestion of cobaltous chloride resulted from its former use as an additive in some beers. Many heavy beer drinkers developed potentially fatal CARDIOMYOPATHY which was specifically linked to beer with added cobaltous chloride (HSDB). While it is not clear how much a concern this should be for persons with occupational exposure, at least one case of occupationally-related cardiomyopathy associated with cobaltous chloride exposure has been reported (Kennedy, 1981).
- Other known effects of cobaltous chloride in humans include its ability to induce GOITER by interfering with the uptake of iodine (Breidahl & Fraser, 1955). Kidney insufficiency was also seen in this population. Cobaltous chloride administered as a treatment for anemia caused an elevation in blood sugar only in diabetics (Schleisner, 1960), a finding consistent with its ability to damage the pancreas in experimental animals.
- In rats exposed by the inhalation route, cobaltous chloride elevated serum cholesterol and other progenitors of atherosclerosis, and the chloride was more potent than metallic cobalt for producing these effects (pp 31-33) Popov, 1982). It induced polycythemia in guinea pigs (Cajano, 1951), a finding consistent with its hematopoietic effect. When injected into the peritoneal cavity of rats, cobaltous chloride induced SIDEROSIS (deposits of iron in tissues) (Guillet, 1957).
- When inhaled by rabbits, cobaltous chloride increased the number of pulmonary macrophages, but was somewhat different from soluble nickel in this response (Johanssen, 1983). It altered the response of rats to conditioned stimuli when given orally (Nation, 1983), suggesting a possible neurological effect.
-RANGE OF TOXICITY
MAXIMUM TOLERATED EXPOSURE
- Carcinogenicity Ratings for CAS7646-79-9 :
ACGIH (American Conference of Governmental Industrial Hygienists, 2010): Not Listed EPA (U.S. Environmental Protection Agency, 2011): Not Listed IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 2B ; Listed as: Cobalt[II] chloride 2B : The agent (mixture) is possibly carcinogenic to humans. The exposure circumstance entails exposures that are possibly carcinogenic to humans. This category is used for agents, mixtures and exposure circumstances for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals. It may also be used when there is inadequate evidence of carcinogenicity in humans but there is sufficient evidence of carcinogenicity in experimental animals. In some instances, an agent, mixture or exposure circumstance for which there is inadequate evidence of carcinogenicity in humans but limited evidence of carcinogenicity in experimental animals together with supporting evidence from other relevant data may be placed in this group.
NIOSH (National Institute for Occupational Safety and Health, 2007): Not Listed MAK (DFG, 2002): Not Listed NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): Not Listed
TOXICITY AND RISK ASSESSMENT VALUES
- EPA Risk Assessment Values for CAS7646-79-9 (U.S. Environmental Protection Agency, 2011):
-STANDARDS AND LABELS
WORKPLACE STANDARDS
- ACGIH TLV Values for CAS7646-79-9 (American Conference of Governmental Industrial Hygienists, 2010):
- AIHA WEEL Values for CAS7646-79-9 (AIHA, 2006):
- NIOSH REL and IDLH Values for CAS7646-79-9 (National Institute for Occupational Safety and Health, 2007):
- OSHA PEL Values for CAS7646-79-9 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):
- OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS7646-79-9 (U.S. Occupational Safety and Health Administration, 2010):
ENVIRONMENTAL STANDARDS
- EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS7646-79-9 (U.S. Environmental Protection Agency, 2010):
- EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS7646-79-9 (U.S. Environmental Protection Agency, 2010):
- EPA RCRA Hazardous Waste Number for CAS7646-79-9 (U.S. Environmental Protection Agency, 2010b):
- EPA SARA Title III, Extremely Hazardous Substance List for CAS7646-79-9 (U.S. Environmental Protection Agency, 2010):
- EPA SARA Title III, Community Right-to-Know for CAS7646-79-9 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):
- DOT List of Marine Pollutants for CAS7646-79-9 (49 CFR 172.101 - App. B, 2005):
- EPA TSCA Inventory for CAS7646-79-9 (EPA, 2005):
LABELS
- NFPA Hazard Ratings for CAS7646-79-9 (NFPA, 2002):
-PERSONAL PROTECTION
SUMMARY
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
PROTECTIVE CLOTHING
- CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 7646-79-9.
-PHYSICAL HAZARDS
FIRE HAZARD
- FLAMMABILITY CLASSIFICATION
- NFPA Flammability Rating for CAS7646-79-9 (NFPA, 2002):
- FIRE CONTROL/EXTINGUISHING AGENTS
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- NFPA Extinguishing Methods for CAS7646-79-9 (NFPA, 2002):
EVACUATION PROCEDURES
- Editor's Note: An ERG guide with information appropriate to this material does not exist.
- AIHA ERPG Values for CAS7646-79-9 (AIHA, 2006):
- DOE TEEL Values for CAS7646-79-9 (U.S. Department of Energy, Office of Emergency Management, 2010):
Listed as Cobalt chloride TEEL-0 (units = mg/m3): 0.0441 TEEL-1 (units = mg/m3): 0.132 TEEL-2 (units = mg/m3): 25 TEEL-3 (units = mg/m3): 500 Definitions: TEEL-0: The threshold concentration below which most people will experience no adverse health effects. TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure. TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape. TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.
- AEGL Values for CAS7646-79-9 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 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62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):
- NIOSH IDLH Values for CAS7646-79-9 (National Institute for Occupational Safety and Health, 2007):
CONTAINMENT/WASTE TREATMENT OPTIONS
-PHYSICAL/CHEMICAL PROPERTIES
-REFERENCES
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