A) MANAGEMENT OF MILD TO MODERATE TOXICITY
1) Treatment consists of predominantly symptomatic and supportive care. Patients who develop significant nausea and vomiting may benefit from IV fluid hydration. There is no specific antidote to Lycoperdon toxicity.
B) MANAGEMENT OF SEVERE TOXICITY
1) Patients who develop severe toxicity with fever and respiratory symptoms or pneumonitis may require supplemental oxygen, and rarely intubation. Corticosteroids have been used to treat pneumonitis, and antifungals such as amphotericin B or azole medications have been used to treat complicated cases, but efficacy is not clear.
C) DECONTAMINATION
1) PREHOSPITAL: No specific gastric decontamination is required. Patients with inhalational exposure to spores should be removed to fresh air. If Lycoperdon spores contact the eyes, immediately rinse the eyes with copious amounts of water, occasionally lifting the lower and upper lids.
2) HOSPITAL: No specific gastric decontamination is required.
D) AIRWAY MANAGEMENT
1) Rarely, patients with signs and symptoms of hypoxic respiratory failure may need intubation for respiratory support.
E) ANTIDOTE
1) None
F) ENHANCED ELIMINATION PROCEDURE
1) There is no specific role for hemodialysis or other enhanced elimination procedures.
G) PATIENT DISPOSITION
1) HOME CRITERIA: Asymptomatic patients, or patients with mild gastrointestinal upset after ingestion or mild respiratory irritation after inhalation can be managed at home.
2) OBSERVATION CRITERIA: Patients with known exposure to these mushrooms, who have fever, respiratory symptoms, or significant nausea or vomiting should be evaluated at a healthcare facility.
3) ADMISSION CRITERIA: Patients with significant dehydration, fever, or respiratory symptoms should be admitted for hydration, supplemental oxygen as needed, and monitoring. Patients with severe respiratory symptoms or respiratory failure should be admitted to an ICU setting.
4) CONSULT CRITERIA: Contact your local poison center or a medical toxicologist for patients with significant symptoms, those in whom the diagnosis is in doubt, and for assistance with mushroom identification. A mycologist (may be available through your poison center, botanic garden, or local mycology society) can assist with mushroom identification.
H) PITFALLS
1) Ingestion rarely causes significant toxicity; do not overtreat. Manifestations of pulmonary toxicity may be delayed. Patients who are discharged should be given careful follow-up instructions.
I) PREDISPOSING CONDITIONS
1) Patients with underlying asthma or COPD may develop more severe pulmonary reactions after inhalation.
J) DIFFERENTIAL DIAGNOSIS
1) Bacterial pneumonia, atypical pneumonia, viral pneumonitis, chemical pneumonitis, fungal pulmonary infection, reactive airways disease, acute lung injury/acute respiratory disease syndrome (ALI/ARDS).