CHLOROMETHYL METHYL ETHER

Chloromethyl methyl ether is primarily used as a chemical intermediate. Specifically, it is used in the preparation of ion-exchange resins, the synthesis of chloromethylated compounds, and the manufacture of water repellants and industrial polymers. It is also used as an alkylating agent and a solvent (ACGIH, 1991; Budavari, 1996) Hathaway, 1996; (HSDB , 1998; NFPA, 1997).

FORMS

The commercial product usually contains 1% to 7% bis(chloromethyl)ether, a highly carcinogenic compound (Budavari, 1996; Sittig, 1991).

SOURCES

Chloromethyl methyl ether is prepared by passing hydrogen chloride through a formaldehyde and methanol mixture (Ashford, 1994; Budavari, 1996).

-CLINICAL EFFECTS

GENERAL CLINICAL EFFECTS

Chloromethyl methyl ether is irritating to the eyes, skin, and mucous membranes. Signs and symptoms following exposure may include sore throat, cough, wheezing, pulmonary congestion, bronchial secretions, blood stained sputum, weight loss, fever, and chills. Pulmonary edema, pneumonia, and skin burns and necrosis may occur. Pulmonary edema and hemorrhage and necrotizing bronchitis have occurred in experimental animals.

Inhalation may cause death from noncardiogenic pulmonary edema or chemical pneumonitis. Chronic bronchitis, lung cancer, and possibly laryngeal cancer are associated with chronic inhalation exposure to chloromethyl ethers.

Chloromethyl methyl ether is a suspected human carcinogen; oat cell lung cancer has been associated with chronic exposure. Its contaminant, bis-chloromethyl ether, is also a known human carcinogen.

POTENTIAL HEALTH HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

TOXIC; may be fatal if inhaled, ingested or absorbed through skin.
Inhalation or contact with some of these materials will irritate or burn skin and eyes.
Fire will produce irritating, corrosive and/or toxic gases.
Vapors may cause dizziness or suffocation.
Runoff from fire control or dilution water may cause pollution.

-MEDICAL TREATMENT

LIFE SUPPORT

Support respiratory and cardiovascular function.

SUMMARY

FIRST AID - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Move victim to fresh air.
Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing.
Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Wash skin with soap and water.
Keep victim warm and quiet.
In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

FIRST AID

FIRST AID

EYE EXPOSURE - Immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical.
DERMAL EXPOSURE - Immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.
INHALATION EXPOSURE - Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
ORAL EXPOSURE - If this chemical has been swallowed, get medical attention immediately.
TARGET ORGANS - Eyes, skin and respiratory system (National Institute for Occupational Safety and Health, 2007).

GENERAL

Move victims of inhalation exposure from the toxic environment and administer 100% humidified supplemental oxygen with assisted ventilation as required. Exposed skin and eyes should be copiously flushed with water. Ingestion may result in significant esophageal or gastrointestinal tract irritation or burns, and EMESIS SHOULD NOT BE INDUCED. Cautious gastric lavage followed by administration of activated charcoal may be of benefit if the patient is seen soon after the exposure.

INHALATION EXPOSURE

INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents.
ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed.

DERMAL EXPOSURE

Remove contaminated clothes. Irrigate exposed skin with copious amounts of water for at least 15 minutes or longer, depending amount and duration of exposure. A physician may need to examine the area if irritation or pain persist.

EYE EXPOSURE

DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

ORAL EXPOSURE

Because of the potential for gastrointestinal tract irritation or burns, DO NOT induce emesis.
Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.
PREHOSPITAL ACTIVATED CHARCOAL ADMINISTRATION

Consider prehospital administration of activated charcoal as an aqueous slurry in patients with a potentially toxic ingestion who are awake and able to protect their airway. Activated charcoal is most effective when administered within one hour of ingestion. Administration in the prehospital setting has the potential to significantly decrease the time from toxin ingestion to activated charcoal administration, although it has not been shown to affect outcome (Alaspaa et al, 2005; Thakore & Murphy, 2002; Spiller & Rogers, 2002).

In patients who are at risk for the abrupt onset of seizures or mental status depression, activated charcoal should not be administered in the prehospital setting, due to the risk of aspiration in the event of spontaneous emesis.
The addition of flavoring agents (cola drinks, chocolate milk, cherry syrup) to activated charcoal improves the palatability for children and may facilitate successful administration (Guenther Skokan et al, 2001; Dagnone et al, 2002).

ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury.

-RANGE OF TOXICITY

MINIMUM LETHAL EXPOSURE

Chronic occupational exposure to chloromethyl methyl ether has caused fatal lung cancer in several cases (Hathaway et al, 1996; HSDB , 1998).

Commercial grade chloromethyl methyl ether (CMME) contains bis(chloromethyl)ether (BCME), which is highly carcinogenic. Differentiation between the carcinogenic effects of the two compounds is difficult. However, since commercial CMME contains BCME and the hydrolysis products, formaldehyde and hydrogen chloride, may recombine to form BCME, chloromethyl methyl ether is also considered a carcinogen (Hathaway et al, 1996).

MAXIMUM TOLERATED EXPOSURE

The maximum tolerated human exposure to this agent has not been delineated.

Carcinogenicity Ratings for CAS107-30-2 :

ACGIH (American Conference of Governmental Industrial Hygienists, 2010): A2 ; Listed as: Chloromethyl methyl ether

A2 :Suspected Human Carcinogen: Human data are accepted as adequate in quality but are conflicting or insufficient to classify the agent as a confirmed human carcinogen; OR, the agent is carcinogenic in experimental animals at dose(s), by route(s) of exposure, at site(s), of histologic type(s), or by mechanism(s) considered relevant to worker exposure. The A2 is used primarily when there is limited evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in experimental animals with relevance to humans.

EPA (U.S. Environmental Protection Agency, 2011): A ; Listed as: Chloromethyl methyl ether (CMME)

A : Human Carcinogen.

IARC (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): Not Listed
NIOSH (National Institute for Occupational Safety and Health, 2007): Ca ; Listed as: Chloromethyl methyl ether

Ca : NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A in the NIOSH Pocket Guide to Chemical Hazards).

MAK (DFG, 2002): Category 1 ; Listed as: Monochlorodimethyl ether

Category 1 : Substances that cause cancer in man and can be assumed to make a significant contribution to cancer risk. Epidemiological studies provide adequate evidence of a positive correlation between the exposure of humans and the occurence of cancer. Limited epidemiological data can be substantiated by evidence that the substance causes cancer by a mode of action that is relevant to man.

NTP (U.S. Department of Health and Human Services, Public Health Service, National Toxicology Project ): K ; Listed as: Chloromethyl Methyl Ether

K : KNOWN = Known to be a human carcinogen

TOXICITY AND RISK ASSESSMENT VALUES

EPA IRIS

EPA Risk Assessment Values for CAS107-30-2 (U.S. Environmental Protection Agency, 2011):

Oral:

Slope Factor:
RfD:

Inhalation:

Unit Risk:
RfC:

Drinking Water:

Unit Risk:

TOXICITY VALUES

References: Lewis, 1996 RTECS, 1998
- LC50- (INHALATION)HAMSTER:
- LC50- (INHALATION)MOUSE:
- LC50- (INHALATION)RAT:
- TCLo- (INHALATION)HAMSTER:
- TCLo- (INHALATION)MOUSE:
- TCLo- (INHALATION)RAT:
- TD- (SUBCUTANEOUS)MOUSE:
- TDLo- (SUBCUTANEOUS)MOUSE:

-STANDARDS AND LABELS

WORKPLACE STANDARDS

ACGIH TLV Values for CAS107-30-2 (American Conference of Governmental Industrial Hygienists, 2010):

Editor's Note: The listed values are recommendations or guidelines developed by ACGIH(R) to assist in the control of health hazards. They should only be used, interpreted and applied by individuals trained in industrial hygiene. Before applying these values, it is imperative to read the introduction to each section in the current TLVs(R) and BEI(R) Book and become familiar with the constraints and limitations to their use. Always consult the Documentation of the TLVs(R) and BEIs(R) before applying these recommendations and guidelines.

Adopted Value

Chloromethyl methyl ether

TLV:

TLV-TWA:
TLV-STEL:
TLV-Ceiling:

Notations and Endnotes:

Carcinogenicity Category: A2
Codes: L
Definitions:

A2: Suspected Human Carcinogen: Human data are accepted as adequate in quality but are conflicting or insufficient to classify the agent as a confirmed human carcinogen; OR, the agent is carcinogenic in experimental animals at dose(s), by route(s) of exposure, at site(s), of histologic type(s), or by mechanism(s) considered relevant to worker exposure. The A2 is used primarily when there is limited evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in experimental animals with relevance to humans.
L: Exposure by all routes should be carefully controlled to levels as low as possible.

TLV Basis - Critical Effect(s): Lung cancer
Molecular Weight: 80.5

For gases and vapors, to convert the TLV from ppm to mg/m(3):

[(TLV in ppm)(gram molecular weight of substance)]/24.45

For gases and vapors, to convert the TLV from mg/m(3) to ppm:

[(TLV in mg/m(3))(24.45)]/gram molecular weight of substance

AIHA WEEL Values for CAS107-30-2 (AIHA, 2006):

Not Listed

NIOSH REL and IDLH Values for CAS107-30-2 (National Institute for Occupational Safety and Health, 2007):

Listed as: Chloromethyl methyl ether
REL:

TWA:
STEL:
Ceiling:
Carcinogen Listing: (Ca) NIOSH considers this substance to be a potential occupational carcinogen (See Appendix A in the NIOSH Pocket Guide to Chemical Hazards).
Skin Designation: Not Listed
Note(s): See Appendix A

IDLH: Not Listed

OSHA PEL Values for CAS107-30-2 (U.S. Occupational Safety, and Health Administration (OSHA), 2010):

Listed as: Chloromethyl methyl ether; see 29 CFR 1910.1006
Table Z-1 for Chloromethyl methyl ether; see 29 CFR 1910.1006:

8-hour TWA:

ppm:

Parts of vapor or gas per million parts of contaminated air by volume at 25 degrees C and 760 torr.

mg/m3:

Milligrams of substances per cubic meter of air. When entry is in this column only, the value is exact; when listed with a ppm entry, it is approximate.

Ceiling Value:
Skin Designation: No
Notation(s): Not Listed

OSHA List of Highly Hazardous Chemicals, Toxics, and Reactives for CAS107-30-2 (U.S. Occupational Safety and Health Administration, 2010):

Threshold Quantity, in pounds:500

ENVIRONMENTAL STANDARDS

EPA CERCLA, Hazardous Substances and Reportable Quantities for CAS107-30-2 (U.S. Environmental Protection Agency, 2010):

Listed as: Chloromethyl methyl ether
Final Reportable Quantity, in pounds (kilograms):

10 (4.54)

Additional Information:
Listed as: Methane, chloromethoxy-
Final Reportable Quantity, in pounds (kilograms):

10 (4.54)

Additional Information:

EPA CERCLA, Hazardous Substances and Reportable Quantities, Radionuclides for CAS107-30-2 (U.S. Environmental Protection Agency, 2010):

Not Listed

EPA RCRA Hazardous Waste Number for CAS107-30-2 (U.S. Environmental Protection Agency, 2010b):

Listed as: Chloromethyl methyl ether
P or U series number: U046
Footnote:
Listed as: Methane, chloromethoxy-
P or U series number: U046
Footnote:
Editor's Note: The D, F, and K series waste numbers and Appendix VIII to Part 261 -- Hazardous Constituents were not included. Please refer to 40 CFR Part 261.

EPA SARA Title III, Extremely Hazardous Substance List for CAS107-30-2 (U.S. Environmental Protection Agency, 2010):

Listed as: Chloromethyl Methyl Ether
Reportable Quantity, in pounds: 10

Only the statutory or final RQ is shown. For more information, see 40 CFR table 302.4.

Threshold Planning Quantity, in pounds:

100
Amount necessary to be covered by this standard. See 40 CFR 355.30.

Note(s): b

b: The calculated TPQ changed after technical review as described in a technical support document for the final rule, April 22, 1987.

EPA SARA Title III, Community Right-to-Know for CAS107-30-2 (40 CFR 372.65, 2006; 40 CFR 372.28, 2006):

Listed as: Chloromethyl methyl ether
Effective Date for Reporting Under 40 CFR 372.30: 1/1/87
Lower Thresholds for Chemicals of Special Concern under 40 CFR 372.28:

DOT List of Marine Pollutants for CAS107-30-2 (49 CFR 172.101 - App. B, 2005):

Not Listed

EPA TSCA Inventory for CAS107-30-2 (EPA, 2005):

Listed as: Methane, chloromethoxy-

SHIPPING REGULATIONS

SURFACE

DOT -- Table of Hazardous Materials and Special Provisions for UN/NA Number 1239 (49 CFR 172.101, 2005):

Hazardous materials descriptions and proper shipping name: Methyl chloromethylether

Symbol(s): Not Listed
Hazard class or Division: 6.1

6.1: Poisonous materials. See 49 CFR section 173.132 for definitions.

Identification Number: UN1239
Packing Group: I

I: Packing Group I - indicates the degree of danger presented by the material is great.

Label(s) required (if not excepted): 6.1, 3

6.1: Poison Inhalation Hazard (inhalation hazard, Zone A or B) or Poison (other than inhalation hazard, Zone A or B; the packing group for a material is indicated in column 5 of the table.).
3: Flammable Liquid.

Special Provisions: 1, B9, B14, B30, B72, T22, TP2, TP38, TP44

1: This material is poisonous by inhalation (see sxn. 171.8 of this subchapter) in Hazard Zone A (see sxn. 173.116(a) or sxn. 173.133(a) of this subchapter), and must be described as an inhalation hazard under the provisions of this subchapter.
B9: Bottom outlets are not authorized.
B14: Each bulk packaging, except a tank car or a multi-unit-tank car tank, must be insulated with an insulating material so that the overall thermal conductance at 15.5 °C (60 °F) is no more than 1.5333 kilojoules per hour per square meter per degree Celsius (0.075 Btu per hour per square foot per degree Fahrenheit) temperature differential. Insulating materials must not promote corrosion to steel when wet.
B30: MC 312, MC 330, MC 331 and DOT 412 cargo tanks and DOT 51 portable tanks must be made of stainless steel, except that steel other than stainless steel may be used in accordance with the provisions of sxn. 173.24b(b) of this subchapter. Thickness of stainless steel for tank shell and heads for cargo tanks and portable tanks must be the greater of 7.62 mm (0.300 inch) or the thickness required for a tank with a design pressure at least equal to 1.5 times the vapor pressure of the lading at 46 °C (115 °F). In addition, MC 312 and DOT 412 cargo tank motor vehicles must: a. Be ASME Code (U) stamped for 100% radiography of all pressure-retaining welds; b. Have accident damage protection which conforms with sxn. 178.345-8 of this subchapter; c. Have a MAWP or design pressure of at least 87 psig: and d. Have a bolted manway cover.
B72: Tank cars must have a test pressure of 34.47 Bar (500 psig) or greater and conform to Class 105J, 106, or 110.
T22: Minimum test pressure (bar): 10; Minimum shell thickness (in mm-reference steel) (See sxn.178.274(d)): 10 mm; Pressure-relief requirements (See sxn.178.275(g)): sxn. 178.275(g)(3); Bottom opening requirements (See sxn.178.275(d)): Prohibited.
TP2: a. The maximum degree of filling must not exceed the degree of filling determined by the following: [Degree of filling = 95/1+alpha(tr - tf)], where tr is the maximum mean bulk temperature during transport, tf is the temperature in degrees celsius of the liquid during filling, and alpha is the mean coefficient of cubical expansion of the liquid between the mean temperature of the liquid during filling (tf) and the maximum mean bulk temperature during transportation (tr) both in degrees celsius; and b. For liquids transported under ambient conditions a may be calculated using the formula: [alpha = (d15-d50)/(35 x d50)], where d15 and d50 are the densities (in units of mass per unit volume) of the liquid at 15 degrees C (59 degrees F) and 50 degrees C (122 degrees F), respectively.
TP38: Each portable tank must be insulated with an insulating material so that the overall thermal conductance at 15.5 °C (60 °F) is no more than 1.5333 kilojoules per hour per square meter per degree Celsius (0.075 Btu per hour per square foot per degree Fahrenheit) temperature differential. Insulating materials may not promote corrosion to steel when wet.
TP44: Each portable tank must be made of stainless steel, except that steel other than stainless steel may be used in accordance with the provisions of sxn. 173.24b(b) of this subchapter. Thickness of stainless steel for tank shell and heads must be the greater of 7.62 mm (0.300 inch) or the thickness required for a portable tank with a design pressure at least equal to 1.5 times the vapor pressure of the hazardous material at 46 °C (115 °F).

Packaging Authorizations (refer to 49 CFR 173.***):

Exceptions: None
Non-bulk packaging: 226
Bulk packaging: 244

Quantity Limitations:

Passenger aircraft or railcar: Forbidden
Cargo aircraft only: Forbidden

Vessel Stowage Requirements:

Vessel stowage location: D

D: The material must be stowed "on deck only" on a cargo vessel and on a passenger vessel carrying a number of passengers limited to not more than the larger of 25 passengers or one passenger per each 3 m of overall vessel length, but the material is prohibited on passenger vessels in which the limiting number of passengers is exceeded.

Vessel stowage other: 40

40: Stow "clear of living quarters".

ICAO International Shipping Name for UN1239 (ICAO, 2002):

Proper Shipping Name: Methyl chloromethyl ether
UN Number: 1239

LABELS

NFPA

NFPA Hazard Ratings for CAS107-30-2 (NFPA, 2002):

Not Listed

-HANDLING AND STORAGE

SUMMARY

INDUSTRIAL CHEMICALS

This compound should be stored in a dry, cool, well-ventilated area away from oxidizers and peroxides. Shipping containers include: glass bottles in wooden boxes; nickel pails, cans, or drums. Broken packages should not be handled unless appropriate protective equipment is worn (AAR, 1996; (NFPA, 1997).

HANDLING

Appropriate protective equipment should always be worn when handling broken packages (AAR, 1996).

Chloromethyl methyl ether remains stable during transport (CHRIS , 1998).

STORAGE

CONTAINER

Ship chloromethyl methyl ether in glass bottles placed in wooden boxes or in nickel pails, cans, or drums (NFPA, 1997).
Closed containers may explode when heated (NFPA, 1997).
Chloromethyl methyl ether becomes contaminated with the potent human carcinogen bis(chloromethyl)ether if it is not very rapidly utilized (ACGIH, 1991).

ROOM/CABINET RECOMMENDATIONS

This compound must be stored in a dry, cool, well-ventilated area, preferably in outside or detached storage (NFPA, 1997).

INCOMPATIBILITIES

Keep chloromethyl methyl ether separate from oxidizers and peroxides (NFPA, 1997).
This compound reacts with water, forming formaldehyde and hydrochloric acid (NIOSH , 1998).

-PERSONAL PROTECTION

SUMMARY

RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Wear positive pressure self-contained breathing apparatus (SCBA).
Wear chemical protective that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

Wear appropriate full body protective clothing, including gloves, boots, and a positive pressure self-contained breathing apparatus, to prevent skin contact and avoid breathing vapors, as well as appropriate eye protection to prevent eye contact whenever there is possibility of exposure to chloromethyl methyl ether (AAR, 1996; (NFPA, 1997; NIOSH , 1998; Sittig, 1991).

Any work area where there is a possibility of exposure to chloromethyl methyl ether should include facilities for quickly drenching the body for emergency use. Immediately wash contaminated skin and remove and replace any clothing which becomes contaminated. Also, immediately remove work clothing that becomes wet due to its flammability hazard. Any clothing which may have become contaminated should be left on the work premises for decontamination or disposal. Personnel should wash at the end of each work shift (AAR, 1996; (NFPA, 1997; NIOSH , 1998; Sittig, 1991).

HSDB (1998) lists several precautions for CARCINOGENS.

In the laboratory, prohibit smoking, drinking, eating, storage of food and beverage containers or utensils, and the application of cosmetics. Persons should remove gloves and wash hands with liquid detergent after working with carcinogens. For containment of in vitro procedures, a vertical laminar-flow biological safety cabinet may be used. The safest method for administering volatile carcinogens is through injection of a solution. Other methods of administration should be done under hoods. Labs should be periodically monitored for contamination build-up. Clean-up of contaminated areas should avoid contamination of drains or ventilation ducts and permanent equipment. Contaminated gowns should be decontaminated or burned. Clearly mark doors leading into areas where carcinogens are used and limit access to persons involved in the experiment.
In an animal laboratory, persons should remove outdoor clothing and wear protective suits (disposable, one-piece, and close-fitting at ankles and wrists). If contamination occurs, persons should remove clothing immediately and shower. When carcinogens are administered in diet or applied to the skin, animals should be kept in cages with solid bottoms and sides and cages should be fitted with a filter top. If volatile carcinogens are used, filter tops should not be used.
In a chemical laboratory, personnel should always wear gloves, gowns, carefully-fitted masks or respirators, and disposable plastic aprons. Gowns should be of a distinctive color as a reminder that they should not be worn out of the lab.

EYE/FACE PROTECTION

Appropriate eye protection should be worn to prevent eye contact when working with chloromethyl methyl ether. Contact lenses should not be worn (NIOSH , 1998).

Eyewash fountains should be placed where there is any possibility of workers being exposed to this compound, whether or not eye protection is worn (NIOSH , 1998).

RESPIRATORY PROTECTION

Refer to "Recommendations for respirator selection" in the NIOSH Pocket Guide to Chemical Hazards on TOMES Plus(R) for respirator information.

PROTECTIVE CLOTHING

CHEMICAL PROTECTIVE CLOTHING. Search results for CAS 107-30-2.

All data are compiled from published sources and are NOT recommended specifically by Truven Health Analytics. The appearance of specific manufacturers or products in this section does not represent an endorsement by Truven Health Analytics. No attempt has been made to verify the data presented. All product recommendations should be confirmed with the specific manufacturer for verification of product performance.
CLOTHING

Plastic Laminate

DuPont Personal Protection

CPF 4

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): 288
Permeation Rate (mcg/cm2/min): 0.67
Notes: Not Listed
Citation: (DuPont, 2002)

Responder

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): None detected
Notes: Not Listed
Citation: (DuPont, 2002)

Tychem 10,000

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): Not Tested
Permeation Rate (mcg/cm2/min): Not Tested
Notes: liquid
Citation: (DuPont, 2002)

Tychem 7500

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): Not Tested
Permeation Rate (mcg/cm2/min): Not Tested
Notes: liquid
Citation: (DuPont, 2002)

Tychem 9400

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): 0.03
Notes: liquid
Citation: (DuPont, 2002)

Tychem BR

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): 0.03
Notes: Not Listed
Citation: (DuPont, 2002)

Tychem F

Degradation Rating: Not Listed
Breakthrough Time (minutes): 46
Permeation Rate (mcg/cm2/min): 0.7
Notes: Not Listed
Citation: (DuPont, 2003)

Tychem LV

Degradation Rating: Not Listed
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): 0.03
Notes: Not Listed
Citation: (DuPont, 2003)

Tychem QC

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): Not Tested
Permeation Rate (mcg/cm2/min): Not Tested
Notes: liquid
Citation: (DuPont, 2002)

Tychem SL

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): Not Tested
Permeation Rate (mcg/cm2/min): Not Tested
Notes: liquid
Citation: (DuPont, 2002)

Tychem ThermoPro

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): 46
Permeation Rate (mcg/cm2/min): 0.7
Notes: Not Listed
Citation: (DuPont, 2003)

Tychem TK

Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): 0.03
Notes: Not Listed
Citation: (DuPont, 2002)
Degradation Rating: No Degradation Rating provided
Breakthrough Time (minutes): >480
Permeation Rate (mcg/cm2/min): 0.03
Notes: liquid
Citation: (DuPont, 2002)

FOOTWEAR

Specific recommendations and test data for this product type were not found in the available manufacturers' product literature.

GLOVES

Specific recommendations and test data for this product type were not found in the available manufacturers' product literature.

GENERAL INFORMATION

This section provides a compilation of chemical resistance information and test data for specific protective clothing products. Chemical resistance information includes both degradation resistance ratings and permeation resistance data. This information is designed to assist in the selection of appropriate protective clothing. Only data on specific products and manufacturers are included. Generic information or recommendations are not provided since significant differences can exist in the chemical resistance for apparent similar product types.
Specific product information is organized by general product type (gloves, garments, and footwear), material type, and manufacturer. The category 'garments' may include totally encapsulating suits, splash suits, as well as other items (e.g., coveralls, jackets, and aprons). Specific manufacturers should be contacted to determine the features of available styles/models.
In addition to chemical resistance information, there are many critical variables in the selection of protective clothing which cannot be represented in this summary of the literature. Some factors to be considered in choosing protective clothing include, but are not limited to: overall clothing integrity, physical hazard resistance, durability, human factors, ease of decontamination, and cost. Overall clothing integrity refers to a specific design's ability to offer consistent protection for all clothing-covered areas of the body. Physical hazards include resisting the effects of abrasion, cuts, tears, and punctures. Human factors entail effects on wearer mobility, visibility, and hearing for garments; dexterity, tactility, and grip for gloves; ankle support and weight for footwear; and, any effect of the clothing on the function of the wearer. There are several variations in the design for gloves, garments, and footwear that affect these factors. Protective clothing must properly be sized and correctly fit the wearer to ensure its proper use and function.
As required in the U.S.A., protective clothing should be selected based on a risk assessment of the workplace. This risk assessment must account for the identification of existing as well as potential hazards and involve the recommendation of protective clothing appropriate for the identified hazards. Therefore, the recommendations in this section should not be used as the sole basis for decisions on choice of protective clothing, but rather should be used as a tool by qualified occupational health and safety professionals or other technically qualified persons in conjunction with a review of all mitigating factors. Consult the OSHA PPE Standard (29 CFR 1910.132 - 1910.138) for regulations and additional guidance regarding the selection and use of protective clothing and equipment. For general information on protective clothing selection, refer to the "PERSONAL PROTECTIVE EQUIPMENT - OSHA PUB 3077" document.
PROTECTIVE CLOTHING SELECTION

Determine the type of protective clothing item needed based on a risk assessment (e.g., gloves, garments, footwear).
For high risk situations, choose clothing that covers all parts of the body that may be exposed. In many cases, multiple clothing items will be required. Low risk situations may permit partial body protective clothing. Select protective clothing products that have reported chemical resistance data. High risk situations involving full body clothing or extended chemical contact often require permeation resistance data to determine the barrier effectiveness of materials used in the construction of clothing. Relatively low risk situations, where only splash or incidental exposure occur, may allow use of protective clothing based on degradation or penetration resistance data. Specifics on the interpretation of chemical resistance data are presented below.
Other factors must be considered in addition to chemical resistance. The selected chemical protective clothing item should offer the optimal combination of protection against identified hazards while allowing maximum function and comfort.

INTERPRETATION OF DEGRADATION RATINGS

Degradation refers to physical changes in a material as the result of chemical exposure. Degradation may become evident in visible changes, such as discoloration, swelling, delamination, deterioration, or disintegration. Degradation effects may also be measured by weight change or other changes in a material's physical properties (e.g., strength, elasticity, hardness).
Degradation resistance ratings are provided by manufacturers to rate the amount of degradation that occurs for a particular protective clothing material when contacted by a chemical. All degradation ratings are qualitative and include ratings, such as "EXCELLENT," "GOOD," "FAIR," "POOR," and "NOT RECOMMENDED." There is no standard test method for the measurement of chemical degradation resistance; therefore, manufacturer ratings may be based on different testing approaches. This makes comparison of degradation ratings between manufacturers unreliable.
The use of degradation resistance ratings alone to recommend protective clothing, particularly for high hazard situations, should be avoided. Degradation resistance testing does not directly assess the barrier quality of protective clothing, since materials can show relatively little degradation but still allow either permeation or penetration by a chemical. Degradation resistance ratings can be used to exclude protective clothing materials from consideration. Protective clothing materials with a "NOT RECOMMENDED" degradation resistance rating should never be used.
For some products, the rating "NO PENETRATION" is provided. This refers to penetration resistance test results that are based on a different procedure (American Society for Testing and Materials (ASTM) Standard Test Method F 903). Penetration resistance testing involves placing a material sample in a test cell, exposing the exterior side of the material to a chemical, and then observing the interior side of the material for visible signs of liquid penetration. Part of the test is conducted at an elevated pressure. Test results are reported as pass (no penetration) or fail (penetration detected). Unlike degradation testing, penetration testing provides an assessment of protective clothing material barrier performance. Since penetration resistance testing examines only observable amounts of liquid penetration, permeation may still occur. The use of penetration resistance data must be restricted to liquid chemicals, and should be limited to scenarios where there is no reasonable vapor exposure hazard under the conditions of exposure.

INTERPRETATION OF PERMEATION DATA

Permeation is the process of chemical movement through a material on a molecular level. Permeation resistance refers to the ability of a material to retard or prevent chemical movement through it. Permeation may occur without any visible signs of degradation.
Permeation resistance is measured using a test cell which is divided into two halves by a protective clothing specimen. Chemical is placed on the challenge side, while the collection side is periodically monitored for permeating chemical. Permeation data were obtained in accordance with the American Society for Testing and Materials (ASTM) Standard Test Method F 739 (Resistance of Materials Used in Protective Clothing to Permeation by Liquids and Gases), unless stated otherwise. In the case of chemicals that are classified as warfare agents, the data were obtained in accordance with the Military Standard 282 (MIL-STD-282) (Military Standard, Filter Units, Protective Clothing, Gas-Mask Components, and Related Products: Performance Test Methods).
Permeation rate is the amount of chemical that passes through a material for a measured surface area per unit time. In this section, permeation rate is expressed in micrograms per square centimeter per minute (mcg/cm(2)/min). The reported permeation rate is either the steady-state rate or the maximum rate observed during testing. In some cases, very large permeation rates exceed measurement techniques and are reported as ">" (greater than) or "HIGH."
Breakthrough time is the elapsed time, in minutes, from the time the chemical comes in contact with the material exterior surface, to the time that chemical is detected on the interior surface. When no breakthrough is detected, the breakthrough time is report as ">" the testing period. If permeation breakthrough is rapid, results are reported as "<" (less than) the earlier sampling time or as "IMMEDIATELY" (which usually means breakthrough in less than 4 minutes).
The breakthrough time should exceed the expected use period of the selected protective clothing. Additionally, there are several other factors that must be taken into account to provide appropriate protection.
Permeation testing is usually conducted with full strength, undiluted chemical for the duration of the test period. Actual exposures may involve diluted chemical for short or intermittent exposure periods.
Permeation testing is usually conducted at room temperature. Permeation occurs faster at elevated temperatures (short breakthrough times and higher permeation rates) and slower at reduced temperatures (long breakthrough times and lower permeation rates).
Permeation resistance of mixtures cannot usually be determined on the basis of the individual chemicals making up the mixture. Synergistic effects may occur and result in more rapid permeation than accounted for by the individual mixture chemicals.
Permeation rates may be used to calculate potential wearer exposure; however, several assumptions must be made about the extent of exposure and condition of clothing wear. Furthermore, there are few chemicals with dermal exposure limits, making it difficult to determine an acceptable skin exposure level.

COMPANY INFORMATION

DuPont Personal Protection P. O. Box 80705 Wilmington, DE 19880-0705 USA Phone: (302) 774-1000 Toll-Free: (800) 931-3456 Website: http://personalprotection.dupont.com Email: personalprotection@usa.dupont.com

REFERENCES

CHEMICAL PROTECTIVE CLOTHING CITATIONS

The following sources were consulted for chemical protective clothing data:

(Ansell-Edmont, 2001)
(Bata Shoe Company, 1995)
(Best Manufacturing, 2002)
(Best Manufacturing, 2004)
(Boss Manufacturing Company, 1998)
(ChemFab Corporation, 1993)
(Comasec Safety, Inc., 2003)
(Comasec Safety, Inc., 2003a)
(DuPont, 2002)
(DuPont, 2002)
(DuPont, 2003)
(Guardian Manufacturing Group, 2001)
(ILC Dover, Inc., 1998)
(Kappler Inc., 2001)
(Kimberly-Clark, 2002)
(LaCrosse-Rainfair, 1997)
(MAPA Professional, 2003)
(MAPA Professional, 2004)
(Mar-Mac Manufacturing, Inc, 1995)
(Marigold Industrial, 2003)
(Memphis Glove Company, 2001)
(Montgomery Safety Products, 1995)
(Nat-Wear, 2001)
(Neese Industries, Inc., 2003)
(North, 2002)
(North, 2002)
(Playtex, 1995)
(River City, 1995)
(Safety 4, 2002)
(Servus, 1995)
(Standard Safety Equipment, 1995)
(Tingley, 2002)
(Trelleborg-Viking, Inc., 2001)
(Trelleborg-Viking, Inc., 2002)
(Wells Lamont Industrial, 2002)
(Workrite, 1997)

-PHYSICAL HAZARDS

FIRE HAZARD

SUMMARY

POTENTIAL FIRE OR EXPLOSION HAZARDS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)
- HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
- Vapors may form explosive mixtures with air.
- Vapors may travel to source of ignition and flash back.
- Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks).
- Vapor explosion and poison hazard indoors, outdoors or in sewers.
- Those substances designated with a "P" may polymerize explosively when heated or involved in a fire.
- Runoff to sewer may create fire or explosion hazard.
- Containers may explode when heated.
- Many liquids are lighter than water.
Chloromethyl methyl ether is a flammable, reactive chemical that is a dangerous fire and explosion hazard when exposed to heat or flame. Fight fire from a protected location or from as far a distance as possible using dry chemical, alcohol foam, carbon dioxide, or water spray (AAR, 1996; (Lewis, 1996; NFPA, 1997; Sittig, 1991).

FLAMMABILITY CLASSIFICATION

NFPA Flammability Rating for CAS107-30-2 (NFPA, 2002):

Not Listed

FIRE CONTROL/EXTINGUISHING AGENTS

FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient.

SMALL FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Water spray, fog or alcohol-resistant foam.
Move containers from fire area if you can do it without risk.
Dike fire control water for later disposal; do not scatter the material.
Use water spray or fog; do not use straight streams.

TANK OR CAR/TRAILER LOAD FIRE PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
ALWAYS stay away from tanks engulfed in fire.
For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

NFPA Extinguishing Methods for CAS107-30-2 (NFPA, 2002):

Not Listed

Fire should not be extinguished unless flow of the liquid can be stopped. Fight fire from a protected location or from as far a distance as possible using dry chemical, alcohol foam, carbon dioxide, or water spray. Streams of water may not be effective, however water may be used in flooding quantities as fog. Cool affected containers using water spray to prevent explosion that can occur due to the heat of the fire. If a rising sound from a venting safety device or any discoloration of tanks due to the fire occur, immediately withdraw (AAR, 1996; (Lewis, 1996; NFPA, 1997; Sittig, 1991).

COMBUSTION TOXICITY

Toxic gases and irritants, including hydrogen chloride and phosgene gases, may be released following combustion (CHRIS , 1998; NFPA, 1997).

EXPLOSION HAZARD

A vapor trail of this compound can result in flashbacks (NFPA, 1997; Sittig, 1991).

Exposure to heat, flame, or sparks may result in explosive peroxides (Pohanish & Greene, 1997; Sittig, 1991).

Explosion may occur if chloromethyl methyl ether is ignited in an enclosed area (CHRIS , 1998).

This compound forms an explosive mixture with air (Pohanish & Greene, 1997).

DUST/VAPOR HAZARD

Toxic chloride fumes are emitted when this compound is heated to decomposition (Lewis, 1996).

A powerful tear gas may be formed by unburned chloromethyl methyl ether (CHRIS , 1998) Sittig, 1998).

An irritating formaldehyde gas may form when the compound is wet (CHRIS , 1998) Sittig, 1998).

Toxic gases and irritants, including hydrogen chloride and phosgene gases, may be released following combustion (CHRIS , 1998; NFPA, 1997).

REACTIVITY HAZARD

This compound reacts with water, producing hydrochloric acid, which is corrosive to metal, and formaldehyde (AAR, 1996; (NFPA, 1997) NIOSH, 1997; (Pohanish & Greene, 1997).

Polymerization can occur due to elevated temperature or upon contact with oxidizers, peroxides, or sunlight (NFPA, 1997).

Shock-sensitive peroxides may be produced upon prolonged exposure to air (NFPA, 1997).

EVACUATION PROCEDURES

SUMMARY

Initial Isolation and Protective Action Distances (ERG, 2004)

Data presented from the Emergency Response Guidebook Table of Initial Isolation and Protective Action Distances are for use when a spill has occurred and there is no fire. If there is a fire, or if a fire is involved, evacuation information presented under FIRE - PUBLIC SAFETY EVACUATION DISTANCES should be used.
Generally, a small spill is one that involves a single, small package such as a drum containing up to approximately 200 liters, a small cylinder, or a small leak from a large package. A large spill is one that involves a spill from a large package, or multiple spills from many small packages.
Suggested distances to protect from vapors of toxic-by-inhalation and/or water-reactive materials during the first 30 minutes following the spill.

DOT ID No. 1239 - Methyl chloromethyl ether

SMALL SPILLS

First isolate in all directions: 30 meters (100 feet).
Note wind direction.
Then protect persons downwind:

during the DAY for: 0.3 kilometers (0.2 miles); or
during the NIGHT for: 1 kilometers (0.6 miles).

LARGE SPILLS

First isolate in all directions: 270 meters (900 feet).
Note wind direction.
Then protect persons downwind:

during the DAY for: 2.5 kilometers (1.6 miles); or
during the NIGHT for: 5.6 kilometers (3.5 miles).

SPILL - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

Increase, in the downwind direction, as necessary, the isolation distance of at least 50 meters (150 feet) in all directions.

FIRE - PUBLIC SAFETY EVACUATION DISTANCES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)

If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

PUBLIC SAFETY MEASURES - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131(ERG, 2004)

CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number:

MEXICO:

SETIQ:

01-800-00-214-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5559-1588;
For calls originating elsewhere, call: 011-52-555-559-1588.

CENACOM:

01-800-00-413-00 in the Mexican Republic;
For calls originating in Mexico City and the Metropolitan Area: 5550-1496, 5550-1552, 5550-1485, or 5550-4885;
For calls originating elsewhere, call: 011-52-555-550-1496, or 011-52-555-550-1552; 011-52-555-550-1485, or 011-52-555-550-4885.

ARGENTINA:

CIQUIME:

0-800-222-2933 in the Republic of Argentina;
For calls originating elsewhere, call: +54-11-4613-1100.

BRAZIL:

PRÓ-QUÍMICA:

0-800-118270 (Toll-free in Brazil);
For calls originating elsewhere, call: +55-11-232-1144 (Collect calls are accepted).

COLUMBIA:

CISPROQUIM:

01-800-091-6012 in Colombia;
For calls originating in Bogotá, Colombia, call: 288-6012;
For calls originating elsewhere, call: 011-57-1-288-6012.

CANADA:

CANUTEC:

613-996-6666 (Collect calls are accepted);
*666 cellular (in Canada only).

UNITED STATES:

CHEMTREC®:

1-800-424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
703-527-3887 for calls originating elsewhere (Collect calls are accepted).

CHEM-TEL, INC.:

1-800-255-3924 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
813-248-0585 for calls originating elsewhere (Collect calls are accepted).

INFOTRAC:

1-800-535-5053 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
352-323-3500 for calls originating elsewhere (Collect calls are accepted).

3E COMPANY:

1-800-451-8346 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
760-602-8703 for calls originating elsewhere (Collect calls are accepted).

NATIONAL RESPONSE CENTER (NRC):

1-800-424-8802 - (24 hours) (Toll-free in the U.S., Canada, and the U.S. Virgin Islands);
202-267-2675 for calls in the District of Columbia.

MILITARY SHIPMENTS:

703-697-0218 - Explosives/ammunition incidents (Collect calls are accepted);
1-800-851-8061 - All other dangerous goods incidents.

NATIONWIDE POISON CONTROL CENTER (United States only):

1-800-222-1222 (Toll-free in the U.S.).

For additional details see the section entitled "WHO TO CALL FOR ASSISTANCE" under the ERG Instructions.
As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.
Keep unauthorized personnel away.
Stay upwind.
Keep out of low areas.
Ventilate closed spaces before entering.

Evacuation or isolation may be required. Consider evacuation of a 1/3rd mile radius if containers are exposed to direct flame or fire becomes uncontrollable. Keep upwind and avoid breathing vapors. Ventilate the area after all ignition sources have been removed. (AAR, 1996; (NFPA, 1997; Sittig, 1991).

AIHA ERPG Values for CAS107-30-2 (AIHA, 2006):

Listed as Chloromethyl Methyl Ether
ERPG-1 (units = ppm): Not appropriate
ERPG-2 (units = ppm): 1.0
ERPG-3 (units = ppm): 10
Under Ballot, Review, or Consideration: No
Definitions:

ERPG-1: The ERPG-1 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing more than mild, transient adverse health effects or perceiving a clearly defined objectionable odor.
ERPG-2: The ERPG-2 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing irreversible or other serious health effects or symptoms that could impair an individual's ability to take protective action.
ERPG-3: The ERPG-3 is the maximum airborne concentration below which it is believed nearly all individuals could be exposed for up to one hour without experiencing or developing life-threatening health effects.

DOE TEEL Values for CAS107-30-2 (U.S. Department of Energy, Office of Emergency Management, 2010):

Listed as Chloromethyl methyl ether
TEEL-0 (units = ppm): 0.02
TEEL-1 (units = ppm): 0.06
TEEL-2 (units = ppm): 0.47
TEEL-3 (units = ppm): 2
Definitions:

TEEL-0: The threshold concentration below which most people will experience no adverse health effects.
TEEL-1: The airborne concentration (expressed as ppm [parts per million] or mg/m(3) [milligrams per cubic meter]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. However, these effects are not disabling and are transient and reversible upon cessation of exposure.
TEEL-2: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting, adverse health effects or an impaired ability to escape.
TEEL-3: The airborne concentration (expressed as ppm or mg/m(3)) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death.

AEGL Values for CAS107-30-2 (National Research Council, 2010; National Research Council, 2009; National Research Council, 2008; National Research Council, 2007; NRC, 2001; NRC, 2002; NRC, 2003; NRC, 2004; NRC, 2004; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; United States Environmental Protection Agency Office of Pollution Prevention and Toxics, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2009; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2008; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2007; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2005; National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances, 2006; 62 FR 58840, 1997; 65 FR 14186, 2000; 65 FR 39264, 2000; 65 FR 77866, 2000; 66 FR 21940, 2001; 67 FR 7164, 2002; 68 FR 42710, 2003; 69 FR 54144, 2004):

Listed as: Chloromethyl methyl ether (CMME)
Proposed Value:

AEGL-1

10 min exposure:

ppm:
mg/m3:

30 min exposure:

ppm:
mg/m3:

1 hr exposure:

ppm:
mg/m3:

4 hr exposure:

ppm:
mg/m3:

8 hr exposure:

ppm:
mg/m3:

Definitions:

AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling, are transient, and are reversible upon cessation of exposure.

Listed as: Chloromethyl methyl ether (CMME)
Proposed Value:

AEGL-2

10 min exposure:

ppm: 0.076 ppm
mg/m3: 0.25 mg/m(3)

30 min exposure:

ppm: 0.076 ppm
mg/m3: 0.25 mg/m(3)

1 hr exposure:

ppm: 0.061 ppm
mg/m3: 0.2 mg/m(3)

4 hr exposure:

ppm: 0.038 ppm
mg/m3: 0.13 mg/m(3)

8 hr exposure:

ppm: 0.025 ppm
mg/m3: 0.082 mg/m(3)

Definitions:

AEGL-2 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape.

Listed as: Chloromethyl methyl ether (CMME)
Proposed Value:

AEGL-3

10 min exposure:

ppm: 1.2 ppm
mg/m3: 3.9 mg/m(3)

30 min exposure:

ppm: 1.2 ppm
mg/m3: 3.9 mg/m(3)

1 hr exposure:

ppm: 0.94 ppm
mg/m3: 3.1 mg/m(3)

4 hr exposure:

ppm: 0.59 ppm
mg/m3: 2 mg/m(3)

8 hr exposure:

ppm: 0.43 ppm
mg/m3: 1.4 mg/m(3)

Definitions:

AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening health effects or death.

NIOSH IDLH Values for CAS107-30-2 (National Institute for Occupational Safety and Health, 2007):

Not Listed

CONTAINMENT/WASTE TREATMENT OPTIONS

SUMMARY

SPILL OR LEAK PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)
- Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire.
- ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
- All equipment used when handling the product must be grounded.
- Do not touch or walk through spilled material.
- Stop leak if you can do it without risk.
- Prevent entry into waterways, sewers, basements or confined areas.
- A vapor suppressing foam may be used to reduce vapors.
RECOMMENDED PROTECTIVE CLOTHING - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)
- Wear positive pressure self-contained breathing apparatus (SCBA).
- Wear chemical protective that is specifically recommended by the manufacturer. It may provide little or no thermal protection.
- Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
Only persons wearing protective clothing, including boots, gloves, goggles, and a positive pressure self-contained breathing apparatus should be allowed in the contaminated area (AAR, 1996; (NFPA, 1997; Sittig, 1991).
If it is not a hazard to personnel, attempt to stop or control any leaks and prevent the compound from entering water supplies. If necessary, build dikes to contain the flow of the liquid (AAR, 1996; (NFPA, 1997; Sittig, 1991).
Reduce vapors and dilute liquid spill using water spray. Rinse the material with sodium bicarbonate or lime solution. The liquid should be absorbed in a non-combustible material and placed into containers for disposal (NFPA, 1997; Sittig, 1991).

SMALL LEAK/SPILL

SMALL SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)
- Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal.
- Use clean non-sparking tools to collect absorbed material.

LARGE LEAK/SPILL

LARGE SPILL PRECAUTIONS - EMERGENCY RESPONSE GUIDEBOOK, GUIDE 131 (ERG, 2004)
- Dike far ahead of liquid spill for later disposal.
- Water spray may reduce vapor; but may not prevent ignition in closed spaces.

WASTE TREATMENT OPTIONS

PHYSICAL TREATMENT

Mix chloromethyl methyl ether with another combustible fuel for incineration and make sure combustion is complete to prevent phosgene formation. This process produces halo acids that require an acid scrubber for removal (Sittig, 1991).
Waste management activities associated with material disposition are unique to individual situations. Proper waste characterization and decisions regarding waste management should be coordinated with the appropriate local, state, or federal authorities to ensure compliance with all applicable rules and regulations.

-ENVIRONMENTAL HAZARD MANAGEMENT

POLLUTION HAZARD

Chloromethyl methyl ether does not occur in nature, but may be released to the environment in exhaust gases from its use as a chemical intermediate. It should not exist in wastewater from chemical manufacturing plants due to instantaneous hydrolysis in water (HSDB , 1998).

ENVIRONMENTAL FATE AND KINETICS

This compound hydrolyzes in humid air with a half-life of 3.5 minutes to 6.5 hours. The estimated half-life for the reaction of chloromethyl methyl ether with photochemically produced hydroxyl radicals is 5.7 days (HSDB , 1998).
Howard et al (1991) lists an estimated photooxidation half-life in air of 22.7 hours to 9.5 days.

WATER

SURFACE WATER
- It hydrolyzes instantaneously in water, producing formaldehyde, hydrogen chloride, and methanol. The half-life in pure water is <1 second (HSDB , 1998).
- The half-life for both surface water and ground water may range from 39 seconds to 1.98 minutes (Howard et al, 1991).

SOIL

TERRESTRIAL
- Chloromethyl methyl ether is expected to disappear quickly from moist soil, based on its rapid hydrolysis (HSDB , 1998).
- The estimated half-life in soil ranges from 39 seconds to 1.98 minutes (Howard et al, 1991).

ABIOTIC DEGRADATION

The hydrolysis half-life of chloromethyl methyl ether in pure water is <1 second; in humid air it ranges from 3.5 minutes to 6.5 hours for a surface catalyzed reaction. The reaction produces formaldehyde, hydrogen chloride, and methanol. This compound is also expected to react with photochemically produced hydroxyl radicals, with an estimated half-life of 5.7 days (HSDB , 1998).

BIODEGRADATION

The estimated aerobic half-life in an unacclimated aqueous environment ranges from 1-4 weeks (Howard et al, 1991).

The estimated anaerobic half-life in an unacclimated aqueous environment ranges from 4-16 weeks (Howard et al, 1991).

ENVIRONMENTAL TOXICITY

Chloromethyl methyl ether will not bioaccumulate in the food chain due to the extremely short hydrolysis half-life (HSDB , 1998).

-PHYSICAL/CHEMICAL PROPERTIES

MOLECULAR WEIGHT

80.51

DESCRIPTION/PHYSICAL STATE

Chloromethyl methyl ether is a colorless liquid that emits an irritating odor (Budavari, 1996) Hathaway, 1996; (NFPA, 1997; NIOSH , 1998).

VAPOR PRESSURE

192 mmHg (at 70 degrees F) (NIOSH , 1998)

SPECIFIC GRAVITY

OTHER TEMPERATURE AND/OR PRESSURE

1.06 (at 20/4 degrees C) (NIOSH , 1998)
1.0605 (at 20/4 degrees C) (Budavari, 1996)
1.070 (at 20/4 degrees C) (ACGIH, 1991)
1.074 (at 20/4 degrees C) (Clayton & Clayton, 1993)
1.0625 (at 10/4 degrees C) (Lewis, 1997)

TEMPERATURE AND/OR PRESSURE NOT LISTED

1.06 (NFPA, 1997)

DENSITY

NORMAL TEMPERATURE AND PRESSURE

(25 degrees C; 77 degrees F and 760 mmHg)
1.07 kg/L (at 25 degrees C) (CHRIS , 1998)

OTHER TEMPERATURE AND/OR PRESSURE

1.06 kg/L (at 20 degrees C) (Ashford, 1994)

FREEZING/MELTING POINT

FREEZING POINT

-154 degrees F (NIOSH , 1998)
-103.5 degrees C; -154.3 degrees F; 169.7 degrees K (CHRIS , 1998)

MELTING POINT

-103.5 degrees C (ACGIH, 1991; Clayton & Clayton, 1993)
-103 degrees C; -154 degrees F (NFPA, 1997; Ashford, 1994)

BOILING POINT

59 degrees C; 138 degrees F (Budavari, 1996; NFPA, 1997; NIOSH , 1998)

59.5 degrees C (at 760 mmHg) (ACGIH, 1991; Lewis, 1996)

60 degrees C; 140 degrees F; 333 degrees K (CHRIS , 1998)

FLASH POINT

32 degrees F (open cup) (NIOSH , 1998)

<73.4 degrees F (Lewis, 1996)

15 degrees C; 60 degrees F (NFPA, 1997)

-103.5 degrees C (Lewis, 1997)

-4 degrees F (AAR, 1996)

0 degrees F (open cup) (CHRIS , 1998)

-17.8 degrees C; 0 degrees F (Pohanish & Greene, 1997)

EXPLOSIVE LIMITS

LOWER

Unknown (NIOSH , 1998)

UPPER

Unknown (NIOSH , 1998)

SOLUBILITY

IN WATER

This compound decomposes in water (AAR, 1996; (Lewis, 1997; NFPA, 1997).

IN ORGANIC SOLVENTS

Chloromethyl methyl ether is soluble in alcohol, ether, acetone, chloroform, and other organic solvents (HSDB , 1998; Lewis, 1997).
It decomposes in hot alcohol (ACGIH, 1991; Clayton & Clayton, 1993).
This compound is soluble in oxygenated solvents (Ashford, 1994).

SPECTRAL CONSTANTS

6991 (Coblentz Society Spectral Collection) (HSDB , 1998)
2:115H (Aldrich Library of Infrared Spectra, Aldrich Chemical Co, Milwaukee, WI) (HSDB , 1998)

MASS

105 (Atlas of Mass Spectral Data, John Wiley & Sons, New York) (HSDB , 1998)
28 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63) (HSDB , 1998)

OTHER/PHYSICAL

SURFACE TENSION

30 dynes/cm; 0.030 N/m (at 20 degrees C) (estimated) (CHRIS , 1998)

HEAT OF COMBUSTION

-7300 Btu/lb; -4100 cal/g; -170x10(5) J/kg (estimated) (CHRIS , 1998)

INDEX OF REFRACTION

1.39737 (Budavari, 1996)
1.3974 (at 20 degrees C/D) (HSDB , 1998)

IONIZATION POTENTIAL

10.25 eV (NIOSH , 1998)

NUCLEAR MAGNETIC RESONANCE

9193 (Sadtler Research Laboratories Spectral Collection) (HSDB , 1998)
1:133B (Aldrich Library of Mass Spectra, Aldrich Chemical Co, Milwaukee, WI) (HSDB , 1998)

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CHLOROMETHYL METHYL ETHER

Classification | Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents

Information to evaluate chemical incidents